Eunyoung Choi, Ph.D.

Associate Professor
Faculty Appointments
Associate Professor of Surgery
Ph.D., Gwangju Institute of Science and Technology, Gwangju, South KoreaM.S., Gwangju Institute of Science and Technology, Gwangju, South KoreaB.S., Seoul Women's University, Seoul, South Korea
Office Address
2213 Garland Avenue
10435F MRBIV
Nashville, TN 37232
Research Description
The Choi lab performs basic and pre-clinical researches that combine multidisciplinary approaches to understand mechanisms of carcinogenic transition in gastric carcinogenesis using novel in vivo and in vitro models which are unique in the gastric cancer field.
Research Keywords
Carcinogenesis, Organoid, Transgenic animal, Cancer, Stomach Cancer, Cancer stem cell, Oncogene
Min J, Zhang C, Bliton RJ, Caldwell B, Caplan L, Presentation KS, Park DJ, Kong SH, Lee HS, Washington MK, Kim WH, Lau KS, Magness ST, Lee HJ, Yang HK, Goldenring JR, Choi E. Dysplastic Stem Cell Plasticity Functions as a Driving Force for Neoplastic Transformation of Precancerous Gastric Mucosa. Gastroenterology [print-electronic]. 2022 Oct; 163(4): 875-90. PMID: 35700772, PMCID: PMC9509466, PII: S0016-5085(22)00626-6, DOI: 10.1053/j.gastro.2022.06.021, ISSN: 1528-0012.

Caldwell B, Meyer AR, Weis JA, Engevik AC, Choi E. Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa. Gut [print-electronic]. 2022 Jun; 71(6): 1068-77. PMID: 34497145, PMCID: PMC8901801, PII: gutjnl-2021-325310, DOI: 10.1136/gutjnl-2021-325310, ISSN: 1468-3288.

Lee JH, Kim S, Han S, Min J, Caldwell B, Bamford AD, Rocha ASB, Park J, Lee S, Wu SS, Lee H, Fink J, Pilat-Carotta S, Kim J, Josserand M, Szep-Bakonyi R, An Y, Ju YS, Philpott A, Simons BD, Stange DE, Choi E, Koo BK, Kim JK. P57Kip2 imposes the reserve stem cell state of gastric chief cells. Cell Stem Cell. 2022 May 5/5/2022; 29(5): 826-839.e9. PMID: 35523142, PMCID: PMC9097776, PII: S1934-5909(22)00154-0, DOI: 10.1016/j.stem.2022.04.001, ISSN: 1875-9777.

Lee SH, Jang B, Min J, Contreras-Panta EW, Presentation KS, Delgado AG, Piazuelo MB, Choi E, Goldenring JR. Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal Metaplasia. Cell Mol Gastroenterol Hepatol [print-electronic]. 2022; 13(1): 199-217. PMID: 34455107, PMCID: PMC8593616, PII: S2352-345X(21)00184-3, DOI: 10.1016/j.jcmgh.2021.08.017, ISSN: 2352-345X.

Osipovich AB, Dudek KD, Greenfest-Allen E, Cartailler JP, Manduchi E, Potter Case L, Choi E, Chapman AG, Clayton HW, Gu G, Stoeckert CJ, Magnuson MA. A developmental lineage-based gene co-expression network for mouse pancreatic ß-cells reveals a role for Zfp800 in pancreas development. Development. 2021 Mar 3/21/2021; 148(6): PMID: 33653874, PMCID: PMC8015253, PII: dev.196964, DOI: 10.1242/dev.196964, ISSN: 1477-9129.

O'Brien VP, Koehne AL, Dubrulle J, Rodriguez AE, Leverich CK, Kong VP, Campbell JS, Pierce RH, Goldenring JR, Choi E, Salama NR. Sustained Helicobacter pylori infection accelerates gastric dysplasia in a mouse model. Life Sci Alliance [electronic-print]. 2021 Feb; 4(2): PMID: 33310760, PMCID: PMC7768197, PII: 4/2/e202000967, DOI: 10.26508/lsa.202000967, ISSN: 2575-1077.

Riera KM, Jang B, Min J, Roland JT, Yang Q, Fesmire WT, Camilleri-Broet S, Ferri L, Kim WH, Choi E, Goldenring JR. Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa. J Pathol [print-electronic]. 2020 Jul; 251(3): 336-47. PMID: 32432338, PMCID: PMC8010636, DOI: 10.1002/path.5469, ISSN: 1096-9896.

Min J, Han TS, Sohn Y, Shimizu T, Choi B, Bae SW, Hur K, Kong SH, Suh YS, Lee HJ, Kim JS, Min JK, Kim WH, Kim VN, Choi E, Goldenring JR, Yang HK. MicroRNA-30a arbitrates intestinal-type early gastric carcinogenesis by directly targeting ITGA2. Gastric Cancer [print-electronic]. 2020 Jul; 23(4): 600-13. PMID: 32112274, PMCID: PMC7306433, PII: 10.1007/s10120-020-01052-w, DOI: 10.1007/s10120-020-01052-w, ISSN: 1436-3305.

Shimizu T, Sohn Y, Choi E, Petersen CP, Prasad N, Goldenring JR. Decrease in MiR-148a Expression During Initiation of Chief Cell Transdifferentiation. Cell Mol Gastroenterol Hepatol [print-electronic]. 2020; 9(1): 61-78. PMID: 31473306, PMCID: PMC6881610, PII: S2352-345X(19)30114-6, DOI: 10.1016/j.jcmgh.2019.08.008, ISSN: 2352-345X.

Min J, Vega PN, Engevik AC, Williams JA, Yang Q, Patterson LM, Simmons AJ, Bliton RJ, Betts JW, Lau KS, Magness ST, Goldenring JR, Choi E. Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach. Nat Commun. 2019 Dec 12/5/2019; 10(1): 5549. PMID: 31804471, PMCID: PMC6895174, PII: 10.1038/s41467-019-13479-6, DOI: 10.1038/s41467-019-13479-6, ISSN: 2041-1723.

Wroblewski LE, Choi E, Petersen C, Delgado AG, Piazuelo MB, Romero-Gallo J, Lantz TL, Zavros Y, Coffey RJ, Goldenring JR, Zemper AE, Peek RM. Targeted mobilization of Lrig1+ gastric epithelial stem cell populations by a carcinogenic Helicobacter pylori type IV secretion system. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2019 Sep 9/24/2019; 116(39): 19652-8. PMID: 31488717, PMCID: PMC6765285, PII: 1903798116, DOI: 10.1073/pnas.1903798116, ISSN: 1091-6490.

Yang Q, Yasuda T, Choi E, Toyoda T, Roland JT, Uchida E, Yoshida H, Seto Y, Goldenring JR, Nomura S. MEK Inhibitor Reverses Metaplasia and Allows Re-Emergence of Normal Lineages in Helicobacter pylori-Infected Gerbils. Gastroenterology [print-electronic]. 2019 Feb; 156(3): 577-581.e4. PMID: 30391471, PMCID: PMC6368860, PII: S0016-5085(18)35206-5, DOI: 10.1053/j.gastro.2018.10.049, ISSN: 1528-0012.

Meyer AR, Engevik AC, Willet SG, Williams JA, Zou Y, Massion PP, Mills JC, Choi E, Goldenring JR. Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury. Cell Mol Gastroenterol Hepatol [print-electronic]. 2019; 8(3): 379-405. PMID: 31071489, PMCID: PMC6713894, PII: S2352-345X(19)30060-8, DOI: 10.1016/j.jcmgh.2019.04.015, ISSN: 2352-345X.

Choi E, Means AL, Coffey RJ, Goldenring JR. Active Kras Expression in Gastric Isthmal Progenitor Cells Induces Foveolar Hyperplasia but Not Metaplasia. Cell Mol Gastroenterol Hepatol [print-electronic]. 2019; 7(1): 251-253.e1. PMID: 30585163, PMCID: PMC6305842, PII: S2352-345X(18)30129-2, DOI: 10.1016/j.jcmgh.2018.09.007, ISSN: 2352-345X.

Pinzon-Guzman C, Meyer AR, Wise R, Choi E, Muthupalani S, Wang TC, Fox JG, Goldenring JR. Evaluation of Lineage Changes in the Gastric Mucosa Following Infection With Helicobacter pylori and Specified Intestinal Flora in INS-GAS Mice. J. Histochem. Cytochem [print-electronic]. 2018 Jul 7/1/2018; 22155418785621. PMID: 29969055, PMCID: PMC6309034, DOI: 10.1369/0022155418785621, ISSN: 1551-5044.

Choi E, Lantz TL, Vlacich G, Keeley TM, Samuelson LC, Coffey RJ, Goldenring JR, Powell AE. Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut [print-electronic]. 2017 Aug 8/16/2017; PMID: 28814482, PII: gutjnl-2017-313874, DOI: 10.1136/gutjnl-2017-313874, ISSN: 1468-3288.

Petersen CP, Meyer AR, De Salvo C, Choi E, Schlegel C, Petersen A, Engevik AC, Prasad N, Levy SE, Peebles RS, Pizarro TT, Goldenring JR. A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut [print-electronic]. 2017 Feb 2/14/2017; PMID: 28196875, PII: gutjnl-2016-312779, DOI: 10.1136/gutjnl-2016-312779, ISSN: 1468-3288.

Jeong S, Choi E, Petersen CP, Roland JT, Federico A, Ippolito R, D'Armiento FP, Nardone G, Nagano O, Saya H, Romano M, Goldenring JR. Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis. United European Gastroenterol J [print-electronic]. 2017 Feb; 5(1): 37-44. PMID: 28405320, PMCID: PMC5384548, PII: 10.1177_2050640616644142, DOI: 10.1177/2050640616644142, ISSN: 2050-6406.

Weis VG, Petersen CP, Weis JA, Meyer AR, Choi E, Mills JC, Goldenring JR. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2017 Jan 1/1/2017; 312(1): G67-G76. PMID: 27881402, PMCID: PMC5283902, PII: ajpgi.00326.2016, DOI: 10.1152/ajpgi.00326.2016, ISSN: 1522-1547.

O'Neil A, Petersen CP, Choi E, Engevik AC, Goldenring JR. Unique Cellular Lineage Composition of the First Gland of the Mouse Gastric Corpus. J. Histochem. Cytochem [print-electronic]. 2017 Jan; 65(1): 47-58. PMID: 27872404, PMCID: PMC5256201, PII: 0022155416678182, DOI: 10.1369/0022155416678182, ISSN: 1551-5044.

Engevik AC, Feng R, Choi E, White S, Bertaux-Skeirik N, Li J, Mahe MM, Aihara E, Yang L, DiPasquale B, Oh S, Engevik KA, Giraud AS, Montrose MH, Medvedovic M, Helmrath MA, Goldenring JR, Zavros Y. The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach. Cell Mol Gastroenterol Hepatol. 2016 Sep; 2(5): 605-24. PMID: 27990460, PMCID: PMC5042762, PII: S2352-345X(16)30044-3, DOI: 10.1016/j.jcmgh.2016.05.004, ISSN: 2352-345X.

Shimizu T, Choi E, Petersen CP, Noto JM, Romero-Gallo J, Piazuelo MB, Washington MK, Peek RM, Goldenring JR. Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori. J. Pathol [print-electronic]. 2016 Aug; 239(4): 399-410. PMID: 27125972, PMCID: PMC4958595, DOI: 10.1002/path.4735, ISSN: 1096-9896.

Choi E, Hendley AM, Bailey JM, Leach SD, Goldenring JR. Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. Gastroenterology [print-electronic]. 2016 Apr; 150(4): 918-30.e13. PMID: 26677984, PMCID: PMC4808451, PII: S0016-5085(15)01735-7, DOI: 10.1053/j.gastro.2015.11.049, ISSN: 1528-0012.

Weis VG, Knowles BC, Choi E, Goldstein AE, Williams JA, Manning EH, Roland JT, Lapierre LA, Goldenring JR. Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Cell Mol Gastroenterol Hepatol. 2016 Feb 2/1/2016; 2(2): 131-57. PMID: 27019864, PMCID: PMC4806369, DOI: 10.1016/j.jcmgh.2015.11.009, ISSN: 2352-345X.

Choi E, Petersen CP, Lapierre LA, Williams JA, Weis VG, Goldenring JR, Nam KT. Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin. Am. J. Pathol [print-electronic]. 2015 Aug; 185(8): 2219-31. PMID: 26073039, PMCID: PMC4530133, PII: S0002-9440(15)00267-9, DOI: 10.1016/j.ajpath.2015.04.009, ISSN: 1525-2191.

Choi E, Roland JT, Barlow BJ, O'Neal R, Rich AE, Nam KT, Shi C, Goldenring JR. Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. Gut [print-electronic]. 2014 Nov; 63(11): 1711-20. PMID: 24488499, PMCID: PMC4117823, PII: gutjnl-2013-305964, DOI: 10.1136/gutjnl-2013-305964, ISSN: 1468-3288.

Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ, Grapin-Botton A, Magnuson MA. Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct; 30(10): 2297-308. PMID: 22865702, PMCID: PMC3448801, DOI: 10.1002/stem.1192, ISSN: 1549-4918.

Potter LA, Choi E, Hipkens SB, Wright CV, Magnuson MA. A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1. Genesis [print-electronic]. 2012 Apr; 50(4): 384-92. PMID: 21913313, PMCID: PMC3870909, DOI: 10.1002/dvg.20804, ISSN: 1526-968X.

Choi E, Cho C. Expression of a sperm flagellum component encoded by the Als2cr12 gene. Gene Expr. Patterns [print-electronic]. 2011 Jun; 11(5-6): 327-33. PMID: 21402173, PII: S1567-133X(11)00028-7, DOI: 10.1016/j.gep.2011.03.003, ISSN: 1872-7298.

Han C, Choi E, Park I, Lee B, Jin S, Kim DH, Nishimura H, Cho C. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Biol. Reprod [print-electronic]. 2009 May; 80(5): 1001-8. PMID: 19129510, PII: biolreprod.108.073700, DOI: 10.1095/biolreprod.108.073700, ISSN: 0006-3363.

Choi E, Han C, Park I, Lee B, Jin S, Choi H, Kim DH, Park ZY, Eddy EM, Cho C. A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis. J. Biol. Chem [print-electronic]. 2008 Dec 12/12/2008; 283(50): 35283-94. PMID: 18849567, PMCID: PMC2596390, PII: M805590200, DOI: 10.1074/jbc.M805590200, ISSN: 0021-9258.

Baek N, Woo JM, Han C, Choi E, Park I, Kim DH, Eddy EM, Cho C. Characterization of eight novel proteins with male germ cell-specific expression in mouse. Reprod. Biol. Endocrinol. 2008 Jul 7/24/2008; 6: 32. PMID: 18652659, PMCID: PMC2500023, PII: 1477-7827-6-32, DOI: 10.1186/1477-7827-6-32, ISSN: 1477-7827.

Park I, Hong SE, Kim TW, Lee J, Oh J, Choi E, Han C, Lee H, Han Kim D, Cho C. Comprehensive identification and characterization of novel cardiac genes in mouse. J. Mol. Cell. Cardiol [print-electronic]. 2007 Aug; 43(2): 93-106. PMID: 17599348, PII: S0022-2828(07)01057-7, DOI: 10.1016/j.yjmcc.2007.05.018, ISSN: 0022-2828.

Choi E, Lee J, Oh J, Park I, Han C, Yi C, Kim DH, Cho BN, Eddy EM, Cho C. Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library. BMC Genomics. 2007 Jul 7/28/2007; 8: 256. PMID: 17662146, PMCID: PMC1955454, PII: 1471-2164-8-256, DOI: 10.1186/1471-2164-8-256, ISSN: 1471-2164.

Lee J, Oh J, Choi E, Park I, Han C, Kim DH, Choi BC, Kim JW, Cho C. Differentially expressed genes implicated in unexplained recurrent spontaneous abortion. Int. J. Biochem. Cell Biol [print-electronic]. 2007; 39(12): 2265-77. PMID: 17681868, PII: S1357-2725(07)00209-9, DOI: 10.1016/j.biocel.2007.06.012, ISSN: 1357-2725.

Oh J, Lee J, Woo JM, Choi E, Park I, Han C, Baek N, Lee H, Kim DH, Cho C. Systematic identification and integrative analysis of novel genes expressed specifically or predominantly in mouse epididymis. BMC Genomics. 2006 Dec 12/13/2006; 7: 314. PMID: 17166261, PMCID: PMC1764739, PII: 1471-2164-7-314, DOI: 10.1186/1471-2164-7-314, ISSN: 1471-2164.

Kim T, Oh J, Woo JM, Choi E, Im SH, Yoo YJ, Kim DH, Nishimura H, Cho C. Expression and relationship of male reproductive ADAMs in mouse. Biol. Reprod [print-electronic]. 2006 Apr; 74(4): 744-50. PMID: 16407499, PII: biolreprod.105.048892, DOI: 10.1095/biolreprod.105.048892, ISSN: 0006-3363.

Oh J, Woo JM, Choi E, Kim T, Cho BN, Park ZY, Kim YC, Kim DH, Cho C. Molecular, biochemical, and cellular characterization of epididymal ADAMs, ADAM7 and ADAM28. Biochem. Biophys. Res. Commun. 2005 Jun 6/17/2005; 331(4): 1374-83. PMID: 15883027, PII: S0006-291X(05)00835-1, DOI: 10.1016/j.bbrc.2005.04.067, ISSN: 0006-291X.

Hong S, Choi I, Woo JM, Oh J, Kim T, Choi E, Kim TW, Jung YK, Kim DH, Sun CH, Yi GS, Eddy EM, Cho C. Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. J. Biol. Chem [print-electronic]. 2005 Mar 3/4/2005; 280(9): 7685-93. PMID: 15613475, PII: M412444200, DOI: 10.1074/jbc.M412444200, ISSN: 0021-9258.

Available Postdoctoral Position Details
Posted: 4/14/2020

The Choi Lab is seeking a highly motivated, recent PhD or MD/PhD graduate to participate in gastric cancer research.

The Choi Lab studies basic and pre-clinical research projects to understand mechanisms of carcinogenic transition in gastric carcinogenesis. The Choi Lab is a multiple (NCI and DOD) funded gastric cancer research laboratory and uses novel in vivo mouse models and in vitro dysplasia organoid models which are unique in the gastric cancer field.

Positions are available to understand the biology of gastric carcinogenesis and oncogenic roles of Kras activation in the stomach and to assess functional roles of Sox9 as a putative master regulator of metaplasia development and progression.

Specific techniques for these studies include Animal surgical techniques, Single cell RNA sequencing, 3D organoid culture, Live cell/organoid microscopy and Multiplex fluorescence imaging and analysis.

Common techniques include Molecular biology, cell biology and Confocal fluorescence microscopy.  

Successful candidates:

1. A PhD degree in cell biology or cancer biology

2. A track record of original publications, with at least one first authored scientific publication

3. Experience with mouse transgenic models

4. Strong communication skills in English, oral and written

5. One or two first-author peer-reviewed publications

If interested, please contact Eunyoung Choi,, with a full CV, three references, earliest start date and a statement with career goal and research experience.