Jonathan D. Brown, M.D.

Assistant Professor

jonathan.d.brown@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Molecular Physiology & Biophysics
Education
M.D., New York Medical College, Valhalla, New YorkB.A., Classics with Departmental Honors, Brown University, Providence, Rhode Island
Research Keywords
Cardiometabolic disease, Epigenomics
Publications
Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Huh SJ, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, Peluffo G, Brown J, D'Santos C, Krop IE, Dillon D, McKeown M, Ott C, Qi J, Ni M, Rao PK, Duarte M, Wu SY, Chiang CM, Anders L, Young RA, Winer EP, Letai A, Barry WT, Carroll JS, Long HW, Brown M, Liu XS, Meyer CA, Bradner JE, Polyak K. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature [print-electronic]. 2016 Jan 1/21/2016; 529(7586): 413-7. PMID: 26735014, PII: nature16508, DOI: 10.1038/nature16508, ISSN: 1476-4687.

Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI. Differential role of an NF-kB transcriptional response element in endothelial versus intimal cell VCAM-1 expression. Circ. Res. 2015 Jul 7/3/2015; 117(2): 166-77. PMID: 26034041, PII: CIRCRESAHA.117.306666, DOI: 10.1161/CIRCRESAHA.117.306666, ISSN: 1524-4571.

Brown JD. Bariatric surgery: "Roux"-minating on endothelial cell and high-density lipoprotein function [editorial]. Circulation [print-electronic]. 2015 Mar 3/10/2015; 131(10): 845-7. PMID: 25673671, PII: CIRCULATIONAHA.115.015343, DOI: 10.1161/CIRCULATIONAHA.115.015343, ISSN: 1524-4539.

Brown JD, Lin CY, Duan Q, Griffin G, Federation AJ, Paranal RM, Bair S, Newton G, Lichtman AH, Kung AL, Yang T, Wang H, Luscinskas FW, Croce KJ, Bradner JE, Plutzky J. NF-kB directs dynamic super enhancer formation in inflammation and atherogenesis. Mol. Cell. 2014 Oct 10/23/2014; 56(2): 219-31. PMID: 25263595, PMCID: PMC4224636, PII: S1097-2765(14)00679-0, DOI: 10.1016/j.molcel.2014.08.024, ISSN: 1097-4164.

Nallamshetty S, Le PT, Wang H, Issacsohn MJ, Reeder DJ, Rhee EJ, Kiefer FW, Brown JD, Rosen CJ, Plutzky J. Retinaldehyde dehydrogenase 1 deficiency inhibits PPARg-mediated bone loss and marrow adiposity. Bone. 2014 Oct; 67: 281-91. PMID: 25064526, PMCID: PMC4209126, PII: S8756-3282(14)00256-7, DOI: 10.1016/j.bone.2014.07.005, ISSN: 1873-2763.

Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2013 Aug; 33(8): 1788-94. PMID: 23723371, PMCID: PMC3794714, PII: ATVBAHA.113.301300, DOI: 10.1161/ATVBAHA.113.301300, ISSN: 1524-4636.

Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM. BET bromodomains mediate transcriptional pause release in heart failure. 2013.

Liu S1, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid intergates hepatic lipogenesis and peripheral fatty acid use. 2013.

Nallamshetty S, Wang H, Rhee EJ, Kiefer FW, Brown JD, Lotinun S, Le P, Baron R, Rosen CJ, Plutzky J. Deficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo. PLoS ONE. 2013; 8(8): e71307. PMID: 23951127, PMCID: PMC3739807, PII: PONE-D-13-12923, DOI: 10.1371/journal.pone.0071307, ISSN: 1932-6203.

Kiefer FW, Orasanu G, Nallamshetty S, Brown JD, Wang H, Luger P, Qi NR, Burant CF, Duester G, Plutzky J. Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism. Endocrinology [print-electronic]. 2012 Jul; 153(7): 3089-99. PMID: 22555438, PMCID: PMC3380298, PII: en.2011-2104, DOI: 10.1210/en.2011-2104, ISSN: 1945-7170.

Kiefer FW, Vernochet C, O'Brien P, Spoerl S, Brown JD, Nallamshetty S, Zeyda M, Stulnig TM, Cohen DE, Kahn CR, Plutzky J. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat. Med. 2012 Jun; 18(6): 918-25. PMID: 22561685, PMCID: PMC3792792, PII: nm.2757, DOI: 10.1038/nm.2757, ISSN: 1546-170X.

Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J. VLDL hydrolysis by hepatic lipase regulates PPARd transcriptional responses. PLoS ONE [print-electronic]. 2011; 6(7): e21209. PMID: 21750705, PMCID: PMC3130023, PII: PONE-D-11-04131, DOI: 10.1371/journal.pone.0021209, ISSN: 1932-6203.

Chutkow WA, Birkenfeld AL, Brown JD, Lee HY, Frederick DW, Yoshioka J, Patwari P, Kursawe R, Cushman SW, Plutzky J, Shulman GI, Samuel VT, Lee RT. Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes [print-electronic]. 2010 Jun; 59(6): 1424-34. PMID: 20299477, PMCID: PMC2874703, PII: db09-1212, DOI: 10.2337/db09-1212, ISSN: 1939-327X.

Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J. PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. J. Clin. Invest [print-electronic]. 2009 Jan; 119(1): 110-24. PMID: 19065047, PMCID: PMC2613459, PII: 36233, DOI: 10.1172/JCI36233, ISSN: 0021-9738.

Brown JD, Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation. 2007 Jan 1/30/2007; 115(4): 518-33. PMID: 17261671, PII: 115/4/518, DOI: 10.1161/CIRCULATIONAHA.104.475673, ISSN: 1524-4539.

Brown JD, DiChiara MR, Anderson KR, Gimbrone MA, Topper JN. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J. Biol. Chem. 1999 Mar 3/26/1999; 274(13): 8797-805. PMID: 10085121, ISSN: 0021-9258.

Topper JN, DiChiara MR, Brown JD, Williams AJ, Falb D, Collins T, Gimbrone MA. CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 1998 Aug 8/4/1998; 95(16): 9506-11. PMID: 9689110, PMCID: PMC21368, ISSN: 0027-8424.

Available Postdoctoral Position Details
Posted: 11/3/2015
The laboratory is seeking a postdoctoral research fellow to study transcriptional mechanisms controlling pathways of inflammation and metabolism relevant to cardiovascular disease. A major focus of the laboratory is to explore how chromatin and enhancers regulate proinflammatory gene expression in vascular cells. A second project is exploring enhancer function in liver during feed/fast response and  during development of hepatic steatosis.  The laboratory employs genome-wide experimental techniques in vitro and in vivo to probe transcriptional mechanisms and enhancer function along with novel tool compounds that disrupt enhancer dependent signaling to RNA polymerase.