Jennifer M. Colby, Ph.D.

Assistant Professor
Faculty Appointments
Assistant Professor of Pathology, Microbiology and Immunology
Ph.D., Molecular Toxicology, University of California, Berkeley, CaliforniaB.S., Molecular and Cellular Biology, with honors, Vanderbilt University, Nashville, Tennessee
Office Address
Vanderbilt University Medical Center
4918B TVC
1301 Medical Center Drive
Nashville, TN 37232-5310
Research Description
I am generally interested in expanding mass spectrometry based diagnostics in the clinical laboratory, with a special focus on toxicology and therapeutic drug monitoring applications.
Research Keywords
Mass spectrometry, chromatography, laboratory developed tests, toxicology, therapeutic drug monitoring
Colby JM, Patel PC, Fu DY, Rutherford NJ. Commonly used fluoroquinolones cross-react with urine drug screens for opiates, buprenorphine, and amphetamines. Clin. Biochem [print-electronic]. 2019 Apr 4/13/2019; PMID: 30991036, PII: S0009-9120(19)30092-X, DOI: 10.1016/j.clinbiochem.2019.04.009, ISSN: 1873-2933.

Van Wijk XMR, Goodnough R, Colby JM. Mass spectrometry in emergency toxicology: Current state and future applications. Crit Rev Clin Lab Sci [print-electronic]. 2019 Apr 4/1/2019; 1-14. PMID: 30931660, DOI: 10.1080/10408363.2019.1585415, ISSN: 1549-781X.

Colby JM, Patrick SW. Reply [letter]. J. Pediatr [print-electronic]. 2019 Mar 3/27/2019; PMID: 30928145, PII: S0022-3476(19)30258-6, DOI: 10.1016/j.jpeds.2019.02.026, ISSN: 1097-6833.

Chambliss AB, Hayden J, Colby JM. Evaluation of procalcitonin immunoassay concordance near clinical decision points. Clin. Chem. Lab. Med [print-electronic]. 2019 Feb 2/14/2019; PMID: 30763263, PII: /j/cclm.ahead-of-print/cclm-2018-1362/cclm-2018-1362.xml, DOI: 10.1515/cclm-2018-1362, ISSN: 1437-4331.

Colby JM, Lynch KL. Drug Screening Using Liquid Chromatography Quadrupole Time-of-Flight (LC-QqTOF) Mass Spectrometry. Methods Mol. Biol. 2019; 1872: 181-90. PMID: 30350290, DOI: 10.1007/978-1-4939-8823-5_17, ISSN: 1940-6029.

Colby JM, Adams BC, Morad A, Presley LD, Patrick SW. Umbilical Cord Tissue and Meconium May Not Be Equivalent for Confirming in Utero Substance Exposure. J. Pediatr [print-electronic]. 2018 Oct 10/17/2018; PMID: 30342870, PII: S0022-3476(18)31376-3, DOI: 10.1016/j.jpeds.2018.09.046, ISSN: 1097-6833.

Wiencek JR, Dietzen DJ, Murray T, Dawling S, Colby JM, Nichols JH. Persistently Increased Alloisoleucine in a Patient with Seizures. Clin. Chem. 2018 Oct; 64(10): 1433-7. PMID: 30266717, PII: 64/10/1433, DOI: 10.1373/clinchem.2017.278804, ISSN: 1530-8561.

Rutherford NJ, Thoren KL, Shajani-Yi Z, Colby JM. Voxelotor (GBT440) produces interference in measurements of hemoglobin S [letter]. Clin. Chim. Acta [print-electronic]. 2018 Jul; 482: 57-9. PMID: 29601794, PII: S0009-8981(18)30148-7, DOI: 10.1016/j.cca.2018.03.032, ISSN: 1873-3492.

Verhoven SM, Groszek JJ, Fissell WH, Seegmiller A, Colby J, Patel P, Verstraete A, Shotwell M. Therapeutic drug monitoring of piperacillin and tazobactam by RP-HPLC of residual blood specimens. Clin. Chim. Acta [print-electronic]. 2018 Jul; 482: 60-4. PMID: 29596815, PMCID: PMC5970981, PII: S0009-8981(18)30137-2, DOI: 10.1016/j.cca.2018.03.021, ISSN: 1873-3492.

Wabuyele SL, Colby JM, McMillin GA. Detection of Drug-Exposed Newborns. Ther Drug Monit. 2018 Apr; 40(2): 166-85. PMID: 29419722, DOI: 10.1097/FTD.0000000000000485, ISSN: 1536-3694.

Colby JM, Thoren KL, Lynch KL. Suspect Screening Using LC-QqTOF Is a Useful Tool for Detecting Drugs in Biological Samples. J Anal Toxicol [print-electronic]. 2018 Jan 1/4/2018; PMID: 29309651, PII: 4788580, DOI: 10.1093/jat/bkx107, ISSN: 1945-2403.

Colby JM. Comparison of umbilical cord tissue and meconium for the confirmation of in utero drug exposure. Clin. Biochem [print-electronic]. 2017 Mar 3/11/2017; PMID: 28288850, PII: S0009-9120(16)30708-1, DOI: 10.1016/j.clinbiochem.2017.03.006, ISSN: 1873-2933.

Ghosal K, Colby JM, Das D, Joy ST, Arora PS, Krantz BA. Dynamic Phenylalanine Clamp Interactions Define Single-Channel Polypeptide Translocation through the Anthrax Toxin Protective Antigen Channel. J. Mol. Biol [print-electronic]. 2017 Feb 2/10/2017; PMID: 28192089, PII: S0022-2836(17)30069-4, DOI: 10.1016/j.jmb.2017.02.005, ISSN: 1089-8638.

Colby JM, Thoren KL, Lynch KL. Optimization and Validation of High-Resolution Mass Spectrometry Data Analysis Parameters. J Anal Toxicol [print-electronic]. 2017 Jan; 41(1): 1-5. PMID: 28130542, PII: bkw112, DOI: 10.1093/jat/bkw112, ISSN: 1945-2403.

Wiencek JR, Colby JM, Nichols JH. Rapid Assessment of Drugs of Abuse. Adv Clin Chem [print-electronic]. 2017; 80: 193-225. PMID: 28431640, PII: S0065-2423(16)30099-3, DOI: 10.1016/bs.acc.2016.11.003, ISSN: 0065-2423.

Thoren KL, Colby JM, Shugarts SB, Wu AH, Lynch KL. Comparison of Information-Dependent Acquisition on a Tandem Quadrupole TOF vs a Triple Quadrupole Linear Ion Trap Mass Spectrometer for Broad-Spectrum Drug Screening. Clin. Chem [print-electronic]. 2016 Jan; 62(1): 170-8. PMID: 26453698, PII: clinchem.2015.241315, DOI: 10.1373/clinchem.2015.241315, ISSN: 1530-8561.

Colby JM, Krantz BA. Peptide Probes Reveal a Hydrophobic Steric Ratchet in the Anthrax Toxin Protective Antigen Translocase. J. Mol. Biol [print-electronic]. 2015 Nov 11/6/2015; 427(22): 3598-606. PMID: 26363343, PII: S0022-2836(15)00496-9, DOI: 10.1016/j.jmb.2015.09.007, ISSN: 1089-8638.

Colby JM, Wu AH, Lynch KL. Analysis of codeine positivity in urine of pain management patients. J Anal Toxicol [print-electronic]. 2015 Jun; 39(5): 407-10. PMID: 25840440, PII: bkv031, DOI: 10.1093/jat/bkv031, ISSN: 1945-2403.

Al-Abri SA, Anderson IB, Pedram F, Colby JM, Olson KR. Massive naproxen overdose with serial serum levels. J Med Toxicol. 2015 Mar; 11(1): 102-5. PMID: 24756481, PMCID: PMC4371030, DOI: 10.1007/s13181-014-0396-1, ISSN: 1937-6995.

Al-Abri S, Meier KH, Colby JM, Smollin CG, Benowitz NL. Cardiogenic shock after use of fluoroamphetamine confirmed with serum and urine levels. Clin Toxicol (Phila) [print-electronic]. 2014 Dec; 52(10): 1292-5. PMID: 25350468, DOI: 10.3109/15563650.2014.974262, ISSN: 1556-9519.

Wang BT, Colby JM, Wu AH, Lynch KL. Cross-reactivity of acetylfentanyl and risperidone with a fentanyl immunoassay. J Anal Toxicol [print-electronic]. 2014 Nov; 38(9): 672-5. PMID: 25248490, PII: bku103, DOI: 10.1093/jat/bku103, ISSN: 1945-2403.

Elzie CA, Colby J, Sammons MA, Janetopoulos C. Dynamic localization of G proteins in Dictyostelium discoideum. J. Cell. Sci [print-electronic]. 2009 Aug 8/1/2009; 122(Pt 15): 2597-603. PMID: 19584094, PMCID: PMC2909314, PII: jcs.046300, DOI: 10.1242/jcs.046300, ISSN: 0021-9533.