Nashville, TN 37232
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD. Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med [print-electronic]. 2018 Jun; 24(6): 857-67. PMID: 29867235, PII: 10.1038/s41591-018-0042-6, DOI: 10.1038/s41591-018-0042-6, ISSN: 1546-170X.
Zhou T, Zheng A, Baxa U, Chuang GY, Georgiev IS, Kong R, O'Dell S, Shahzad-Ul-Hussan S, Shen CH, Tsybovsky Y, Bailer RT, Gift SK, Louder MK, McKee K, Rawi R, Stevenson CH, Stewart-Jones GBE, Taft JD, Waltari E, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CD, Wu CY, , Mullikin JC, Bewley CA, Burton DR, Polonis VR, Shapiro L, Wong CH, Mascola JR, Kwong PD, Wu X. A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope. Immunity [print-electronic]. 2018 Mar 3/20/2018; 48(3): 500-513.e6. PMID: 29548671, PII: S1074-7613(18)30071-2, DOI: 10.1016/j.immuni.2018.02.013, ISSN: 1097-4180.
Zhou T, Zheng A, Baxa U, Chuang GY, Georgiev IS, Kong R, O'Dell S, Shahzad-Ul-Hussan S, Shen CH, Tsybovsky Y, Bailer RT, Gift SK, Louder MK, McKee K, Rawi R, Stevenson CH, Stewart-Jones GBE, Taft JD, Waltari E, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CD, Wu CY, , Mullikin JC, Bewley CA, Burton DR, Polonis VR, Shapiro L, Wong CH, Mascola JR, Kwong PD, Wu X. A Neutralizing Antibody Recognizing Primarily N-linked Glycan Targets the Silent Face of the HIV Envelope. Immunity [print-electronic]. 2018 Mar 3/7/2018; PMID: 29548671, PII: S1074-7613(18)30071-2, DOI: 10.1016/j.immuni.2018.02.013, ISSN: 1097-4180.
Georgiev IS, Joyce MG, Chen RE, Leung K, McKee K, Druz A, Van Galen JG, Kanekiyo M, Tsybovsky Y, Yang ES, Yang Y, Acharya P, Pancera M, Thomas PV, Wanninger T, Yassine HM, Baxa U, Doria-Rose NA, Cheng C, Graham BS, Mascola JR, Kwong PD. Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens. ACS Infect Dis [print-electronic]. 2018 Mar 3/6/2018; PMID: 29451984, DOI: 10.1021/acsinfecdis.7b00192, ISSN: 2373-8227.
Kwon YD, Chuang GY, Zhang B, Bailer RT, Doria-Rose NA, Gindin TS, Lin B, Louder MK, McKee K, O'Dell S, Pegu A, Schmidt SD, Asokan M, Chen X, Choe M, Georgiev IS, Jin V, Pancera M, Rawi R, Wang K, Chaudhuri R, Kueltzo LA, Manceva SD, Todd JP, Scorpio DG, Kim M, Reinherz EL, Wagh K, Korber BM, Connors M, Shapiro L, Mascola JR, Kwong PD. Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody. Cell Rep. 2018 Feb 2/13/2018; 22(7): 1798-809. PMID: 29444432, PII: S2211-1247(18)30040-8, DOI: 10.1016/j.celrep.2018.01.023, ISSN: 2211-1247.
Koethe JR, McDonnell W, Kennedy A, Abana CO, Pilkinton M, Setliff I, Georgiev I, Barnett L, Hager CC, Smith R, Kalams SA, Hasty A, Mallal S. Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons. J. Acquir. Immune Defic. Syndr. 2018 Feb 2/1/2018; 77(2): e14-e21. PMID: 29040163, PMCID: PMC5762435, DOI: 10.1097/QAI.0000000000001573, ISSN: 1944-7884.
González N, McKee K, Lynch RM, Georgiev IS, Jimenez L, Grau E, Yuste E, Kwong PD, Mascola JR, Alcamí J. Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors. PLoS ONE. 2018; 13(3): e0193773. PMID: 29558468, PII: PONE-D-17-37790, DOI: 10.1371/journal.pone.0193773, ISSN: 1932-6203.
Saunders KO, Verkoczy LK, Jiang C, Zhang J, Parks R, Chen H, Housman M, Bouton-Verville H, Shen X, Trama AM, Scearce R, Sutherland L, Santra S, Newman A, Eaton A, Xu K, Georgiev IS, Joyce MG, Tomaras GD, Bonsignori M, Reed SG, Salazar A, Mascola JR, Moody MA, Cain DW, Centlivre M, Zurawski S, Zurawski G, Erickson HP, Kwong PD, Alam SM, Levy Y, Montefiori DC, Haynes BF. Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models. Cell Rep. 2017 Dec 12/26/2017; 21(13): 3681-90. PMID: 29281818, PMCID: PMC5777169, PII: S2211-1247(17)31837-5, DOI: 10.1016/j.celrep.2017.12.028, ISSN: 2211-1247.
Joyce MG, Georgiev IS, Yang Y, Druz A, Geng H, Chuang GY, Kwon YD, Pancera M, Rawi R, Sastry M, Stewart-Jones GBE, Zheng A, Zhou T, Choe M, Van Galen JG, Chen RE, Lees CR, Narpala S, Chambers M, Tsybovsky Y, Baxa U, McDermott AB, Mascola JR, Kwong PD. Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains. Cell Rep. 2017 Dec 12/5/2017; 21(10): 2992-3002. PMID: 29212041, PII: S2211-1247(17)31636-4, DOI: 10.1016/j.celrep.2017.11.016, ISSN: 2211-1247.
Julg B, Tartaglia LJ, Keele BF, Wagh K, Pegu A, Sok D, Abbink P, Schmidt SD, Wang K, Chen X, Joyce MG, Georgiev IS, Choe M, Kwong PD, Doria-Rose NA, Le K, Louder MK, Bailer RT, Moore PL, Korber B, Seaman MS, Abdool Karim SS, Morris L, Koup RA, Mascola JR, Burton DR, Barouch DH. Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge. Sci Transl Med. 2017 Sep 9/6/2017; 9(406): PMID: 28878010, PMCID: PMC5755978, PII: 9/406/eaal1321, DOI: 10.1126/scitranslmed.aal1321, ISSN: 1946-6242.
Surdel MC, Horvath DJ, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, Lacy DB, Dailey HA, Skaar EP. Antibacterial photosensitization through activation of coproporphyrinogen oxidase. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Aug 8/8/2017; 114(32): E6652-E6659. PMID: 28739897, PMCID: PMC5559000, PII: 1700469114, DOI: 10.1073/pnas.1700469114, ISSN: 1091-6490.
Cale EM, Gorman J, Radakovich NA, Crooks ET, Osawa K, Tong T, Li J, Nagarajan R, Ozorowski G, Ambrozak DR, Asokan M, Bailer RT, Bennici AK, Chen X, Doria-Rose NA, Druz A, Feng Y, Joyce MG, Louder MK, O'Dell S, Oliver C, Pancera M, Connors M, Hope TJ, Kepler TB, Wyatt RT, Ward AB, Georgiev IS, Kwong PD, Mascola JR, Binley JM. Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop. Immunity. 2017 May 5/16/2017; 46(5): 777-791.e10. PMID: 28514685, PMCID: PMC5512451, PII: S1074-7613(17)30176-0, DOI: 10.1016/j.immuni.2017.04.011, ISSN: 1097-4180.
Chuang GY, Geng H, Pancera M, Xu K, Cheng C, Acharya P, Chambers M, Druz A, Tsybovsky Y, Wanninger TG, Yang Y, Doria-Rose NA, Georgiev IS, Gorman J, Joyce MG, O'Dell S, Zhou T, McDermott AB, Mascola JR, Kwong PD. Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity. J. Virol [electronic-print]. 2017 May 5/15/2017; 91(10): PMID: 28275193, PMCID: PMC5411596, PII: JVI.02268-16, DOI: 10.1128/JVI.02268-16, ISSN: 1098-5514.
Zhou T, Doria-Rose NA, Cheng C, Stewart-Jones GBE, Chuang GY, Chambers M, Druz A, Geng H, McKee K, Kwon YD, O'Dell S, Sastry M, Schmidt SD, Xu K, Chen L, Chen RE, Louder MK, Pancera M, Wanninger TG, Zhang B, Zheng A, Farney SK, Foulds KE, Georgiev IS, Joyce MG, Lemmin T, Narpala S, Rawi R, Soto C, Todd JP, Shen CH, Tsybovsky Y, Yang Y, Zhao P, Haynes BF, Stamatatos L, Tiemeyer M, Wells L, Scorpio DG, Shapiro L, McDermott AB, Mascola JR, Kwong PD. Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation. Cell Rep. 2017 Apr 4/25/2017; 19(4): 719-32. PMID: 28445724, PMCID: PMC5538809, PII: S2211-1247(17)30488-6, DOI: 10.1016/j.celrep.2017.04.013, ISSN: 2211-1247.
Alam SM, Aussedat B, Vohra Y, Meyerhoff RR, Cale EM, Walkowicz WE, Radakovich NA, Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce MG, Pancera M, Druz A, Georgiev IS, Von Holle T, Eaton A, Fox C, Reed SG, Louder M, Bailer RT, Morris L, Abdool-Karim SS, Cohen M, Liao HX, Montefiori DC, Park PK, Fernández-Tejada A, Wiehe K, Santra S, Kepler TB, Saunders KO, Sodroski J, Kwong PD, Mascola JR, Bonsignori M, Moody MA, Danishefsky S, Haynes BF. Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. Sci Transl Med. 2017 Mar 3/15/2017; 9(381): PMID: 28298421, PMCID: PMC5562351, PII: 9/381/eaai7521, DOI: 10.1126/scitranslmed.aai7521, ISSN: 1946-6242.
Jain S, Jou JD, Georgiev IS, Donald BR. A critical analysis of computational protein design with sparse residue interaction graphs. PLoS Comput. Biol. 2017 Mar; 13(3): e1005346. PMID: 28358804, PMCID: PMC5391103, PII: PCOMPBIOL-D-15-02026, DOI: 10.1371/journal.pcbi.1005346, ISSN: 1553-7358.
Williams LD, Ofek G, Schätzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, Parks RJ, Marshall DJ, Anasti K, Yang G, Nie X, Tumba NL, Wiehe K, Wagh K, Korber B, Kepler TB, Munir Alam S, Morris L, Kamanga G, Cohen MS, Bonsignori M, Xia SM, Montefiori DC, Kelsoe G, Gao F, Mascola JR, Moody MA, Saunders KO, Liao HX, Tomaras GD, Georgiou G, Haynes BF. Potent and broad HIV-neutralizing antibodies in memory B cells and plasma. Sci Immunol. 2017 Jan 1/27/2017; 2(7): PMID: 28783671, PII: 2/7/eaal2200, DOI: 10.1126/sciimmunol.aal2200, ISSN: 2470-9468.
Doria-Rose NA, Altae-Tran HR, Roark RS, Schmidt SD, Sutton MS, Louder MK, Chuang GY, Bailer RT, Cortez V, Kong R, McKee K, O'Dell S, Wang F, Abdool Karim SS, Binley JM, Connors M, Haynes BF, Martin MA, Montefiori DC, Morris L, Overbaugh J, Kwong PD, Mascola JR, Georgiev IS. Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting. PLoS Pathog. 2017 Jan; 13(1): e1006148. PMID: 28052137, PII: PPATHOGENS-D-16-01532, DOI: 10.1371/journal.ppat.1006148, ISSN: 1553-7374.
Kwong PD, Chuang GY, DeKosky BJ, Gindin T, Georgiev IS, Lemmin T, Schramm CA, Sheng Z, Soto C, Yang AS, Mascola JR, Shapiro L. Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1. Immunol. Rev. 2017 Jan; 275(1): 108-28. PMID: 28133812, PMCID: PMC5516196, DOI: 10.1111/imr.12480, ISSN: 1600-065X.
Ojewole A, Lowegard A, Gainza P, Reeve SM, Georgiev I, Anderson AC, Donald BR. OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design. Methods Mol. Biol. 2017; 1529: 291-306. PMID: 27914058, PMCID: PMC5192561, DOI: 10.1007/978-1-4939-6637-0_15, ISSN: 1940-6029.
Longo NS, Sutton MS, Shiakolas AR, Guenaga J, Jarosinski MC, Georgiev IS, McKee K, Bailer RT, Louder MK, O'Dell S, Connors M, Wyatt RT, Mascola JR, Doria-Rose NA. Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding. J. Virol [electronic-print]. 2016 Dec 12/1/2016; 90(23): 10574-86. PMID: 27654288, PMCID: PMC5110179, PII: JVI.01012-16, DOI: 10.1128/JVI.01012-16, ISSN: 1098-5514.
Huang J, Kang BH, Ishida E, Zhou T, Griesman T, Sheng Z, Wu F, Doria-Rose NA, Zhang B, McKee K, O'Dell S, Chuang GY, Druz A, Georgiev IS, Schramm CA, Zheng A, Joyce MG, Asokan M, Ransier A, Darko S, Migueles SA, Bailer RT, Louder MK, Alam SM, Parks R, Kelsoe G, Von Holle T, Haynes BF, Douek DC, Hirsch V, Seaman MS, Shapiro L, Mascola JR, Kwong PD, Connors M. Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity. 2016 Nov 11/15/2016; 45(5): 1108-21. PMID: 27851912, PII: S1074-7613(16)30438-1, DOI: 10.1016/j.immuni.2016.10.027, ISSN: 1097-4180.
Francica JR, Lynn GM, Laga R, Joyce MG, Ruckwardt TJ, Morabito KM, Chen M, Chaudhuri R, Zhang B, Sastry M, Druz A, Ko K, Choe M, Pechar M, Georgiev IS, Kueltzo LA, Seymour LW, Mascola JR, Kwong PD, Graham BS, Seder RA. Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant. Bioconjug. Chem [print-electronic]. 2016 Oct 10/19/2016; 27(10): 2372-85. PMID: 27583777, DOI: 10.1021/acs.bioconjchem.6b00370, ISSN: 1520-4812.
Tian M, Cheng C, Chen X, Duan H, Cheng HL, Dao M, Sheng Z, Kimble M, Wang L, Lin S, Schmidt SD, Du Z, Joyce MG, Chen Y, DeKosky BJ, Chen Y, Normandin E, Cantor E, Chen RE, Doria-Rose NA, Zhang Y, Shi W, Kong WP, Choe M, Henry AR, Laboune F, Georgiev IS, Huang PY, Jain S, McGuire AT, Georgeson E, Menis S, Douek DC, Schief WR, Stamatatos L, Kwong PD, Shapiro L, Haynes BF, Mascola JR, Alt FW. Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires. Cell. 2016 Sep 9/8/2016; 166(6): 1471-1484.e18. PMID: 27610571, PMCID: PMC5103708, PII: S0092-8674(16)30975-8, DOI: 10.1016/j.cell.2016.07.029, ISSN: 1097-4172.
Joyce MG, Zhang B, Ou L, Chen M, Chuang GY, Druz A, Kong WP, Lai YT, Rundlet EJ, Tsybovsky Y, Yang Y, Georgiev IS, Guttman M, Lees CR, Pancera M, Sastry M, Soto C, Stewart-Jones GBE, Thomas PV, Van Galen JG, Baxa U, Lee KK, Mascola JR, Graham BS, Kwong PD. Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV. Nat. Struct. Mol. Biol [print-electronic]. 2016 Sep; 23(9): 811-20. PMID: 27478931, PMCID: PMC5016229, DOI: 10.1038/nsmb.3267, ISSN: 1545-9985.
Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, Zhang B, Zhang Y, Asokan M, Boyington JC, Bylund T, Darko S, Lees CR, Ransier A, Shen CH, Wang L, Whittle JR, Wu X, Yassine HM, Santos C, Matsuoka Y, Tsybovsky Y, Baxa U, , Mullikin JC, Subbarao K, Douek DC, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Shapiro L, Kwong PD, Mascola JR, McDermott AB. Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses. Cell [print-electronic]. 2016 Jul 7/28/2016; 166(3): 609-23. PMID: 27453470, PMCID: PMC4978566, PII: S0092-8674(16)30851-0, DOI: 10.1016/j.cell.2016.06.043, ISSN: 1097-4172.
Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, Zhang B, Zhang Y, Asokan M, Boyington JC, Bylund T, Darko S, Lees CR, Ransier A, Shen CH, Wang L, Whittle JR, Wu X, Yassine HM, Santos C, Matsuoka Y, Tsybovsky Y, Baxa U, , Mullikin JC, Subbarao K, Douek DC, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Shapiro L, Kwong PD, Mascola JR, McDermott AB. Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses. Cell [print-electronic]. 2016 Jul 7/28/2016; 166(3): 609-23. PMID: 27453470, PMCID: PMC4978566, PII: S0092-8674(16)30851-0, DOI: 10.1016/j.cell.2016.06.043, ISSN: 1097-4172.
Kwon YD, Georgiev IS, Ofek G, Zhang B, Asokan M, Bailer RT, Bao A, Caruso W, Chen X, Choe M, Druz A, Ko SY, Louder MK, McKee K, O'Dell S, Pegu A, Rudicell RS, Shi W, Wang K, Yang Y, Alger M, Bender MF, Carlton K, Cooper JW, Blinn J, Eudailey J, Lloyd K, Parks R, Alam SM, Haynes BF, Padte NN, Yu J, Ho DD, Huang J, Connors M, Schwartz RM, Mascola JR, Kwong PD. Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. J. Virol [electronic-print]. 2016 Jul 7/1/2016; 90(13): 5899-914. PMID: 27053554, PMCID: PMC4907239, PII: JVI.03246-15, DOI: 10.1128/JVI.03246-15, ISSN: 1098-5514.
Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K, Ozorowski G, Soto C, Taft JD, Bailer RT, Cale EM, Chen L, Choi CW, Chuang GY, Doria-Rose NA, Druz A, Georgiev IS, Gorman J, Huang J, Joyce MG, Louder MK, Ma X, McKee K, O'Dell S, Pancera M, Yang Y, Blanchard SC, Mothes W, Burton DR, Koff WC, Connors M, Ward AB, Kwong PD, Mascola JR. Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. Science. 2016 May 5/13/2016; 352(6287): 828-33. PMID: 27174988, PMCID: PMC4917739, PII: 352/6287/828, DOI: 10.1126/science.aae0474, ISSN: 1095-9203.
Stewart-Jones GB, Soto C, Lemmin T, Chuang GY, Druz A, Kong R, Thomas PV, Wagh K, Zhou T, Behrens AJ, Bylund T, Choi CW, Davison JR, Georgiev IS, Joyce MG, Kwon YD, Pancera M, Taft J, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CC, Wu CY, Bewley CA, Burton DR, Koff WC, Connors M, Crispin M, Baxa U, Korber BT, Wong CH, Mascola JR, Kwong PD. Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. Cell [print-electronic]. 2016 May 5/5/2016; 165(4): 813-26. PMID: 27114034, PMCID: PMC5543418, PII: S0092-8674(16)30401-9, DOI: 10.1016/j.cell.2016.04.010, ISSN: 1097-4172.
Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C, , Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF. Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell [print-electronic]. 2016 Mar 3/2/2016; PMID: 26949186, PII: S0092-8674(16)30124-6, DOI: 10.1016/j.cell.2016.02.022, ISSN: 1097-4172.
Jou JD, Jain S, Georgiev IS, Donald BR. BWM*: A Novel, Provable, Ensemble-based Dynamic Programming Algorithm for Sparse Approximations of Computational Protein Design. J. Comput. Biol [print-electronic]. 2016 Jan 1/8/2016; PMID: 26744898, DOI: 10.1089/cmb.2015.0194, ISSN: 1557-8666.
Gorman J, Soto C, Yang MM, Davenport TM, Guttman M, Bailer RT, Chambers M, Chuang GY, DeKosky BJ, Doria-Rose NA, Druz A, Ernandes MJ, Georgiev IS, Jarosinski MC, Joyce MG, Lemmin TM, Leung S, Louder MK, McDaniel JR, Narpala S, Pancera M, Stuckey J, Wu X, Yang Y, Zhang B, Zhou T, Program NC, Mullikin JC, Baxa U, Georgiou G, McDermott AB, Bonsignori M, Haynes BF, Moore PL, Morris L, Lee KK, Shapiro L, Mascola JR, Kwong PD. Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. Nat. Struct. Mol. Biol [print-electronic]. 2016 Jan; 23(1): 81-90. PMID: 26689967, PII: nsmb.3144, DOI: 10.1038/nsmb.3144, ISSN: 1545-9985.
Asokan M, Rudicell RS, Louder M, McKee K, O'Dell S, Stewart-Jones G, Wang K, Xu L, Chen X, Choe M, Chuang G, Georgiev IS, Joyce MG, Kirys T, Ko S, Pegu A, Shi W, Todd JP, Yang Z, Bailer RT, Rao S, Kwong PD, Nabel GJ, Mascola JR. Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization. J. Virol [print-electronic]. 2015 Dec 12/15/2015; 89(24): 12501-12. PMID: 26446600, PMCID: PMC4665248, PII: JVI.02097-15, DOI: 10.1128/JVI.02097-15, ISSN: 1098-5514.
Ngwuta JO, Chen M, Modjarrad K, Joyce MG, Kanekiyo M, Kumar A, Yassine HM, Moin SM, Killikelly AM, Chuang GY, Druz A, Georgiev IS, Rundlet EJ, Sastry M, Stewart-Jones GB, Yang Y, Zhang B, Nason MC, Capella C, Peeples ME, Ledgerwood JE, McLellan JS, Kwong PD, Graham BS. Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera. Sci Transl Med. 2015 Oct 10/14/2015; 7(309): 309ra162. PMID: 26468324, PMCID: PMC4672383, PII: 7/309/309ra162, DOI: 10.1126/scitranslmed.aac4241, ISSN: 1946-6242.
Saunders KO, Wang L, Joyce MG, Yang ZY, Balazs AB, Cheng C, Ko SY, Kong WP, Rudicell RS, Georgiev IS, Duan L, Foulds KE, Donaldson M, Xu L, Schmidt SD, Todd JP, Baltimore D, Roederer M, Haase AT, Kwong PD, Rao SS, Mascola JR, Nabel GJ. Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection. J. Virol. 2015 Aug; 89(16): 8334-45. PMID: 26041300, PMCID: PMC4524228, PII: JVI.00908-15, DOI: 10.1128/JVI.00908-15, ISSN: 1098-5514.
Cortez V, Wang B, Dingens A, Chen MM, Ronen K, Georgiev IS, McClelland RS, Overbaugh J. The Broad Neutralizing Antibody Responses after HIV-1 Superinfection Are Not Dominated by Antibodies Directed to Epitopes Common in Single Infection. PLoS Pathog. 2015 Jul; 11(7): e1004973. PMID: 26158467, PMCID: PMC4497680, PII: PPATHOGENS-D-14-03005, DOI: 10.1371/journal.ppat.1004973, ISSN: 1553-7374.
Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD. Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nat. Struct. Mol. Biol [print-electronic]. 2015 Jul; 22(7): 522-31. PMID: 26098315, PMCID: PMC4706170, PII: nsmb.3051, DOI: 10.1038/nsmb.3051, ISSN: 1545-9985.
Fong Y, Datta S, Georgiev IS, Kwong PD, Tomaras GD. Kernel-based logistic regression model for protein sequence without vectorialization. Biostatistics [print-electronic]. 2015 Jul; 16(3): 480-92. PMID: 25532524, PII: kxu056, DOI: 10.1093/biostatistics/kxu056, ISSN: 1468-4357.
Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS, , Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell [print-electronic]. 2015 Jun 6/4/2015; 161(6): 1280-92. PMID: 26004070, PMCID: PMC4683157, PII: S0092-8674(15)00554-1, DOI: 10.1016/j.cell.2015.05.007, ISSN: 1097-4172.
Chuang GY, Zhang B, McKee K, O'Dell S, Kwon YD, Zhou T, Blinn J, Lloyd K, Parks R, Von Holle T, Ko SY, Kong WP, Pegu A, Wang K, Baruah K, Crispin M, Mascola JR, Moody MA, Haynes BF, Georgiev IS, Kwong PD. Eliminating antibody polyreactivity through addition of N-linked glycosylation. Protein Sci [print-electronic]. 2015 Jun; 24(6): 1019-30. PMID: 25800131, PMCID: PMC4456115, DOI: 10.1002/pro.2682, ISSN: 1469-896X.
Saunders KO, Pegu A, Georgiev IS, Zeng M, Joyce MG, Yang ZY, Ko SY, Chen X, Schmidt SD, Haase AT, Todd JP, Bao S, Kwong PD, Rao SS, Mascola JR, Nabel GJ. Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection. J. Virol [print-electronic]. 2015 Jun; 89(11): 5895-903. PMID: 25787288, PMCID: PMC4442454, PII: JVI.00210-15, DOI: 10.1128/JVI.00210-15, ISSN: 1098-5514.
Crooks ET, Tong T, Chakrabarti B, Narayan K, Georgiev IS, Menis S, Huang X, Kulp D, Osawa K, Muranaka J, Stewart-Jones G, Destefano J, O'Dell S, LaBranche C, Robinson JE, Montefiori DC, McKee K, Du SX, Doria-Rose N, Kwong PD, Mascola JR, Zhu P, Schief WR, Wyatt RT, Whalen RG, Binley JM. Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site. PLoS Pathog. 2015 May; 11(5): e1004932. PMID: 26023780, PMCID: PMC4449185, PII: PPATHOGENS-D-15-00215, DOI: 10.1371/journal.ppat.1004932, ISSN: 1553-7374.
Georgiev IS, Joyce MG, Yang Y, Sastry M, Zhang B, Baxa U, Chen RE, Druz A, Lees CR, Narpala S, Schön A, Van Galen J, Chuang GY, Gorman J, Harned A, Pancera M, Stewart-Jones GB, Cheng C, Freire E, McDermott AB, Mascola JR, Kwong PD. Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env. J. Virol [print-electronic]. 2015 May; 89(10): 5318-29. PMID: 25740988, PMCID: PMC4442528, PII: JVI.03451-14, DOI: 10.1128/JVI.03451-14, ISSN: 1098-5514.
Wu X, Zhang Z, Schramm CA, Joyce MG, Kwon YD, Zhou T, Sheng Z, Zhang B, O'Dell S, McKee K, Georgiev IS, Chuang GY, Longo NS, Lynch RM, Saunders KO, Soto C, Srivatsan S, Yang Y, Bailer RT, Louder MK, , Mullikin JC, Connors M, Kwong PD, Mascola JR, Shapiro L. Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell [print-electronic]. 2015 Apr 4/23/2015; 161(3): 470-85. PMID: 25865483, PMCID: PMC4706178, PII: S0092-8674(15)00257-3, DOI: 10.1016/j.cell.2015.03.004, ISSN: 1097-4172.
Edlefsen PT, Rolland M, Hertz T, Tovanabutra S, Gartland AJ, deCamp AC, Magaret CA, Ahmed H, Gottardo R, Juraska M, McCoy C, Larsen BB, Sanders-Buell E, Carrico C, Menis S, Bose M, , Arroyo MA, O'Connell RJ, Nitayaphan S, Pitisuttithum P, Kaewkungwal J, Rerks-Ngarm S, Robb ML, Kirys T, Georgiev IS, Kwong PD, Scheffler K, Pond SL, Carlson JM, Michael NL, Schief WR, Mullins JI, Kim JH, Gilbert PB. Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial. PLoS Comput. Biol. 2015 Feb; 11(2): e1003973. PMID: 25646817, PMCID: PMC4315437, PII: PCOMPBIOL-D-14-01370, DOI: 10.1371/journal.pcbi.1003973, ISSN: 1553-7358.
Reeve SM, Gainza P, Frey KM, Georgiev I, Donald BR, Anderson AC. Protein design algorithms predict viable resistance to an experimental antifolate. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 Jan 1/20/2015; 112(3): 749-54. PMID: 25552560, PMCID: PMC4311853, PII: 1411548112, DOI: 10.1073/pnas.1411548112, ISSN: 1091-6490.
Pegu A, Asokan M, Wu L, Wang K, Hataye J, Casazza JP, Guo X, Shi W, Georgiev I, Zhou T, Chen X, O'Dell S, Todd JP, Kwong PD, Rao SS, Yang ZY, Koup RA, Mascola JR, Nabel GJ. Activation and lysis of human CD4 cells latently infected with HIV-1. Nat Commun. 2015; 6: 8447. PMID: 26485194, PMCID: PMC4633990, PII: ncomms9447, DOI: 10.1038/ncomms9447, ISSN: 2041-1723.
Stewart-Jones GB, Thomas PV, Chen M, Druz A, Joyce MG, Kong WP, Sastry M, Soto C, Yang Y, Zhang B, Chen L, Chuang GY, Georgiev IS, McLellan JS, Srivatsan S, Zhou T, Baxa U, Mascola JR, Graham BS, Kwong PD. A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus. PLoS ONE. 2015; 10(6): e0128779. PMID: 26098893, PMCID: PMC4476739, PII: PONE-D-15-10558, DOI: 10.1371/journal.pone.0128779, ISSN: 1932-6203.
Huang J, Kang BH, Pancera M, Lee JH, Tong T, Feng Y, Imamichi H, Georgiev IS, Chuang GY, Druz A, Doria-Rose NA, Laub L, Sliepen K, van Gils MJ, de la Peña AT, Derking R, Klasse PJ, Migueles SA, Bailer RT, Alam M, Pugach P, Haynes BF, Wyatt RT, Sanders RW, Binley JM, Ward AB, Mascola JR, Kwong PD, Connors M. Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface. Nature [print-electronic]. 2014 Nov 11/6/2014; 515(7525): 138-42. PMID: 25186731, PMCID: PMC4224615, PII: nature13601, DOI: 10.1038/nature13601, ISSN: 1476-4687.
Rudicell RS, Kwon YD, Ko SY, Pegu A, Louder MK, Georgiev IS, Wu X, Zhu J, Boyington JC, Chen X, Shi W, Yang ZY, Doria-Rose NA, McKee K, O'Dell S, Schmidt SD, Chuang GY, Druz A, Soto C, Yang Y, Zhang B, Zhou T, Todd JP, Lloyd KE, Eudailey J, Roberts KE, Donald BR, Bailer RT, Ledgerwood J, , Mullikin JC, Shapiro L, Koup RA, Graham BS, Nason MC, Connors M, Haynes BF, Rao SS, Roederer M, Kwong PD, Mascola JR, Nabel GJ. Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. J. Virol [print-electronic]. 2014 Nov; 88(21): 12669-82. PMID: 25142607, PMCID: PMC4248941, PII: JVI.02213-14, DOI: 10.1128/JVI.02213-14, ISSN: 1098-5514.
Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature [print-electronic]. 2014 Oct 10/23/2014; 514(7523): 455-61. PMID: 25296255, PMCID: PMC4348022, PII: nature13808, DOI: 10.1038/nature13808, ISSN: 1476-4687.
Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF. Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies. Cell Host Microbe. 2014 Sep 9/10/2014; 16(3): 304-13. PMID: 25211073, PMCID: PMC4163498, PII: S1931-3128(14)00298-4, DOI: 10.1016/j.chom.2014.08.006, ISSN: 1934-6069.
Chuang GY, Liou D, Kwong PD, Georgiev IS. NEP: web server for epitope prediction based on antibody neutralization of viral strains with diverse sequences. Nucleic Acids Res [print-electronic]. 2014 Jul; 42(Web Server issue): W64-71. PMID: 24782517, PMCID: PMC4086065, PII: gku318, DOI: 10.1093/nar/gku318, ISSN: 1362-4962.
Doria-Rose NA, Schramm CA, Gorman J, Moore PL, Bhiman JN, DeKosky BJ, Ernandes MJ, Georgiev IS, Kim HJ, Pancera M, Staupe RP, Altae-Tran HR, Bailer RT, Crooks ET, Cupo A, Druz A, Garrett NJ, Hoi KH, Kong R, Louder MK, Longo NS, McKee K, Nonyane M, O'Dell S, Roark RS, Rudicell RS, Schmidt SD, Sheward DJ, Soto C, Wibmer CK, Yang Y, Zhang Z, , Mullikin JC, Binley JM, Sanders RW, Wilson IA, Moore JP, Ward AB, Georgiou G, Williamson C, Abdool Karim SS, Morris L, Kwong PD, Shapiro L, Mascola JR. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature [print-electronic]. 2014 May 5/1/2014; 509(7498): 55-62. PMID: 24590074, PMCID: PMC4395007, PII: nature13036, DOI: 10.1038/nature13036, ISSN: 1476-4687.
Ofek G, Zirkle B, Yang Y, Zhu Z, McKee K, Zhang B, Chuang GY, Georgiev IS, O'Dell S, Doria-Rose N, Mascola JR, Dimitrov DS, Kwong PD. Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66.6. J. Virol [print-electronic]. 2014 Mar; 88(5): 2426-41. PMID: 24335316, PMCID: PMC3958054, PII: JVI.02837-13, DOI: 10.1128/JVI.02837-13, ISSN: 1098-5514.
Georgiev IS, Rudicell RS, Saunders KO, Shi W, Kirys T, McKee K, O'Dell S, Chuang GY, Yang ZY, Ofek G, Connors M, Mascola JR, Nabel GJ, Kwong PD. Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline. J. Immunol [print-electronic]. 2014 Feb 2/1/2014; 192(3): 1100-6. PMID: 24391217, PMCID: PMC4140862, PII: jimmunol.1302515, DOI: 10.4049/jimmunol.1302515, ISSN: 1550-6606.
Georgiev IS, Gordon Joyce M, Zhou T, Kwong PD. Elicitation of HIV-1-neutralizing antibodies against the CD4-binding site. Curr Opin HIV AIDS. 2013 Sep; 8(5): 382-92. PMID: 23924998, PMCID: PMC4154626, PII: 01222929-201309000-00006, DOI: 10.1097/COH.0b013e328363a90e, ISSN: 1746-6318.
Chuang GY, Acharya P, Schmidt SD, Yang Y, Louder MK, Zhou T, Kwon YD, Pancera M, Bailer RT, Doria-Rose NA, Nussenzweig MC, Mascola JR, Kwong PD, Georgiev IS. Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains. J. Virol [print-electronic]. 2013 Sep; 87(18): 10047-58. PMID: 23843642, PMCID: PMC3753990, PII: JVI.00984-13, DOI: 10.1128/JVI.00984-13, ISSN: 1098-5514.
Acharya P, Luongo TS, Georgiev IS, Matz J, Schmidt SD, Louder MK, Kessler P, Yang Y, McKee K, O'Dell S, Chen L, Baty D, Chames P, Martin L, Mascola JR, Kwong PD. Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites. J. Virol [print-electronic]. 2013 Sep; 87(18): 10173-81. PMID: 23843638, PMCID: PMC3753989, PII: JVI.01332-13, DOI: 10.1128/JVI.01332-13, ISSN: 1098-5514.
Zhou T, Zhu J, Wu X, Moquin S, Zhang B, Acharya P, Georgiev IS, Altae-Tran HR, Chuang GY, Joyce MG, Kwon YD, Longo NS, Louder MK, Luongo T, McKee K, Schramm CA, Skinner J, Yang Y, Yang Z, Zhang Z, Zheng A, Bonsignori M, Haynes BF, Scheid JF, Nussenzweig MC, Simek M, Burton DR, Koff WC, , Mullikin JC, Connors M, Shapiro L, Nabel GJ, Mascola JR, Kwong PD. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity [print-electronic]. 2013 Aug 8/22/2013; 39(2): 245-58. PMID: 23911655, PMCID: PMC3985390, PII: S1074-7613(13)00297-5, DOI: 10.1016/j.immuni.2013.04.012, ISSN: 1097-4180.
Georgiev IS, Doria-Rose NA, Zhou T, Kwon YD, Staupe RP, Moquin S, Chuang GY, Louder MK, Schmidt SD, Altae-Tran HR, Bailer RT, McKee K, Nason M, O'Dell S, Ofek G, Pancera M, Srivatsan S, Shapiro L, Connors M, Migueles SA, Morris L, Nishimura Y, Martin MA, Mascola JR, Kwong PD. Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. Science. 2013 May 5/10/2013; 340(6133): 751-6. PMID: 23661761, PII: 340/6133/751, DOI: 10.1126/science.1233989, ISSN: 1095-9203.
Klein F, Diskin R, Scheid JF, Gaebler C, Mouquet H, Georgiev IS, Pancera M, Zhou T, Incesu RB, Fu BZ, Gnanapragasam PN, Oliveira TY, Seaman MS, Kwong PD, Bjorkman PJ, Nussenzweig MC. Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell. 2013 Mar 3/28/2013; 153(1): 126-38. PMID: 23540694, PMCID: PMC3792590, PII: S0092-8674(13)00340-1, DOI: 10.1016/j.cell.2013.03.018, ISSN: 1097-4172.
Gainza P, Roberts KE, Georgiev I, Lilien RH, Keedy DA, Chen CY, Reza F, Anderson AC, Richardson DC, Richardson JS, Donald BR. OSPREY: protein design with ensembles, flexibility, and provable algorithms. Meth. Enzymol. 2013; 523: 87-107. PMID: 23422427, PMCID: PMC3692370, PII: B978-0-12-394292-0.00005-9, DOI: 10.1016/B978-0-12-394292-0.00005-9, ISSN: 1557-7988.
Kong R, Li H, Georgiev I, Changela A, Bibollet-Ruche F, Decker JM, Rowland-Jones SL, Jaye A, Guan Y, Lewis GK, Langedijk JP, Hahn BH, Kwong PD, Robinson JE, Shaw GM. Epitope mapping of broadly neutralizing HIV-2 human monoclonal antibodies. J. Virol [print-electronic]. 2012 Nov; 86(22): 12115-28. PMID: 22933274, PMCID: PMC3486499, PII: JVI.01632-12, DOI: 10.1128/JVI.01632-12, ISSN: 1098-5514.
Rolland M, Edlefsen PT, Larsen BB, Tovanabutra S, Sanders-Buell E, Hertz T, deCamp AC, Carrico C, Menis S, Magaret CA, Ahmed H, Juraska M, Chen L, Konopa P, Nariya S, Stoddard JN, Wong K, Zhao H, Deng W, Maust BS, Bose M, Howell S, Bates A, Lazzaro M, O'Sullivan A, Lei E, Bradfield A, Ibitamuno G, Assawadarachai V, O'Connell RJ, deSouza MS, Nitayaphan S, Rerks-Ngarm S, Robb ML, McLellan JS, Georgiev I, Kwong PD, Carlson JM, Michael NL, Schief WR, Gilbert PB, Mullins JI, Kim JH. Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2. Nature [print-electronic]. 2012 Oct 10/18/2012; 490(7420): 417-20. PMID: 22960785, PMCID: PMC3551291, PII: nature11519, DOI: 10.1038/nature11519, ISSN: 1476-4687.
Chuang GY, Boyington JC, Joyce MG, Zhu J, Nabel GJ, Kwong PD, Georgiev I. Computational prediction of N-linked glycosylation incorporating structural properties and patterns. Bioinformatics [print-electronic]. 2012 Sep 9/1/2012; 28(17): 2249-55. PMID: 22782545, PMCID: PMC3426846, PII: bts426, DOI: 10.1093/bioinformatics/bts426, ISSN: 1367-4811.
Doria-Rose NA, Georgiev I, O'Dell S, Chuang GY, Staupe RP, McLellan JS, Gorman J, Pancera M, Bonsignori M, Haynes BF, Burton DR, Koff WC, Kwong PD, Mascola JR. A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies. J. Virol [print-electronic]. 2012 Aug; 86(15): 8319-23. PMID: 22623764, PMCID: PMC3421697, PII: JVI.00696-12, DOI: 10.1128/JVI.00696-12, ISSN: 1098-5514.
Hansman GS, Taylor DW, McLellan JS, Smith TJ, Georgiev I, Tame JR, Park SY, Yamazaki M, Gondaira F, Miki M, Katayama K, Murata K, Kwong PD. Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle. J. Virol [print-electronic]. 2012 Apr; 86(7): 3635-46. PMID: 22278249, PMCID: PMC3302548, PII: JVI.06868-11, DOI: 10.1128/JVI.06868-11, ISSN: 1098-5514.
Keedy DA, Georgiev I, Triplett EB, Donald BR, Richardson DC, Richardson JS. The role of local backrub motions in evolved and designed mutations. PLoS Comput. Biol [print-electronic]. 2012; 8(8): e1002629. PMID: 22876172, PMCID: PMC3410847, PII: PCOMPBIOL-D-11-01659, DOI: 10.1371/journal.pcbi.1002629, ISSN: 1553-7358.
Bar KJ, Tsao CY, Iyer SS, Decker JM, Yang Y, Bonsignori M, Chen X, Hwang KK, Montefiori DC, Liao HX, Hraber P, Fischer W, Li H, Wang S, Sterrett S, Keele BF, Ganusov VV, Perelson AS, Korber BT, Georgiev I, McLellan JS, Pavlicek JW, Gao F, Haynes BF, Hahn BH, Kwong PD, Shaw GM. Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape. PLoS Pathog [print-electronic]. 2012; 8(5): e1002721. PMID: 22693447, PMCID: PMC3364956, PII: PPATHOGENS-D-12-00368, DOI: 10.1371/journal.ppat.1002721, ISSN: 1553-7374.
Kong R, Li H, Bibollet-Ruche F, Decker JM, Zheng NN, Gottlieb GS, Kiviat NB, Sow PS, Georgiev I, Hahn BH, Kwong PD, Robinson JE, Shaw GM. Broad and potent neutralizing antibody responses elicited in natural HIV-2 infection. J. Virol [print-electronic]. 2012 Jan; 86(2): 947-60. PMID: 22031948, PMCID: PMC3255805, PII: JVI.06155-11, DOI: 10.1128/JVI.06155-11, ISSN: 1098-5514.
Hansman GS, Shahzad-Ul-Hussan S, McLellan JS, Chuang GY, Georgiev I, Shimoike T, Katayama K, Bewley CA, Kwong PD. Structural basis for norovirus inhibition and fucose mimicry by citrate. J. Virol [print-electronic]. 2012 Jan; 86(1): 284-92. PMID: 22031945, PMCID: PMC3255897, PII: JVI.05909-11, DOI: 10.1128/JVI.05909-11, ISSN: 1098-5514.
McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Kwon YD, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 2011 Dec 12/15/2011; 480(7377): 336-43. PMID: 22113616, PMCID: PMC3406929, PII: nature10696, DOI: 10.1038/nature10696, ISSN: 1476-4687.
Wu X, Zhou T, Zhu J, Zhang B, Georgiev I, Wang C, Chen X, Longo NS, Louder M, McKee K, O'Dell S, Perfetto S, Schmidt SD, Shi W, Wu L, Yang Y, Yang ZY, Yang Z, Zhang Z, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Simek M, Burton DR, Koff WC, Doria-Rose NA, Connors M, , Mullikin JC, Nabel GJ, Roederer M, Shapiro L, Kwong PD, Mascola JR. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science [print-electronic]. 2011 Sep 9/16/2011; 333(6049): 1593-602. PMID: 21835983, PMCID: PMC3516815, PII: science.1207532, DOI: 10.1126/science.1207532, ISSN: 1095-9203.
Sastry M, Xu L, Georgiev IS, Bewley CA, Nabel GJ, Kwong PD. Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy. J. Biomol. NMR [print-electronic]. 2011 Jul; 50(3): 197-207. PMID: 21667299, PMCID: PMC3133704, DOI: 10.1007/s10858-011-9506-4, ISSN: 1573-5001.
Hansman GS, Biertümpfel C, Georgiev I, McLellan JS, Chen L, Zhou T, Katayama K, Kwong PD. Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability. J. Virol [print-electronic]. 2011 Jul; 85(13): 6687-701. PMID: 21525337, PMCID: PMC3126497, PII: JVI.00246-11, DOI: 10.1128/JVI.00246-11, ISSN: 1098-5514.
Zhou T, Georgiev I, Wu X, Yang ZY, Dai K, Finzi A, Kwon YD, Scheid JF, Shi W, Xu L, Yang Y, Zhu J, Nussenzweig MC, Sodroski J, Shapiro L, Nabel GJ, Mascola JR, Kwong PD. Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science [print-electronic]. 2010 Aug 8/13/2010; 329(5993): 811-7. PMID: 20616231, PMCID: PMC2981354, PII: science.1192819, DOI: 10.1126/science.1192819, ISSN: 1095-9203.
Frey KM, Georgiev I, Donald BR, Anderson AC. Predicting resistance mutations using protein design algorithms. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Aug 8/3/2010; 107(31): 13707-12. PMID: 20643959, PMCID: PMC2922245, PII: 1002162107, DOI: 10.1073/pnas.1002162107, ISSN: 1091-6490.
Chen CY, Georgiev I, Anderson AC, Donald BR. Computational structure-based redesign of enzyme activity. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2009 Mar 3/10/2009; 106(10): 3764-9. PMID: 19228942, PMCID: PMC2645347, PII: 0900266106, DOI: 10.1073/pnas.0900266106, ISSN: 1091-6490.
Georgiev I, Lilien RH, Donald BR. The minimized dead-end elimination criterion and its application to protein redesign in a hybrid scoring and search algorithm for computing partition functions over molecular ensembles. J Comput Chem. 2008 Jul 7/30/2008; 29(10): 1527-42. PMID: 18293294, PMCID: PMC3263346, DOI: 10.1002/jcc.20909, ISSN: 1096-987X.
Georgiev I, Keedy D, Richardson JS, Richardson DC, Donald BR. Algorithm for backrub motions in protein design. Bioinformatics. 2008 Jul 7/1/2008; 24(13): i196-204. PMID: 18586714, PMCID: PMC2718647, PII: btn169, DOI: 10.1093/bioinformatics/btn169, ISSN: 1367-4811.
Georgiev I, Donald BR. Dead-end elimination with backbone flexibility. Bioinformatics. 2007 Jul 7/1/2007; 23(13): i185-94. PMID: 17646295, PII: 23/13/i185, DOI: 10.1093/bioinformatics/btm197, ISSN: 1367-4811.
Stevens BW, Lilien RH, Georgiev I, Donald BR, Anderson AC. Redesigning the PheA domain of gramicidin synthetase leads to a new understanding of the enzyme's mechanism and selectivity. Biochemistry [print-electronic]. 2006 Dec 12/26/2006; 45(51): 15495-504. PMID: 17176071, DOI: 10.1021/bi061788m, ISSN: 1520-4995.
Georgiev I, Lilien RH, Donald BR. Improved Pruning algorithms and Divide-and-Conquer strategies for Dead-End Elimination, with application to protein design. Bioinformatics. 2006 Jul 7/15/2006; 22(14): e174-83. PMID: 16873469, PII: 22/14/e174, DOI: 10.1093/bioinformatics/btl220, ISSN: 1367-4811.
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5/4/2018 | Postdoctoral Position in Zika vaccine development Georgiev Laboratory Vanderbilt Vaccine Center The Georgiev Laboratory at the Vanderbilt Vaccine Center (https://www.vumc.org/ig-lab/) has an opening for an NIH-funded postdoctoral position in the area of Zika vaccine development. Applicants who meet the following requirements will be considered for the position: *Ph.D. in immunology, virology, computational biology, or a closely related field *Prior experience in several of the following areas: - Protein expression and purification - Vaccine studies in animal models - Assays for characterizing antibody-antigen interactions, such as virus neutralization assays - Serologic analysis of immune responses - Antigen-specific B-cell sorting - Next-generation sequencing of antibody repertoires *Experience in computational biology, big data analysis, and/or structural biology is a plus. *Strong oral and written communication skills *Clear sense of organization, purpose, and accountability
Interested applicants should send a cover letter and a current CV to Ivelin Georgiev, ivelin.georgiev@vanderbilt.edu .
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10/31/2017 | Postdoctoral Position in HIV-1 Immunology Georgiev Laboratory Vanderbilt Vaccine Center The Georgiev Laboratory at the Vanderbilt Vaccine Center (https://www.vumc.org/ig-lab/) has an opening for an R01-funded postdoctoral position in the area of HIV-1 immunology, with a primary focus on characterization of immune responses to HIV-1 infection. Applicants who meet the following requirements will be considered for the position: *Ph.D. in immunology, virology, computational biology, or a closely related field *Prior experience in several of the following areas: - Assays for characterizing antibody-antigen interactions, such as virus neutralization assays - Serologic analysis of immune responses - Antigen-specific B-cell sorting - Next-generation sequencing of antibody repertoires - Protein expression and purification, and site-directed mutagenesis *Experience in computational biology, big data analysis, and/or structural biology is a plus. *Strong oral and written communication skills *Clear sense of organization, purpose, and accountability Interested applicants should send a current CV and a brief statement of interest to Ivelin Georgiev, ivelin.georgiev@vanderbilt.edu. |