Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Biology, University of Maryland, College Park, MarylandB.S., Biochemistry, University of Nairobi, Nairobi, Kenya
Publications
Hansen ME, Hunt SC, Stone RC, Horvath K, Herbig U, Ranciaro A, Hirbo J, Beggs W, Reiner AP, Wilson JG, Kimura M, De Vivo I, Chen MM, Kark JD, Levy D, Nyambo T, Tishkoff SA, Aviv A. Shorter telomere length in Europeans than in Africans due to polygenetic adaptation. Hum. Mol. Genet [print-electronic]. 2016 Jun 6/1/2016; 25(11): 2324-30. PMID: 26936823, PMCID: PMC5081046, PII: ddw070, DOI: 10.1093/hmg/ddw070, ISSN: 1460-2083.
Kim M, Cooper BA, Venkat R, Phillips JB, Eidem HR, Hirbo J, Nutakki S, Williams SM, Muglia LJ, Capra JA, Petren K, Abbot P, Rokas A, McGary KL. GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes. Nucleic Acids Res [print-electronic]. 2016 Jan 1/4/2016; 44(D1): D908-16. PMID: 26567549, PMCID: PMC4702823, PII: gkv1137, DOI: 10.1093/nar/gkv1137, ISSN: 1362-4962.
Hirbo J, Eidem H, Rokas A, Abbot P. Integrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy Phenotypes. PLoS ONE. 2015; 10(12): e0144155. PMID: 26641094, PMCID: PMC4671692, PII: PONE-D-15-37377, DOI: 10.1371/journal.pone.0144155, ISSN: 1932-6203.
Campbell MC, Hirbo JB, Townsend JP, Tishkoff SA. The peopling of the African continent and the diaspora into the new world. Curr. Opin. Genet. Dev. 2014 Dec; 29: 120-32. PMID: 25461616, PMCID: PMC4308437, PII: S0959-437X(14)00098-7, DOI: 10.1016/j.gde.2014.09.003, ISSN: 1879-0380.
Gomez F, Hirbo J, Tishkoff SA. Genetic variation and adaptation in Africa: implications for human evolution and disease. Cold Spring Harb Perspect Biol. 2014 Jul 7/1/2014; 6(7): a008524. PMID: 24984772, PMCID: PMC4067985, PII: 6/7/a008524, DOI: 10.1101/cshperspect.a008524, ISSN: 1943-0264.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA. Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa. J. Hum. Genet [print-electronic]. 2014 Jun; 59(6): 349-52. PMID: 24785689, PMCID: PMC4075171, PII: jhg201429, DOI: 10.1038/jhg.2014.29, ISSN: 1435-232X.
Ranciaro A, Campbell MC, Hirbo JB, Ko WY, Froment A, Anagnostou P, Kotze MJ, Ibrahim M, Nyambo T, Omar SA, Tishkoff SA. Genetic origins of lactase persistence and the spread of pastoralism in Africa. Am. J. Hum. Genet [print-electronic]. 2014 Apr 4/3/2014; 94(4): 496-510. PMID: 24630847, PMCID: PMC3980415, PII: S0002-9297(14)00067-6, DOI: 10.1016/j.ajhg.2014.02.009, ISSN: 1537-6605.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA. Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa. Mol. Biol. Evol [print-electronic]. 2014 Feb; 31(2): 288-302. PMID: 24177185, PMCID: PMC3907056, PII: mst211, DOI: 10.1093/molbev/mst211, ISSN: 1537-1719.
Elhassan N, Gebremeskel EI, Elnour MA, Isabirye D, Okello J, Hussien A, Kwiatksowski D, Hirbo J, Tishkoff S, Ibrahim ME. The episode of genetic drift defining the migration of humans out of Africa is derived from a large east African population size. PLoS ONE. 2014; 9(5): e97674. PMID: 24845801, PMCID: PMC4028218, PII: PONE-D-13-19054, DOI: 10.1371/journal.pone.0097674, ISSN: 1932-6203.
Gomez F, Tomas G, Ko WY, Ranciaro A, Froment A, Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Hirbo JB, Rocha J, Tishkoff SA. Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure. Hum. Genet [print-electronic]. 2013 Sep; 132(9): 987-99. PMID: 23609612, PMCID: PMC3916218, DOI: 10.1007/s00439-013-1284-5, ISSN: 1432-1203.
Ko WY, Rajan P, Gomez F, Scheinfeldt L, An P, Winkler CA, Froment A, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA. Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations. Am. J. Hum. Genet [print-electronic]. 2013 Jul 7/11/2013; 93(1): 54-66. PMID: 23768513, PMCID: PMC3710747, PII: S0002-9297(13)00227-9, DOI: 10.1016/j.ajhg.2013.05.014, ISSN: 1537-6605.
Campbell MC, Ranciaro A, Froment A, Hirbo J, Omar S, Bodo JM, Nyambo T, Lema G, Zinshteyn D, Drayna D, Breslin PA, Tishkoff SA. Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa. Mol. Biol. Evol [print-electronic]. 2012 Apr; 29(4): 1141-53. PMID: 22130969, PMCID: PMC3341826, PII: msr293, DOI: 10.1093/molbev/msr293, ISSN: 1537-1719.
Ko WY, Kaercher KA, Giombini E, Marcatili P, Froment A, Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA. Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations. Am. J. Hum. Genet. 2011 Jun 6/10/2011; 88(6): 741-54. PMID: 21664997, PMCID: PMC3113242, PII: S0002-9297(11)00196-0, DOI: 10.1016/j.ajhg.2011.05.005, ISSN: 1537-6605.
Tishkoff SA, Reed FA, Friedlaender FR, Ehret C, Ranciaro A, Froment A, Hirbo JB, Awomoyi AA, Bodo JM, Doumbo O, Ibrahim M, Juma AT, Kotze MJ, Lema G, Moore JH, Mortensen H, Nyambo TB, Omar SA, Powell K, Pretorius GS, Smith MW, Thera MA, Wambebe C, Weber JL, Williams SM. The genetic structure and history of Africans and African Americans. Science [print-electronic]. 2009 May 5/22/2009; 324(5930): 1035-44. PMID: 19407144, PMCID: PMC2947357, PII: 1172257, DOI: 10.1126/science.1172257, ISSN: 1095-9203.
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P. Convergent adaptation of human lactase persistence in Africa and Europe. Nat. Genet [print-electronic]. 2007 Jan; 39(1): 31-40. PMID: 17159977, PMCID: PMC2672153, PII: ng1946, DOI: 10.1038/ng1946, ISSN: 1061-4036.
Kim M, Cooper BA, Venkat R, Phillips JB, Eidem HR, Hirbo J, Nutakki S, Williams SM, Muglia LJ, Capra JA, Petren K, Abbot P, Rokas A, McGary KL. GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes. Nucleic Acids Res [print-electronic]. 2016 Jan 1/4/2016; 44(D1): D908-16. PMID: 26567549, PMCID: PMC4702823, PII: gkv1137, DOI: 10.1093/nar/gkv1137, ISSN: 1362-4962.
Hirbo J, Eidem H, Rokas A, Abbot P. Integrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy Phenotypes. PLoS ONE. 2015; 10(12): e0144155. PMID: 26641094, PMCID: PMC4671692, PII: PONE-D-15-37377, DOI: 10.1371/journal.pone.0144155, ISSN: 1932-6203.
Campbell MC, Hirbo JB, Townsend JP, Tishkoff SA. The peopling of the African continent and the diaspora into the new world. Curr. Opin. Genet. Dev. 2014 Dec; 29: 120-32. PMID: 25461616, PMCID: PMC4308437, PII: S0959-437X(14)00098-7, DOI: 10.1016/j.gde.2014.09.003, ISSN: 1879-0380.
Gomez F, Hirbo J, Tishkoff SA. Genetic variation and adaptation in Africa: implications for human evolution and disease. Cold Spring Harb Perspect Biol. 2014 Jul 7/1/2014; 6(7): a008524. PMID: 24984772, PMCID: PMC4067985, PII: 6/7/a008524, DOI: 10.1101/cshperspect.a008524, ISSN: 1943-0264.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA. Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa. J. Hum. Genet [print-electronic]. 2014 Jun; 59(6): 349-52. PMID: 24785689, PMCID: PMC4075171, PII: jhg201429, DOI: 10.1038/jhg.2014.29, ISSN: 1435-232X.
Ranciaro A, Campbell MC, Hirbo JB, Ko WY, Froment A, Anagnostou P, Kotze MJ, Ibrahim M, Nyambo T, Omar SA, Tishkoff SA. Genetic origins of lactase persistence and the spread of pastoralism in Africa. Am. J. Hum. Genet [print-electronic]. 2014 Apr 4/3/2014; 94(4): 496-510. PMID: 24630847, PMCID: PMC3980415, PII: S0002-9297(14)00067-6, DOI: 10.1016/j.ajhg.2014.02.009, ISSN: 1537-6605.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA. Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa. Mol. Biol. Evol [print-electronic]. 2014 Feb; 31(2): 288-302. PMID: 24177185, PMCID: PMC3907056, PII: mst211, DOI: 10.1093/molbev/mst211, ISSN: 1537-1719.
Elhassan N, Gebremeskel EI, Elnour MA, Isabirye D, Okello J, Hussien A, Kwiatksowski D, Hirbo J, Tishkoff S, Ibrahim ME. The episode of genetic drift defining the migration of humans out of Africa is derived from a large east African population size. PLoS ONE. 2014; 9(5): e97674. PMID: 24845801, PMCID: PMC4028218, PII: PONE-D-13-19054, DOI: 10.1371/journal.pone.0097674, ISSN: 1932-6203.
Gomez F, Tomas G, Ko WY, Ranciaro A, Froment A, Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Hirbo JB, Rocha J, Tishkoff SA. Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure. Hum. Genet [print-electronic]. 2013 Sep; 132(9): 987-99. PMID: 23609612, PMCID: PMC3916218, DOI: 10.1007/s00439-013-1284-5, ISSN: 1432-1203.
Ko WY, Rajan P, Gomez F, Scheinfeldt L, An P, Winkler CA, Froment A, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA. Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations. Am. J. Hum. Genet [print-electronic]. 2013 Jul 7/11/2013; 93(1): 54-66. PMID: 23768513, PMCID: PMC3710747, PII: S0002-9297(13)00227-9, DOI: 10.1016/j.ajhg.2013.05.014, ISSN: 1537-6605.
Campbell MC, Ranciaro A, Froment A, Hirbo J, Omar S, Bodo JM, Nyambo T, Lema G, Zinshteyn D, Drayna D, Breslin PA, Tishkoff SA. Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa. Mol. Biol. Evol [print-electronic]. 2012 Apr; 29(4): 1141-53. PMID: 22130969, PMCID: PMC3341826, PII: msr293, DOI: 10.1093/molbev/msr293, ISSN: 1537-1719.
Ko WY, Kaercher KA, Giombini E, Marcatili P, Froment A, Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA. Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations. Am. J. Hum. Genet. 2011 Jun 6/10/2011; 88(6): 741-54. PMID: 21664997, PMCID: PMC3113242, PII: S0002-9297(11)00196-0, DOI: 10.1016/j.ajhg.2011.05.005, ISSN: 1537-6605.
Tishkoff SA, Reed FA, Friedlaender FR, Ehret C, Ranciaro A, Froment A, Hirbo JB, Awomoyi AA, Bodo JM, Doumbo O, Ibrahim M, Juma AT, Kotze MJ, Lema G, Moore JH, Mortensen H, Nyambo TB, Omar SA, Powell K, Pretorius GS, Smith MW, Thera MA, Wambebe C, Weber JL, Williams SM. The genetic structure and history of Africans and African Americans. Science [print-electronic]. 2009 May 5/22/2009; 324(5930): 1035-44. PMID: 19407144, PMCID: PMC2947357, PII: 1172257, DOI: 10.1126/science.1172257, ISSN: 1095-9203.
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P. Convergent adaptation of human lactase persistence in Africa and Europe. Nat. Genet [print-electronic]. 2007 Jan; 39(1): 31-40. PMID: 17159977, PMCID: PMC2672153, PII: ng1946, DOI: 10.1038/ng1946, ISSN: 1061-4036.