Jane F. Ferguson, Ph.D.

Assistant Professor

jane.f.ferguson@vanderbilt.edu

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Faculty Appointments
Assistant Professor of Medicine
Education
Ph.D., University of Dublin Trinity College, Dublin, IrelandB.A., Trinity College, Dublin, Ireland
Office Address
2525 West End Suite 300-A
Research Description
My research focuses on the genetics of cardiometabolic diseases, with a particular focus on functional genomics and clinical translation. I am interested in the interactions between genetic and environmental factors in disease development, and in the use of evoked phenotypes as a tool for genomic discovery. My current research projects include: 1) Understanding the determinants of alpha-aminoadipic acid and its relationship to diabetes ; 2) Novel metabolomic biomarkers of disease; 3) The interaction between diet and the microbiome in cardiometabolic risk; 4) Understanding the genomic determinants of febrile illness.
Publications
Mohammadkhah AI, Simpson EB, Patterson SG, Ferguson JF. Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease. Children (Basel). 2018 Nov 11/27/2018; 5(12): PMID: 30486462, PMCID: PMC6306821, PII: children5120160, DOI: 10.3390/children5120160, ISSN: 2227-9067.

Ferguson JF, Roberts-Lee K, Borcea C, Smith HM, Midgette Y, Shah R. Omega-3 polyunsaturated fatty acids attenuate inflammatory activation and alter differentiation in human adipocytes. J. Nutr. Biochem [print-electronic]. 2018 Oct 10/11/2018; 64: 45-9. PMID: 30428424, PII: S0955-2863(18)30295-X, DOI: 10.1016/j.jnutbio.2018.09.027, ISSN: 1873-4847.

Feng Q, Wei WQ, Chung CP, Levinson RT, Sundermann AC, Mosley JD, Bastarache L, Ferguson JF, Cox NJ, Roden DM, Denny JC, Linton MF, Edwards DRV, Stein CM. Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational study using electronic health records. PLoS Med. 2018 Aug; 15(8): e1002642. PMID: 30153257, PMCID: PMC6112635, PII: PMEDICINE-D-17-03325, DOI: 10.1371/journal.pmed.1002642, ISSN: 1549-1676.

Zhang X, Xue C, Lin J, Ferguson JF, Weiner A, Liu W, Han Y, Hinkle C, Li W, Jiang H, Gosai S, Hachet M, Garcia BA, Gregory BD, Soccio RE, Hogenesch JB, Seale P, Li M, Reilly MP. Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of linc-ADAL in adipocyte metabolism. Sci Transl Med. 2018 Jun 6/20/2018; 10(446): PMID: 29925637, PII: 10/446/eaar5987, DOI: 10.1126/scitranslmed.aar5987, ISSN: 1946-6242.

Musunuru K, Arora P, Cooke JP, Ferguson JF, Hershberger RE, Hickey KT, Lee JM, Lima JAC, Loscalzo J, Pereira NL, Russell MW, Shah SH, Sheikh F, Wang TJ, MacRae CA, . Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2018 Jun; 11(6): e000046. PMID: 29844141, PII: HCG.0000000000000046, DOI: 10.1161/HCG.0000000000000046, ISSN: 2574-8300.

Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, de Ferranti SD, Ferguson JF, Fornage M, Gillespie C, Isasi CR, Jiménez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Lutsey PL, Mackey JS, Matchar DB, Matsushita K, Mussolino ME, Nasir K, O'Flaherty M, Palaniappan LP, Pandey A, Pandey DK, Reeves MJ, Ritchey MD, Rodriguez CJ, Roth GA, Rosamond WD, Sampson UKA, Satou GM, Shah SH, Spartano NL, Tirschwell DL, Tsao CW, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P, . Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation [print-electronic]. 2018 Mar 3/20/2018; 137(12): e67-e492. PMID: 29386200, PII: CIR.0000000000000558, DOI: 10.1161/CIR.0000000000000558, ISSN: 1524-4539.

Bachmann KN, Deger SM, Alsouqi A, Huang S, Xu M, Ferguson JF, Su YR, Niswender KD, Ikizler TA, Wang TJ. Acute effects of insulin on circulating natriuretic peptide levels in humans. PLoS ONE. 2018; 13(5): e0196869. PMID: 29758041, PMCID: PMC5951576, PII: PONE-D-17-42749, DOI: 10.1371/journal.pone.0196869, ISSN: 1932-6203.

Zhang H, Hinkle CC, O'Neill SM, Shi J, Caughey J, Lynch E, Lynch G, Gerelus M, Tsai ASD, Shah R, Ferguson JF, Ahima RS, Reilly MP. Synergistic modulation of inflammatory but not metabolic effects of high-fat feeding by CCR2 and CX3CR1. Obesity (Silver Spring) [print-electronic]. 2017 Jun 6/26/2017; PMID: 28650582, DOI: 10.1002/oby.21900, ISSN: 1930-739X.

Saleheen D, Zhao W, Young R, Nelson CP, Ho W, Ferguson JF, Rasheed A, Ou K, Nurnberg ST, Bauer RC, Goel A, Do R, Stewart AFR, Hartiala J, Zhang W, Thorleifsson G, Strawbridge RJ, Sinisalo J, Kanoni S, Sedaghat S, Marouli E, Kristiansson K, Hua Zhao J, Scott R, Gauguier D, Shah SH, Smith AV, van Zuydam N, Cox AJ, Willenborg C, Kessler T, Zeng L, Province MA, Ganna A, Lind L, Pedersen NL, White CC, Joensuu A, Edi Kleber M, Hall AS, März W, Salomaa V, O'Donnell C, Ingelsson E, Feitosa MF, Erdmann J, Bowden DW, Palmer CNA, Gudnason V, Faire U, Zalloua P, Wareham N, Thompson JR, Kuulasmaa K, Dedoussis G, Perola M, Dehghan A, Chambers JC, Kooner J, Allayee H, Deloukas P, McPherson R, Stefansson K, Schunkert H, Kathiresan S, Farrall M, Marcel Frossard P, Rader DJ, Samani NJ, Reilly MP. Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions. Circulation [print-electronic]. 2017 Jun 6/13/2017; 135(24): 2336-53. PMID: 28461624, PII: CIRCULATIONAHA.116.022069, DOI: 10.1161/CIRCULATIONAHA.116.022069, ISSN: 1524-4539.

Xue C, Zhang X, Zhang H, Ferguson JF, Wang Y, Hinkle CC, Li M, Reilly MP. De novo RNA sequence assembly during in vivo inflammatory stress reveals hundreds of unannotated lincRNAs in human blood CD14(+) monocytes and in adipose tissue. Physiol. Genomics [print-electronic]. 2017 Jun 6/1/2017; 49(6): 287-305. PMID: 28389524, PMCID: PMC5495909, PII: physiolgenomics.00001.2017, DOI: 10.1152/physiolgenomics.00001.2017, ISSN: 1531-2267.

Shah RD, Xue C, Zhang H, Tuteja S, Li M, Reilly MP, Ferguson JF. Expression of Calgranulin Genes S100A8, S100A9 and S100A12 Is Modulated by n-3 PUFA during Inflammation in Adipose Tissue and Mononuclear Cells. PLoS ONE. 2017; 12(1): e0169614. PMID: 28125622, PMCID: PMC5268473, PII: PONE-D-16-19159, DOI: 10.1371/journal.pone.0169614, ISSN: 1932-6203.

, Young DR, Hivert MF, Alhassan S, Camhi SM, Ferguson JF, Katzmarzyk PT, Lewis CE, Owen N, Perry CK, Siddique J, Yong CM, . Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association. Circulation [print-electronic]. 2016 Sep 9/27/2016; 134(13): e262-79. PMID: 27528691, PII: CIR.0000000000000440, DOI: 10.1161/CIR.0000000000000440, ISSN: 1524-4539.

Ferguson JF, Allayee H, Gerszten RE, Ideraabdullah F, Kris-Etherton PM, Ordovás JM, Rimm EB, Wang TJ, Bennett BJ, . Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet [print-electronic]. 2016 Jun; 9(3): 291-313. PMID: 27095829, PII: HCG.0000000000000030, DOI: 10.1161/HCG.0000000000000030, ISSN: 1942-3268.

Ferguson JF, Xue C, Hu Y, Li M, Reilly MP. Adipose tissue RNASeq reveals novel gene-nutrient interactions following n-3 PUFA supplementation and evoked inflammation in humans. J. Nutr. Biochem [print-electronic]. 2016 Apr; 30: 126-32. PMID: 27012629, PMCID: PMC4808243, PII: S0955-2863(16)00008-5, DOI: 10.1016/j.jnutbio.2015.12.010, ISSN: 1873-4847.

Ferguson JF, Wang TJ. Branched-Chain Amino Acids and Cardiovascular Disease: Does Diet Matter? [editorial]. Clin. Chem [print-electronic]. 2016 Apr; 62(4): 545-7. PMID: 26883074, PII: clinchem.2016.254318, DOI: 10.1373/clinchem.2016.254318, ISSN: 1530-8561.

Skarke C, Alamuddin N, Lawson JA, Li X, Ferguson JF, Reilly MP, FitzGerald GA. Bioactive products formed in humans from fish oils. J. Lipid Res [print-electronic]. 2015 Sep; 56(9): 1808-20. PMID: 26180051, PMCID: PMC4548785, PII: jlr.M060392, DOI: 10.1194/jlr.M060392, ISSN: 1539-7262.

Ferguson JF, Shah RY, Shah R, Mehta NN, Rickels MR, Reilly MP. Activation of innate immunity modulates insulin sensitivity, glucose effectiveness and pancreatic ß-cell function in both African ancestry and European ancestry healthy humans. Metab. Clin. Exp [print-electronic]. 2015 Apr; 64(4): 513-20. PMID: 25579865, PMCID: PMC4346476, PII: S0026-0495(14)00395-3, DOI: 10.1016/j.metabol.2014.12.007, ISSN: 1532-8600.

Ferguson JF, Shah RY, Shah R, Mehta NN, Rickels MR, Reilly MP. Activation of innate immunity modulates insulin sensitivity, glucose effectiveness and pancreatic ß-cell function in both African ancestry and European ancestry healthy humans. Metab. Clin. Exp [print-electronic]. 2015 Apr; 64(4): 513-20. PMID: 25579865, PMCID: PMC4346476, PII: S0026-0495(14)00395-3, DOI: 10.1016/j.metabol.2014.12.007, ISSN: 1532-8600.

Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP. Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Hum. Mol. Genet [print-electronic]. 2015 Mar 3/15/2015; 24(6): 1801-12. PMID: 25416278, PMCID: PMC4351381, PII: ddu589, DOI: 10.1093/hmg/ddu589, ISSN: 1460-2083.

Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP. Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Hum. Mol. Genet [print-electronic]. 2015 Mar 3/15/2015; 24(6): 1801-12. PMID: 25416278, PMCID: PMC4351381, PII: ddu589, DOI: 10.1093/hmg/ddu589, ISSN: 1460-2083.

Patel PN, Shah RY, Ferguson JF, Reilly MP. Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2015 Mar; 35(3): 525-34. PMID: 25550206, PMCID: PMC4344396, PII: ATVBAHA.114.304455, DOI: 10.1161/ATVBAHA.114.304455, ISSN: 1524-4636.

Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH. PCSK9 is a critical regulator of the innate immune response and septic shock outcome. Sci Transl Med. 2014 Oct 10/15/2014; 6(258): 258ra143. PMID: 25320235, PMCID: PMC4342147, PII: 6/258/258ra143, DOI: 10.1126/scitranslmed.3008782, ISSN: 1946-6242.

Prenner SB, Mulvey CK, Ferguson JF, Rickels MR, Bhatt AB, Reilly MP. Very low density lipoprotein cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating levels of triglycerides. Atherosclerosis [print-electronic]. 2014 Oct; 236(2): 244-50. PMID: 25105581, PMCID: PMC4209900, PII: S0021-9150(14)01284-2, DOI: 10.1016/j.atherosclerosis.2014.07.008, ISSN: 1879-1484.

Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP. A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock. Am. J. Respir. Crit. Care Med. 2014 Sep 9/15/2014; 190(6): 656-64. PMID: 25089931, PMCID: PMC4214110, DOI: 10.1164/rccm.201403-0586OC, ISSN: 1535-4970.

Ferguson JF, Ryan MF, Gibney ER, Brennan L, Roche HM, Reilly MP. Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers. Nutr Metab Cardiovasc Dis [print-electronic]. 2014 Sep; 24(9): 996-1003. PMID: 24875672, PMCID: PMC4130742, PII: S0939-4753(14)00130-6, DOI: 10.1016/j.numecd.2014.03.010, ISSN: 1590-3729.

Rickels MR, Kong SM, Fuller C, Dalton-Bakes C, Ferguson JF, Reilly MP, Teff KL, Naji A. Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2014 May 5/15/2014; 306(10): E1217-24. PMID: 24691031, PMCID: PMC4025062, PII: ajpendo.00667.2013, DOI: 10.1152/ajpendo.00667.2013, ISSN: 1522-1555.

Liu Y, Ferguson JF, Xue C, Ballantyne RL, Silverman IM, Gosai SJ, Serfecz J, Morley MP, Gregory BD, Li M, Reilly MP. Tissue-specific RNA-Seq in human evoked inflammation identifies blood and adipose LincRNA signatures of cardiometabolic diseases. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2014 Apr; 34(4): 902-12. PMID: 24504737, PMCID: PMC3966947, PII: ATVBAHA.113.303123, DOI: 10.1161/ATVBAHA.113.303123, ISSN: 1524-4636.

Ferguson JF, Mulvey CK, Patel PN, Shah RY, Doveikis J, Zhang W, Tabita-Martinez J, Terembula K, Eiden M, Koulman A, Griffin JL, Mehta NN, Shah R, Propert KJ, Song WL, Reilly MP. Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers. Mol Nutr Food Res [print-electronic]. 2014 Mar; 58(3): 601-13. PMID: 24190860, PMCID: PMC3947472, DOI: 10.1002/mnfr.201300368, ISSN: 1613-4133.

Hu Y, Liu Y, Mao X, Jia C, Ferguson JF, Xue C, Reilly MP, Li H, Li M. PennSeq: accurate isoform-specific gene expression quantification in RNA-Seq by modeling non-uniform read distribution. Nucleic Acids Res [print-electronic]. 2014 Feb; 42(3): e20. PMID: 24362841, PMCID: PMC3919567, PII: gkt1304, DOI: 10.1093/nar/gkt1304, ISSN: 1362-4962.

Walsh MC, McLoughlin GA, Roche HM, Ferguson JF, Drevon CA, Saris WH, Lovegrove JA, Risérus U, López-Miranda J, Defoort C, Kiec-Wilk B, Brennan L, Gibney MJ. Impact of geographical region on urinary metabolomic and plasma fatty acid profiles in subjects with the metabolic syndrome across Europe: the LIPGENE study. Br. J. Nutr [print-electronic]. 2014 Feb; 111(3): 424-31. PMID: 24047691, PII: S0007114513002602, DOI: 10.1017/S0007114513002602, ISSN: 1475-2662.

Mulvey CK, McNeill AM, Girman CJ, Churchill TW, Terembula K, Ferguson JF, Shah R, Mehta NN, Qasim AN, Rickels MR, Reilly MP. Differential associations of oral glucose tolerance test-derived measures of insulin sensitivity and pancreatic ß-cell function with coronary artery calcification and microalbuminuria in type 2 diabetes. Diabetes Care [print-electronic]. 2014; 37(1): 124-33. PMID: 23949560, PMCID: PMC3867998, PII: dc12-1880, DOI: 10.2337/dc12-1880, ISSN: 1935-5548.

Rickels MR, Kong SM, Fuller C, Dalton-Bakes C, Ferguson JF, Reilly MP, Teff KL, Naji A. Improvement in insulin sensitivity after human islet transplantation for type 1 diabetes. J. Clin. Endocrinol. Metab [print-electronic]. 2013 Nov; 98(11): E1780-5. PMID: 24085506, PMCID: PMC3816271, PII: jc.2013-1764, DOI: 10.1210/jc.2013-1764, ISSN: 1945-7197.

Ferguson JF, Matthews GJ, Townsend RR, Raj DS, Kanetsky PA, Budoff M, Fischer MJ, Rosas SE, Kanthety R, Rahman M, Master SR, Qasim A, Li M, Mehta NN, Shen H, Mitchell BD, O'Connell JR, Shuldiner AR, Ho WK, Young R, Rasheed A, Danesh J, He J, Kusek JW, Ojo AO, Flack J, Go AS, Gadegbeku CA, Wright JT, Saleheen D, Feldman HI, Rader DJ, Foulkes AS, Reilly MP, . Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort). J. Am. Coll. Cardiol [print-electronic]. 2013 Aug 8/27/2013; 62(9): 789-98. PMID: 23727086, PMCID: PMC3953823, PII: S0735-1097(13)02075-5, DOI: 10.1016/j.jacc.2013.01.103, ISSN: 1558-3597.

Ferguson JF. Meat-loving microbes: do steak-eating bacteria promote atherosclerosis?. Circ Cardiovasc Genet. 2013 Jun; 6(3): 308-9. PMID: 23778590, PII: CIRCGENETICS.113.000213, DOI: 10.1161/CIRCGENETICS.113.000213, ISSN: 1942-3268.

Wojczynski MK, Li M, Bielak LF, Kerr KF, Reiner AP, Wong ND, Yanek LR, Qu L, White CC, Lange LA, Ferguson JF, He J, Young T, Mosley TH, Smith JA, Kral BG, Guo X, Wong Q, Ganesh SK, Heckbert SR, Griswold ME, O'Leary DH, Budoff M, Carr JJ, Taylor HA, Bluemke DA, Demissie S, Hwang SJ, Paltoo DN, Polak JF, Psaty BM, Becker DM, Province MA, Post WS, O'Donnell CJ, Wilson JG, Harris TB, Kavousi M, Cupples LA, Rotter JI, Fornage M, Becker LC, Peyser PA, Borecki IB, Reilly MP. Genetics of coronary artery calcification among African Americans, a meta-analysis. BMC Med. Genet. 2013; 14: 75. PMID: 23870195, PMCID: PMC3733595, PII: 1471-2350-14-75, DOI: 10.1186/1471-2350-14-75, ISSN: 1471-2350.

Liu Y, Ferguson JF, Xue C, Silverman IM, Gregory B, Reilly MP, Li M. Evaluating the impact of sequencing depth on transcriptome profiling in human adipose. PLoS ONE [electronic-print]. 2013; 8(6): e66883. PMID: 23826166, PMCID: PMC3691247, PII: PONE-D-13-06298, DOI: 10.1371/journal.pone.0066883, ISSN: 1932-6203.

Ferguson JF, Patel PN, Shah RY, Mulvey CK, Gadi R, Nijjar PS, Usman HM, Mehta NN, Shah R, Master SR, Propert KJ, Reilly MP. Race and gender variation in response to evoked inflammation. J Transl Med. 2013; 11: 63. PMID: 23497455, PMCID: PMC3636014, PII: 1479-5876-11-63, DOI: 10.1186/1479-5876-11-63, ISSN: 1479-5876.

Foulkes AS, Matthews GJ, Das U, Ferguson JF, Lin R, Reilly MP. Mixed modeling of meta-analysis P-values (MixMAP) suggests multiple novel gene loci for low density lipoprotein cholesterol. PLoS ONE [print-electronic]. 2013; 8(2): e54812. PMID: 23405096, PMCID: PMC3566142, PII: PONE-D-12-18267, DOI: 10.1371/journal.pone.0054812, ISSN: 1932-6203.

Ferguson JF. Increasing power: multivariate analysis of metabolic networks reveals novel atherosclerosis loci. Circ Cardiovasc Genet. 2012 Oct 10/1/2012; 5(5): 595-6. PMID: 23074341, PII: 5/5/595, DOI: 10.1161/CIRCGENETICS.112.964882, ISSN: 1942-3268.

Oliver E, McGillicuddy FC, Harford KA, Reynolds CM, Phillips CM, Ferguson JF, Roche HM. Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA. J. Nutr. Biochem [print-electronic]. 2012 Sep; 23(9): 1192-200. PMID: 22137266, PII: S0955-2863(11)00210-5, DOI: 10.1016/j.jnutbio.2011.06.014, ISSN: 1873-4847.

Mulvey CK, Ferguson JF, Tabita-Martinez J, Kong S, Shah RY, Patel PN, Master SR, Usman MH, Propert KJ, Shah R, Mehta NN, Reilly MP. Peroxisome Proliferator-Activated Receptor-a Agonism With Fenofibrate Does Not Suppress Inflammatory Responses to Evoked Endotoxemia. J Am Heart Assoc [print-electronic]. 2012 Aug; 1(4): e002923. PMID: 23130172, PMCID: PMC3487364, PII: jah362, DOI: 10.1161/JAHA.112.002923, ISSN: 2047-9980.

Ferguson JF. Omics gets personal: integrative profiling of health and disease. Circ Cardiovasc Genet. 2012 Jun; 5(3): 381-2. PMID: 22715285, PII: 5/3/381, DOI: 10.1161/CIRCGENETICS.112.963801, ISSN: 1942-3268.

Wassel CL, Lamina C, Nambi V, Coassin S, Mukamal KJ, Ganesh SK, Jacobs DR, Franceschini N, Papanicolaou GJ, Gibson Q, Yanek LR, van der Harst P, Ferguson JF, Crawford DC, Waite LL, Allison MA, Criqui MH, McDermott MM, Mehra R, Cupples LA, Hwang SJ, Redline S, Kaplan RC, Heiss G, Rotter JI, Boerwinkle E, Taylor HA, Eraso LH, Haun M, Li M, Meisinger C, O'Connell JR, Shuldiner AR, Tybjærg-Hansen A, Frikke-Schmidt R, Kollerits B, Rantner B, Dieplinger B, Stadler M, Mueller T, Haltmayer M, Klein-Weigel P, Summerer M, Wichmann HE, Asselbergs FW, Navis G, Mateo Leach I, Brown-Gentry K, Goodloe R, Assimes TL, Becker DM, Cooke JP, Absher DM, Olin JW, Mitchell BD, Reilly MP, Mohler ER, North KE, Reiner AP, Kronenberg F, Murabito JM. Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. Atherosclerosis [print-electronic]. 2012 May; 222(1): 138-47. PMID: 22361517, PMCID: PMC3596171, PII: S0021-9150(12)00072-X, DOI: 10.1016/j.atherosclerosis.2012.01.039, ISSN: 1879-1484.

Davies RW, Wells GA, Stewart AF, Erdmann J, Shah SH, Ferguson JF, Hall AS, Anand SS, Burnett MS, Epstein SE, Dandona S, Chen L, Nahrstaedt J, Loley C, König IR, Kraus WE, Granger CB, Engert JC, Hengstenberg C, Wichmann HE, Schreiber S, Tang WH, Ellis SG, Rader DJ, Hazen SL, Reilly MP, Samani NJ, Schunkert H, Roberts R, McPherson R. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet [print-electronic]. 2012 Apr 4/1/2012; 5(2): 217-25. PMID: 22319020, PMCID: PMC3335297, PII: CIRCGENETICS.111.961243, DOI: 10.1161/CIRCGENETICS.111.961243, ISSN: 1942-3268.

Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Böhm BO, Braund PS, Burton PR, Chandrupatla HR, Clarke R, Cooper-DeHoff RM, Crook ED, Davey-Smith G, Day IN, de Boer A, de Groot MC, Drenos F, Ferguson J, Fox CS, Furlong CE, Gibson Q, Gieger C, Gilhuijs-Pederson LA, Glessner JT, Goel A, Gong Y, Grant SF, Grobbee DE, Hastie C, Humphries SE, Kim CE, Kivimaki M, Kleber M, Meisinger C, Kumari M, Langaee TY, Lawlor DA, Li M, Lobmeyer MT, Maitland-van der Zee AH, Meijs MF, Molony CM, Morrow DA, Murugesan G, Musani SK, Nelson CP, Newhouse SJ, O'Connell JR, Padmanabhan S, Palmen J, Patel SR, Pepine CJ, Pettinger M, Price TS, Rafelt S, Ranchalis J, Rasheed A, Rosenthal E, Ruczinski I, Shah S, Shen H, Silbernagel G, Smith EN, Spijkerman AW, Stanton A, Steffes MW, Thorand B, Trip M, van der Harst P, van der A DL, van Iperen EP, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Wolffenbuttel BH, Young T, Zafarmand MH, Zmuda JM, , , Boehnke M, Altshuler D, McCarthy M, Kao WH, Pankow JS, Cappola TP, Sever P, Poulter N, Caulfield M, Dominiczak A, Shields DC, Bhatt DL, Zhang L, Curtis SP, Danesh J, Casas JP, van der Schouw YT, Onland-Moret NC, Doevendans PA, Dorn GW, Farrall M, FitzGerald GA, Hamsten A, Hegele R, Hingorani AD, Hofker MH, Huggins GS, Illig T, Jarvik GP, Johnson JA, Klungel OH, Knowler WC, Koenig W, März W, Meigs JB, Melander O, Munroe PB, Mitchell BD, Bielinski SJ, Rader DJ, Reilly MP, Rich SS, Rotter JI, Saleheen D, Samani NJ, Schadt EE, Shuldiner AR, Silverstein R, Kottke-Marchant K, Talmud PJ, Watkins H, Asselbergs FW, de Bakker PI, McCaffery J, Wijmenga C, Sabatine MS, Wilson JG, Reiner A, Bowden DW, Hakonarson H, Siscovick DS, Keating BJ. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am. J. Hum. Genet [print-electronic]. 2012 Mar 3/9/2012; 90(3): 410-25. PMID: 22325160, PMCID: PMC3309185, PII: S0002-9297(12)00031-6, DOI: 10.1016/j.ajhg.2011.12.022, ISSN: 1537-6605.

Ferguson JF, Hinkle CC, Mehta NN, Bagheri R, Derohannessian SL, Shah R, Mucksavage MI, Bradfield JP, Hakonarson H, Wang X, Master SR, Rader DJ, Li M, Reilly MP. Translational studies of lipoprotein-associated phospholipase A2 in inflammation and atherosclerosis. J. Am. Coll. Cardiol. 2012 Feb 2/21/2012; 59(8): 764-72. PMID: 22340269, PMCID: PMC3285416, PII: S0735-1097(11)05099-6, DOI: 10.1016/j.jacc.2011.11.019, ISSN: 1558-3597.

Barth AS, Ferguson JF, Musunuru K. Top advances in functional genomics and translational biology for 2011. Circ Cardiovasc Genet. 2012 Feb 2/1/2012; 5(1): 143-5. PMID: 22337927, PII: 5/1/143, DOI: 10.1161/CIRCGENETICS.111.962621, ISSN: 1942-3268.

Mehta NN, Heffron SP, Patel PN, Ferguson J, Shah RD, Hinkle CC, Krishnamoorthy P, Shah R, Tabita-Martinez J, Terembula K, Master SR, Rickels MR, Reilly MP. A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial. J Transl Med. 2012; 10: 124. PMID: 22709547, PMCID: PMC3477112, PII: 1479-5876-10-124, DOI: 10.1186/1479-5876-10-124, ISSN: 1479-5876.

Garcia-Rios A, Delgado-Lista J, Perez-Martinez P, Phillips CM, Ferguson JF, Gjelstad IM, Williams CM, Karlström B, Kiec-Wilk B, Blaak EE, Lairon D, Planells R, Malczewska-Malec M, Defoort C, Riserus U, Saris WH, Lovegrove JA, Drevon CA, Roche HM, Lopez-Miranda J. Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism. Atherosclerosis [print-electronic]. 2011 Oct; 218(2): 416-22. PMID: 21840003, PII: S0021-9150(11)00713-1, DOI: 10.1016/j.atherosclerosis.2011.07.092, ISSN: 1879-1484.

. Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet [print-electronic]. 2011 Sep; 7(9): e1002260. PMID: 21966275, PMCID: PMC3178591, PII: PGENETICS-D-11-00460, DOI: 10.1371/journal.pgen.1002260, ISSN: 1553-7404.

Perez-Martinez P, Delgado-Lista J, Garcia-Rios A, Ferguson JF, Gulseth HL, Williams CM, Karlström B, Kiec-Wilk B, Blaak EE, Helal O, Malczewska-Malec M, Defoort C, Risérus U, Saris WH, Lovegrove JA, Drevon CA, Roche HM, Lopez-Miranda J. Calpain-10 interacts with plasma saturated fatty acid concentrations to influence insulin resistance in individuals with the metabolic syndrome. Am. J. Clin. Nutr [print-electronic]. 2011 May; 93(5): 1136-41. PMID: 21389182, PII: ajcn.110.010512, DOI: 10.3945/ajcn.110.010512, ISSN: 1938-3207.

Shah R, Hinkle CC, Ferguson JF, Mehta NN, Li M, Qu L, Lu Y, Putt ME, Ahima RS, Reilly MP. Fractalkine is a novel human adipochemokine associated with type 2 diabetes. Diabetes. 2011 May; 60(5): 1512-8. PMID: 21525510, PMCID: PMC3292325, PII: 60/5/1512, DOI: 10.2337/db10-0956, ISSN: 1939-327X.

Mehta NN, Li M, William D, Khera AV, DerOhannessian S, Qu L, Ferguson JF, McLaughlin C, Shaikh LH, Shah R, Patel PN, Bradfield JP, He J, Stylianou IM, Hakonarson H, Rader DJ, Reilly MP. The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels. Eur. Heart J [print-electronic]. 2011 Apr; 32(8): 963-71. PMID: 21415067, PMCID: PMC3076669, PII: ehr091, DOI: 10.1093/eurheartj/ehr091, ISSN: 1522-9645.

Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Burnett MS, Devaney JM, Knouff CW, Thompson JR, Horne BD, Stewart AF, Assimes TL, Wild PS, Allayee H, Nitschke PL, Patel RS, , , Martinelli N, Girelli D, Quyyumi AA, Anderson JL, Erdmann J, Hall AS, Schunkert H, Quertermous T, Blankenberg S, Hazen SL, Roberts R, Kathiresan S, Samani NJ, Epstein SE, Rader DJ. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet [print-electronic]. 2011 Jan 1/29/2011; 377(9763): 383-92. PMID: 21239051, PMCID: PMC3297116, PII: S0140-6736(10)61996-4, DOI: 10.1016/S0140-6736(10)61996-4, ISSN: 1474-547X.

Eliot M, Ferguson J, Reilly MP, Foulkes AS. Ridge regression for longitudinal biomarker data. Int J Biostat [print-electronic]. 2011; 7(1): Article 37. PMID: 22049265, PMCID: PMC3202941, DOI: 10.2202/1557-4679.1353, ISSN: 1557-4679.

Shen H, Bielak LF, Ferguson JF, Streeten EA, Yerges-Armstrong LM, Liu J, Post W, O'Connell JR, Hixson JE, Kardia SL, Sun YV, Jhun MA, Wang X, Mehta NN, Li M, Koller DL, Hakonarson H, Keating BJ, Rader DJ, Shuldiner AR, Peyser PA, Reilly MP, Mitchell BD. Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2010 Dec; 30(12): 2648-54. PMID: 20847308, PMCID: PMC2988112, PII: ATVBAHA.110.211805, DOI: 10.1161/ATVBAHA.110.211805, ISSN: 1524-4636.

Ferguson JF, Phillips CM, McMonagle J, Pérez-Martínez P, Shaw DI, Lovegrove JA, Helal O, Defoort C, Gjelstad IM, Drevon CA, Blaak EE, Saris WH, Leszczynska-Golabek I, Kiec-Wilk B, Risérus U, Karlström B, Lopez-Miranda J, Roche HM. NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids. Atherosclerosis [print-electronic]. 2010 Aug; 211(2): 539-44. PMID: 20409549, PII: S0021-9150(10)00243-1, DOI: 10.1016/j.atherosclerosis.2010.03.027, ISSN: 1879-1484.

Ferguson JF, Phillips CM, Tierney AC, Pérez-Martínez P, Defoort C, Helal O, Lairon D, Planells R, Shaw DI, Lovegrove JA, Gjelstad IM, Drevon CA, Blaak EE, Saris WH, Leszczynska-Golabek I, Kiec-Wilk B, Risérus U, Karlström B, Miranda JL, Roche HM. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am. J. Clin. Nutr [print-electronic]. 2010 Mar; 91(3): 794-801. PMID: 20032495, PII: ajcn.2009.28255, DOI: 10.3945/ajcn.2009.28255, ISSN: 1938-3207.

Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Mehegan J, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM. Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components. J. Clin. Endocrinol. Metab [print-electronic]. 2010 Mar; 95(3): 1386-94. PMID: 20080841, PII: jc.2009-1081, DOI: 10.1210/jc.2009-1081, ISSN: 1945-7197.

Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM. Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome. Am. J. Clin. Nutr [print-electronic]. 2009 Dec; 90(6): 1665-73. PMID: 19828715, PII: ajcn.2009.28101, DOI: 10.3945/ajcn.2009.28101, ISSN: 1938-3207.

Available Postdoctoral Position Details
Posted: 1/24/2019

We have an opening for a postdoctoral candidate to investigate determinants of alpha-aminoadipic acid and relationship to diabetes. This position is within the Ferguson Lab, in the Division of Cardiovascular Medicine, Vanderbilt University Medical Center. This project is focused on understanding how a novel metabolite, 2-AAA, is related to risk of diabetes, and requires translational integration of human clinical and genomic data, in addition to functional assays. The ideal candidate has a strong background in human genetics and molecular biology, with previous experience in in elucidating molecular mechanisms of human genetic variants using functional assays.


To apply, please email Dr. Jane Ferguson (jane.f.ferguson@vumc.org), including: 1) A cover letter describing your interest in the position, including research experience and career goals; 2) Your current Curriculum Vitae; 3) Contact information for 3 references.