Timothy James Hohman, Ph.D.

Assistant Professor

timothy.j.hohman@vanderbilt.edu
Faculty Appointments
Assistant Professor of Neurology Assistant Professor of Pharmacology
Education
Ph.D., Cognitive Neuroscience, American University, Washington, District of ColumbiaM.A., Psychology, American University, Washington, District of ColumbiaB.A., Psychology, Gordon College, Wenham, Massachusetts
Office Address
The Center for Human Genetics Research
511B Light Hall
Nashville, TN 37203
Research Description
Dr. Timothy Hohman is an Assistant Professor of Neurology and a cognitive neuroscientist. As a core faculty member of the Vanderbilt Memory & Alzheimer's Center (VMAC), Dr. Hohman’s research leverages advanced computational approaches from genomics, proteomics, and neuroscience to identify novel markers of Alzheimer’s disease (AD) risk and resilience. His interdisciplinary collaborations with the Alzheimer’s Disease Genetics Consortium and other AD work groups seek to develop new directions in research by emphasizing the biology of resilience and highlighting complex genotype-phenotype interactions.

Within the VMAC, Dr. Hohman oversees the extensive computational resources of the center and provides key support in the development of neuroimaging, proteomic, and big-data analytical pipelines. Additionally, Dr. Hohman acts as the center’s primary liaison in efforts to leverage publicly available data sources to answer novel research questions.
Research Keywords
Alzheimer's Disease, Neuroimaging, Genetics, Proteomics, Biomarkers, Big Data
Publications
Osborn KE, Liu D, Samuels LR, Moore EE, Cambronero FE, Acosta LMY, Bell SP, Babicz MA, Gordon EA, Pechman KR, Davis LT, Gifford KA, Hohman TJ, Blennow K, Zetterberg H, Jefferson AL. Cerebrospinal fluid ß-amyloid42 and neurofilament light relate to white matter hyperintensities. Neurobiol. Aging [print-electronic]. 2018 Aug; 68: 18-25. PMID: 29702372, PII: S0197-4580(18)30117-9, DOI: 10.1016/j.neurobiolaging.2018.03.028, ISSN: 1558-1497.

Jefferson AL, Cambronero FE, Liu D, Moore EE, Neal JE, Terry JG, Nair S, Pechman KR, Rane S, Davis LT, Gifford KA, Hohman TJ, Bell SP, Wang TJ, Beckman JA, Carr JJ. Higher Aortic Stiffness is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults. Circulation [print-electronic]. 2018 Jul 7/17/2018; PMID: 30018169, PII: CIRCULATIONAHA.118.032410, DOI: 10.1161/CIRCULATIONAHA.118.032410, ISSN: 1524-4539.

Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, , , Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol [print-electronic]. 2018 Jul 7/2/2018; PMID: 29967939, PII: 10.1007/s00401-018-1881-4, DOI: 10.1007/s00401-018-1881-4, ISSN: 1432-0533.

Cambronero FE, Liu D, Neal JE, Moore EE, Gifford KA, Terry JG, Nair S, Pechman KR, Osborn KE, Hohman TJ, Bell SP, Sweatt JD, Wang TJ, Beckman JA, Carr JJ, Jefferson AL. APOE genotype modifies the association between central arterial stiffening and cognition in older adults. Neurobiol. Aging [print-electronic]. 2018 Jul; 67: 120-7. PMID: 29656011, PMCID: PMC5985659, PII: S0197-4580(18)30051-4, DOI: 10.1016/j.neurobiolaging.2018.02.009, ISSN: 1558-1497.

Moore EE, Hohman TJ, Badami FS, Pechman KR, Osborn KE, Acosta LMY, Bell SP, Babicz MA, Gifford KA, Anderson AW, Goldstein LE, Blennow K, Zetterberg H, Jefferson AL. Neurofilament relates to white matter microstructure in older adults. Neurobiol. Aging [print-electronic]. 2018 Jun 6/28/2018; 70: 233-41. PMID: 30036759, PII: S0197-4580(18)30228-8, DOI: 10.1016/j.neurobiolaging.2018.06.023, ISSN: 1558-1497.

Moore EE, Liu D, Pechman KR, Terry JG, Nair S, Cambronero FE, Bell SP, Gifford KA, Anderson AW, Hohman TJ, Carr JJ, Jefferson AL. Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults. J Am Heart Assoc. 2018 Jun 6/26/2018; 7(13): PMID: 29945917, PII: JAHA.118.009041, DOI: 10.1161/JAHA.118.009041, ISSN: 2047-9980.

Hohman TJ, Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Bennett DA, Schneider JA, Jefferson AL, . Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol [print-electronic]. 2018 May 5/7/2018; PMID: 29801024, PII: 2679880, DOI: 10.1001/jamaneurol.2018.0821, ISSN: 2168-6157.

Gifford KA, Liu D, Neal JE, Acosta LMY, Bell SP, Wiggins ME, Wisniewski KM, Godfrey M, Logan LA, Hohman TJ, Pechman KR, Libon DJ, Blennow K, Zetterberg H, Jefferson AL. Validity and Normative Data for the Biber Figure Learning Test: A Visual Supraspan Memory Measure. Assessment [print-electronic]. 2018 May 5/1/2018; 1073191118773870. PMID: 29809069, DOI: 10.1177/1073191118773870, ISSN: 1552-3489.

Kresge HA, Khan OA, Wagener MA, Liu D, Terry JG, Nair S, Cambronero FE, Gifford KA, Osborn KE, Hohman TJ, Pechman KR, Bell SP, Wang TJ, Carr JJ, Jefferson AL. Subclinical Compromise in Cardiac Strain Relates to Lower Cognitive Performances in Older Adults. J Am Heart Assoc. 2018 Feb 2/13/2018; 7(4): PMID: 29440034, PMCID: PMC5850190, PII: JAHA.117.007562, DOI: 10.1161/JAHA.117.007562, ISSN: 2047-9980.

Emrani S, Libon DJ, Lamar M, Price CC, Jefferson AL, Gifford KA, Hohman TJ, Nation DA, Delano-Wood L, Jak A, Bangen KJ, Bondi MW, Brickman AM, Manly J, Swenson R, Au R, . Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall. J. Alzheimers Dis. 2018; 61(3): 917-28. PMID: 29254087, PMCID: PMC5901759, PII: JAD170555, DOI: 10.3233/JAD-170555, ISSN: 1875-8908.

Jefferson AL, Liu D, Gupta DK, Pechman KR, Watchmaker JM, Gordon EA, Rane S, Bell SP, Mendes LA, Davis LT, Gifford KA, Hohman TJ, Wang TJ, Donahue MJ. Lower cardiac index levels relate to lower cerebral blood flow in older adults. Neurology [print-electronic]. 2017 Dec 12/5/2017; 89(23): 2327-34. PMID: 29117962, PMCID: PMC5719926, PII: WNL.0000000000004707, DOI: 10.1212/WNL.0000000000004707, ISSN: 1526-632X.

Hohman TJ, Tommet D, Marks S, Contreras J, Jones R, Mungas D, . Evaluating Alzheimer's disease biomarkers as mediators of age-related cognitive decline. Neurobiol. Aging [print-electronic]. 2017 Jul 7/4/2017; 58: 120-8. PMID: 28732249, PII: S0197-4580(17)30218-X, DOI: 10.1016/j.neurobiolaging.2017.06.022, ISSN: 1558-1497.

Beason-Held LL, Hohman TJ, Venkatraman V, An Y, Resnick SM. Brain network changes and memory decline in aging. Brain Imaging Behav. 2017 Jun; 11(3): 859-73. PMID: 27319002, PMCID: PMC5164979, PII: 10.1007/s11682-016-9560-3, DOI: 10.1007/s11682-016-9560-3, ISSN: 1931-7565.

Hohman TJ, Dumitrescu L, Cox NJ, Jefferson AL, . Genetic resilience to amyloid related cognitive decline. Brain Imaging Behav. 2017 Apr; 11(2): 401-9. PMID: 27743375, PMCID: PMC5392179, PII: 10.1007/s11682-016-9615-5, DOI: 10.1007/s11682-016-9615-5, ISSN: 1931-7565.

Koran MEI, Wagener M, Hohman TJ, . Sex differences in the association between AD biomarkers and cognitive decline. Brain Imaging Behav. 2017 Feb; 11(1): 205-13. PMID: 26843008, PMCID: PMC4972701, PII: 10.1007/s11682-016-9523-8, DOI: 10.1007/s11682-016-9523-8, ISSN: 1931-7565.

Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M. Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Mol. Psychiatry [print-electronic]. 2017 Jan; 22(1): 13-23. PMID: 27872486, PII: mp2016206, DOI: 10.1038/mp.2016.206, ISSN: 1476-5578.

Hohman TJ, Dumitrescu L, Oksol A, Wagener M, Gifford KA, Jefferson AL, . APOE allele frequencies in suspected non-amyloid pathophysiology (SNAP) and the prodromal stages of Alzheimer's Disease. PLoS ONE. 2017; 12(11): e0188501. PMID: 29190651, PMCID: PMC5708777, PII: PONE-D-17-26261, DOI: 10.1371/journal.pone.0188501, ISSN: 1932-6203.

Bell SP, Liu D, Samuels LR, Shah AS, Gifford KA, Hohman TJ, Jefferson AL. Late-Life Body Mass Index, Rapid Weight Loss, Apolipoprotein E e4 and the Risk of Cognitive Decline and Incident Dementia. J Nutr Health Aging. 2017; 21(10): 1259-67. PMID: 29188888, PMCID: PMC5736008, DOI: 10.1007/s12603-017-0906-3, ISSN: 1760-4788.

Hohman TJ, McLaren DG, Mormino EC, Gifford KA, Libon DJ, Jefferson AL, . Asymptomatic Alzheimer disease: Defining resilience. Neurology [print-electronic]. 2016 Dec 12/6/2016; 87(23): 2443-50. PMID: 27815399, PMCID: PMC5177674, PII: WNL.0000000000003397, DOI: 10.1212/WNL.0000000000003397, ISSN: 1526-632X.

Lane EM, Hohman TJ, Jefferson AL, . Insulin-like growth factor binding protein-2 interactions with Alzheimer's disease biomarkers. Brain Imaging Behav [print-electronic]. 2016 Nov 11/5/2016; PMID: 27817134, PMCID: PMC5419882, PII: 10.1007/s11682-016-9636-0, DOI: 10.1007/s11682-016-9636-0, ISSN: 1931-7565.

Jefferson AL, Gifford KA, Acosta LM, Bell SP, Donahue MJ, Davis LT, Gottlieb J, Gupta DK, Hohman TJ, Lane EM, Libon DJ, Mendes LA, Niswender K, Pechman KR, Rane S, Ruberg FL, Su YR, Zetterberg H, Liu D. The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview. J. Alzheimers Dis. 2016 Mar 3/8/2016; 52(2): 539-59. PMID: 26967211, PMCID: PMC4866875, PII: JAD150914, DOI: 10.3233/JAD-150914, ISSN: 1875-8908.

Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hardy J, Hendrie HC, Hall KS, Goate AM, Lang R, Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD, Mayeux R, Haines JL, Thornton-Wells TA, . Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement [print-electronic]. 2016 Mar; 12(3): 233-43. PMID: 26092349, PMCID: PMC4681680, PII: S1552-5260(15)00190-9, DOI: 10.1016/j.jalz.2015.02.012, ISSN: 1552-5279.

Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, . Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol. Aging [print-electronic]. 2016 Feb; 38: 141-50. PMID: 26827652, PMCID: PMC4735733, PII: S0197-4580(15)00543-6, DOI: 10.1016/j.neurobiolaging.2015.10.031, ISSN: 1558-1497.

Hohman TJ, Chibnik L, Bush WS, Jefferson AL, De Jaeger PL, Thornton-Wells TA, Bennett DA, Schneider JA. GSK3ß Interactions with Amyloid Genes: An Autopsy Verification and Extension. Neurotox Res [print-electronic]. 2015 Oct; 28(3): 232-8. PMID: 26194614, PMCID: PMC4625986, DOI: 10.1007/s12640-015-9541-0, ISSN: 1476-3524.

Vega JN, Hohman TJ, Pryweller JR, Dykens EM, Thornton-Wells TA. Resting-State Functional Connectivity in Individuals with Down Syndrome and Williams Syndrome Compared with Typically Developing Controls. Brain Connect [print-electronic]. 2015 Oct; 5(8): 461-75. PMID: 25712025, PMCID: PMC4601631, DOI: 10.1089/brain.2014.0266, ISSN: 2158-0022.

Hohman TJ, Samuels LR, Liu D, Gifford KA, Mukherjee S, Benson EM, Abel T, Ruberg FL, Jefferson AL, . Stroke risk interacts with Alzheimer's disease biomarkers on brain aging outcomes. Neurobiol. Aging [print-electronic]. 2015 Sep; 36(9): 2501-8. PMID: 26119224, PMCID: PMC4523400, PII: S0197-4580(15)00305-X, DOI: 10.1016/j.neurobiolaging.2015.05.021, ISSN: 1558-1497.

Gifford KA, Phillips JS, Samuels LR, Lane EM, Bell SP, Liu D, Hohman TJ, Romano RR, Fritzsche LR, Lu Z, Jefferson AL, . Associations between Verbal Learning Slope and Neuroimaging Markers across the Cognitive Aging Spectrum. J Int Neuropsychol Soc. 2015 Jul; 21(6): 455-67. PMID: 26219209, PMCID: PMC4657447, PII: S1355617715000430, DOI: 10.1017/S1355617715000430, ISSN: 1469-7661.

Hohman TJ, Bell SP, Jefferson AL, . The role of vascular endothelial growth factor in neurodegeneration and cognitive decline: exploring interactions with biomarkers of Alzheimer disease. JAMA Neurol. 2015 May; 72(5): 520-9. PMID: 25751166, PMCID: PMC4428948, PII: 2190749, DOI: 10.1001/jamaneurol.2014.4761, ISSN: 2168-6157.

Gifford KA, Liu D, Hohman TJ, Xu M, Han X, Romano RR, Fritzsche LR, Abel T, Jefferson AL. A Mutual Self- and Informant-Report of Cognitive Complaint Correlates with Neuropathological Outcomes in Mild Cognitive Impairment. PLoS ONE. 2015; 10(11): e0141831. PMID: 26539829, PMCID: PMC4634952, PII: PONE-D-15-16003, DOI: 10.1371/journal.pone.0141831, ISSN: 1932-6203.

Jefferson AL, Hohman TJ, Liu D, Haj-Hassan S, Gifford KA, Benson EM, Skinner JS, Lu Z, Sparling J, Sumner EC, Bell S, Ruberg FL. Adverse vascular risk is related to cognitive decline in older adults. J. Alzheimers Dis. 2015; 44(4): 1361-73. PMID: 25471188, PMCID: PMC4336578, PII: 306700R180011678, DOI: 10.3233/JAD-141812, ISSN: 1875-8908.

Hohman TJ, Koran ME, Thornton-Wells TA, . Genetic modification of the relationship between phosphorylated tau and neurodegeneration. Alzheimers Dement [print-electronic]. 2014 Nov; 10(6): 637-645.e1. PMID: 24656848, PMCID: PMC4169762, PII: S1552-5260(14)00013-2, DOI: 10.1016/j.jalz.2013.12.022, ISSN: 1552-5279.

Hohman TJ, Koran ME, Thornton-Wells TA, . Interactions between GSK3ß and amyloid genes explain variance in amyloid burden. Neurobiol. Aging [print-electronic]. 2014 Mar; 35(3): 460-5. PMID: 24112793, PMCID: PMC3864626, PII: S0197-4580(13)00383-7, DOI: 10.1016/j.neurobiolaging.2013.08.032, ISSN: 1558-1497.

Hohman TJ, Koran ME, Thornton-Wells TA, . Genetic variation modifies risk for neurodegeneration based on biomarker status. Front Aging Neurosci. 2014; 6: 183. PMID: 25140149, PMCID: PMC4121544, DOI: 10.3389/fnagi.2014.00183, ISSN: 1663-4365.

Koran ME, Hohman TJ, Edwards CM, Vega JN, Pryweller JR, Slosky LE, Crockett G, Villa de Rey L, Meda SA, Dankner N, Avery SN, Blackford JU, Dykens EM, Thornton-Wells TA. Differences in age-related effects on brain volume in Down syndrome as compared to Williams syndrome and typical development. J Neurodev Disord [print-electronic]. 2014; 6(1): 8. PMID: 24713364, PMCID: PMC4022321, PII: 1866-1955-6-8, DOI: 10.1186/1866-1955-6-8, ISSN: 1866-1947.

Koran ME, Hohman TJ, Meda SA, Thornton-Wells TA. Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size. J. Alzheimers Dis. 2014; 38(1): 145-54. PMID: 24077433, PMCID: PMC3815519, PII: J60822865MH1116G, DOI: 10.3233/JAD-130989, ISSN: 1875-8908.

Koran ME, Hohman TJ, Thornton-Wells TA. Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography. Hum. Genet [print-electronic]. 2014 Jan; 133(1): 85-93. PMID: 24026422, PMCID: PMC4045094, DOI: 10.1007/s00439-013-1354-8, ISSN: 1432-1203.

Hohman TJ, Koran ME, Thornton-Wells T, . Epistatic genetic effects among Alzheimer's candidate genes. PLoS ONE. 2013; 8(11): e80839. PMID: 24260488, PMCID: PMC3832488, PII: PONE-D-13-33213, DOI: 10.1371/journal.pone.0080839, ISSN: 1932-6203.