Hind Lal, Ph.D.

Assistant Professor

hind.lal@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Pharmacology
Education
Ph.D., Microbiology, Molecular Biology, and Toxicology, Avadh University, Faizabad, IndiaM.Sc., Microbiology and Molecular Biology, Avadh University, Faizabad, IndiaB.Sc., Biology and Chemistry, Kamla Nehru Institute of Physical and Social Sciences, Sultanpur, India
Publications
Gupte M, Lal H, Ahmad F, Sawyer DB, Hill MF. Chronic Neuregulin-1ß Treatment Mitigates the Progression of Postmyocardial Infarction Heart Failure in the Setting of Type 1 Diabetes Mellitus by Suppressing Myocardial Apoptosis, Fibrosis, and Key Oxidant-Producing Enzymes. J. Card. Fail [print-electronic]. 2017 Dec; 23(12): 887-99. PMID: 28870731, PMCID: PMC5716474, PII: S1071-9164(17)31159-4, DOI: 10.1016/j.cardfail.2017.08.456, ISSN: 1532-8414.

Guo Y, Gupte M, Umbarkar P, Singh AP, Sui JY, Force T, Lal H. Entanglement of GSK-3ß, ß-catenin and TGF-ß1 signaling network to regulate myocardial fibrosis. J. Mol. Cell. Cardiol [print-electronic]. 2017 Sep; 110: 109-20. PMID: 28756206, PMCID: PMC5581678, PII: S0022-2828(17)30164-5, DOI: 10.1016/j.yjmcc.2017.07.011, ISSN: 1095-8584.

Gupte M, Umbarkar P, Lal H. Mechanistic Insights of Empagliflozin-Mediated Cardiac Benefits: Nearing the Starting Line : Editorial to: "Empagliflozin Improves Left Ventricular Diastolic Dysfunction in a Genetic Model of Type 2 Diabetes" by N. Hammoudi et al [editorial]. Cardiovasc Drugs Ther [print-electronic]. 2017 Jul 7/21/2017; PMID: 28733758, PII: 10.1007/s10557-017-6741-2, DOI: 10.1007/s10557-017-6741-2, ISSN: 1573-7241.

Qin P, Arabacilar P, Bernard RE, Bao W, Olzinski AR, Guo Y, Lal H, Eisennagel SH, Platchek MC, Xie W, Del Rosario J, Nayal M, Lu Q, Roethke T, Schnackenberg CG, Wright F, Quaile MP, Halsey WS, Hughes AM, Sathe GM, Livi GP, Kirkpatrick RB, Qu XA, Rajpal DK, Faelth Savitski M, Bantscheff M, Joberty G, Bergamini G, Force TL, Gatto GJ, Hu E, Willette RN. Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress. J Am Heart Assoc. 2017 May 5/9/2017; 6(5): PMID: 28487390, PII: JAHA.116.004453, DOI: 10.1161/JAHA.116.004453, ISSN: 2047-9980.

Zhou J, Ahmad F, Lal H, Force T. Response by Zhou et al to Letter Regarding Article, "Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy" [letter]. Circ. Res. 2016 Jul 7/8/2016; 119(2): e29-30. PMID: 27390340, PII: CIRCRESAHA.116.309093, DOI: 10.1161/CIRCRESAHA.116.309093, ISSN: 1524-4571.

Zhou J, Ahmad F, Parikh S, Hoffman NE, Rajan S, Verma VK, Song J, Yuan A, Shanmughapriya S, Guo Y, Gao E, Koch W, Woodgett JR, Madesh M, Kishore R, Lal H, Force T. Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy. Circ. Res [print-electronic]. 2016 Apr 4/15/2016; 118(8): 1208-22. PMID: 26976650, PMCID: PMC4843504, PII: CIRCRESAHA.116.308544, DOI: 10.1161/CIRCRESAHA.116.308544, ISSN: 1524-4571.

Lal H, Ahmad F, Woodgett J, Force T. The GSK-3 family as therapeutic target for myocardial diseases. Circ. Res. 2015 Jan 1/2/2015; 116(1): 138-49. PMID: 25552693, PMCID: PMC4283216, PII: CIRCRESAHA.116.303613, DOI: 10.1161/CIRCRESAHA.116.303613, ISSN: 1524-4571.

Ahmad F, Lal H, Zhou J, Vagnozzi RJ, Yu JE, Shang X, Woodgett JR, Gao E, Force T. Cardiomyocyte-specific deletion of Gsk3a mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure. J. Am. Coll. Cardiol. 2014 Aug 8/19/2014; 64(7): 696-706. PMID: 25125302, PMCID: PMC4142642, PII: S0735-1097(14)04094-7, DOI: 10.1016/j.jacc.2014.04.068, ISSN: 1558-3597.

Lal H, Ahmad F, Zhou J, Yu JE, Vagnozzi RJ, Guo Y, Yu D, Tsai EJ, Woodgett J, Gao E, Force T. Cardiac fibroblast glycogen synthase kinase-3ß regulates ventricular remodeling and dysfunction in ischemic heart. Circulation [print-electronic]. 2014 Jul 7/29/2014; 130(5): 419-30. PMID: 24899689, PMCID: PMC4153405, PII: CIRCULATIONAHA.113.008364, DOI: 10.1161/CIRCULATIONAHA.113.008364, ISSN: 1524-4539.

Duran JM, Makarewich CA, Trappanese D, Gross P, Husain S, Dunn J, Lal H, Sharp TE, Starosta T, Vagnozzi RJ, Berretta RM, Barbe M, Yu D, Gao E, Kubo H, Force T, Houser SR. Sorafenib cardiotoxicity increases mortality after myocardial infarction. Circ. Res [print-electronic]. 2014 May 5/23/2014; 114(11): 1700-12. PMID: 24718482, PMCID: PMC4037647, PII: CIRCRESAHA.114.303200, DOI: 10.1161/CIRCRESAHA.114.303200, ISSN: 1524-4571.

Springer J, Tschirner A, Haghikia A, von Haehling S, Lal H, Grzesiak A, Kaschina E, Palus S, Pötsch M, von Websky K, Hocher B, Latouche C, Jaisser F, Morawietz L, Coats AJ, Beadle J, Argiles JM, Thum T, Földes G, Doehner W, Hilfiker-Kleiner D, Force T, Anker SD. Prevention of liver cancer cachexia-induced cardiac wasting and heart failure. Eur. Heart J [print-electronic]. 2014 Apr; 35(14): 932-41. PMID: 23990596, PMCID: PMC3977133, PII: eht302, DOI: 10.1093/eurheartj/eht302, ISSN: 1522-9645.

Lal H, Ahmad F, Parikh S, Force T. Troponin I-interacting protein kinase: a novel cardiac-specific kinase, emerging as a molecular target for the treatment of cardiac disease. Circ. J [print-electronic]. 2014; 78(7): 1514-9. PMID: 24899531, PMCID: PMC4151348, PII: DN/JST.JSTAGE/circj/CJ-14-0543, ISSN: 1347-4820.

Golden HB, Watson LE, Nizamutdinov D, Feng H, Gerilechaogetu F, Lal H, Verma SK, Mukhopadhyay S, Foster DM, Dillmann WH, Dostal DE. Anthrax lethal toxin induces acute diastolic dysfunction in rats through disruption of the phospholamban signaling network. Int. J. Cardiol [print-electronic]. 2013 Oct 10/9/2013; 168(4): 3884-95. PMID: 23907041, PMCID: PMC4112368, PII: S0167-5273(13)01104-2, DOI: 10.1016/j.ijcard.2013.06.050, ISSN: 1874-1754.

Lal H, Verma SK, Feng H, Golden HB, Gerilechaogetu F, Nizamutdinov D, Foster DM, Glaser SS, Dostal DE. Caveolin and ß1-integrin coordinate angiotensinogen expression in cardiac myocytes. Int. J. Cardiol [print-electronic]. 2013 Sep 9/20/2013; 168(1): 436-45. PMID: 23058350, PMCID: PMC3574965, PII: S0167-5273(12)01252-1, DOI: 10.1016/j.ijcard.2012.09.131, ISSN: 1874-1754.

Zhou J, Freeman TA, Ahmad F, Shang X, Mangano E, Gao E, Farber J, Wang Y, Ma XL, Woodgett J, Vagnozzi RJ, Lal H, Force T. GSK-3a is a central regulator of age-related pathologies in mice. J. Clin. Invest [print-electronic]. 2013 Apr; 123(4): 1821-32. PMID: 23549082, PMCID: PMC3613907, PII: 64398, DOI: 10.1172/JCI64398, ISSN: 1558-8238.

Lal H, Kolaja KL, Force T. Cancer genetics and the cardiotoxicity of the therapeutics. J. Am. Coll. Cardiol. 2013 Jan 1/22/2013; 61(3): 267-74. PMID: 23328609, PII: S0735-1097(12)04489-0, DOI: 10.1016/j.jacc.2012.05.066, ISSN: 1558-3597.

Lal H, Zhou J, Ahmad F, Zaka R, Vagnozzi RJ, Decaul M, Woodgett J, Gao E, Force T. Glycogen synthase kinase-3a limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death. Circulation [print-electronic]. 2012 Jan 1/3/2012; 125(1): 65-75. PMID: 22086876, PMCID: PMC4365497, PII: CIRCULATIONAHA.111.050666, DOI: 10.1161/CIRCULATIONAHA.111.050666, ISSN: 1524-4539.

Hernández G, Lal H, Fidalgo M, Guerrero A, Zalvide J, Force T, Pombo CM. A novel cardioprotective p38-MAPK/mTOR pathway. Exp. Cell Res [print-electronic]. 2011 Dec 12/10/2011; 317(20): 2938-49. PMID: 22001647, PMCID: PMC3215777, PII: S0014-4827(11)00370-3, DOI: 10.1016/j.yexcr.2011.09.011, ISSN: 1090-2422.

Verma SK, Lal H, Golden HB, Gerilechaogetu F, Smith M, Guleria RS, Foster DM, Lu G, Dostal DE. Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts. Cardiovasc. Res [print-electronic]. 2011 Apr 4/1/2011; 90(1): 88-96. PMID: 21131638, PMCID: PMC3058736, PII: cvq385, DOI: 10.1093/cvr/cvq385, ISSN: 1755-3245.

Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J. Clin. Invest. 2010 Jul; 120(7): 2280-91. PMID: 20516643, PMCID: PMC2898595, PII: 41407, DOI: 10.1172/JCI41407, ISSN: 1558-8238.

Woulfe KC, Gao E, Lal H, Harris D, Fan Q, Vagnozzi R, DeCaul M, Shang X, Patel S, Woodgett JR, Force T, Zhou J. Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circ. Res [print-electronic]. 2010 May 5/28/2010; 106(10): 1635-45. PMID: 20360256, PMCID: PMC2895414, PII: CIRCRESAHA.109.211482, DOI: 10.1161/CIRCRESAHA.109.211482, ISSN: 1524-4571.

Golden HB, Watson LE, Lal H, Verma SK, Foster DM, Kuo SR, Sharma A, Frankel A, Dostal DE. Anthrax toxin: pathologic effects on the cardiovascular system. Front Biosci (Landmark Ed). 2009; 14: 2335-57. PMID: 19273204, PII: 3382, ISSN: 1093-4715.

Lal H, Verma SK, Foster DM, Golden HB, Reneau JC, Watson LE, Singh H, Dostal DE. Integrins and proximal signaling mechanisms in cardiovascular disease. Front Biosci (Landmark Ed). 2009; 14: 2307-34. PMID: 19273203, PII: 3381, ISSN: 1093-4715.

Lal H, Verma SK, Golden HB, Foster DM, Smith M, Dostal DE. Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: opposing roles of JNK1/2 and p38alpha MAP kinases. J. Mol. Cell. Cardiol [print-electronic]. 2008 Dec; 45(6): 770-8. PMID: 18926830, PMCID: PMC2645232, PII: S0022-2828(08)00708-6, DOI: 10.1016/j.yjmcc.2008.09.121, ISSN: 1095-8584.

Lal H, Guleria RS, Foster DM, Lu G, Watson LE, Sanghi S, Smith M, Dostal DE. Integrins: novel therapeutic targets for cardiovascular diseases. Cardiovasc Hematol Agents Med Chem. 2007 Apr; 5(2): 109-32. PMID: 17430135, ISSN: 1871-5257.

Watson LE, Mock J, Lal H, Lu G, Bourdeau RW, Tang WJ, Leppla SH, Dostal DE, Frankel AE. Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Front. Biosci. 2007; 12: 4670-5. PMID: 17485403, PII: 2416, ISSN: 1093-9946.