Kristen M. Ogden, Ph.D.

Associate Professor

kristen.ogden@vanderbilt.edu

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Faculty Appointments
Associate Professor of Pediatrics Associate Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Microbiology and Immunology, Vanderbilt University, Nashville, TennesseeB.S., Microbiology, Auburn University, Auburn, Alabama
Office Address
1161 21st Ave S
Nashville, TN 37232
Research Description
Research in the Ogden lab is focused on understanding mechanisms by which segmented, double stranded RNA viruses, including rotavirus and reovirus, acquire genetic diversity and impacts of this diversity on virus and host populations. Rotavirus is an important cause of diarrheal disease that results in the deaths of hundreds of thousands of infants and young children each year, and reovirus is an oncolytic virus that infects many mammalian species, including humans, but causes disease only in newborn animals. Themes we are currently exploring in our laboratory include (i) the frequency and dynamics of genome segment reassortment during co-infection, (ii) the composition and effects of defective viral genome segments, (iii) virus egress and transport in extracellular vesicles, (iv) effects of outer-capsid proteins on target cell selection, and (v) other tropism and pathogenesis determinants, including fusion-associated small transmembrane (FAST) proteins.
Research Keywords
RNA, virus, virology, rotavirus, reovirus, evolution, evolutionary biology, vaccine, oncolytic, receptor, entry, vesicle, host-pathogen interaction, molecular biology, microbiology
Publications
Diller JR, Thoner TW, Ogden KM. Mammalian orthoreoviruses exhibit rare genotype variability in genome constellations. Infect Genet Evol [print-electronic]. 2023 Jun; 110: 105421. PMID: 36871695, PMCID: PMC10112866, PII: S1567-1348(23)00019-9, DOI: 10.1016/j.meegid.2023.105421, ISSN: 1567-7257.

Dos Santos Natividade R, Koehler M, Gomes PSFC, Simpson JD, Smith SC, Gomes DEB, de Lhoneux J, Yang J, Ray A, Dermody TS, Bernardi RC, Ogden KM, Alsteens D. Deciphering molecular mechanisms stabilizing the reovirus-binding complex. Proc Natl Acad Sci U S A [print-electronic]. 2023 May 5/23/2023; 120(21): e2220741120. PMID: 37186838, PMCID: PMC10214207, DOI: 10.1073/pnas.2220741120, ISSN: 1091-6490.

Smelser WW, Wang J, Ogden KM, Chang SS, Kirschner AN. Intravesical oncolytic virotherapy and immunotherapy for non-muscle-invasive bladder cancer mouse model. BJU Int [print-electronic]. 2023 Mar 3/24/2023; PMID: 36961272, DOI: 10.1111/bju.16012, ISSN: 1464-410X.

Thoner TW, Meloy MM, Long JM, Diller JR, Slaughter JC, Ogden KM. Reovirus Efficiently Reassorts Genome Segments during Coinfection and Superinfection. J Virol [print-electronic]. 2022 Sep 9/28/2022; 96(18): e0091022. PMID: 36094315, PMCID: PMC9517712, DOI: 10.1128/jvi.00910-22, ISSN: 1098-5514.

Diller JR, Carter MH, Kanai Y, Sanchez SV, Kobayashi T, Ogden KM. Monoreassortant Rotaviruses of Multiple G Types Are Differentially Neutralized by Sera From Infants Vaccinated With ROTARIX and RotaTeq. J Infect Dis. 2021 Nov 11/22/2021; 224(10): 1720-9. PMID: 34628500, PII: 6386353, DOI: 10.1093/infdis/jiab479, ISSN: 1537-6613.

Thoner TW, Ye X, Karijolich J, Ogden KM. Reovirus Low-Density Particles Package Cellular RNA. Viruses. 2021 Jun 6/8/2021; 13(6): PMID: 34201386, PMCID: PMC8228547, PII: v13061096, DOI: 10.3390/v13061096, ISSN: 1999-4915.

Smith SC, Gribble J, Diller JR, Wiebe MA, Thoner TW, Denison MR, Ogden KM. Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage. J Virol [print-electronic]. 2021 Jan 1/20/2021; PMID: 33472930, PMCID: PMC8103698, PII: JVI.02181-20, DOI: 10.1128/JVI.02181-20, ISSN: 1098-5514.

Diller JR, Halloran SR, Koehler M, Dos Santos Natividade R, Alsteens D, Stehle T, Dermody TS, Ogden KM. Reovirus s1 Conformational Flexibility Modulates the Efficiency of Host Cell Attachment. J Virol [electronic-print]. 2020 Nov 11/9/2020; 94(23): PMID: 32938765, PMCID: PMC7654274, PII: JVI.01163-20, DOI: 10.1128/JVI.01163-20, ISSN: 1098-5514.

Ogden K. Reoviridae transcription is more than an open-and-shut case. Nat Struct Mol Biol. 2019 Nov; 26(11): 991-3. PMID: 31695186, PII: 10.1038/s41594-019-0328-5, DOI: 10.1038/s41594-019-0328-5, ISSN: 1545-9985.

Diller JR, Parrington HM, Patton JT, Ogden KM. Rotavirus species B encodes a functional fusion-associated small transmembrane (FAST) protein. J. Virol [print-electronic]. 2019 Aug 8/2/2019; PMID: 31375572, PII: JVI.00813-19, DOI: 10.1128/JVI.00813-19, ISSN: 1098-5514.

Heinrich MJ, Purcell CA, Pruijssers AJ, Zhao Y, Spurlock CF, Sriram S, Ogden KM, Dermody TS, Scholz MB, Crooke PS, Karijolich J, Aune TM. Endogenous double-stranded Alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis. J. Autoimmun [print-electronic]. 2019 Jun; 100: 40-51. PMID: 30826177, PMCID: PMC6513682, PII: S0896-8411(18)30699-1, DOI: 10.1016/j.jaut.2019.02.003, ISSN: 1095-9157.

Ogden KM, Tan Y, Akopov A, Stewart LS, McHenry R, Fonnesbeck CJ, Piya B, Carter MH, Fedorova NB, Halpin RA, Shilts MH, Edwards KM, Payne DC, Esona MD, Mijatovic-Rustempasic S, Chappell JD, Patton JT, Halasa NB, Das SR. Multiple introductions and antigenic mismatch with vaccines may contribute to increased predominance of G12P[8] rotaviruses in the United States. J. Virol [print-electronic]. 2018 Oct 10/17/2018; PMID: 30333170, PII: JVI.01476-18, DOI: 10.1128/JVI.01476-18, ISSN: 1098-5514.

Dietrich MH, Ogden KM, Long JM, Ebenhoch R, Thor A, Dermody TS, Stehle T. Structural and Functional Features of the Reovirus s1 Tail. J. Virol [electronic-print]. 2018 Jul 7/15/2018; 92(14): PMID: 29695426, PMCID: PMC6026731, PII: JVI.00336-18, DOI: 10.1128/JVI.00336-18, ISSN: 1098-5514.

Dietrich MH, Ogden KM, Katen SP, Reiss K, Sutherland DM, Carnahan RH, Goff M, Cooper T, Dermody TS, Stehle T. Structural Insights into Reovirus s1 Interactions with Two Neutralizing Antibodies. J. Virol [electronic-print]. 2017 Feb 2/15/2017; 91(4): PMID: 27928010, PMCID: PMC5286903, PII: JVI.01621-16, DOI: 10.1128/JVI.01621-16, ISSN: 1098-5514.