Nancy J Cox, Ph.D.

Professor

nancy.j.cox@vanderbilt.edu
Faculty Appointments
Professor of Medicine
Education
Ph.D., Yale University, New Haven, ConnecticutB.Sc., University of Notre Dame, South Bend, Indiana
Office Address
519C Light Hall
Nashville, TN 37232-0275
Publications
Morselli LL, Gamazon ER, Tasali E, Cox NJ, Van Cauter E, Davis LK. Shared Genetic Control of Brain Activity During Sleep and Insulin Secretion: A Laboratory-Based Family Study. Diabetes [print-electronic]. 2017 Oct 10/30/2017; PMID: 29084784, PII: db16-1229, DOI: 10.2337/db16-1229, ISSN: 1939-327X.

Dolan ME, El Charif O, Wheeler HE, Gamazon ER, Ardeshir-Rouhani-Fard S, Monahan P, Feldman DR, Hamilton RJ, Vaughn DJ, Beard CJ, Fung C, Kim J, Fossa SD, Hertz DL, Mushiroda T, Kubo M, Einhorn LH, Cox NJ, Travis LB, . Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer. Clin. Cancer Res [print-electronic]. 2017 Oct 10/1/2017; 23(19): 5757-68. PMID: 28611204, PMCID: PMC5626588, PII: 1078-0432.CCR-16-3224, DOI: 10.1158/1078-0432.CCR-16-3224, ISSN: 1078-0432.

Wang K, Gaitsch H, Poon H, Cox NJ, Rzhetsky A. Classification of common human diseases derived from shared genetic and environmental determinants. Nat. Genet [print-electronic]. 2017 Sep; 49(9): 1319-25. PMID: 28783162, PMCID: PMC5577363, PII: ng.3931, DOI: 10.1038/ng.3931, ISSN: 1546-1718.

Mechanic LE, Lindström S, Daily KM, Sieberts SK, Amos CI, Chen HS, Cox NJ, Dathe M, Feuer EJ, Guertin MJ, Hoffman J, Liu Y, Moore JH, Myers CL, Ritchie MD, Schildkraut J, Schumacher F, Witte JS, Wang W, Williams SM, , , Gillanders EM. Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology [editorial]. PLoS Genet. 2017 Sep; 13(9): e1006945. PMID: 28957327, PMCID: PMC5619686, PII: PGENETICS-D-17-01043, DOI: 10.1371/journal.pgen.1006945, ISSN: 1553-7404.

Cox NJ. Reaching for the next branch on the biobank tree of knowledge. Nature genetics. 2017 Aug 8/30/2017; 49(9) Sect. 1295,1296.

Gamazon ER, Konkashbaev A, Derks EM, Cox NJ, Lee Y. Evidence of selection on splicing-associated loci in human populations and relevance to disease loci mapping. Sci Rep. 2017 Jul 7/20/2017; 7(1): 5980. PMID: 28729732, PMCID: PMC5519721, PII: 10.1038/s41598-017-05744-9, DOI: 10.1038/s41598-017-05744-9, ISSN: 2045-2322.

Wheeler HE, Gamazon ER, Frisina RD, Perez-Cervantes C, El Charif O, Mapes B, Fossa SD, Feldman DR, Hamilton RJ, Vaughn DJ, Beard CJ, Fung C, Kollmannsberger C, Kim J, Mushiroda T, Kubo M, Ardeshir-Rouhani-Fard S, Einhorn LH, Cox NJ, Dolan ME, Travis LB. Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Clin. Cancer Res [print-electronic]. 2017 Jul 7/1/2017; 23(13): 3325-33. PMID: 28039263, PMCID: PMC5493516, PII: 1078-0432.CCR-16-2809, DOI: 10.1158/1078-0432.CCR-16-2809, ISSN: 1078-0432.

Huang AY, Yu D, Davis LK, Sul JH, Tsetsos F, Ramensky V, Zelaya I, Ramos EM, Osiecki L, Chen JA, McGrath LM, Illmann C, Sandor P, Barr CL, Grados M, Singer HS, Nöthen MM, Hebebrand J, King RA, Dion Y, Rouleau G, Budman CL, Depienne C, Worbe Y, Hartmann A, Müller-Vahl KR, Stuhrmann M, Aschauer H, Stamenkovic M, Schloegelhofer M, Konstantinidis A, Lyon GJ, McMahon WM, Barta C, Tarnok Z, Nagy P, Batterson JR, Rizzo R, Cath DC, Wolanczyk T, Berlin C, Malaty IA, Okun MS, Woods DW, Rees E, Pato CN, Pato MT, Knowles JA, Posthuma D, Pauls DL, Cox NJ, Neale BM, Freimer NB, Paschou P, Mathews CA, Scharf JM, Coppola G, , . Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome. Neuron. 2017 Jun 6/21/2017; 94(6): 1101-1111.e7. PMID: 28641109, PMCID: PMC5568251, PII: S0896-6273(17)30508-1, DOI: 10.1016/j.neuron.2017.06.010, ISSN: 1097-4199.

Hohman TJ, Dumitrescu L, Cox NJ, Jefferson AL, . Genetic resilience to amyloid related cognitive decline. Brain Imaging Behav. 2017 Apr; 11(2): 401-9. PMID: 27743375, PMCID: PMC5392179, PII: 10.1007/s11682-016-9615-5, DOI: 10.1007/s11682-016-9615-5, ISSN: 1931-7565.

Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Biesecker LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL, Roden D, Rodriguez LL, Williams MS, Cooper GM, Cox NJ, Herman GE, Kingsmore S, Lo C, Lutz C, MacRae CA, Nussbaum RL, Ordovas JM, Ramos EM, Robinson PN, Rubinstein WS, Seidman C, Stranger BE, Wang H, Westerfield M, Bult C. Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research. Cell. 2017 Mar 3/23/2017; 169(1): 6-12. PMID: 28340351, PMCID: PMC5511379, PII: S0092-8674(17)30284-2, DOI: 10.1016/j.cell.2017.03.005, ISSN: 1097-4172.

Chen R, Davis LK, Guter S, Wei Q, Jacob S, Potter MH, Cox NJ, Cook EH, Sutcliffe JS, Li B. Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism. Mol Autism. 2017; 8: 14. PMID: 28344757, PMCID: PMC5361831, PII: 130, DOI: 10.1186/s13229-017-0130-3, ISSN: 2040-2392.

Parra EJ, Mazurek A, Gignoux CR, Sockell A, Agostino M, Morris AP, Petty LE, Hanis CL, Cox NJ, Valladares-Salgado A, Below JE, Cruz M. Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. PLoS ONE. 2017; 12(2): e0172880. PMID: 28245265, PMCID: PMC5330487, PII: PONE-D-16-39411, DOI: 10.1371/journal.pone.0172880, ISSN: 1932-6203.

Wei WQ, Bastarache LA, Carroll RJ, Marlo JE, Osterman TJ, Gamazon ER, Cox NJ, Roden DM, Denny JC. Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record. PLoS ONE. 2017; 12(7): e0175508. PMID: 28686612, PMCID: PMC5501393, PII: PONE-D-16-36822, DOI: 10.1371/journal.pone.0175508, ISSN: 1932-6203.

Hillenmeyer S, Davis LK, Gamazon ER, Cook EH, Cox NJ, Altman RB. STAMS: STRING-assisted module search for genome wide association studies and application to autism. Bioinformatics [print-electronic]. 2016 Dec 12/15/2016; 32(24): 3815-22. PMID: 27542772, PMCID: PMC5167061, PII: btw530, DOI: 10.1093/bioinformatics/btw530, ISSN: 1367-4811.

Geeleher P, Gamazon ER, Seoighe C, Cox NJ, Huang RS. Consistency in large pharmacogenomic studies. Nature. 2016 Nov 11/30/2016; 540(7631): E1-E2. PMID: 27905415, PII: nature19838, DOI: 10.1038/nature19838, ISSN: 1476-4687.

Huo D, Feng Y, Haddad S, Zheng Y, Yao S, Han YJ, Ogundiran TO, Adebamowo C, Ojengbede O, Falusi AG, Zheng W, Blot W, Cai Q, Signorello L, John EM, Bernstein L, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Nathanson KL, Domchek SM, Rebbeck TR, Ruiz-Narváez EA, Sucheston-Campbell LE, Bensen JT, Simon MS, Hennis A, Nemesure B, Leske MC, Ambs S, Chen LS, Qian F, Gamazon ER, Lunetta KL, Cox NJ, Chanock SJ, Kolonel LN, Olshan AF, Ambrosone CB, Olopade OI, Palmer JR, Haiman CA. Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Hum. Mol. Genet. 2016 Nov 11/1/2016; 25(21): 4835-46. PMID: 28171663, PII: 2525910, DOI: 10.1093/hmg/ddw305, ISSN: 1460-2083.

Wheeler HE, Shah KP, Brenner J, Garcia T, Aquino-Michaels K, , Cox NJ, Nicolae DL, Im HK. Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues. PLoS Genet. 2016 Nov; 12(11): e1006423. PMID: 27835642, PMCID: PMC5106030, PII: PGENETICS-D-16-00755, DOI: 10.1371/journal.pgen.1006423, ISSN: 1553-7404.

Geeleher P, Cox NJ, Huang RS. Cancer biomarker discovery is improved by accounting for variability in general levels of drug sensitivity in pre-clinical models. Genome Biol. 2016 Sep 9/21/2016; 17(1): 190. PMID: 27654937, PMCID: PMC5031330, PII: 10.1186/s13059-016-1050-9, DOI: 10.1186/s13059-016-1050-9, ISSN: 1474-760X.

Hanis CL, Redline S, Cade BE, Bell GI, Cox NJ, Below JE, Brown EL, Aguilar D. Beyond type 2 diabetes, obesity and hypertension: an axis including sleep apnea, left ventricular hypertrophy, endothelial dysfunction, and aortic stiffness among Mexican Americans in Starr County, Texas. Cardiovasc Diabetol. 2016 Jun 6/8/2016; 15: 86. PMID: 27266869, PMCID: PMC4897940, PII: 10.1186/s12933-016-0405-6, DOI: 10.1186/s12933-016-0405-6, ISSN: 1475-2840.

Horikoshi M, Pasquali L, Wiltshire S, Huyghe JR, Mahajan A, Asimit JL, Ferreira T, Locke AE, Robertson NR, Wang X, Sim X, Fujita H, Hara K, Young R, Zhang W, Choi S, Chen H, Kaur I, Takeuchi F, Fontanillas P, Thuillier D, Yengo L, Below JE, Tam CH, Wu Y, Abecasis G, Altshuler D, Bell GI, Blangero J, Burtt NP, Duggirala R, Florez JC, Hanis CL, Seielstad M, Atzmon G, Chan JC, Ma RC, Froguel P, Wilson JG, Bharadwaj D, Dupuis J, Meigs JB, Cho YS, Park T, Kooner JS, Chambers JC, Saleheen D, Kadowaki T, Tai ES, Mohlke KL, Cox NJ, Ferrer J, Zeggini E, Kato N, Teo YY, Boehnke M, McCarthy MI, Morris AP, . Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Hum. Mol. Genet [print-electronic]. 2016 May 5/15/2016; 25(10): 2070-81. PMID: 26911676, PMCID: PMC5062576, PII: ddw048, DOI: 10.1093/hmg/ddw048, ISSN: 1460-2083.

Wang J, Gamazon ER, Pierce BL, Stranger BE, Im HK, Gibbons RD, Cox NJ, Nicolae DL, Chen LS. Imputing Gene Expression in Uncollected Tissues Within and Beyond GTEx. Am. J. Hum. Genet [print-electronic]. 2016 Apr 4/7/2016; 98(4): 697-708. PMID: 27040689, PMCID: PMC4833292, PII: S0002-9297(16)00071-9, DOI: 10.1016/j.ajhg.2016.02.020, ISSN: 1537-6605.

Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Pharmacogenomics J [print-electronic]. 2016 Feb 2/9/2016; PMID: 26856248, PII: tpj201593, DOI: 10.1038/tpj.2015.93, ISSN: 1473-1150.

Below JE, Parra EJ, Gamazon ER, Torres J, Krithika S, Candille S, Lu Y, Manichakul A, Peralta-Romero J, Duan Q, Li Y, Morris AP, Gottesman O, Bottinger E, Wang XQ, Taylor KD, Ida Chen YD, Rotter JI, Rich SS, Loos RJ, Tang H, Cox NJ, Cruz M, Hanis CL, Valladares-Salgado A. Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs. Sci Rep. 2016; 6: 19429. PMID: 26780889, PMCID: PMC4726092, PII: srep19429, DOI: 10.1038/srep19429, ISSN: 2045-2322.

Hungate EA, Vora SR, Gamazon ER, Moriyama T, Best T, Hulur I, Lee Y, Evans TJ, Ellinghaus E, Stanulla M, Rudant J, Orsi L, Clavel J, Milne E, Scott RJ, Pui CH, Cox NJ, Loh ML, Yang JJ, Skol AD, Onel K. A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology. Nat Commun. 2016; 7: 10635. PMID: 26868379, PII: ncomms10635, DOI: 10.1038/ncomms10635, ISSN: 2041-1723.

Kutny MA, Alonzo TA, Gamazon ER, Gerbing RB, Geraghty D, Lange B, Heerema NA, Sung L, Aplenc R, Franklin J, Raimondi SC, Hirsch BA, Konkashbaev A, Cox NJ, Onel K, Gamis AS, Meshinchi S. Ethnic variation of TET2 SNP rs2454206 and association with clinical outcome in childhood AML: a report from the Children's Oncology Group. Leukemia [print-electronic]. 2015 Dec; 29(12): 2424-6. PMID: 26126966, PMCID: PMC4675677, PII: leu2015171, DOI: 10.1038/leu.2015.171, ISSN: 1476-5551.

Gamazon ER, Wheeler HE, Shah KP, Mozaffari SV, Aquino-Michaels K, Carroll RJ, Eyler AE, Denny JC, , Nicolae DL, Cox NJ, Im HK. A gene-based association method for mapping traits using reference transcriptome data. Nat. Genet [print-electronic]. 2015 Sep; 47(9): 1091-8. PMID: 26258848, PMCID: PMC4552594, PII: ng.3367, DOI: 10.1038/ng.3367, ISSN: 1546-1718.

Evans PD, Mueller KL, Gamazon ER, Cox NJ, Tomblin JB. A genome-wide sib-pair scan for quantitative language traits reveals linkage to chromosomes 10 and 13. Genes Brain Behav. 2015 Jun; 14(5): 387-97. PMID: 25997078, PMCID: PMC4755290, DOI: 10.1111/gbb.12223, ISSN: 1601-183X.

Chen R, Wei Q, Zhan X, Zhong X, Sutcliffe JS, Cox NJ, Cook EH, Li C, Chen W, Li B. A haplotype-based framework for group-wise transmission/disequilibrium tests for rare variant association analysis. Bioinformatics [print-electronic]. 2015 May 5/1/2015; 31(9): 1452-9. PMID: 25568282, PMCID: PMC4410665, PII: btu860, DOI: 10.1093/bioinformatics/btu860, ISSN: 1367-4811.

Goetz MP, Sun JX, Suman VJ, Silva GO, Perou CM, Nakamura Y, Cox NJ, Stephens PJ, Miller VA, Ross JS, Chen D, Safgren SL, Kuffel MJ, Ames MM, Kalari KR, Gomez HL, Gonzalez-Angulo AM, Burgues O, Brauch HB, Ingle JN, Ratain MJ, Yelensky R. Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies. J. Natl. Cancer Inst. 2015 Feb; 107(2): PMID: 25490892, PMCID: PMC4565524, PII: dju401, DOI: 10.1093/jnci/dju401, ISSN: 1460-2105.

Trubetskoy V, Rodriguez A, Dave U, Campbell N, Crawford EL, Cook EH, Sutcliffe JS, Foster I, Madduri R, Cox NJ, Davis LK. Consensus Genotyper for Exome Sequencing (CGES): improving the quality of exome variant genotypes. Bioinformatics [print-electronic]. 2015 Jan 1/15/2015; 31(2): 187-93. PMID: 25270638, PMCID: PMC4287941, PII: btu591, DOI: 10.1093/bioinformatics/btu591, ISSN: 1367-4811.

Zhang W, Gamazon ER, Zhang X, Konkashbaev A, Liu C, Szilágyi KL, Dolan ME, Cox NJ. SCAN database: facilitating integrative analyses of cytosine modification and expression QTL. Database (Oxford) [electronic-print]. 2015; 2015: PMID: 25818895, PMCID: PMC4375357, PII: bav025, DOI: 10.1093/database/bav025, ISSN: 1758-0463.

McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, Scharf JM. Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry [print-electronic]. 2014 Aug; 53(8): 910-9. PMID: 25062598, PMCID: PMC4218748, PII: S0890-8567(14)00404-3, DOI: 10.1016/j.jaac.2014.04.022, ISSN: 1527-5418.

Delahanty RJ, Kang JQ, Brune CW, Kistner EO, Courchesne E, Cox NJ, Cook EH, Macdonald RL, Sutcliffe JS. Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism. Mol. Psychiatry [print-electronic]. 2011 Jan; 16(1): 86-96. PMID: 19935738, PMCID: PMC3428055, PII: mp2009118, DOI: 10.1038/mp.2009.118, ISSN: 1476-5578.

Available Postdoctoral Position Details
Posted: 12/16/2015
Post-doctoral Opportunity in Genetic Studies of Eye Diseases

We are a seeking post-doctoral fellow with expertise in molecular genetic techniques and/or quantitative genomics to identify and then characterize genetic risk factors for human eye diseases. Candidates should possess skills in any of the following: use of -omics technologies, experience with validation studies in cell lines, mice or zebrafish, and the ability to mine results from genome studies in BioVU, the biobank at Vanderbilt University. This opportunity comes via the training program Quantitative Ocular Genomics and offers salary support, travel funds, and the opportunity to build a career in a stimulating research environment.

Vanderbilt University Medical Center is an Equal Opportunity/Affirmative Action Employer