Jeffrey C. Rathmell, Ph.D.


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Faculty Appointments
Professor of Pathology, Microbiology and Immunology Professor of Molecular Physiology & BiophysicsCornelius Vanderbilt Chair in Immunobiology
Ph.D., Immunology, Stanford University, Stanford, CaliforniaB.S., Biology, University of Northern Iowa, Cedar Falls, Iowa
Research Description
There has been a growing appreciation that metabolism is intimately linked to nearly all aspects of cell function and fate. The field of immunometabolism aims to understand how metabolic pathways are regulated in immune cells, how specific metabolic programs alter immune function, and how immunity in turn may influence metabolism. The Rathmell lab focuses on how metabolic pathways influence the function and fate of lymphocytes in inflammatory diseases and anti-tumor immunity. Our work is highly interdisciplinary in which we use animal models and genetic approaches in the fields of immunology, cancer biology, and cell metabolism to understand human disease. Ultimately the goals of these projects are to exploit the specific metabolic programs of each immune cell type or activation state to selectively impact effector lymphocytes in inflammatory diseases and cancer.
Research Keywords
Immunometabolism in inflammatory disease, cancer, and anti-tumor immunity
Rathmell JC. Obesity, Immunity, and Cancer. N Engl J Med. 2021 Mar 3/25/2021; 384(12): 1160-2. PMID: 33761213, DOI: 10.1056/NEJMcibr2035081, ISSN: 1533-4406.

Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E. Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy. Cancer Res [print-electronic]. 2021 Mar 3/22/2021; PMID: 33753374, PII: 0008-5472.CAN-20-2870, DOI: 10.1158/0008-5472.CAN-20-2870, ISSN: 1538-7445.

Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC. Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. J Immunol [print-electronic]. 2021 Mar 3/15/2021; 206(6): 1127-39. PMID: 33558372, PMCID: PMC7946768, PII: jimmunol.2001029, DOI: 10.4049/jimmunol.2001029, ISSN: 1550-6606.

Levine LS, Hiam-Galvez KJ, Marquez DM, Tenvooren I, Madden MZ, Contreras DC, Dahunsi DO, Irish JM, Oluwole OO, Rathmell JC, Spitzer MH. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. Immunity [print-electronic]. 2021 Mar 3/6/2021; PMID: 33705706, PII: S1074-7613(21)00084-4, DOI: 10.1016/j.immuni.2021.02.018, ISSN: 1097-4180.

Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. J Clin Invest. 2021 Feb 2/15/2021; 131(4): PMID: 33320840, PMCID: PMC7880417, PII: 140100, DOI: 10.1172/JCI140100, ISSN: 1558-8238.

Jia W, Poe JC, Su H, Anand S, Matsushima GK, Rathmell JC, Maillard I, Radojcic V, Imai K, Reyes NJ, Cardona DM, Li Z, Suthers A, Curry-Chisolm I, DiCioccio RA, Saban DR, Chen BJ, Chao NJ, Sarantopoulos S. BAFF Promotes Heightened BCR Responsiveness and Manifestations of Chronic GVHD after Allogeneic Stem Cell Transplantation. Blood [print-electronic]. 2021 Feb 2/3/2021; PMID: 33534893, PII: S0006-4971(21)00239-1, DOI: 10.1182/blood.2020008040, ISSN: 1528-0020.

Rathmell JC, Rathmell WK. Pushing the boundaries with collision collaboration: the marriage of ideas. J Clin Invest. 2021 Jan 1/19/2021; 131(2): PMID: 33463534, PMCID: PMC7810468, PII: 145964, DOI: 10.1172/JCI145964, ISSN: 1558-8238.

Ramsey HE, Greenwood D, Zhang S, Childress M, Arrate MP, Gorska AE, Fuller L, Zhao Y, Stengel K, Fischer MA, Stubbs MC, Liu PCC, Boyd K, Rathmell JC, Hiebert SW, Savona MR. BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia. Clin Cancer Res [print-electronic]. 2021 Jan 1/15/2021; 27(2): 598-607. PMID: 33148670, PII: 1078-0432.CCR-20-1346, DOI: 10.1158/1078-0432.CCR-20-1346, ISSN: 1557-3265.

Wu H, Herr D, MacIver NJ, Rathmell JC, Gerriets VA. CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism. Int Immunopharmacol [print-electronic]. 2020 Nov; 88: 106922. PMID: 32866787, PMCID: PMC7657973, PII: S1567-5769(20)32094-4, DOI: 10.1016/j.intimp.2020.106922, ISSN: 1878-1705.

Beckermann KE, Hongo R, Ye X, Young K, Carbonell K, Healey DCC, Siska PJ, Barone S, Roe CE, Smith CC, Vincent BG, Mason FM, Irish JM, Rathmell WK, Rathmell JC. CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation. JCI Insight. 2020 Aug 8/20/2020; 5(16): PMID: 32814710, PMCID: PMC7455120, PII: 138729, DOI: 10.1172/jci.insight.138729, ISSN: 2379-3708.

Contat C, Ancey PB, Zangger N, Sabatino S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, Clerc-Rosset S, Knott GW, Rathmell JC, Abel ED, Meibom A, Meylan E. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. Elife. 2020 Jun 6/23/2020; 9: PMID: 32571479, PMCID: PMC7311173, PII: 53618, DOI: 10.7554/eLife.53618, ISSN: 2050-084X.

Bader JE, Voss K, Rathmell JC. Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy. Mol Cell. 2020 Jun 6/18/2020; 78(6): 1019-33. PMID: 32559423, PMCID: PMC7339967, PII: S1097-2765(20)30355-5, DOI: 10.1016/j.molcel.2020.05.034, ISSN: 1097-4164.

Jiang X, Dudzinski S, Beckermann KE, Young K, McKinley E, J McIntyre O, Rathmell JC, Xu J, Gore JC. MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy. J Immunother Cancer. 2020 Jun; 8(1): PMID: 32581044, PMCID: PMC7312343, PII: jitc-2019-000328, DOI: 10.1136/jitc-2019-000328, ISSN: 2051-1426.

Raddatz MA, Huffstater T, Bersi MR, Reinfeld BI, Madden MZ, Booton SE, Rathmell WK, Rathmell JC, Lindman BR, Madhur MS, Merryman WD. Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing. Arterioscler Thromb Vasc Biol [print-electronic]. 2020 Jun; 40(6): e153-e165. PMID: 32295422, PMCID: PMC7285853, DOI: 10.1161/ATVBAHA.120.314360, ISSN: 1524-4636.

Lim AR, Rathmell WK, Rathmell JC. The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy. Elife. 2020 May 5/5/2020; 9: PMID: 32367803, PMCID: PMC7200151, PII: 55185, DOI: 10.7554/eLife.55185, ISSN: 2050-084X.

Makowski L, Chaib M, Rathmell JC. Immunometabolism: From basic mechanisms to translation. Immunol Rev. 2020 May; 295(1): 5-14. PMID: 32320073, DOI: 10.1111/imr.12858, ISSN: 1600-065X.

Li C, Zhu B, Son YM, Wang Z, Jiang L, Xiang M, Ye Z, Beckermann KE, Wu Y, Jenkins JW, Siska PJ, Vincent BG, Prakash YS, Peikert T, Edelson BT, Taneja R, Kaplan MH, Rathmell JC, Dong H, Hitosugi T, Sun J. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. Immunity. 2019 Sep 9/17/2019; 51(3): 491-507.e7. PMID: 31533057, PII: S1074-7613(19)30364-4, DOI: 10.1016/j.immuni.2019.08.013, ISSN: 1097-4180.

Dudzinski SO, Cameron BD, Wang J, Rathmell JC, Giorgio TD, Kirschner AN. Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer. J Immunother Cancer. 2019 Aug 8/14/2019; 7(1): 218. PMID: 31412954, PMCID: PMC6694548, PII: 10.1186/s40425-019-0704-z, DOI: 10.1186/s40425-019-0704-z, ISSN: 2051-1426.

van Bruggen JAC, Martens AWJ, Fraietta JA, Hofland T, Tonino SH, Eldering E, Levin MD, Siska PJ, Endstra S, Rathmell JC, June CH, Porter DL, Melenhorst JJ, Kater AP, van der Windt GJW. Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy. Blood [print-electronic]. 2019 Jul 7/4/2019; 134(1): 44-58. PMID: 31076448, PII: blood.2018885863, DOI: 10.1182/blood.2018885863, ISSN: 1528-0020.

Savona MR, Rathmell JC. Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade. Cancer Discov. 2019 Jul; 9(7): 831-3. PMID: 31262744, PII: 9/7/831, DOI: 10.1158/2159-8290.CD-19-0510, ISSN: 2159-8290.

Babaer D, Amara S, McAdory BS, Johnson O, Myles EL, Zent R, Rathmell JC, Tiriveedhi V. Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells. Cancers (Basel). 2019 May 5/14/2019; 11(5): PMID: 31091800, PMCID: PMC6562487, PII: cancers11050672, DOI: 10.3390/cancers11050672, ISSN: 2072-6694.

Sinclair LV, Howden AJ, Brenes A, Spinelli L, Hukelmann JL, Macintyre AN, Liu X, Thomson S, Taylor PM, Rathmell JC, Locasale JW, Lamond AI, Cantrell DA. Antigen receptor control of methionine metabolism in T cells. Elife. 2019 Mar 3/27/2019; 8: PMID: 30916644, PMCID: PMC6497464, PII: 44210, DOI: 10.7554/eLife.44210, ISSN: 2050-084X.

Freemerman AJ, Zhao L, Pingili AK, Teng B, Cozzo AJ, Fuller AM, Johnson AR, Milner JJ, Lim MF, Galanko JA, Beck MA, Bear JE, Rotty JD, Bezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale JW, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L. Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1. J. Immunol [print-electronic]. 2019 Feb 2/15/2019; 202(4): 1265-86. PMID: 30659108, PMCID: PMC6360258, PII: jimmunol.1800002, DOI: 10.4049/jimmunol.1800002, ISSN: 1550-6606.

Chatterjee S, Chakraborty P, Daenthanasanmak A, Iamsawat S, Andrejeva G, Luevano LA, Wolf M, Baliga U, Krieg C, Beeson CC, Mehrotra M, Hill EG, Rathmell JC, Yu XZ, Kraft AS, Mehrotra S. Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response. Clin. Cancer Res [print-electronic]. 2019 Feb 2/1/2019; 25(3): 1036-49. PMID: 30327305, PMCID: PMC6361669, PII: 1078-0432.CCR-18-0706, DOI: 10.1158/1078-0432.CCR-18-0706, ISSN: 1078-0432.

Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL, Hoehn KL, Rathmell JC, Bullock TNJ. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. Sci Immunol. 2019 Jan 1/25/2019; 4(31): PMID: 30683669, PII: 4/31/eaap9520, DOI: 10.1126/sciimmunol.aap9520, ISSN: 2470-9468.

Greenplate AR, McClanahan DD, Oberholtzer BK, Doxie DB, Roe CE, Diggins KE, Leelatian N, Rasmussen ML, Kelley MC, Gama V, Siska PJ, Rathmell JC, Ferrell PB, Johnson DB, Irish JM. Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types. Cancer Immunol Res [print-electronic]. 2019 Jan; 7(1): 86-99. PMID: 30413431, PMCID: PMC6318034, PII: 2326-6066.CIR-17-0692, DOI: 10.1158/2326-6066.CIR-17-0692, ISSN: 2326-6074.

Fuseini H, Cephus JY, Wu P, Davis JB, Contreras DC, Gandhi VD, Rathmell JC, Newcomb DC. ERa Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation. Front Immunol. 2019; 10: 2740. PMID: 31849948, PMCID: PMC6892971, DOI: 10.3389/fimmu.2019.02740, ISSN: 1664-3224.

Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC. Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. Cell [print-electronic]. 2018 Dec 12/13/2018; 175(7): 1780-1795.e19. PMID: 30392958, PMCID: PMC6361668, PII: S0092-8674(18)31309-6, DOI: 10.1016/j.cell.2018.10.001, ISSN: 1097-4172.

Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature [print-electronic]. 2018 Nov; 563(7733): 714-8. PMID: 30464343, PMCID: PMC6331005, PII: 10.1038/s41586-018-0735-5, DOI: 10.1038/s41586-018-0735-5, ISSN: 1476-4687.

Rathmell WK, Rathmell JC, Linehan WM. Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions. J. Clin. Oncol [print-electronic]. 2018 Oct 10/29/2018; JCO2018792309. PMID: 30372395, PMCID: PMC6488445, DOI: 10.1200/JCO.2018.79.2309, ISSN: 1527-7755.

Priyadharshini B, Loschi M, Newton RH, Zhang JW, Finn KK, Gerriets VA, Huynh A, Rathmell JC, Blazar BR, Turka LA. Cutting Edge: TGF-ß and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets. J. Immunol [print-electronic]. 2018 Oct 10/15/2018; 201(8): 2215-9. PMID: 30209190, PMCID: PMC6179917, PII: jimmunol.1800311, DOI: 10.4049/jimmunol.1800311, ISSN: 1550-6606.

Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP. XCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. Oncogene [print-electronic]. 2018 Sep; 37(36): 5007-19. PMID: 29789716, PMCID: PMC6127081, PII: 10.1038/s41388-018-0307-z, DOI: 10.1038/s41388-018-0307-z, ISSN: 1476-5594.

Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat. Med [print-electronic]. 2018 May; 24(5): 617-27. PMID: 29662201, PMCID: PMC6095711, PII: 10.1038/s41591-018-0003-0, DOI: 10.1038/s41591-018-0003-0, ISSN: 1546-170X.

Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat. Med [print-electronic]. 2018 Feb; 24(2): 194-202. PMID: 29334372, PMCID: PMC5803339, PII: nm.4464, DOI: 10.1038/nm.4464, ISSN: 1546-170X.

Chen YH, Kratchmarov R, Lin WW, Rothman NJ, Yen B, Adams WC, Nish SA, Rathmell JC, Reiner SL. Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway. Cell Rep [print-electronic]. 2018 Jan 1/23/2018; 22(4): 860-8. PMID: 29420173, PMCID: PMC5806629, PII: S2211-1247(17)31924-1, DOI: 10.1016/j.celrep.2017.12.087, ISSN: 2211-1247.

Sugiura A, Rathmell JC. Metabolic Barriers to T Cell Function in Tumors. J. Immunol. 2018 Jan 1/15/2018; 200(2): 400-7. PMID: 29311381, PMCID: PMC5777533, PII: 200/2/400, DOI: 10.4049/jimmunol.1701041, ISSN: 1550-6606.

Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, Helke K, Husain S, Garrett-Mayer E, Hardiman G, Mehrotra M, Nishimura MI, Beeson CC, Bupp MG, Wu J, Ogretmen B, Paulos CM, Rathmell J, Yu XZ, Mehrotra S. CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metab [print-electronic]. 2018 Jan 1/9/2018; 27(1): 85-100.e8. PMID: 29129787, PMCID: PMC5837048, PII: S1550-4131(17)30618-6, DOI: 10.1016/j.cmet.2017.10.006, ISSN: 1932-7420.

Zhang Q, Jeppesen DK, Higginbotham JN, Demory Beckler M, Poulin EJ, Walsh AJ, Skala MC, McKinley ET, Manning HC, Hight MR, Schulte ML, Watt KR, Ayers GD, Wolf MM, Andrejeva G, Rathmell JC, Franklin JL, Coffey RJ. Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cell Mol Gastroenterol Hepatol. 2018; 5(4): 627-629.e6. PMID: 29930982, PMCID: PMC6009797, PII: S2352-345X(18)30020-1, DOI: 10.1016/j.jcmgh.2018.01.013, ISSN: 2352-345X.

Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab [print-electronic]. 2017 Oct 10/3/2017; 26(4): 648-659.e8. PMID: 28918937, PMCID: PMC5629112, PII: S1550-4131(17)30502-8, DOI: 10.1016/j.cmet.2017.08.017, ISSN: 1932-7420.

Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL. MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation. Cell Metab. 2017 Oct 10/3/2017; 26(4): 633-647.e7. PMID: 28978427, PMCID: PMC5650077, PII: S1550-4131(17)30560-0, DOI: 10.1016/j.cmet.2017.09.009, ISSN: 1932-7420.

Afzal J, Chan A, Karakas MF, Woldemichael K, Vakrou S, Guan Y, Rathmell J, Wahl R, Pomper M, Foster DB, Aon MA, Tsui B, O'Rourke B, Abraham MR. Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status. JACC Basic Transl Sci [print-electronic]. 2017 Oct; 2(5): 543-60. PMID: 29520378, PMCID: PMC5839118, PII: S2452-302X(17)30219-X, DOI: 10.1016/j.jacbts.2017.03.016, ISSN: 2452-302X.

Andrejeva G, Rathmell JC. Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors. Cell Metab. 2017 Jul 7/5/2017; 26(1): 49-70. PMID: 28683294, PII: S1550-4131(17)30346-7, DOI: 10.1016/j.cmet.2017.06.004, ISSN: 1932-7420.

MacIver NJ, Rathmell JC. Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate [editorial]. Curr. Opin. Immunol [print-electronic]. 2017 Jul 7/3/2017; PMID: 28684058, PII: S0952-7915(17)30101-2, DOI: 10.1016/j.coi.2017.06.002, ISSN: 1879-0372.

Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. JCI Insight [print-electronic]. 2017 Jun 6/15/2017; 2(12): PMID: 28614802, PMCID: PMC5470888, PII: 93411, DOI: 10.1172/jci.insight.93411, ISSN: 2379-3708.

Beckermann KE, Dudzinski SO, Rathmell JC. Dysfunctional T cell metabolism in the tumor microenvironment. Cytokine Growth Factor Rev [print-electronic]. 2017 Jun; 35: 7-14. PMID: 28456467, PII: S1359-6101(17)30052-7, DOI: 10.1016/j.cytogfr.2017.04.003, ISSN: 1879-0305.

Olenchock BA, Rathmell JC, Vander Heiden MG. Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. Immunity. 2017 May 5/16/2017; 46(5): 703-13. PMID: 28514672, PII: S1074-7613(17)30178-4, DOI: 10.1016/j.immuni.2017.04.013, ISSN: 1097-4180.

Rhoads JP, Major AS, Rathmell JC. Fine tuning of immunometabolism for the treatment of rheumatic diseases. Nat Rev Rheumatol [print-electronic]. 2017 May; 13(5): 313-20. PMID: 28381829, PMCID: PMC5502208, PII: nrrheum.2017.54, DOI: 10.1038/nrrheum.2017.54, ISSN: 1759-4804.

Schmidt EA, Fee BE, Henry SC, Nichols AG, Shinohara ML, Rathmell JC, MacIver NJ, Coers J, Ilkayeva OR, Koves TR, Taylor GA. Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. J. Biol. Chem [print-electronic]. 2017 Mar 3/17/2017; 292(11): 4651-62. PMID: 28154172, PMCID: PMC5377780, PII: M116.770735, DOI: 10.1074/jbc.M116.770735, ISSN: 1083-351X.

Siska PJ, Johnpulle RAN, Zhou A, Bordeaux J, Kim JY, Dabbas B, Dakappagari N, Rathmell JC, Rathmell WK, Morgans AK, Balko JM, Johnson DB. Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling. Oncoimmunology. 2017; 6(4): e1305535. PMID: 28507813, PMCID: PMC5414873, PII: 1305535, DOI: 10.1080/2162402X.2017.1305535, ISSN: 2162-4011.

Adams WC, Chen YH, Kratchmarov R, Yen B, Nish SA, Lin WW, Rothman NJ, Luchsinger LL, Klein U, Busslinger M, Rathmell JC, Snoeck HW, Reiner SL. Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. Cell Rep. 2016 Dec 12/20/2016; 17(12): 3142-52. PMID: 28009285, PMCID: PMC5189677, PII: S2211-1247(16)31639-4, DOI: 10.1016/j.celrep.2016.11.065, ISSN: 2211-1247.

Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat. Immunol [print-electronic]. 2016 Dec; 17(12): 1459-66. PMID: 27695003, PII: ni.3577, DOI: 10.1038/ni.3577, ISSN: 1529-2916.

Siska PJ, Rathmell JC. Metabolic Signaling Drives IFN-¿. Cell Metab. 2016 Nov 11/8/2016; 24(5): 651-2. PMID: 27829134, PII: S1550-4131(16)30550-2, DOI: 10.1016/j.cmet.2016.10.018, ISSN: 1932-7420.

Siska PJ, Kim B, Ji X, Hoeksema MD, Massion PP, Beckermann KE, Wu J, Chi JT, Hong J, Rathmell JC. Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. J. Immunol. Methods [print-electronic]. 2016 Nov; 438: 51-8. PMID: 27594594, PMCID: PMC5065394, PII: S0022-1759(16)30188-0, DOI: 10.1016/j.jim.2016.08.013, ISSN: 1872-7905.

Johnson MO, Siska PJ, Contreras DC, Rathmell JC. Nutrients and the microenvironment to feed a T cell army. Semin. Immunol [print-electronic]. 2016 Oct 10/3/2016; PMID: 27712958, PII: S1044-5323(16)30096-3, DOI: 10.1016/j.smim.2016.09.003, ISSN: 1096-3618.

Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H. MTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. Immunity [print-electronic]. 2016 Sep 9/20/2016; 45(3): 540-54. PMID: 27637146, PMCID: PMC5050556, PII: S1074-7613(16)30341-7, DOI: 10.1016/j.immuni.2016.08.017, ISSN: 1097-4180.

Siska PJ, van der Windt GJ, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC. Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. J. Immunol [print-electronic]. 2016 Sep 9/15/2016; 197(6): 2532-40. PMID: 27511728, PMCID: PMC5010978, PII: jimmunol.1502464, DOI: 10.4049/jimmunol.1502464, ISSN: 1550-6606.

O'Neill LA, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nat. Rev. Immunol [print-electronic]. 2016 Jul 7/11/2016; PMID: 27396447, PII: nri.2016.70, DOI: 10.1038/nri.2016.70, ISSN: 1474-1741.

Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metab. 2016 Apr 4/12/2016; 23(4): 649-62. PMID: 27076078, PMCID: PMC4832577, PII: S1550-4131(16)30111-5, DOI: 10.1016/j.cmet.2016.03.008, ISSN: 1932-7420.

Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG. Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev. Cell. 2016 Mar 3/7/2016; 36(5): 540-9. PMID: 26954548, PMCID: PMC4766004, PII: S1534-5807(16)30036-3, DOI: 10.1016/j.devcel.2016.02.012, ISSN: 1878-1551.

Johnson MO, Rathmell JC. AIF Is "Always In Fashion" for T Cells. Immunity. 2016 Jan 1/19/2016; 44(1): 11-3. PMID: 26789917, PII: S1074-7613(15)00541-5, DOI: 10.1016/j.immuni.2015.12.015, ISSN: 1097-4180.

Kang S, Keener AB, Jones SZ, Benschop RJ, Caro-Maldonado A, Rathmell JC, Clarke SH, Matsushima GK, Whitmire JK, Vilen BJ. IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF. J. Immunol [print-electronic]. 2016 Jan 1/1/2016; 196(1): 196-206. PMID: 26621863, PMCID: PMC4684997, PII: jimmunol.1402527, DOI: 10.4049/jimmunol.1402527, ISSN: 1550-6606.

Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV. MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metab [print-electronic]. 2015 Dec 12/1/2015; 22(6): 1009-19. PMID: 26387865, PII: S1550-4131(15)00460-X, DOI: 10.1016/j.cmet.2015.09.003, ISSN: 1932-7420.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AM, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HP, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HM, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin. Cancer Biol. 2015 Dec; 35 Suppl: S276-304. PMID: 26590477, PMCID: PMC4819002, PII: S1044-579X(15)00088-7, DOI: 10.1016/j.semcancer.2015.09.007, ISSN: 1096-3650.

Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell [print-electronic]. 2015 Sep 9/10/2015; 162(6): 1217-28. PMID: 26321681, PMCID: PMC4567953, PII: S0092-8674(15)01025-9, DOI: 10.1016/j.cell.2015.08.012, ISSN: 1097-4172.

Siska PJ, Rathmell JC. PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1. Mol. Cell. 2015 Jun 6/4/2015; 58(5): 711-2. PMID: 26046643, PII: S1097-2765(15)00392-5, DOI: 10.1016/j.molcel.2015.05.025, ISSN: 1097-4164.

Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, Rathmell JC, Dewhirst MW, Kirsch DG. HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. Radiat. Res [print-electronic]. 2015 Jun; 183(6): 594-609. PMID: 25973951, PII: 10.1667/RR14016.1, DOI: 10.1667/RR14016.1, ISSN: 1938-5404.

Siska PJ, Rathmell JC. T cell metabolic fitness in antitumor immunity. Trends Immunol [print-electronic]. 2015 Apr; 36(4): 257-64. PMID: 25773310, PMCID: PMC4393792, PII: S1471-4906(15)00038-1, DOI: 10.1016/, ISSN: 1471-4981.

Kishton RJ, Rathmell JC. Novel therapeutic targets of tumor metabolism. Cancer J. 2015 Mar; 21(2): 62-9. PMID: 25815845, PMCID: PMC4380246, PII: 00130404-201503000-00004, DOI: 10.1097/PPO.0000000000000099, ISSN: 1540-336X.

Kountikov EI, Poe JC, Maclver NJ, Rathmell JC, Tedder TF. A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. Am. J. Pathol [print-electronic]. 2015 Mar; 185(3): 617-30. PMID: 25542773, PMCID: PMC4348474, PII: S0002-9440(14)00669-5, DOI: 10.1016/j.ajpath.2014.10.025, ISSN: 1525-2191.

Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat. Immunol [print-electronic]. 2015 Feb; 16(2): 188-96. PMID: 25559257, PMCID: PMC4297515, PII: ni.3077, DOI: 10.1038/ni.3077, ISSN: 1529-2916.

Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, Smith PA, Schneider MA, MacIver NJ, Locasale JW, Newgard CB, Shinohara ML, Rathmell JC. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J. Clin. Invest [print-electronic]. 2015 Jan; 125(1): 194-207. PMID: 25437876, PMCID: PMC4382238, PII: 76012, DOI: 10.1172/JCI76012, ISSN: 1558-8238.

Stathem M, Marimuthu S, O'Neal J, Rathmell JC, Chesney JA, Beverly LJ, Siskind LJ. Glucose availability and glycolytic metabolism dictate glycosphingolipid levels. J. Cell. Biochem. 2015 Jan; 116(1): 67-80. PMID: 25145677, PMCID: PMC4229434, DOI: 10.1002/jcb.24943, ISSN: 1097-4644.

Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, Wood KC. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 12/23/2014; 7(357): ra121. PMID: 25538079, PMCID: PMC4353587, PII: 7/357/ra121, DOI: 10.1126/scisignal.aaa1877, ISSN: 1937-9145.

Wang B, Liu TY, Lai CH, Rao YH, Choi MC, Chi JT, Dai JW, Rathmell JC, Yao TP. Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. Mol. Biol. Cell [print-electronic]. 2014 Nov 11/1/2014; 25(21): 3300-7. PMID: 25187650, PMCID: PMC4214777, PII: mbc.E13-12-0757, DOI: 10.1091/mbc.E13-12-0757, ISSN: 1939-4586.

Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab [print-electronic]. 2014 Jul 7/1/2014; 20(1): 61-72. PMID: 24930970, PMCID: PMC4079750, PII: S1550-4131(14)00212-5, DOI: 10.1016/j.cmet.2014.05.004, ISSN: 1932-7420.

Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J. Immunol [print-electronic]. 2014 Apr 4/15/2014; 192(8): 3626-36. PMID: 24616478, PMCID: PMC3984038, PII: jimmunol.1302062, DOI: 10.4049/jimmunol.1302062, ISSN: 1550-6606.

Freemerman AJ, Johnson AR, Sacks GN, Milner JJ, Kirk EL, Troester MA, Macintyre AN, Goraksha-Hicks P, Rathmell JC, Makowski L. Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. J. Biol. Chem [print-electronic]. 2014 Mar 3/14/2014; 289(11): 7884-96. PMID: 24492615, PMCID: PMC3953299, PII: M113.522037, DOI: 10.1074/jbc.M113.522037, ISSN: 1083-351X.

Liu T, Kishton RJ, Macintyre AN, Gerriets VA, Xiang H, Liu X, Abel ED, Rizzieri D, Locasale JW, Rathmell JC. Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. Cell Death Dis. 2014; 5: e1470. PMID: 25321477, PMCID: PMC4237255, PII: cddis2014431, DOI: 10.1038/cddis.2014.431, ISSN: 2041-4889.

Cao Y, Rathmell JC, Macintyre AN. Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. PLoS ONE. 2014; 9(8): e104104. PMID: 25090630, PMCID: PMC4121309, PII: PONE-D-14-06298, DOI: 10.1371/journal.pone.0104104, ISSN: 1932-6203.

Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK. HIF1a and HIF2a exert distinct nutrient preferences in renal cells. PLoS ONE. 2014; 9(5): e98705. PMID: 24879016, PMCID: PMC4039535, PII: PONE-D-13-47383, DOI: 10.1371/journal.pone.0098705, ISSN: 1932-6203.

Saucillo DC, Gerriets VA, Sheng J, Rathmell JC, Maciver NJ. Leptin metabolically licenses T cells for activation to link nutrition and immunity. J. Immunol [print-electronic]. 2014 Jan 1/1/2014; 192(1): 136-44. PMID: 24273001, PMCID: PMC3872216, PII: jimmunol.1301158, DOI: 10.4049/jimmunol.1301158, ISSN: 1550-6606.

Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, Koretzky GA. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat. Immunol [print-electronic]. 2013 Jun; 14(6): 611-8. PMID: 23644504, PMCID: PMC3711189, PII: ni.2607, DOI: 10.1038/ni.2607, ISSN: 1529-2916.

Macintyre AN, Rathmell JC. Activated lymphocytes as a metabolic model for carcinogenesis. Cancer Metab. 2013; 1(1): 5. PMID: 24280044, PMCID: PMC3834493, PII: 2049-3002-1-5, DOI: 10.1186/2049-3002-1-5, ISSN: 2049-3002.