Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Inflammation and Immunology, University of Vienna, Vienna, AustriaM.Sc., Biomedicine, Universität Bonn, Bonn, GermanyB.Sc., Ecology and Evolutionary Biology, University of Tennessee, Knoxville, Tennessee
Publications
Silver AJ, Brown DJ, Olmstead SD, Watke JM, Gorska AE, Tanner L, Ramsey HE, Savona MR. Interallelic gene conversion of leukemia-associated single nucleotide variants. Gene [print-electronic]. 2025 Jul 7/20/2025; 958: 149493. PMID: 40222687, PII: S0378-1119(25)00281-1, DOI: 10.1016/j.gene.2025.149493, ISSN: 1879-0038.
Ramsey HE, Gorska AE, Smith BN, Monteith AJ, Fuller L, Arrate MP, Savona MR. TLR3 agonism augments CD47 inhibition in acute myeloid leukemia. Haematologica. 2024 Jul 7/1/2024; 109(7): 2111-21. PMID: 38152031, PMCID: PMC11215363, DOI: 10.3324/haematol.2023.283850, ISSN: 1592-8721.
Monteith AJ, Ramsey HE, Silver AJ, Brown D, Greenwood D, Smith BN, Wise AD, Liu J, Olmstead SD, Watke J, Arrate MP, Gorska AE, Fuller L, Locasale JW, Stubbs MC, Rathmell JC, Savona MR. Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia. Cancer Res. 2024 Apr 4/1/2024; 84(7): 1101-14. PMID: 38285895, PMCID: PMC10984779, PII: 733995, DOI: 10.1158/0008-5472.CAN-23-0291, ISSN: 1538-7445.
Lovewell RR, Hong J, Kundu S, Fielder CM, Hu Q, Kim KW, Ramsey HE, Gorska AE, Fuller LS, Tian L, Kothari P, Paucarmayta A, Mason EF, Meza I, Manzanarez Y, Bosiacki J, Maloveste K, Mitchell N, Barbu EA, Morawski A, Maloveste S, Cusumano Z, Patel SJ, Savona MR, Langermann S, Myint H, Flies DB, Kim TK. LAIR-1 agonism as a therapy for acute myeloid leukemia. J Clin Invest. 2023 Nov 11/15/2023; 133(22): PMID: 37966113, PMCID: PMC10650974, PII: 169519, DOI: 10.1172/JCI169519, ISSN: 1558-8238.
Greenwood DL, Ramsey HE, Nguyen PTT, Patterson AR, Voss K, Bader JE, Sugiura A, Bacigalupa ZA, Schaefer S, Ye X, Dahunsi DO, Madden MZ, Wellen KE, Savona MR, Ferrell PB, Rathmell JC. Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk. Immunohorizons. 2022 Dec 12/1/2022; 6(12): 837-50. PMID: 36547387, PMCID: PMC9935084, PII: 237588, DOI: 10.4049/immunohorizons.2200086, ISSN: 2573-7732.
Cojocari D, Smith BN, Purkal JJ, Arrate MP, Huska JD, Xiao Y, Gorska A, Hogdal LJ, Ramsey HE, Boghaert ER, Phillips DC, Savona MR. Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia. Haematologica. 2022 Apr 4/1/2022; 107(4): 825-35. PMID: 33853293, PMCID: PMC8968901, DOI: 10.3324/haematol.2020.272609, ISSN: 1592-8721.
Reisman BJ, Guo H, Ramsey HE, Wright MT, Reinfeld BI, Ferrell PB, Sulikowski GA, Rathmell WK, Savona MR, Plate L, Rubinstein JL, Bachmann BO. Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase. Nat Chem Biol [print-electronic]. 2022 Apr; 18(4): 360-7. PMID: 34857958, PMCID: PMC8967781, PII: 10.1038/s41589-021-00900-9, DOI: 10.1038/s41589-021-00900-9, ISSN: 1552-4469.
Liu ZJ, Deschmann E, Ramsey HE, Feldman HA, Psaila B, Cooper N, Vlachodimitropoulou E, Porter J, Bussel J, Georgieff M, Sola-Visner M. Iron status influences the response of cord blood megakaryocyte progenitors to eltrombopag in vitro. Blood Adv. 2022 Jan 1/11/2022; 6(1): 13-27. PMID: 34654056, PMCID: PMC8753208, PII: 477337, DOI: 10.1182/bloodadvances.2021004207, ISSN: 2473-9537.
Ramsey HE, Stengel K, Pino JC, Johnston G, Childress M, Gorska AE, Arrate PM, Fuller L, Villaume M, Fischer MA, Ferrell PB, Roe CE, Zou J, Lubbock ALR, Stubbs M, Zinkel S, Irish JM, Lopez CF, Hiebert S, Savona MR. Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation. Target Oncol [print-electronic]. 2021 Sep; 16(5): 663-74. PMID: 34324169, PMCID: PMC8667588, PII: 10.1007/s11523-021-00830-5, DOI: 10.1007/s11523-021-00830-5, ISSN: 1776-260X.
Villaume MT, Arrate MP, Ramsey HE, Sunthankar KI, Jenkins MT, Moyo TK, Smith BN, Fischer MA, Childress MA, Gorska AE, Ferrell PB, Savona MR. The delta isoform of phosphatidylinositol-3-kinase predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib. Exp Hematol [print-electronic]. 2021 May; 97: 57-65.e5-65.e5. PMID: 33617893, PMCID: PMC9059134, PII: S0301-472X(21)00089-8, DOI: 10.1016/j.exphem.2021.02.008, ISSN: 1873-2399.
Ramsey HE, Greenwood D, Zhang S, Childress M, Arrate MP, Gorska AE, Fuller L, Zhao Y, Stengel K, Fischer MA, Stubbs MC, Liu PCC, Boyd K, Rathmell JC, Hiebert SW, Savona MR. BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia. Clin Cancer Res [print-electronic]. 2020 Nov 11/4/2020; PMID: 33148670, PII: 1078-0432.CCR-20-1346, DOI: 10.1158/1078-0432.CCR-20-1346, ISSN: 1557-3265.
Johnston G, Ramsey HE, Liu Q, Wang J, Stengel KR, Sampathi S, Acharya P, Arrate M, Stubbs MC, Burn T, Savona MR, Hiebert SW. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia. Gene [print-electronic]. 2020 Aug 8/20/2020; 752: 144758. PMID: 32422235, PMCID: PMC7401316, PII: S0378-1119(20)30427-3, DOI: 10.1016/j.gene.2020.144758, ISSN: 1879-0038.
Ramsey HE, Oganesian A, Gorska AE, Fuller L, Arrate M, Boyd K, Keer H, Azab M, Savona MR. Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model. Target Oncol. 2020 Apr; 15(2): 231-40. PMID: 32222953, PMCID: PMC7182630, PII: 10.1007/s11523-020-00709-x, DOI: 10.1007/s11523-020-00709-x, ISSN: 1776-260X.
Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A, Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT. Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia. Cancer Discov [print-electronic]. 2020 Apr; 10(4): 536-51. PMID: 31974170, PMCID: PMC7124979, PII: 2159-8290.CD-19-0710, DOI: 10.1158/2159-8290.CD-19-0710, ISSN: 2159-8290.
Fischer MA, Friedlander SY, Arrate MP, Chang H, Gorska AE, Fuller LD, Ramsey HE, Kashyap T, Argueta C, Debler S, Byrne M, Villaume MT, Shaver AC, Senapedis W, Landesman Y, Baloglu E, Shacham S, Savona MR. Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies. Blood Adv. 2020 Feb 2/11/2020; 4(3): 586-98. PMID: 32045477, PMCID: PMC7013257, PII: 441055, DOI: 10.1182/bloodadvances.2019000359, ISSN: 2473-9537.
Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook RS, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW. Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J. Med. Chem [print-electronic]. 2019 Apr 4/16/2019; PMID: 30929420, DOI: 10.1021/acs.jmedchem.8b01991, ISSN: 1520-4804.
Zhang S, Zhao Y, Heaster TM, Fischer MA, Stengel KR, Zhou X, Ramsey H, Zhou MM, Savona MR, Skala MC, Hiebert SW. BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML. J. Cell. Biochem [print-electronic]. 2018 Nov 11/11/2018; PMID: 30417424, DOI: 10.1002/jcb.28005, ISSN: 1097-4644.
Ramsey HE, Fischer MA, Lee T, Gorska AE, Arrate MP, Fuller L, Boyd KL, Strickland SA, Sensintaffar J, Hogdal LJ, Ayers GD, Olejniczak ET, Fesik SW, Savona MR. A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute Myelogenous Leukemia. Cancer Discov [print-electronic]. 2018 Sep 9/5/2018; PMID: 30185627, PII: 2159-8290.CD-18-0140, DOI: 10.1158/2159-8290.CD-18-0140, ISSN: 2159-8290.
Lorenz V, Ramsey H, Liu ZJ, Italiano J, Hoffmeister K, Bihorel S, Mager D, Hu Z, Slayton WB, Kile BT, Sola-Visner M, Ferrer-Marin F. Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice. Thromb. Haemost [print-electronic]. 2017 Dec; 117(12): 2322-33. PMID: 29212120, PMCID: PMC5911346, DOI: 10.1160/TH17-06-0433, ISSN: 2567-689X.
Sparger KA, Ramsey H, Lorenz V, Liu ZJ, Feldman HA, Li N, Laforest T, Sola-Visner MC. Developmental differences between newborn and adult mice in response to romiplostim. Platelets [print-electronic]. 2017 May 5/26/2017; 1-8. PMID: 28548028, DOI: 10.1080/09537104.2017.1316481, ISSN: 1369-1635.
Shahid M, Javed AA, Chandra D, Ramsey HE, Shah D, Khan MF, Zhao L, Wu MX. IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity. Sci Rep. 2016 Apr 4/11/2016; 6: 24135. PMID: 27063893, PMCID: PMC4827096, PII: srep24135, DOI: 10.1038/srep24135, ISSN: 2045-2322.
Gattringer M, Baranyi U, Pilat N, Hock K, Klaus C, Ramsey HE, Wrba F, Valenta R, Wekerle T. Anti-OX40L alone or in combination with anti-CD40L and CTLA4Ig does not inhibit the humoral and cellular response to a major grass pollen allergen. Clin. Exp. Allergy. 2016 Feb; 46(2): 354-64. PMID: 26464312, DOI: 10.1111/cea.12661, ISSN: 1365-2222.
Pilat N, Klaus C, Schwarz C, Hock K, Oberhuber R, Schwaiger E, Gattringer M, Ramsey H, Baranyi U, Zelger B, Brandacher G, Wrba F, Wekerle T. Rapamycin and CTLA4Ig synergize to induce stable mixed chimerism without the need for CD40 blockade. Am. J. Transplant [print-electronic]. 2015 Jun; 15(6): 1568-79. PMID: 25783859, DOI: 10.1111/ajt.13154, ISSN: 1600-6143.
Ramsey H, Zhang Q, Wu MX. Mitoquinone restores platelet production in irradiation-induced thrombocytopenia. Platelets [print-electronic]. 2015; 26(5): 459-66. PMID: 25025394, PMCID: PMC4382457, DOI: 10.3109/09537104.2014.935315, ISSN: 1369-1635.
Ramsey H, Wu MX. Mitochondrial anti-oxidant protects IEX-1 deficient mice from organ damage during endotoxemia. Int. Immunopharmacol. 2014 Dec; 23(2): 658-63. PMID: 25466275, PMCID: PMC4394602, PII: S1567-5769(14)00401-9, DOI: 10.1016/j.intimp.2014.10.019, ISSN: 1878-1705.
Liu ZJ, Hoffmeister KM, Hu Z, Mager DE, Ait-Oudhia S, Debrincat MA, Pleines I, Josefsson EC, Kile BT, Italiano J, Ramsey H, Grozovsky R, Veng-Pedersen P, Chavda C, Sola-Visner M. Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. Blood [print-electronic]. 2014 May 5/29/2014; 123(22): 3381-9. PMID: 24599546, PMCID: PMC4041172, PII: blood-2013-06-508200, DOI: 10.1182/blood-2013-06-508200, ISSN: 1528-0020.
Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX. Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3). Haematologica [print-electronic]. 2014 Feb; 99(2): 282-91. PMID: 24056813, PMCID: PMC3912958, PII: haematol.2013.092452, DOI: 10.3324/haematol.2013.092452, ISSN: 1592-8721.
Gattringer M, Baranyi U, Pilat N, Hock K, Klaus C, Buchberger E, Ramsey H, Iacomini J, Valenta R, Wekerle T. Engraftment of retrovirally transduced Bet v 1-GFP expressing bone marrow cells leads to allergen-specific tolerance. Immunobiology [print-electronic]. 2013 Sep; 218(9): 1139-46. PMID: 23623394, PII: S0171-2985(13)00058-2, DOI: 10.1016/j.imbio.2013.03.007, ISSN: 1878-3279.
Ramsey H, Pilat N, Hock K, Klaus C, Unger L, Schwarz C, Baranyi U, Gattringer M, Schwaiger E, Wrba F, Wekerle T. Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients. Transpl. Int [print-electronic]. 2013 Feb; 26(2): 206-18. PMID: 23240587, DOI: 10.1111/tri.12021, ISSN: 1432-2277.
Schwaiger E, Klaus C, Matheeussen V, Baranyi U, Pilat N, Ramsey H, Korom S, De Meester I, Wekerle T. Dipeptidyl peptidase IV (DPPIV/CD26) inhibition does not improve engraftment of unfractionated syngeneic or allogeneic bone marrow after nonmyeloablative conditioning. Exp. Hematol [print-electronic]. 2012 Feb; 40(2): 97-106. PMID: 22085453, PMCID: PMC3265670, PII: S0301-472X(11)00543-1, DOI: 10.1016/j.exphem.2011.10.010, ISSN: 1873-2399.
Damrauer SM, Studer P, da Silva CG, Longo CR, Ramsey HE, Csizmadia E, Shrikhande GV, Scali ST, Libermann TA, Bhasin MK, Ferran C. A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS ONE. 2011 Mar 3/17/2011; 6(3): e17715. PMID: 21437236, PMCID: PMC3060102, DOI: 10.1371/journal.pone.0017715, ISSN: 1932-6203.
Ramsey HE, Da Silva CG, Longo CR, Csizmadia E, Studer P, Patel VI, Damrauer SM, Siracuse JJ, Daniel S, Ferran C. A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. Liver Transpl. 2009 Nov; 15(11): 1613-21. PMID: 19877201, PMCID: PMC2976064, DOI: 10.1002/lt.21879, ISSN: 1527-6473.
Daniel S, Patel VI, Shrikhande GV, Scali ST, Ramsey HE, Csizmadia E, Benhaga N, Fisher MD, Arvelo MB, Ferran C. The universal NF-kappaB inhibitor a20 protects from transplant vasculopathy by differentially affecting apoptosis in endothelial and smooth muscle cells. Transplant. Proc. 2006 Dec; 38(10): 3225-7. PMID: 17175229, PMCID: PMC2866740, PII: S0041-1345(06)01415-1, DOI: 10.1016/j.transproceed.2006.10.167, ISSN: 0041-1345.
Patel VI, Daniel S, Longo CR, Shrikhande GV, Scali ST, Czismadia E, Groft CM, Shukri T, Motley-Dore C, Ramsey HE, Fisher MD, Grey ST, Arvelo MB, Ferran C. A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. FASEB J. 2006 Jul; 20(9): 1418-30. PMID: 16816117, PII: 20/9/1418, DOI: 10.1096/fj.05-4981com, ISSN: 1530-6860.
Ramsey HE, Gorska AE, Smith BN, Monteith AJ, Fuller L, Arrate MP, Savona MR. TLR3 agonism augments CD47 inhibition in acute myeloid leukemia. Haematologica. 2024 Jul 7/1/2024; 109(7): 2111-21. PMID: 38152031, PMCID: PMC11215363, DOI: 10.3324/haematol.2023.283850, ISSN: 1592-8721.
Monteith AJ, Ramsey HE, Silver AJ, Brown D, Greenwood D, Smith BN, Wise AD, Liu J, Olmstead SD, Watke J, Arrate MP, Gorska AE, Fuller L, Locasale JW, Stubbs MC, Rathmell JC, Savona MR. Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia. Cancer Res. 2024 Apr 4/1/2024; 84(7): 1101-14. PMID: 38285895, PMCID: PMC10984779, PII: 733995, DOI: 10.1158/0008-5472.CAN-23-0291, ISSN: 1538-7445.
Lovewell RR, Hong J, Kundu S, Fielder CM, Hu Q, Kim KW, Ramsey HE, Gorska AE, Fuller LS, Tian L, Kothari P, Paucarmayta A, Mason EF, Meza I, Manzanarez Y, Bosiacki J, Maloveste K, Mitchell N, Barbu EA, Morawski A, Maloveste S, Cusumano Z, Patel SJ, Savona MR, Langermann S, Myint H, Flies DB, Kim TK. LAIR-1 agonism as a therapy for acute myeloid leukemia. J Clin Invest. 2023 Nov 11/15/2023; 133(22): PMID: 37966113, PMCID: PMC10650974, PII: 169519, DOI: 10.1172/JCI169519, ISSN: 1558-8238.
Greenwood DL, Ramsey HE, Nguyen PTT, Patterson AR, Voss K, Bader JE, Sugiura A, Bacigalupa ZA, Schaefer S, Ye X, Dahunsi DO, Madden MZ, Wellen KE, Savona MR, Ferrell PB, Rathmell JC. Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk. Immunohorizons. 2022 Dec 12/1/2022; 6(12): 837-50. PMID: 36547387, PMCID: PMC9935084, PII: 237588, DOI: 10.4049/immunohorizons.2200086, ISSN: 2573-7732.
Cojocari D, Smith BN, Purkal JJ, Arrate MP, Huska JD, Xiao Y, Gorska A, Hogdal LJ, Ramsey HE, Boghaert ER, Phillips DC, Savona MR. Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia. Haematologica. 2022 Apr 4/1/2022; 107(4): 825-35. PMID: 33853293, PMCID: PMC8968901, DOI: 10.3324/haematol.2020.272609, ISSN: 1592-8721.
Reisman BJ, Guo H, Ramsey HE, Wright MT, Reinfeld BI, Ferrell PB, Sulikowski GA, Rathmell WK, Savona MR, Plate L, Rubinstein JL, Bachmann BO. Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase. Nat Chem Biol [print-electronic]. 2022 Apr; 18(4): 360-7. PMID: 34857958, PMCID: PMC8967781, PII: 10.1038/s41589-021-00900-9, DOI: 10.1038/s41589-021-00900-9, ISSN: 1552-4469.
Liu ZJ, Deschmann E, Ramsey HE, Feldman HA, Psaila B, Cooper N, Vlachodimitropoulou E, Porter J, Bussel J, Georgieff M, Sola-Visner M. Iron status influences the response of cord blood megakaryocyte progenitors to eltrombopag in vitro. Blood Adv. 2022 Jan 1/11/2022; 6(1): 13-27. PMID: 34654056, PMCID: PMC8753208, PII: 477337, DOI: 10.1182/bloodadvances.2021004207, ISSN: 2473-9537.
Ramsey HE, Stengel K, Pino JC, Johnston G, Childress M, Gorska AE, Arrate PM, Fuller L, Villaume M, Fischer MA, Ferrell PB, Roe CE, Zou J, Lubbock ALR, Stubbs M, Zinkel S, Irish JM, Lopez CF, Hiebert S, Savona MR. Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation. Target Oncol [print-electronic]. 2021 Sep; 16(5): 663-74. PMID: 34324169, PMCID: PMC8667588, PII: 10.1007/s11523-021-00830-5, DOI: 10.1007/s11523-021-00830-5, ISSN: 1776-260X.
Villaume MT, Arrate MP, Ramsey HE, Sunthankar KI, Jenkins MT, Moyo TK, Smith BN, Fischer MA, Childress MA, Gorska AE, Ferrell PB, Savona MR. The delta isoform of phosphatidylinositol-3-kinase predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib. Exp Hematol [print-electronic]. 2021 May; 97: 57-65.e5-65.e5. PMID: 33617893, PMCID: PMC9059134, PII: S0301-472X(21)00089-8, DOI: 10.1016/j.exphem.2021.02.008, ISSN: 1873-2399.
Ramsey HE, Greenwood D, Zhang S, Childress M, Arrate MP, Gorska AE, Fuller L, Zhao Y, Stengel K, Fischer MA, Stubbs MC, Liu PCC, Boyd K, Rathmell JC, Hiebert SW, Savona MR. BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia. Clin Cancer Res [print-electronic]. 2020 Nov 11/4/2020; PMID: 33148670, PII: 1078-0432.CCR-20-1346, DOI: 10.1158/1078-0432.CCR-20-1346, ISSN: 1557-3265.
Johnston G, Ramsey HE, Liu Q, Wang J, Stengel KR, Sampathi S, Acharya P, Arrate M, Stubbs MC, Burn T, Savona MR, Hiebert SW. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia. Gene [print-electronic]. 2020 Aug 8/20/2020; 752: 144758. PMID: 32422235, PMCID: PMC7401316, PII: S0378-1119(20)30427-3, DOI: 10.1016/j.gene.2020.144758, ISSN: 1879-0038.
Ramsey HE, Oganesian A, Gorska AE, Fuller L, Arrate M, Boyd K, Keer H, Azab M, Savona MR. Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model. Target Oncol. 2020 Apr; 15(2): 231-40. PMID: 32222953, PMCID: PMC7182630, PII: 10.1007/s11523-020-00709-x, DOI: 10.1007/s11523-020-00709-x, ISSN: 1776-260X.
Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A, Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT. Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia. Cancer Discov [print-electronic]. 2020 Apr; 10(4): 536-51. PMID: 31974170, PMCID: PMC7124979, PII: 2159-8290.CD-19-0710, DOI: 10.1158/2159-8290.CD-19-0710, ISSN: 2159-8290.
Fischer MA, Friedlander SY, Arrate MP, Chang H, Gorska AE, Fuller LD, Ramsey HE, Kashyap T, Argueta C, Debler S, Byrne M, Villaume MT, Shaver AC, Senapedis W, Landesman Y, Baloglu E, Shacham S, Savona MR. Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies. Blood Adv. 2020 Feb 2/11/2020; 4(3): 586-98. PMID: 32045477, PMCID: PMC7013257, PII: 441055, DOI: 10.1182/bloodadvances.2019000359, ISSN: 2473-9537.
Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook RS, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW. Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J. Med. Chem [print-electronic]. 2019 Apr 4/16/2019; PMID: 30929420, DOI: 10.1021/acs.jmedchem.8b01991, ISSN: 1520-4804.
Zhang S, Zhao Y, Heaster TM, Fischer MA, Stengel KR, Zhou X, Ramsey H, Zhou MM, Savona MR, Skala MC, Hiebert SW. BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML. J. Cell. Biochem [print-electronic]. 2018 Nov 11/11/2018; PMID: 30417424, DOI: 10.1002/jcb.28005, ISSN: 1097-4644.
Ramsey HE, Fischer MA, Lee T, Gorska AE, Arrate MP, Fuller L, Boyd KL, Strickland SA, Sensintaffar J, Hogdal LJ, Ayers GD, Olejniczak ET, Fesik SW, Savona MR. A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute Myelogenous Leukemia. Cancer Discov [print-electronic]. 2018 Sep 9/5/2018; PMID: 30185627, PII: 2159-8290.CD-18-0140, DOI: 10.1158/2159-8290.CD-18-0140, ISSN: 2159-8290.
Lorenz V, Ramsey H, Liu ZJ, Italiano J, Hoffmeister K, Bihorel S, Mager D, Hu Z, Slayton WB, Kile BT, Sola-Visner M, Ferrer-Marin F. Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice. Thromb. Haemost [print-electronic]. 2017 Dec; 117(12): 2322-33. PMID: 29212120, PMCID: PMC5911346, DOI: 10.1160/TH17-06-0433, ISSN: 2567-689X.
Sparger KA, Ramsey H, Lorenz V, Liu ZJ, Feldman HA, Li N, Laforest T, Sola-Visner MC. Developmental differences between newborn and adult mice in response to romiplostim. Platelets [print-electronic]. 2017 May 5/26/2017; 1-8. PMID: 28548028, DOI: 10.1080/09537104.2017.1316481, ISSN: 1369-1635.
Shahid M, Javed AA, Chandra D, Ramsey HE, Shah D, Khan MF, Zhao L, Wu MX. IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity. Sci Rep. 2016 Apr 4/11/2016; 6: 24135. PMID: 27063893, PMCID: PMC4827096, PII: srep24135, DOI: 10.1038/srep24135, ISSN: 2045-2322.
Gattringer M, Baranyi U, Pilat N, Hock K, Klaus C, Ramsey HE, Wrba F, Valenta R, Wekerle T. Anti-OX40L alone or in combination with anti-CD40L and CTLA4Ig does not inhibit the humoral and cellular response to a major grass pollen allergen. Clin. Exp. Allergy. 2016 Feb; 46(2): 354-64. PMID: 26464312, DOI: 10.1111/cea.12661, ISSN: 1365-2222.
Pilat N, Klaus C, Schwarz C, Hock K, Oberhuber R, Schwaiger E, Gattringer M, Ramsey H, Baranyi U, Zelger B, Brandacher G, Wrba F, Wekerle T. Rapamycin and CTLA4Ig synergize to induce stable mixed chimerism without the need for CD40 blockade. Am. J. Transplant [print-electronic]. 2015 Jun; 15(6): 1568-79. PMID: 25783859, DOI: 10.1111/ajt.13154, ISSN: 1600-6143.
Ramsey H, Zhang Q, Wu MX. Mitoquinone restores platelet production in irradiation-induced thrombocytopenia. Platelets [print-electronic]. 2015; 26(5): 459-66. PMID: 25025394, PMCID: PMC4382457, DOI: 10.3109/09537104.2014.935315, ISSN: 1369-1635.
Ramsey H, Wu MX. Mitochondrial anti-oxidant protects IEX-1 deficient mice from organ damage during endotoxemia. Int. Immunopharmacol. 2014 Dec; 23(2): 658-63. PMID: 25466275, PMCID: PMC4394602, PII: S1567-5769(14)00401-9, DOI: 10.1016/j.intimp.2014.10.019, ISSN: 1878-1705.
Liu ZJ, Hoffmeister KM, Hu Z, Mager DE, Ait-Oudhia S, Debrincat MA, Pleines I, Josefsson EC, Kile BT, Italiano J, Ramsey H, Grozovsky R, Veng-Pedersen P, Chavda C, Sola-Visner M. Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. Blood [print-electronic]. 2014 May 5/29/2014; 123(22): 3381-9. PMID: 24599546, PMCID: PMC4041172, PII: blood-2013-06-508200, DOI: 10.1182/blood-2013-06-508200, ISSN: 1528-0020.
Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX. Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3). Haematologica [print-electronic]. 2014 Feb; 99(2): 282-91. PMID: 24056813, PMCID: PMC3912958, PII: haematol.2013.092452, DOI: 10.3324/haematol.2013.092452, ISSN: 1592-8721.
Gattringer M, Baranyi U, Pilat N, Hock K, Klaus C, Buchberger E, Ramsey H, Iacomini J, Valenta R, Wekerle T. Engraftment of retrovirally transduced Bet v 1-GFP expressing bone marrow cells leads to allergen-specific tolerance. Immunobiology [print-electronic]. 2013 Sep; 218(9): 1139-46. PMID: 23623394, PII: S0171-2985(13)00058-2, DOI: 10.1016/j.imbio.2013.03.007, ISSN: 1878-3279.
Ramsey H, Pilat N, Hock K, Klaus C, Unger L, Schwarz C, Baranyi U, Gattringer M, Schwaiger E, Wrba F, Wekerle T. Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients. Transpl. Int [print-electronic]. 2013 Feb; 26(2): 206-18. PMID: 23240587, DOI: 10.1111/tri.12021, ISSN: 1432-2277.
Schwaiger E, Klaus C, Matheeussen V, Baranyi U, Pilat N, Ramsey H, Korom S, De Meester I, Wekerle T. Dipeptidyl peptidase IV (DPPIV/CD26) inhibition does not improve engraftment of unfractionated syngeneic or allogeneic bone marrow after nonmyeloablative conditioning. Exp. Hematol [print-electronic]. 2012 Feb; 40(2): 97-106. PMID: 22085453, PMCID: PMC3265670, PII: S0301-472X(11)00543-1, DOI: 10.1016/j.exphem.2011.10.010, ISSN: 1873-2399.
Damrauer SM, Studer P, da Silva CG, Longo CR, Ramsey HE, Csizmadia E, Shrikhande GV, Scali ST, Libermann TA, Bhasin MK, Ferran C. A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS ONE. 2011 Mar 3/17/2011; 6(3): e17715. PMID: 21437236, PMCID: PMC3060102, DOI: 10.1371/journal.pone.0017715, ISSN: 1932-6203.
Ramsey HE, Da Silva CG, Longo CR, Csizmadia E, Studer P, Patel VI, Damrauer SM, Siracuse JJ, Daniel S, Ferran C. A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. Liver Transpl. 2009 Nov; 15(11): 1613-21. PMID: 19877201, PMCID: PMC2976064, DOI: 10.1002/lt.21879, ISSN: 1527-6473.
Daniel S, Patel VI, Shrikhande GV, Scali ST, Ramsey HE, Csizmadia E, Benhaga N, Fisher MD, Arvelo MB, Ferran C. The universal NF-kappaB inhibitor a20 protects from transplant vasculopathy by differentially affecting apoptosis in endothelial and smooth muscle cells. Transplant. Proc. 2006 Dec; 38(10): 3225-7. PMID: 17175229, PMCID: PMC2866740, PII: S0041-1345(06)01415-1, DOI: 10.1016/j.transproceed.2006.10.167, ISSN: 0041-1345.
Patel VI, Daniel S, Longo CR, Shrikhande GV, Scali ST, Czismadia E, Groft CM, Shukri T, Motley-Dore C, Ramsey HE, Fisher MD, Grey ST, Arvelo MB, Ferran C. A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. FASEB J. 2006 Jul; 20(9): 1418-30. PMID: 16816117, PII: 20/9/1418, DOI: 10.1096/fj.05-4981com, ISSN: 1530-6860.