Huan Qiao, M.D., Ph.D.

Research Instructor

huan.qiao@vanderbilt.edu
Faculty Appointments
Research Instructor of Medicine
Education
Ph.D., Peking University, Beijing, ChinaM.D., Nankai University, Tianjin, China
Office Address
777 PRB, 2220 Pierce Avenue South
2220 Pierce Avenue South
Nashville, TN 37232
Research Keywords
lung cancer, ALK fusion, MIG-6, ERBB, acquired resistance mechanism, gene regulation
Publications
Qiao H, Lovly CM. Cracking the Code of Resistance across Multiple Lines of ALK Inhibitor Therapy in Lung Cancer. Cancer Discov. 2016 Oct; 6(10): 1084-6. PMID: 27698100, PMCID: PMC5117458, PII: 6/10/1084, DOI: 10.1158/2159-8290.CD-16-0910, ISSN: 2159-8290.

Qiao H, Liu Y, Veach RA, Wylezinski L, Hawiger J. The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli. J. Biol. Chem [print-electronic]. 2014 Aug 8/8/2014; 289(32): 21973-83. PMID: 24958727, PMCID: PMC4139214, PII: M114.588723, DOI: 10.1074/jbc.M114.588723, ISSN: 1083-351X.

Qiao H, May JM. Interaction of the transcription start site core region and transcription factor YY1 determine ascorbate transporter SVCT2 exon 1a promoter activity. PLoS ONE [print-electronic]. 2012; 7(4): e35746. PMID: 22532872, PMCID: PMC3332055, PII: PONE-D-11-20186, DOI: 10.1371/journal.pone.0035746, ISSN: 1932-6203.

Qiao H, May JM. CpG methylation at the USF-binding site mediates cell-specific transcription of human ascorbate transporter SVCT2 exon 1a. Biochem. J. 2011 Nov 11/15/2011; 440(1): 73-84. PMID: 21770893, PMCID: PMC3709574, PII: BJ20110392, DOI: 10.1042/BJ20110392, ISSN: 1470-8728.

Qiao H, May JM. Regulation of the human ascorbate transporter SVCT2 exon 1b gene by zinc-finger transcription factors. Free Radic. Biol. Med [print-electronic]. 2011 May 5/1/2011; 50(9): 1196-209. PMID: 21335086, PMCID: PMC3070803, PII: S0891-5849(11)00096-7, DOI: 10.1016/j.freeradbiomed.2011.02.006, ISSN: 1873-4596.

May JM, Qu ZC, Qiao H. Transfer of ascorbic acid across the vascular endothelium: mechanism and self-regulation. Am. J. Physiol., Cell Physiol [print-electronic]. 2009 Jul; 297(1): C169-78. PMID: 19419995, PMCID: PMC2711653, PII: 00674.2008, DOI: 10.1152/ajpcell.00674.2008, ISSN: 1522-1563.

Qiao H, Li L, Qu ZC, May JM. Cobalt-induced oxidant stress in cultured endothelial cells: prevention by ascorbate in relation to HIF-1alpha. Biofactors. 2009 May; 35(3): 306-13. PMID: 19396871, PMCID: PMC2714551, DOI: 10.1002/biof.43, ISSN: 0951-6433.

Qiao H, May JM. Macrophage differentiation increases expression of the ascorbate transporter (SVCT2). Free Radic. Biol. Med [print-electronic]. 2009 Apr 4/15/2009; 46(8): 1221-32. PMID: 19232538, PMCID: PMC3732409, PII: S0891-5849(09)00083-5, DOI: 10.1016/j.freeradbiomed.2009.02.004, ISSN: 1873-4596.

Qiao H, Bell J, Juliao S, Li L, May JM. Ascorbic acid uptake and regulation of type I collagen synthesis in cultured vascular smooth muscle cells. J. Vasc. Res [print-electronic]. 2009; 46(1): 15-24. PMID: 18515971, PMCID: PMC3724476, PII: 000135661, DOI: 10.1159/000135661, ISSN: 1423-0135.

Qiao H, May JM. Development of ascorbate transporters in brain cortical capillary endothelial cells in culture. Brain Res [print-electronic]. 2008 May 5/7/2008; 1208: 79-86. PMID: 18394593, PMCID: PMC2453688, PII: S0006-8993(08)00563-5, DOI: 10.1016/j.brainres.2008.02.102, ISSN: 0006-8993.

May JM, Qu ZC, Qiao H, Koury MJ. Maturational loss of the vitamin C transporter in erythrocytes. Biochem. Biophys. Res. Commun [print-electronic]. 2007 Aug 8/17/2007; 360(1): 295-8. PMID: 17586466, PMCID: PMC1964531, PII: S0006-291X(07)01319-8, DOI: 10.1016/j.bbrc.2007.06.072, ISSN: 0006-291X.

Qiao H, Di Stefano L, Tian C, Li YY, Yin YH, Qian XP, Pang XW, Li Y, McNutt MA, Helin K, Zhang Y, Chen WF. Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. J. Biol. Chem [print-electronic]. 2007 Jan 1/5/2007; 282(1): 454-66. PMID: 17062573, PII: M606169200, DOI: 10.1074/jbc.M606169200, ISSN: 0021-9258.

Qiao H, Qian XP, Zhang HG, Tian C, Chen WF. [Estimation of an NY-ESO-1 expressing HCC cell line by NY-ESO-1b specific CD8+T cells in vitro induced by HLA-A2 restricted NY-ESO-1b peptide]. Beijing Da Xue Xue Bao. 2005 Dec 12/18/2005; 37(6): 565-8. PMID: 16378102, ISSN: 1671-167X.

Yin YH, Li YY, Qiao H, Wang HC, Yang XA, Zhang HG, Pang XW, Zhang Y, Chen WF. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma. Br. J. Cancer. 2005 Aug 8/22/2005; 93(4): 458-63. PMID: 16106251, PMCID: PMC2361584, PII: 6602716, DOI: 10.1038/sj.bjc.6602716, ISSN: 0007-0920.

Yang XA, Dong XY, Qiao H, Wang YD, Peng JR, Li Y, Pang XW, Tian C, Chen WF. Immunohistochemical analysis of the expression of FATE/BJ-HCC-2 antigen in normal and malignant tissues. Lab. Invest. 2005 Feb; 85(2): 205-13. PMID: 15580283, PII: 3700220, DOI: 10.1038/labinvest.3700220, ISSN: 0023-6837.

Shang XY, Chen HS, Zhang HG, Pang XW, Qiao H, Peng JR, Qin LL, Fei R, Mei MH, Leng XS, Gnjatic S, Ritter G, Simpson AJ, Old LJ, Chen WF. The spontaneous CD8+ T-cell response to HLA-A2-restricted NY-ESO-1b peptide in hepatocellular carcinoma patients. Clin. Cancer Res. 2004 Oct 10/15/2004; 10(20): 6946-55. PMID: 15501973, PII: 10/20/6946, DOI: 10.1158/1078-0432.CCR-04-0502, ISSN: 1078-0432.