Ciara Martin Shaver, Ph.D., M.D.

Assistant Professor

ciara.shaver@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine
Education
M.D., MD PROGRAM, Northwestern University Feinberg School of Medicine, Chicago, IllinoisPh.D., Immunology and Microbial Pathogenesis, Northwestern University Feinberg School of Medicine, Chicago, IllinoisB.A., Biochemistry and Biology, Rice University, Houston, Texas
Office Address
1161 21st Avenue South
T-1218 MCN
Nashville, TN 37232-2650
Publications
Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax [print-electronic]. 2018 Jun 6/14/2018; PMID: 29903755, PII: thoraxjnl-2017-211280, DOI: 10.1136/thoraxjnl-2017-211280, ISSN: 1468-3296.

Shaver CM, Diamond JM, Schrepfer S, Cantu E. Optimization of oxygenation during ex vivo lung perfusion-Best basic science article in 2017 [letter]. J. Heart Lung Transplant [print-electronic]. 2018 Jun; 37(6): 800-2. PMID: 29525103, PII: S1053-2498(18)31361-5, DOI: 10.1016/j.healun.2018.02.010, ISSN: 1557-3117.

Shaver CM. A Step Closer to Mechanism and Additional Targeted Therapies for Pulmonary Arterial Hypertension: Links between Red Blood Cell Lysis and Vascular Dysfunction in PAH. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2018 Apr 4/24/2018; PMID: 29688757, DOI: 10.1165/rcmb.2018-0136ED, ISSN: 1535-4989.

McNeil JB, Shaver CM, Kerchberger VE, Russell DW, Grove BS, Warren MA, Wickersham NE, Ware LB, McDonald WH, Bastarache JA. Novel Method for Noninvasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2018 Apr 4/15/2018; 197(8): 1027-35. PMID: 29253353, PMCID: PMC5909163, DOI: 10.1164/rccm.201707-1474OC, ISSN: 1535-4970.

Putz ND, Shaver CM, Dufu K, Li CM, Xu Q, Hutchaleelaha A, Lehrer-Graiwer J, Majka SM, Ware LB, Bastarache JA. GBT1118, a compound that increases the oxygen affinity of hemoglobin, improves survival in murine hypoxic acute lung injury. J. Appl. Physiol [print-electronic]. 2018 Apr 4/1/2018; 124(4): 899-905. PMID: 29357510, DOI: 10.1152/japplphysiol.00079.2017, ISSN: 1522-1601.

Shaver CM, Wickersham N, McNeil JB, Nagata H, Miller A, Landstreet SR, Kuck JL, Diamond JM, Lederer DJ, Kawut SM, Palmer SM, Wille KM, Weinacker A, Lama VN, Crespo MM, Orens JB, Shah PD, Hage CA, Cantu E, Porteous MK, Dhillon G, McDyer J, Bastarache JA, Christie JD, Ware LB, . Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury. JCI Insight [print-electronic]. 2018 Jan 1/25/2018; 3(2): PMID: 29367464, PMCID: PMC5821179, PII: 98546, DOI: 10.1172/jci.insight.98546, ISSN: 2379-3708.

Kuck JL, Bastarache JA, Shaver CM, Fessel JP, Dikalov SI, May JM, Ware LB. Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin. Biochem. Biophys. Res. Commun [print-electronic]. 2018 Jan 1/1/2018; 495(1): 433-7. PMID: 29129689, PMCID: PMC5736437, PII: S0006-291X(17)32236-2, DOI: 10.1016/j.bbrc.2017.11.058, ISSN: 1090-2104.

DesPrez K, McNeil JB, Wang C, Bastarache JA, Shaver CM, Ware LB. Oxygenation Saturation Index Predicts Clinical Outcomes in ARDS. Chest [print-electronic]. 2017 Dec; 152(6): 1151-8. PMID: 28823812, PMCID: PMC5812755, PII: S0012-3692(17)31395-8, DOI: 10.1016/j.chest.2017.08.002, ISSN: 1931-3543.

Murphy LS, Wickersham N, McNeil JB, Shaver CM, May AK, Bastarache JA, Ware LB. Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction. Ann Intensive Care. 2017 Oct 10/6/2017; 7(1): 102. PMID: 28986821, PMCID: PMC5630541, PII: 10.1186/s13613-017-0325-y, DOI: 10.1186/s13613-017-0325-y, ISSN: 2110-5820.

Gelman AE, Fisher AJ, Huang HJ, Baz MA, Shaver CM, Egan TM, Mulligan MS. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part III: Mechanisms: A 2016 Consensus Group Statement of the International Society for Heart and Lung Transplantation [editorial]. J. Heart Lung Transplant [print-electronic]. 2017 Oct; 36(10): 1114-20. PMID: 28818404, PMCID: PMC5724959, PII: S1053-2498(17)31905-8, DOI: 10.1016/j.healun.2017.07.014, ISSN: 1557-3117.

Shaver CM, Wickersham N, McNeil JB, Nagata H, Sills G, Kuck JL, Janz DR, Bastarache JA, Ware LB. Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3): S251-S252. PMID: 28945473, PMCID: PMC5711346, DOI: 10.1513/AnnalsATS.201609-693MG, ISSN: 2325-6621.

Shaver CM, Woods J, Clune JK, Grove BS, Wickersham NE, McNeil JB, Shemancik G, Ware LB, Bastarache JA. Circulating microparticle levels are reduced in patients with ARDS. Crit Care. 2017 May 5/25/2017; 21(1): 120. PMID: 28545548, PMCID: PMC5445431, PII: 10.1186/s13054-017-1700-7, DOI: 10.1186/s13054-017-1700-7, ISSN: 1466-609X.

Luo L, Shaver CM, Zhao Z, Koyama T, Calfee CS, Bastarache JA, Ware LB. Clinical Predictors of Hospital Mortality Differ Between Direct and Indirect ARDS. Chest [print-electronic]. 2017 Apr; 151(4): 755-63. PMID: 27663180, PMCID: PMC5472517, PII: S0012-3692(16)59167-3, DOI: 10.1016/j.chest.2016.09.004, ISSN: 1931-3543.

Shaver CM, Ware LB. Primary graft dysfunction: pathophysiology to guide new preventive therapies. Expert Rev Respir Med [print-electronic]. 2017 Feb; 11(2): 119-28. PMID: 28074663, PMCID: PMC5542681, DOI: 10.1080/17476348.2017.1280398, ISSN: 1747-6356.

Janz DR, Semler MW, Lentz RJ, Matthews DT, Assad TR, Norman BC, Keriwala RD, Ferrell BA, Noto MJ, Shaver CM, Richmond BW, Zinggeler Berg J, Rice TW, . Randomized Trial of Video Laryngoscopy for Endotracheal Intubation of Critically Ill Adults. Crit. Care Med. 2016 Nov; 44(11): 1980-7. PMID: 27355526, PMCID: PMC5203695, DOI: 10.1097/CCM.0000000000001841, ISSN: 1530-0293.

Shaver CM, Ware LB. The authors reply. Crit. Care Med. 2016 May; 44(5): e307. PMID: 27083029, PII: 00003246-201605000-00039, DOI: 10.1097/CCM.0000000000001579, ISSN: 1530-0293.

Antoniak S, Tatsumi K, Hisada Y, Milner JJ, Neidich SD, Shaver CM, Pawlinski R, Beck MA, Bastarache JA, Mackman N. Tissue factor Deficiency Increases Alveolar Hemorrhage and Death in Influenza A Infected Mice. J. Thromb. Haemost [print-electronic]. 2016 Mar 3/7/2016; PMID: 26947929, DOI: 10.1111/jth.13307, ISSN: 1538-7836.

Shaver CM, Upchurch CP, Janz DR, Grove BS, Putz N, Wickersham N, Dikalov SI, Ware LB, Bastarache JA. Cell-free hemoglobin: a novel mediator of acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Jan 1/15/2016; ajplung.00155.2015. PMID: 26773065, PMCID: PMC4796260, PII: ajplung.00155.2015, DOI: 10.1152/ajplung.00155.2015, ISSN: 1522-1504.

Shaver CM, Grove BS, Clune JK, Mackman N, Ware LB, Bastarache JA. Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury. Sci Rep. 2016; 6: 22249. PMID: 26924425, PMCID: PMC4770302, PII: srep22249, DOI: 10.1038/srep22249, ISSN: 2045-2322.

Chen W, Janz DR, Shaver CM, Bernard GR, Bastarache JA, Ware LB. Clinical Characteristics and Outcomes Are Similar in ARDS Diagnosed by Oxygen Saturation/Fio2 Ratio Compared With Pao2/Fio2 Ratio. Chest. 2015 Dec; 148(6): 1477-83. PMID: 26271028, PMCID: PMC4665739, PII: S0012-3692(15)50112-8, DOI: 10.1378/chest.15-0169, ISSN: 1931-3543.

Shaver CM, Grove BS, Putz ND, Clune JK, Lawson WE, Carnahan RH, Mackman N, Ware LB, Bastarache JA. Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor. Am. J. Respir. Cell Mol. Biol. 2015 Nov; 53(5): 719-27. PMID: 25884207, PMCID: PMC4742948, DOI: 10.1165/rcmb.2014-0179OC, ISSN: 1535-4989.

Shaver CM, Chen W, Janz DR, May AK, Darbar D, Bernard GR, Bastarache JA, Ware LB. Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit. Care Med. 2015 Oct; 43(10): 2104-11. PMID: 26154932, PMCID: PMC4725582, DOI: 10.1097/CCM.0000000000001166, ISSN: 1530-0293.

Shaver CM, Bastarache JA. Clinical and biological heterogeneity in acute respiratory distress syndrome: direct versus indirect lung injury. Clin. Chest Med [print-electronic]. 2014 Dec; 35(4): 639-53. PMID: 25453415, PMCID: PMC4254695, PII: S0272-5231(14)00073-2, DOI: 10.1016/j.ccm.2014.08.004, ISSN: 1557-8216.

Shaver CM, Castilho JL, Cohen DN, Grogan EL, Miller GG, Dummer JS, Gray JN, Lambright ES, Loyd JE, Robbins IM. Fatal Scopulariopsis infection in a lung transplant recipient: lessons of organ procurement. Am. J. Transplant [print-electronic]. 2014 Dec; 14(12): 2893-7. PMID: 25376207, PMCID: PMC4263480, DOI: 10.1111/ajt.12940, ISSN: 1600-6143.

Stollings JL, Chadha SN, Paul AM, Shaver CM, Hagaman D. Doxycycline desensitization for a suspected case of ehrlichiosis. J Allergy Clin Immunol Pract [print-electronic]. 2014 Jan; 2(1): 103-4. PMID: 24565779, PII: S2213-2198(13)00321-8, DOI: 10.1016/j.jaip.2013.08.002, ISSN: 2213-2198.