Shinji Toki, Ph.D.

Research Assistant Professor

shinji.toki@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., medical science, Kochi University, Kochi, ForeignM.Sc., agricultural science, Tokyo University of Agriculture and Technology, Tokyo, JapanB.Sc., agricultural science, Tokyo University of Agriculture and Technology, Tokyo, Japan
Publications
Toki S, Zhou W, Goleniewska K, Reiss S, Dulek DE, Newcomb DC, Lawson WE, Peebles RS. Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model. Prostaglandins Other Lipid Mediat [print-electronic]. 2018 May; 136: 33-43. PMID: 29660395, PMCID: PMC5970997, PII: S1098-8823(17)30116-8, DOI: 10.1016/j.prostaglandins.2018.04.001, ISSN: 1098-8823.

Bloodworth MH, Rusznak M, Pfister CC, Zhang J, Bastarache L, Calvillo SA, Chappell JD, Boyd KL, Toki S, Newcomb DC, Stier MT, Zhou W, Goleniewska K, Moore ML, Hartert TV, Niswender KD, Peebles RS. Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology. J. Allergy Clin. Immunol [print-electronic]. 2018 Apr 4/17/2018; PMID: 29678751, PII: S0091-6749(18)30561-X, DOI: 10.1016/j.jaci.2018.01.053, ISSN: 1097-6825.

Toki S, Goleniewska K, Reiss S, Zhang J, Bloodworth MH, Stier MT, Zhou W, Newcomb DC, Ware LB, Stanwood GD, Galli A, Boyd KL, Niswender KD, Peebles RS. Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo. J. Allergy Clin. Immunol [print-electronic]. 2018 Jan 1/10/2018; PMID: 29331643, PII: S0091-6749(18)30027-7, DOI: 10.1016/j.jaci.2017.11.043, ISSN: 1097-6825.

Cephus JY, Stier MT, Fuseini H, Yung JA, Toki S, Bloodworth MH, Zhou W, Goleniewska K, Zhang J, Garon SL, Hamilton RG, Poloshukin VV, Boyd KL, Peebles RS, Newcomb DC. Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation. Cell Rep. 2017 Nov 11/28/2017; 21(9): 2487-99. PMID: 29186686, PMCID: PMC5731254, PII: S2211-1247(17)31590-5, DOI: 10.1016/j.celrep.2017.10.110, ISSN: 2211-1247.

Zhou W, Zhang J, Goleniewska K, Dulek DE, Toki S, Newcomb DC, Cephus JY, Collins RD, Wu P, Boothby MR, Peebles RS. Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation. J. Immunol [print-electronic]. 2016 Sep 9/1/2016; 197(5): 1577-86. PMID: 27456482, PMCID: PMC4992670, PII: jimmunol.1501063, DOI: 10.4049/jimmunol.1501063, ISSN: 1550-6606.

Stier MT, Bloodworth MH, Toki S, Newcomb DC, Goleniewska K, Boyd KL, Quitalig M, Hotard AL, Moore ML, Hartert TV, Zhou B, McKenzie AN, Peebles RS. Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin. J. Allergy Clin. Immunol [print-electronic]. 2016 Sep; 138(3): 814-824.e11. PMID: 27156176, PMCID: PMC5014571, PII: S0091-6749(16)30080-X, DOI: 10.1016/j.jaci.2016.01.050, ISSN: 1097-6825.

Toki S, Goleniewska K, Reiss S, Zhou W, Newcomb DC, Bloodworth MH, Stier MT, Boyd KL, Polosukhin VV, Subramaniam S, Peebles RS. The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. Thorax [print-electronic]. 2016 Jul; 71(7): 633-45. PMID: 27071418, PMCID: PMC4941189, PII: thoraxjnl-2015-207728, DOI: 10.1136/thoraxjnl-2015-207728, ISSN: 1468-3296.

Zhou W, Toki S, Zhang J, Goleniewksa K, Newcomb DC, Cephus JY, Dulek DE, Bloodworth MH, Stier MT, Polosuhkin V, Gangula RD, Mallal SA, Broide DH, Peebles RS. Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses. Am. J. Respir. Crit. Care Med. 2016 Jan 1/1/2016; 193(1): 31-42. PMID: 26378386, PMCID: PMC4731613, DOI: 10.1164/rccm.201410-1793OC, ISSN: 1535-4970.

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J. Allergy Clin. Immunol [print-electronic]. 2014 Sep; 134(3): 698-705.e5. PMID: 25042746, PMCID: PMC4358822, PII: S0091-6749(14)00806-9, DOI: 10.1016/j.jaci.2014.06.004, ISSN: 1097-6825.

Dulek DE, Newcomb DC, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill TP, Blackwell TS, Moore ML, Boyd KL, Kolls JK, Peebles RS. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect. Immun [print-electronic]. 2014 Sep; 82(9): 3723-39. PMID: 24958709, PMCID: PMC4187810, PII: IAI.00035-14, DOI: 10.1128/IAI.00035-14, ISSN: 1098-5522.

Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RS. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J. Virol [print-electronic]. 2014 Sep 9/1/2014; 88(17): 9655-72. PMID: 24920804, PMCID: PMC4136353, PII: JVI.03299-13, DOI: 10.1128/JVI.03299-13, ISSN: 1098-5514.

Toki S, Omary RA, Wilson K, Gore JC, Peebles RS, Pham W. A comprehensive analysis of transfection-assisted delivery of iron oxide nanoparticles to dendritic cells. Nanomedicine [print-electronic]. 2013 Nov; 9(8): 1235-44. PMID: 23747738, PMCID: PMC4031028, PII: S1549-9634(13)00261-X, DOI: 10.1016/j.nano.2013.05.010, ISSN: 1549-9642.

Sevin CM, Newcomb DC, Toki S, Han W, Sherrill TP, Boswell MG, Zhu Z, Collins RD, Boyd KL, Goleniewska K, Huckabee MM, Blackwell TS, Peebles RS. Deficiency of gp91phox inhibits allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 2013 Sep; 49(3): 396-402. PMID: 23590311, PMCID: PMC3824054, DOI: 10.1165/rcmb.2012-0442OC, ISSN: 1535-4989.

Newcomb DC, Boswell MG, Reiss S, Zhou W, Goleniewska K, Toki S, Harintho MT, Lukacs NW, Kolls JK, Peebles RS. IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation. Thorax [print-electronic]. 2013 Aug; 68(8): 717-23. PMID: 23422214, PMCID: PMC3916091, PII: thoraxjnl-2012-202404, DOI: 10.1136/thoraxjnl-2012-202404, ISSN: 1468-3296.

Toki S, Goleniewska K, Huckabee MM, Zhou W, Newcomb DC, Fitzgerald GA, Lawson WE, Peebles RS. PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cells. J. Leukoc. Biol [print-electronic]. 2013 Jul; 94(1): 77-88. PMID: 23625201, PMCID: PMC3685021, PII: jlb.1112559, DOI: 10.1189/jlb.1112559, ISSN: 1938-3673.

Zhou W, Dowell DR, Huckabee MM, Newcomb DC, Boswell MG, Goleniewska K, Lotz MT, Toki S, Yin H, Yao S, Natarajan C, Wu P, Sriram S, Breyer RM, Fitzgerald GA, Peebles RS. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. PLoS ONE [print-electronic]. 2012; 7(5): e33518. PMID: 22590492, PMCID: PMC3349674, PII: PONE-D-10-03779, DOI: 10.1371/journal.pone.0033518, ISSN: 1932-6203.

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Oct; 301(4): L615-22. PMID: 21764988, PMCID: PMC3774255, PII: ajplung.00224.2010, DOI: 10.1152/ajplung.00224.2010, ISSN: 1522-1504.