Melissa A. Fischer, Ph.D.

Research Assistant Professor

mel.steaplet@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Biochemistry, Vanderbilt University, Nashville, TennesseeM.S., Biology, Indiana University-Purdue University, Fort Wayne, IndianaB.S.E., Genetic Bioengineering, Purdue University, West Lafayette, Indiana
Publications
Ramsey HE, Fischer MA, Lee T, Gorska AE, Arrate MP, Fuller L, Boyd KL, Strickland SA, Sensintaffar J, Hogdal LJ, Ayers GD, Olejniczak ET, Fesik SW, Savona MR. A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia. Cancer Discov [print-electronic]. 2018 Dec; 8(12): 1566-81. PMID: 30185627, PMCID: PMC6279595, PII: 2159-8290.CD-18-0140, DOI: 10.1158/2159-8290.CD-18-0140, ISSN: 2159-8290.

Zhang S, Zhao Y, Heaster TM, Fischer MA, Stengel KR, Zhou X, Ramsey H, Zhou MM, Savona MR, Skala MC, Hiebert SW. BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML. J. Cell. Biochem [print-electronic]. 2018 Nov 11/11/2018; PMID: 30417424, DOI: 10.1002/jcb.28005, ISSN: 1097-4644.

McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS. MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight. 2017 Aug 8/17/2017; 2(16): PMID: 28814670, PMCID: PMC5621889, PII: 78210, DOI: 10.1172/jci.insight.78210, ISSN: 2379-3708.

Puccetti MV, Fischer MA, Arrate MP, Boyd KL, Duszynski RJ, B├ętous R, Cortez D, Eischen CM. Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution. Oncogene [print-electronic]. 2017 May 5/4/2017; 36(18): 2553-64. PMID: 27797382, PII: onc2016408, DOI: 10.1038/onc.2016.408, ISSN: 1476-5594.

Lee T, Bian Z, Zhao B, Hogdal LJ, Sensintaffar JL, Goodwin CM, Belmar J, Shaw S, Tarr JC, Veerasamy N, Matulis SM, Koss B, Fischer MA, Arnold AL, Camper DV, Browning CF, Rossanese OW, Budhraja A, Opferman J, Boise LH, Savona MR, Letai A, Olejniczak ET, Fesik SW. Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors [letter]. FEBS Lett [print-electronic]. 2017 Jan; 591(1): 240-51. PMID: 27878989, PMCID: PMC5381274, DOI: 10.1002/1873-3468.12497, ISSN: 1873-3468.

Zhao Y, Liu Q, Acharya P, Stengel KR, Sheng Q, Zhou X, Kwak H, Fischer MA, Bradner JE, Strickland SA, Mohan SR, Savona MR, Venters BJ, Zhou MM, Lis JT, Hiebert SW. High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML. Cell Rep [print-electronic]. 2016 Aug 8/16/2016; 16(7): 2003-16. PMID: 27498870, PMCID: PMC4996374, PII: S2211-1247(16)30950-0, DOI: 10.1016/j.celrep.2016.07.032, ISSN: 2211-1247.

Sochacki AL, Fischer MA, Savona MR. Therapeutic approaches in myelofibrosis and myelodysplastic/myeloproliferative overlap syndromes. Onco Targets Ther. 2016; 9: 2273-86. PMID: 27143923, PMCID: PMC4844455, PII: ott-9-2273, DOI: 10.2147/OTT.S83868, ISSN: 1178-6930.

Phiri K, Williams PL, Dugan KB, Fischer MA, Cooper WO, Seage GR, Hernandez-Diaz S. Antiretroviral Therapy Use During Pregnancy and the Risk of Small for Gestational Age Birth in a Medicaid Population. Pediatr. Infect. Dis. J. 2015 Jul; 34(7): e169-75. PMID: 25851070, PMCID: PMC4466082, DOI: 10.1097/INF.0000000000000712, ISSN: 1532-0987.

Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW. HDAC3 is essential for DNA replication in hematopoietic progenitor cells. J. Clin. Invest [print-electronic]. 2013 Jul; 123(7): 3112-23. PMID: 23921131, PMCID: PMC3696547, PII: 60806, DOI: 10.1172/JCI60806, ISSN: 1558-8238.

Fischer MA, Moreno-Miralles I, Hunt A, Chyla BJ, Hiebert SW. Myeloid translocation gene 16 is required for maintenance of haematopoietic stem cell quiescence. EMBO J [print-electronic]. 2012 Mar 3/21/2012; 31(6): 1494-505. PMID: 22266796, PMCID: PMC3321173, PII: emboj2011500, DOI: 10.1038/emboj.2011.500, ISSN: 1460-2075.

Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. Cancer Res [print-electronic]. 2011 Feb 2/15/2011; 71(4): 1302-12. PMID: 21303973, PMCID: PMC3150168, PII: 0008-5472.CAN-10-3317, DOI: 10.1158/0008-5472.CAN-10-3317, ISSN: 1538-7445.

Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert SW. Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol. Cell. Biol [print-electronic]. 2008 Oct; 28(20): 6234-47. PMID: 18710942, PMCID: PMC2577421, PII: MCB.00404-08, DOI: 10.1128/MCB.00404-08, ISSN: 1098-5549.