Kyle M. Hocking, Ph.D.

Research Assistant Professor
Faculty Appointments
Research Assistant Professor of Vascular Surgery Research Assistant Professor of Biomedical Engineering
Ph.D., Biomedical Engineering, Vanderbilt University, Nashville, TennesseeM.E., Biomedical Engineering, Vanderbilt University, Nashville, TennesseeB.E., Biomedical Engineering, Vanderbilt University, Nashville, Tennessee
Wise ES, Stonko DP, Glaser ZA, Garcia KL, Huang JJ, Kim JS, Kallos JA, Starnes JR, Fleming JW, Hocking KM, Brophy CM, Eagle SS. Prediction of Prolonged Ventilation after Coronary Artery Bypass Grafting: Data from an Artificial Neural Network. Heart Surg Forum. 2017 Feb 2/24/2017; 20(1): E007-E014. PMID: 28263144, ISSN: 1522-6662.

Bennett JM, Wise ES, Hocking KM, Brophy CM, Eagle SS. Hyperlactemia Predicts Surgical Mortality in Patients Presenting With Acute Stanford Type-A Aortic Dissection. J. Cardiothorac. Vasc. Anesth [print-electronic]. 2017 Feb; 31(1): 54-60. PMID: 27493094, PII: S1053-0770(16)00264-0, DOI: 10.1053/j.jvca.2016.03.133, ISSN: 1532-8422.

Pedigo SL, Guth CM, Hocking KM, Banathy A, Li FD, Cheung-Flynn J, Brophy CM, Guzman RJ, Komalavilas P. Calcification of Human Saphenous Vein Associated with Endothelial Dysfunction: A Pilot Histopathophysiological and Demographical Study. Front Surg. 2017; 4: 6. PMID: 28232909, PMCID: PMC5298955, DOI: 10.3389/fsurg.2017.00006.

Wise ES, Gadomski SP, Ilg AM, Bermudez C, Chan EW, Izmaylov ML, Gridley SJ, Kaczmarek JV, Melancon SN, Ahmad S, Hocking KM, Diaz JJ, Kavic SM. Independent Preoperative Predictors of Prolonged Length of Stay after Laparoscopic Appendectomy in Patients Over 30 Years of Age: Experience from a Single Institution. Am Surg. 2016 Nov 11/1/2016; 82(11): 1092-7. PMID: 28206936, ISSN: 1555-9823.

Valentine RJ, Boll JM, Hocking KM, Curci JA, Garrard CL, Brophy CM, Naslund TC. Aortic arch involvement worsens the prognosis of type B aortic dissections. J. Vasc. Surg [print-electronic]. 2016 Nov; 64(5): 1212-8. PMID: 27397897, PII: S0741-5214(16)30295-6, DOI: 10.1016/j.jvs.2016.04.054, ISSN: 1097-6809.

Martin JR, Nelson CE, Gupta MK, Yu F, Sarett SM, Hocking KM, Pollins AC, Nanney LB, Davidson JM, Guelcher SA, Duvall CL. Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing. Adv Healthc Mater [print-electronic]. 2016 Nov; 5(21): 2751-7. PMID: 27717176, PMCID: PMC5152672, DOI: 10.1002/adhm.201600820, ISSN: 2192-2659.

Wise ES, Hocking KM, Luo W, Feldman DL, Song J, Komalavilas P, Cheung-Flynn J, Brophy CM. Traditional graft preparation decreases physiologic responses, diminishes viscoelasticity, and reduces cellular viability of the conduit: A porcine saphenous vein model. Vasc Med [print-electronic]. 2016 Oct; 21(5): 413-21. PMID: 27216870, PMCID: PMC5115945, PII: 1358863X16649040, DOI: 10.1177/1358863X16649040, ISSN: 1477-0377.

Hocking KM, Sileshi B, Baudenbacher FJ, Boyer RB, Kohorst KL, Brophy CM, Eagle SS. Peripheral Venous Waveform Analysis for Detecting Hemorrhage and Iatrogenic Volume Overload in a Porcine Model. Shock. 2016 Oct; 46(4): 447-52. PMID: 27070329, DOI: 10.1097/SHK.0000000000000615, ISSN: 1540-0514.

Wise ES, Hocking KM, Weltz A, Uebele A, Diaz JJ, Kavic SM, Kligman MD. Red cell distribution width is a novel biomarker that predicts excess body-mass index loss 1 year after laparoscopic Roux-en-Y gastric bypass. Surg Endosc [print-electronic]. 2016 Oct; 30(10): 4607-12. PMID: 26902617, PMCID: PMC4993689, PII: 10.1007/s00464-016-4798-9, DOI: 10.1007/s00464-016-4798-9, ISSN: 1432-2218.

Hocking KM, Luo W, Li FD, Komalavilas P, Brophy C, Cheung-Flynn J. Brilliant blue FCF is a nontoxic dye for saphenous vein graft marking that abrogates response to injury. J. Vasc. Surg [print-electronic]. 2016 Jul; 64(1): 210-8. PMID: 25704409, PMCID: PMC4544660, PII: S0741-5214(15)00061-0, DOI: 10.1016/j.jvs.2014.12.059, ISSN: 1097-6809.

Boyer RB, Hocking KM, Booth GS, Berry JM, Spain TW, Michaels DR, Sandberg WS, Pilla MA. An Evaluation of Induced Failure Modes in the BelmontĀ® Rapid Infuser. Anesth. Analg. 2016 Apr; 122(4): 1062-9. PMID: 26702866, DOI: 10.1213/ANE.0000000000001110, ISSN: 1526-7598.

Wise ES, McMaster WG, Williamson K, Wergin JE, Hocking KM, Brophy CM. Preoperative Predictors of 30-Day Mortality and Prolonged Length of Stay after Above-Knee Amputation. Ann Vasc Surg [print-electronic]. 2016 Feb; 31: 124-33. PMID: 26616501, PMCID: PMC4744093, PII: S0890-5096(15)00803-1, DOI: 10.1016/j.avsg.2015.08.017, ISSN: 1615-5947.

Wise ES, Ahmad S, Ladner TR, Hocking KM, Kavic SM. Impaired weight loss in laparoscopic adjustable gastric banding patients over 50 years of age: diabetes mellitus as an independent risk factor. Surg Endosc [print-electronic]. 2016 Feb; 30(2): 663-9. PMID: 26091994, PMCID: PMC4685024, PII: 10.1007/s00464-015-4257-z, DOI: 10.1007/s00464-015-4257-z, ISSN: 1432-2218.

Wise ES, Hocking KM, Kavic SM. Prediction of excess weight loss after laparoscopic Roux-en-Y gastric bypass: data from an artificial neural network. Surg Endosc [print-electronic]. 2016 Feb; 30(2): 480-8. PMID: 26017908, PMCID: PMC4662927, PII: 10.1007/s00464-015-4225-7, DOI: 10.1007/s00464-015-4225-7, ISSN: 1432-2218.

Hocking KM, Putumbaka G, Wise ES, Cheung-Flynn J, Brophy CM, Komalavilas P. Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein. PLoS ONE. 2016; 11(5): e0154460. PMID: 27136356, PMCID: PMC4852981, PII: PONE-D-15-27329, DOI: 10.1371/journal.pone.0154460, ISSN: 1932-6203.

Wise ES, Gadomski SP, McMaster WG, Wilson RJ, Nelms JK, Hocking KM, Brophy CM. The influence of VKORC1 and CYP2C9 mutations on warfarin response after total hip and knee arthroplasty. J Orthop. 2015 Dec; 12(Suppl 2): S145-51. PMID: 27047214, PMCID: PMC4796661, PII: S0972-978X(15)00160-9, DOI: 10.1016/j.jor.2015.10.023.

Wise ES, Hocking KM, Eagle S, Absi T, Komalavilas P, Cheung-Flynn J, Brophy CM. Preservation solution impacts physiologic function and cellular viability of human saphenous vein graft. Surgery [print-electronic]. 2015 Aug; 158(2): 537-46. PMID: 26003912, PMCID: PMC4492846, PII: S0039-6060(15)00243-3, DOI: 10.1016/j.surg.2015.03.036, ISSN: 1532-7361.

Wise ES, Hocking KM, Feldman D, Komalavilas P, Cheung-Flynn J, Brophy CM. An Optimized Preparation Technique for Saphenous Vein Graft. Am Surg. 2015 Jul; 81(7): E274-6. PMID: 26140874, PMCID: PMC4635024, ISSN: 1555-9823.

Wise ES, Hocking KM, Brophy CM. Prediction of in-hospital mortality after ruptured abdominal aortic aneurysm repair using an artificial neural network. J. Vasc. Surg [print-electronic]. 2015 Jul; 62(1): 8-15. PMID: 25953014, PMCID: PMC4484301, PII: S0741-5214(15)00289-X, DOI: 10.1016/j.jvs.2015.02.038, ISSN: 1097-6809.

Wise ES, Ladner TR, Song J, Eagle SS, Mocco J, Wergin JE, Hocking KM, Brophy CM. Race as a predictor of delay from diagnosis to endarterectomy in clinically significant carotid stenosis. J. Vasc. Surg [print-electronic]. 2015 Jul; 62(1): 49-56. PMID: 25776188, PMCID: PMC4484302, PII: S0741-5214(15)00187-1, DOI: 10.1016/j.jvs.2015.01.057, ISSN: 1097-6809.

Evans BC, Hocking KM, Kilchrist KV, Wise ES, Brophy CM, Duvall CL. Endosomolytic Nano-Polyplex Platform Technology for Cytosolic Peptide Delivery To Inhibit Pathological Vasoconstriction. ACS Nano [print-electronic]. 2015 Jun 6/23/2015; 9(6): 5893-907. PMID: 26004140, PMCID: PMC4482421, DOI: 10.1021/acsnano.5b00491, ISSN: 1936-086X.

Evans BC, Hocking KM, Osgood MJ, Voskresensky I, Dmowska J, Kilchrist KV, Brophy CM, Duvall CL. MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia. Sci Transl Med. 2015 Jun 6/10/2015; 7(291): 291ra95. PMID: 26062847, PMCID: PMC5371354, PII: 7/291/291ra95, DOI: 10.1126/scitranslmed.aaa4549, ISSN: 1946-6242.

Sileshi B, Hocking KM, Boyer RB, Baudenbacher FJ, Kohurst KL, Brophy CM, Eagle S. Peripheral venous waveform analysis for detecting early hemorrhage: a pilot study [letter]. Intensive Care Med [print-electronic]. 2015 Jun; 41(6): 1147-8. PMID: 25862041, DOI: 10.1007/s00134-015-3787-0, ISSN: 1432-1238.

Voskresensky IV, Wise ES, Hocking KM, Li FD, Osgood MJ, Komalavilas P, Brophy C, Cheung-Flynn J. Brilliant blue FCF as an alternative dye for saphenous vein graft marking: effect on conduit function. JAMA Surg. 2014 Nov; 149(11): 1176-81. PMID: 25251505, PMCID: PMC4237645, PII: 1906151, DOI: 10.1001/jamasurg.2014.2029, ISSN: 2168-6262.

Li FD, Eagle S, Brophy C, Hocking KM, Osgood M, Komalavilas P, Cheung-Flynn J. Pressure control during preparation of saphenous veins. JAMA Surg. 2014 Jul; 149(7): 655-62. PMID: 24759942, PMCID: PMC4102634, PII: 1862292, DOI: 10.1001/jamasurg.2013.5067, ISSN: 2168-6262.

Osgood MJ, Hocking KM, Voskresensky IV, Li FD, Komalavilas P, Cheung-Flynn J, Brophy CM. Surgical vein graft preparation promotes cellular dysfunction, oxidative stress, and intimal hyperplasia in human saphenous vein. J. Vasc. Surg [print-electronic]. 2014 Jul; 60(1): 202-11. PMID: 23911244, PMCID: PMC3926896, PII: S0741-5214(13)01145-2, DOI: 10.1016/j.jvs.2013.06.004, ISSN: 1097-6809.

Nelson CE, Kim AJ, Adolph EJ, Gupta MK, Yu F, Hocking KM, Davidson JM, Guelcher SA, Duvall CL. Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo. Adv. Mater. Weinheim [print-electronic]. 2014 Jan; 26(4): 607-14, 506. PMID: 24338842, PMCID: PMC3951880, DOI: 10.1002/adma.201303520, ISSN: 1521-4095.

Bonner JS, Lantier L, Hocking KM, Kang L, Owolabi M, James FD, Bracy DP, Brophy CM, Wasserman DH. Relaxin treatment reverses insulin resistance in mice fed a high-fat diet. Diabetes [print-electronic]. 2013 Sep; 62(9): 3251-60. PMID: 23801576, PMCID: PMC3749347, PII: db13-0033, DOI: 10.2337/db13-0033, ISSN: 1939-327X.

Li FD, Sexton KW, Hocking KM, Osgood MJ, Eagle S, Cheung-Flynn J, Brophy CM, Komalavilas P. Intimal thickness associated with endothelial dysfunction in human vein grafts. J. Surg. Res [print-electronic]. 2013 Mar; 180(1): e55-62. PMID: 22763213, PMCID: PMC3515722, PII: S0022-4804(12)00548-3, DOI: 10.1016/j.jss.2012.06.017, ISSN: 1095-8673.

Hocking KM, Baudenbacher FJ, Putumbaka G, Venkatraman S, Cheung-Flynn J, Brophy CM, Komalavilas P. Role of cyclic nucleotide-dependent actin cytoskeletal dynamics:Ca(2+)](i) and force suppression in forskolin-pretreated porcine coronary arteries. PLoS ONE [electronic-print]. 2013; 8(4): e60986. PMID: 23593369, PMCID: PMC3625185, PII: PONE-D-12-33807, DOI: 10.1371/journal.pone.0060986, ISSN: 1932-6203.

Osgood MJ, Harrison DG, Sexton KW, Hocking KM, Voskresensky IV, Komalavilas P, Cheung-Flynn J, Guzman RJ, Brophy CM. Role of the renin-angiotensin system in the pathogenesis of intimal hyperplasia: therapeutic potential for prevention of vein graft failure?. Ann Vasc Surg [print-electronic]. 2012 Nov; 26(8): 1130-44. PMID: 22445245, PMCID: PMC4189806, PII: S0890-5096(12)00052-0, DOI: 10.1016/j.avsg.2011.12.001, ISSN: 1615-5947.

Sexton KW, Hocking KM, Wise E, Osgood MJ, Cheung-Flynn J, Komalavilas P, Campbell KE, Dattilo JB, Brophy CM. Women in academic surgery: the pipeline is busted. J Surg Educ [print-electronic]. 2012 Jan; 69(1): 84-90. PMID: 22208838, PMCID: PMC3458116, PII: S1931-7204(11)00229-7, DOI: 10.1016/j.jsurg.2011.07.008, ISSN: 1878-7452.

Hocking KM, Brophy C, Rizvi SZ, Komalavilas P, Eagle S, Leacche M, Balaguer JM, Cheung-Flynn J. Detrimental effects of mechanical stretch on smooth muscle function in saphenous veins. J. Vasc. Surg [print-electronic]. 2011 Feb; 53(2): 454-60. PMID: 21146345, PMCID: PMC3053010, PII: S0741-5214(10)02184-1, DOI: 10.1016/j.jvs.2010.09.010, ISSN: 1097-6809.