Alexandra E. Kovach, M.D.

Assistant Professor

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Faculty Appointments
Assistant Professor of Pathology, Microbiology and Immunology
M.D., Medicine, Case Western Reserve University, Cleveland, OhioB.A., English and Premedical Studies, Columbia University, New York, New York
Office Address
11236 Doctors Office Tower (VCH), Box 3-9065
Nashville, TN 37204
Research Keywords
Lymphoma and lymphoproliferative disorders; pediatric hematopathology
Clinical Research Keywords
Hematopathology and Pediatric Pathology
Shah NN, Szabo A, Huntington SF, Epperla N, Reddy N, Ganguly S, Vose J, Obiozor C, Faruqi F, Kovach AE, Costa LJ, Xaiver AC, Okal R, Kanate AS, Ghosh N, Kharfan-Dabaja MA, Strelec L, Hamadani M, Fenske TS, Calzada O, Cohen JB, Chavez J, Svoboda J. R-CHOP versus dose-adjusted R-EPOCH in frontline management of primary mediastinal B-cell lymphoma: a multi-centre analysis. Br. J. Haematol [print-electronic]. 2018 Feb; 180(4): 534-44. PMID: 29265182, DOI: 10.1111/bjh.15051, ISSN: 1365-2141.

Kovach AE, Pacheco MC. Ganglion Cells Are Frequently Present in Pediatric Mucosal Colorectal Biopsies: H&E Sections and Calretinin Immunohistochemistry in the Evaluation of Children With Chronic Constipation. Pediatr. Dev. Pathol [print-electronic]. 2018 Jan; 21(1): 48-53. PMID: 28508695, DOI: 10.1177/1093526617704594, ISSN: 1093-5266.

Kovach AE, Magcalas PM, Ireland C, McEnany K, Oliveira AM, Kieran MW, Baird CW, Jenkins K, Vargas SO. Paucicellular Fibrointimal Proliferation Characterizes Pediatric Pulmonary Vein Stenosis: Clinicopathologic Analysis of 213 Samples From 97 Patients. Am. J. Surg. Pathol. 2017 Sep; 41(9): 1198-204. PMID: 28622179, DOI: 10.1097/PAS.0000000000000892, ISSN: 1532-0979.

Boyer DF, McKelvie PA, de Leval L, Edlefsen KL, Ko YH, Aberman ZA, Kovach AE, Masih A, Nishino HT, Weiss LM, Meeker AK, Nardi V, Palisoc M, Shao L, Pittaluga S, Ferry JA, Harris NL, Sohani AR. Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation. Am. J. Surg. Pathol. 2017 Mar; 41(3): 299-312. PMID: 28195879, PII: 00000478-201703000-00002, DOI: 10.1097/PAS.0000000000000775, ISSN: 1532-0979.

Bogusz AM, Kovach AE, Le LP, Feng D, Baxter RH, Sohani AR. Diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression shows evidence of active B-cell receptor signaling by quantitative immunofluorescence. PLoS ONE. 2017; 12(2): e0172364. PMID: 28212447, PMCID: PMC5315400, PII: PONE-D-16-39638, DOI: 10.1371/journal.pone.0172364, ISSN: 1932-6203.

Kovach AE, Brunner AM, Fathi AT, Chen YB, Hasserjian RP. Prognostic Significance of Residual Acute Myeloid Leukemia in Bone Marrow Samples Taken Prior to Allogeneic Hematopoietic Cell Transplantation. Am. J. Clin. Pathol. 2017 Jan 1/1/2017; 147(1): 50-9. PMID: 28108471, PII: aqw203, DOI: 10.1093/ajcp/aqw203, ISSN: 1943-7722.

Kamionek M, Ahmadi Moghaddam P, Sakhdari A, Kovach AE, Welch M, Meng X, Dresser K, Tomaszewicz K, Cosar EF, Mark EJ, Fraire AE, Hutchinson L. Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease. Histopathology [print-electronic]. 2016 Sep; 69(3): 499-509. PMID: 26915300, DOI: 10.1111/his.12955, ISSN: 1365-2559.

Louissaint A, Schafernak KT, Geyer JT, Kovach AE, Ghandi M, Gratzinger D, Roth CG, Paxton CN, Kim S, Namgyal C, Morin R, Morgan EA, Neuberg DS, South ST, Harris MH, Hasserjian RP, Hochberg EP, Garraway LA, Harris NL, Weinstock DM. Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations. Blood [print-electronic]. 2016 Aug 8/25/2016; 128(8): 1093-100. PMID: 27325104, PMCID: PMC5000844, PII: blood-2015-12-682591, DOI: 10.1182/blood-2015-12-682591, ISSN: 1528-0020.

Feske SK, Goldberg M, Dudzinski DM, Gonzalez RG, Kovach AE. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 29-2015. A 38-Year-Old Pregnant Woman with Headache and Visual Symptoms. N. Engl. J. Med. 2015 Sep 9/17/2015; 373(12): 1154-64. PMID: 26376139, DOI: 10.1056/NEJMcpc1404335, ISSN: 1533-4406.

Kovach AE, Nucera C, Lam QT, Nguyen A, Dias-Santagata D, Sadow PM. Genomic and immunohistochemical analysis in human adrenal cortical neoplasia reveal beta-catenin mutations as potential prognostic biomarker. Discoveries (Craiova). 2015 Apr; 3(2): PMID: 26317117, PMCID: PMC4548998, DOI: 10.15190/d.2015.32.

Ackman JB, Verzosa S, Kovach AE, Louissaint A, Lanuti M, Wright CD, Shepard JA, Halpern EF. High rate of unnecessary thymectomy and its cause. Can computed tomography distinguish thymoma, lymphoma, thymic hyperplasia, and thymic cysts?. Eur J Radiol [print-electronic]. 2015 Mar; 84(3): 524-33. PMID: 25575742, PII: S0720-048X(14)00571-3, DOI: 10.1016/j.ejrad.2014.11.042, ISSN: 1872-7727.

Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R. On chip analysis of CNS lymphoma in cerebrospinal fluid. Theranostics. 2015; 5(8): 796-804. PMID: 26000053, PMCID: PMC4440438, PII: thnov05p0796, DOI: 10.7150/thno.11220, ISSN: 1838-7640.

Carey CD, Gusenleitner D, Chapuy B, Kovach AE, Kluk MJ, Sun HH, Crossland RE, Bacon CM, Rand V, Dal Cin P, Le LP, Neuberg D, Sohani AR, Shipp MA, Monti S, Rodig SJ. Molecular classification of MYC-driven B-cell lymphomas by targeted gene expression profiling of fixed biopsy specimens. J Mol Diagn [print-electronic]. 2015 Jan; 17(1): 19-30. PMID: 25468432, PMCID: PMC4279427, PII: S1525-1578(14)00204-9, DOI: 10.1016/j.jmoldx.2014.08.006, ISSN: 1943-7811.

Kovach AE, DeLelys ME, Kelliher AS, Dillon LJ, Hasserjian RP, Ferry JA, Preffer FI, Sohani AR. Diagnostic utility of cerebrospinal fluid flow cytometry in patients with and without prior hematologic malignancy. Am. J. Hematol [print-electronic]. 2014 Oct; 89(10): 978-84. PMID: 25042070, DOI: 10.1002/ajh.23806, ISSN: 1096-8652.

Kovach AE, Cheng GZ, Channick CL, Channick RN, Muniappan A, Gaissert HA, Kradin RL. Postradiofrequency ablation inflammatory pseudotumor associated with pulmonary venoocclusive disease: case report and review of the literature. Ann Diagn Pathol [print-electronic]. 2013 Oct; 17(5): 466-9. PMID: 23352326, PII: S1092-9134(12)00172-4, DOI: 10.1016/j.anndiagpath.2012.11.002, ISSN: 1532-8198.

Onozato ML, Kovach AE, Yeap BY, Morales-Oyarvide V, Klepeis VE, Tammireddy S, Heist RS, Mark EJ, Dias-Santagata D, Iafrate AJ, Yagi Y, Mino-Kenudson M. Tumor islands in resected early-stage lung adenocarcinomas are associated with unique clinicopathologic and molecular characteristics and worse prognosis. Am. J. Surg. Pathol. 2013 Feb; 37(2): 287-94. PMID: 23095504, PMCID: PMC3545070, DOI: 10.1097/PAS.0b013e31826885fb, ISSN: 1532-0979.