Faculty Appointments
Assistant Professor of Ophthalmology & Visual Sciences
Assistant Professor of Biomedical Engineering
Education
Ph.D., Synthetic Organic Chemistry, Kochi University, Kochi, ForeignM.S., Synthetic Organic Chemistry, Jahangirnagar University, Dacca, BangladeshB.S., Chemistry, Jahangirnagar University, Dacca, Bangladesh
Research Description
Dr. Uddin is a new investigator in the field of ophthalmology. His current research is focused on the development of molecular imaging technologies including optical imaging, optical coherence tomography (OCT) and nano-scale engineering to identify molecular targets for early disease-detection and treatments in ophthalmology, vascular medicine and oncology. Dr. Uddin is currently using optical imaging techniques and nanotechnology-based approaches for diagnosis and drug delivery in preclinical models of diabetic retinopathy (DR), retinopathy of prematurity (ROP), retinal vein occlusion (RVO) and age-related macular degeneration (AMD).
Research Keywords
medical imaging, optical imaging, Ophthalmology, retinopathy, diabetic retinopathy (DR), age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and retinal vein occlusion (RVO).
Publications
Uddin MI, Kilburn TC, Jamal SZ, Duvall CL, Penn JS. A novel method for visualizing and tracking endogenous mRNA in a specific cell population in pathological neovascularization. Sci Rep. 2021 Jan 1/28/2021; 11(1): 2565. PMID: 33510218, PMCID: PMC7844016, PII: 10.1038/s41598-021-81367-5, DOI: 10.1038/s41598-021-81367-5, ISSN: 2045-2322.
Uddin MI, Kilburn TC, Jamal SZ, Duvall CL, Penn JS. A novel method for visualizing and tracking endogenous mRNA in a specific cell population in pathological neovascularization. Sci Rep. 2021 Jan 1/28/2021; 11(1): 2565. PMID: 33510218, PMCID: PMC7844016, PII: 10.1038/s41598-021-81367-5, DOI: 10.1038/s41598-021-81367-5, ISSN: 2045-2322.
Uddin MI, Kilburn TC, Duvall CL, Penn JS. Visualizing HIF-1a mRNA in a Subpopulation of Bone Marrow-Derived Cells to Predict Retinal Neovascularization. ACS Chem Biol [print-electronic]. 2020 Nov 11/20/2020; 15(11): 3004-12. PMID: 33080135, PMCID: PMC8121337, DOI: 10.1021/acschembio.0c00662, ISSN: 1554-8937.
Uddin MI, Kilburn TC, Duvall CL, Penn JS. Visualizing HIF-1a mRNA in a Subpopulation of Bone Marrow-Derived Cells to Predict Retinal Neovascularization. ACS Chem Biol [print-electronic]. 2020 Nov 11/20/2020; 15(11): 3004-12. PMID: 33080135, PMCID: PMC8121337, DOI: 10.1021/acschembio.0c00662, ISSN: 1554-8937.
Uddin MJ, Wilson AJ, Crews BC, Malerba P, Uddin MI, Kingsley PJ, Ghebreselasie K, Daniel CK, Nickels ML, Tantawy MN, Jashim E, Manning HC, Khabele D, Marnett LJ. Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer. ACS Omega [print-electronic]. 2019 May 5/31/2019; 4(5): 9251-61. PMID: 31172046, PMCID: PMC6545551, DOI: 10.1021/acsomega.9b01093, ISSN: 2470-1343.
Uddin MJ, Wilson AJ, Crews BC, Malerba P, Uddin MI, Kingsley PJ, Ghebreselasie K, Daniel CK, Nickels ML, Tantawy MN, Jashim E, Manning HC, Khabele D, Marnett LJ. Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer. ACS Omega [print-electronic]. 2019 May 5/31/2019; 4(5): 9251-61. PMID: 31172046, PMCID: PMC6545551, DOI: 10.1021/acsomega.9b01093, ISSN: 2470-1343.
Uddin MI, Kilburn TC, Yang R, McCollum GW, Wright DW, Penn JS. Targeted Imaging of VCAM-1 mRNA in a Mouse Model of Laser-Induced Choroidal Neovascularization Using Antisense Hairpin-DNA-Functionalized Gold-Nanoparticles. Mol Pharm [print-electronic]. 2018 Dec 12/3/2018; 15(12): 5514-20. PMID: 30350640, PMCID: PMC7135968, DOI: 10.1021/acs.molpharmaceut.8b00661, ISSN: 1543-8392.
Uddin MI, Kilburn TC, Yang R, McCollum GW, Wright DW, Penn JS. Targeted Imaging of VCAM-1 mRNA in a Mouse Model of Laser-Induced Choroidal Neovascularization Using Antisense Hairpin-DNA-Functionalized Gold-Nanoparticles. Mol Pharm [print-electronic]. 2018 Dec 12/3/2018; 15(12): 5514-20. PMID: 30350640, PMCID: PMC7135968, DOI: 10.1021/acs.molpharmaceut.8b00661, ISSN: 1543-8392.
Uddin MI, Jayagopal A, Wong A, McCollum GW, Wright DW, Penn JS. Real-time imaging of VCAM-1 mRNA in TNF-a activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles. Nanomedicine [print-electronic]. 2018 Jan; 14(1): 63-71. PMID: 28890107, PMCID: PMC5742066, PII: S1549-9634(17)30165-X, DOI: 10.1016/j.nano.2017.08.018, ISSN: 1549-9642.
Uddin MI, Jayagopal A, McCollum GW, Yang R, Penn JS. In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO). Invest. Ophthalmol. Vis. Sci. 2017 Jul 7/1/2017; 58(9): 3818-24. PMID: 28750413, PMCID: PMC5531786, PII: 2646756, DOI: 10.1167/iovs.16-21187, ISSN: 1552-5783.
Uddin MI, Evans SM, Craft JR, Capozzi ME, McCollum GW, Yang R, Marnett LJ, Uddin MJ, Jayagopal A, Penn JS. In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Sci Rep. 2016 Aug 8/5/2016; 6: 31011. PMID: 27491345, PMCID: PMC4974503, PII: srep31011, DOI: 10.1038/srep31011, ISSN: 2045-2322.
Gahlaut N, Suarez S, Uddin MI, Gordon AY, Evans SM, Jayagopal A. Nanoengineering of therapeutics for retinal vascular disease. Eur J Pharm Biopharm [print-electronic]. 2015 Sep; 95(Pt B): 323-30. PMID: 26022642, PMCID: PMC4604030, PII: S0939-6411(15)00219-2, DOI: 10.1016/j.ejpb.2015.05.001, ISSN: 1873-3441.
Uddin MI, Evans SM, Craft JR, Marnett LJ, Uddin MJ, Jayagopal A. Applications of azo-based probes for imaging retinal hypoxia. ACS Med Chem Lett. 2015 Apr 4/9/2015; 6(4): 445-9. PMID: 25893047, PMCID: PMC4394343, DOI: 10.1021/ml5005206.
Evans SM, Kim K, Moore CE, Uddin MI, Capozzi ME, Craft JR, Sulikowski GA, Jayagopal A. Molecular probes for imaging of hypoxia in the retina. Bioconjug. Chem [print-electronic]. 2014 Nov 11/19/2014; 25(11): 2030-7. PMID: 25250692, PMCID: PMC4240343, DOI: 10.1021/bc500400z, ISSN: 1520-4812.
Uddin MI, Buck JR, Schulte ML, Tang D, Saleh SA, Cheung YY, Harp J, Manning HC. Microwave-assisted, one-pot reaction of 7-azaindoles and aldehydes: a facile route to novel di-7-azaindolylmethanes. Tetrahedron Lett. 2014 Jan 1/1/2014; 55(1): PMID: 24396154, PMCID: PMC3880151, DOI: 10.1016/j.tetlet.2013.10.143, ISSN: 0040-4039.
Tang D, McKinley ET, Hight MR, Uddin MI, Harp JM, Fu A, Nickels ML, Buck JR, Manning HC. Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. J. Med. Chem [print-electronic]. 2013 Apr 4/25/2013; 56(8): 3429-33. PMID: 23521048, PMCID: PMC3648642, DOI: 10.1021/jm4001874, ISSN: 1520-4804.
McKinley ET, Smith RA, Zhao P, Fu A, Saleh SA, Uddin MI, Washington MK, Coffey RJ, Manning HC. 3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer. J. Nucl. Med [print-electronic]. 2013 Mar; 54(3): 424-30. PMID: 23341544, PMCID: PMC3633462, PII: jnumed.112.108456, DOI: 10.2967/jnumed.112.108456, ISSN: 1535-5667.
Buck JR, Saleh S, Uddin MI, Manning HC. Rapid, Microwave-Assisted Organic Synthesis of Selective (V600E)BRAF Inhibitors for Preclinical Cancer Research. Tetrahedron Lett [print-electronic]. 2012 Aug 8/8/2012; 53(32): 4161-5. PMID: 23180892, PMCID: PMC3501741, DOI: 10.1016/j.tetlet.2012.05.137, ISSN: 0040-4039.
Uddin MI, Kilburn TC, Jamal SZ, Duvall CL, Penn JS. A novel method for visualizing and tracking endogenous mRNA in a specific cell population in pathological neovascularization. Sci Rep. 2021 Jan 1/28/2021; 11(1): 2565. PMID: 33510218, PMCID: PMC7844016, PII: 10.1038/s41598-021-81367-5, DOI: 10.1038/s41598-021-81367-5, ISSN: 2045-2322.
Uddin MI, Kilburn TC, Duvall CL, Penn JS. Visualizing HIF-1a mRNA in a Subpopulation of Bone Marrow-Derived Cells to Predict Retinal Neovascularization. ACS Chem Biol [print-electronic]. 2020 Nov 11/20/2020; 15(11): 3004-12. PMID: 33080135, PMCID: PMC8121337, DOI: 10.1021/acschembio.0c00662, ISSN: 1554-8937.
Uddin MI, Kilburn TC, Duvall CL, Penn JS. Visualizing HIF-1a mRNA in a Subpopulation of Bone Marrow-Derived Cells to Predict Retinal Neovascularization. ACS Chem Biol [print-electronic]. 2020 Nov 11/20/2020; 15(11): 3004-12. PMID: 33080135, PMCID: PMC8121337, DOI: 10.1021/acschembio.0c00662, ISSN: 1554-8937.
Uddin MJ, Wilson AJ, Crews BC, Malerba P, Uddin MI, Kingsley PJ, Ghebreselasie K, Daniel CK, Nickels ML, Tantawy MN, Jashim E, Manning HC, Khabele D, Marnett LJ. Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer. ACS Omega [print-electronic]. 2019 May 5/31/2019; 4(5): 9251-61. PMID: 31172046, PMCID: PMC6545551, DOI: 10.1021/acsomega.9b01093, ISSN: 2470-1343.
Uddin MJ, Wilson AJ, Crews BC, Malerba P, Uddin MI, Kingsley PJ, Ghebreselasie K, Daniel CK, Nickels ML, Tantawy MN, Jashim E, Manning HC, Khabele D, Marnett LJ. Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer. ACS Omega [print-electronic]. 2019 May 5/31/2019; 4(5): 9251-61. PMID: 31172046, PMCID: PMC6545551, DOI: 10.1021/acsomega.9b01093, ISSN: 2470-1343.
Uddin MI, Kilburn TC, Yang R, McCollum GW, Wright DW, Penn JS. Targeted Imaging of VCAM-1 mRNA in a Mouse Model of Laser-Induced Choroidal Neovascularization Using Antisense Hairpin-DNA-Functionalized Gold-Nanoparticles. Mol Pharm [print-electronic]. 2018 Dec 12/3/2018; 15(12): 5514-20. PMID: 30350640, PMCID: PMC7135968, DOI: 10.1021/acs.molpharmaceut.8b00661, ISSN: 1543-8392.
Uddin MI, Kilburn TC, Yang R, McCollum GW, Wright DW, Penn JS. Targeted Imaging of VCAM-1 mRNA in a Mouse Model of Laser-Induced Choroidal Neovascularization Using Antisense Hairpin-DNA-Functionalized Gold-Nanoparticles. Mol Pharm [print-electronic]. 2018 Dec 12/3/2018; 15(12): 5514-20. PMID: 30350640, PMCID: PMC7135968, DOI: 10.1021/acs.molpharmaceut.8b00661, ISSN: 1543-8392.
Uddin MI, Jayagopal A, Wong A, McCollum GW, Wright DW, Penn JS. Real-time imaging of VCAM-1 mRNA in TNF-a activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles. Nanomedicine [print-electronic]. 2018 Jan; 14(1): 63-71. PMID: 28890107, PMCID: PMC5742066, PII: S1549-9634(17)30165-X, DOI: 10.1016/j.nano.2017.08.018, ISSN: 1549-9642.
Uddin MI, Jayagopal A, McCollum GW, Yang R, Penn JS. In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO). Invest. Ophthalmol. Vis. Sci. 2017 Jul 7/1/2017; 58(9): 3818-24. PMID: 28750413, PMCID: PMC5531786, PII: 2646756, DOI: 10.1167/iovs.16-21187, ISSN: 1552-5783.
Uddin MI, Evans SM, Craft JR, Capozzi ME, McCollum GW, Yang R, Marnett LJ, Uddin MJ, Jayagopal A, Penn JS. In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Sci Rep. 2016 Aug 8/5/2016; 6: 31011. PMID: 27491345, PMCID: PMC4974503, PII: srep31011, DOI: 10.1038/srep31011, ISSN: 2045-2322.
Gahlaut N, Suarez S, Uddin MI, Gordon AY, Evans SM, Jayagopal A. Nanoengineering of therapeutics for retinal vascular disease. Eur J Pharm Biopharm [print-electronic]. 2015 Sep; 95(Pt B): 323-30. PMID: 26022642, PMCID: PMC4604030, PII: S0939-6411(15)00219-2, DOI: 10.1016/j.ejpb.2015.05.001, ISSN: 1873-3441.
Uddin MI, Evans SM, Craft JR, Marnett LJ, Uddin MJ, Jayagopal A. Applications of azo-based probes for imaging retinal hypoxia. ACS Med Chem Lett. 2015 Apr 4/9/2015; 6(4): 445-9. PMID: 25893047, PMCID: PMC4394343, DOI: 10.1021/ml5005206.
Evans SM, Kim K, Moore CE, Uddin MI, Capozzi ME, Craft JR, Sulikowski GA, Jayagopal A. Molecular probes for imaging of hypoxia in the retina. Bioconjug. Chem [print-electronic]. 2014 Nov 11/19/2014; 25(11): 2030-7. PMID: 25250692, PMCID: PMC4240343, DOI: 10.1021/bc500400z, ISSN: 1520-4812.
Uddin MI, Buck JR, Schulte ML, Tang D, Saleh SA, Cheung YY, Harp J, Manning HC. Microwave-assisted, one-pot reaction of 7-azaindoles and aldehydes: a facile route to novel di-7-azaindolylmethanes. Tetrahedron Lett. 2014 Jan 1/1/2014; 55(1): PMID: 24396154, PMCID: PMC3880151, DOI: 10.1016/j.tetlet.2013.10.143, ISSN: 0040-4039.
Tang D, McKinley ET, Hight MR, Uddin MI, Harp JM, Fu A, Nickels ML, Buck JR, Manning HC. Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. J. Med. Chem [print-electronic]. 2013 Apr 4/25/2013; 56(8): 3429-33. PMID: 23521048, PMCID: PMC3648642, DOI: 10.1021/jm4001874, ISSN: 1520-4804.
McKinley ET, Smith RA, Zhao P, Fu A, Saleh SA, Uddin MI, Washington MK, Coffey RJ, Manning HC. 3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer. J. Nucl. Med [print-electronic]. 2013 Mar; 54(3): 424-30. PMID: 23341544, PMCID: PMC3633462, PII: jnumed.112.108456, DOI: 10.2967/jnumed.112.108456, ISSN: 1535-5667.
Buck JR, Saleh S, Uddin MI, Manning HC. Rapid, Microwave-Assisted Organic Synthesis of Selective (V600E)BRAF Inhibitors for Preclinical Cancer Research. Tetrahedron Lett [print-electronic]. 2012 Aug 8/8/2012; 53(32): 4161-5. PMID: 23180892, PMCID: PMC3501741, DOI: 10.1016/j.tetlet.2012.05.137, ISSN: 0040-4039.