Bradley W Richmond, M.D., Ph.D.

Assistant Professor

bradley.richmond@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine
Education
Ph.D., Cell and Develpment Biology, Vanderbilt University, Nashville, TennesseeM.D., MEDICINE, University of Louisville, Louisville, KentuckyB.S., University of Evansville, Evansville, Indiana
Office Address
T1209C-MCN
1161 21st Avenue South
Nashville, TN 37232
Research Description
Dr. Richmond received his undergraduate degree from the University of Evansville in 2003 and his M.D. from the University of Louisville in 2007. He then completed a residency in internal medicine, a clinical fellowship in pulmonary and critical care medicine, and a Ph.D. in cell and developmental biology at Vanderbilt University. Dr. Richmond’s research focuses on how chronic inflammation alters epithelial differentiation in the airways and the consequences of altered epithelial differentiation on host defense and microbial community structure.
Clinical Description
Dr. Richmond currently sees patients at the Veterans Affairs Medical Center in Nashville, TN in both the outpatient and inpatient setting. He has particular clinical interest in chronic obstructive pulmonary disease and deployment-related respiratory disease.
Research Keywords
chronic obstructive pulmonary disease (COPD), mucosal immunity, lung microbiome, epithelial remodeling, animal models of lung disease
Publications
Richmond BW, Guo Y, Yu C, Kendall PL, Mason WR, Cogan JD, Loyd JE. GWAS of 58 Individuals with Fibrosing Mediastinitis Reveals Possible Underlying Genetic Susceptibility. Am. J. Respir. Crit. Care Med [print-electronic]. 2017 Oct 10/18/2017; PMID: 29043856, DOI: 10.1164/rccm.201708-1765LE, ISSN: 1535-4970.

Polosukhin VV, Richmond BW, Du RH, Cates JM, Wu P, Nian H, Massion PP, Ware LB, Lee JW, Kononov AV, Lawson WE, Blackwell TS. Secretory IgA Deficiency in Individual Small Airways Is Associated with Persistent Inflammation and Remodeling. Am. J. Respir. Crit. Care Med. 2017 Apr 4/15/2017; 195(8): 1010-21. PMID: 27911098, PMCID: PMC5422646, DOI: 10.1164/rccm.201604-0759OC, ISSN: 1535-4970.

Kropski JA, Richmond BW, Gaskill CF, Foronjy RF, Majka SM. EXPRESS: Deregulated Angiogenesis in Chronic Lung Diseases: A Role for Lung Mesenchymal Progenitor Cells. Pulm Circ [print-electronic]. 2017 Jan 1/1/2017; 2045893217739807. PMID: 29040010, DOI: 10.1177/2045893217739807, ISSN: 2045-8932.

Janz DR, Semler MW, Lentz RJ, Matthews DT, Assad TR, Norman BC, Keriwala RD, Ferrell BA, Noto MJ, Shaver CM, Richmond BW, Zinggeler Berg J, Rice TW, . Randomized Trial of Video Laryngoscopy for Endotracheal Intubation of Critically Ill Adults. Crit. Care Med. 2016 Nov; 44(11): 1980-7. PMID: 27355526, PMCID: PMC5203695, DOI: 10.1097/CCM.0000000000001841, ISSN: 1530-0293.

Saxon JA, Cheng DS, Han W, Polosukhin VV, McLoed AG, Richmond BW, Gleaves LA, Tanjore H, Sherrill TP, Barham W, Yull FE, Blackwell TS. P52 Overexpression Increases Epithelial Apoptosis, Enhances Lung Injury, and Reduces Survival after Lipopolysaccharide Treatment. J. Immunol [print-electronic]. 2016 Feb 2/15/2016; 196(4): 1891-9. PMID: 26773153, PMCID: PMC4744539, PII: jimmunol.1501555, DOI: 10.4049/jimmunol.1501555, ISSN: 1550-6606.

Richmond BW, Brucker RM, Han W, Du RH, Zhang Y, Cheng DS, Gleaves L, Abdolrasulnia R, Polosukhina D, Clark PE, Bordenstein SR, Blackwell TS, Polosukhin VV. Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency. Nat Commun. 2016; 7: 11240. PMID: 27046438, PMCID: PMC4822073, PII: ncomms11240, DOI: 10.1038/ncomms11240, ISSN: 2041-1723.

Du RH, Richmond BW, Blackwell TS, Cates JM, Massion PP, Ware LB, Lee JW, Kononov AV, Lawson WE, Blackwell TS, Polosukhin VV. Secretory IgA from submucosal glands does not compensate for its airway surface deficiency in chronic obstructive pulmonary disease. Virchows Arch [print-electronic]. 2015 Dec; 467(6): 657-65. PMID: 26432569, PII: 10.1007/s00428-015-1854-0, DOI: 10.1007/s00428-015-1854-0, ISSN: 1432-2307.

Richmond BW, Richter K, King LE, Drake WP. Resolution of chronic ocular sarcoidosis with antimycobacterial therapy. Case Rep Intern Med. 2014; 1(2): PMID: 25580448, PMCID: PMC4286311, DOI: 10.5430/crim.v1n2p216, ISSN: 2332-7243.

Drake WP, Richmond BW, Oswald-Richter K, Yu C, Isom JM, Worrell JA, Shipley GR. Effects of broad-spectrum antimycobacterial therapy on chronic pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2013 Oct; 30(3): 201-11. PMID: 24284293, PMCID: PMC3929334, ISSN: 1124-0490.

Drake WP, Oswald-Richter K, Richmond BW, Isom J, Burke VE, Algood H, Braun N, Taylor T, Pandit KV, Aboud C, Yu C, Kaminski N, Boyd AS, King LE. Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study. JAMA Dermatol. 2013 Sep; 149(9): 1040-9. PMID: 23863960, PMCID: PMC3927541, PII: 1714665, DOI: 10.1001/jamadermatol.2013.4646, ISSN: 2168-6084.

Richmond BW, Worrell JA, Bastarache JA, Gervich DH, Slattery WR, Loyd JE. Histoplasmomas of uncommon size. Chest. 2013 Jun; 143(6): 1795-8. PMID: 23732591, PII: S0012-3692(13)60414-6, DOI: 10.1378/chest.12-2071, ISSN: 1931-3543.

Oswald-Richter KA, Richmond BW, Braun NA, Isom J, Abraham S, Taylor TR, Drake JM, Culver DA, Wilkes DS, Drake WP. Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis. J. Immunol [print-electronic]. 2013 Jun 6/1/2013; 190(11): 5446-53. PMID: 23630356, PMCID: PMC3660530, PII: jimmunol.1202891, DOI: 10.4049/jimmunol.1202891, ISSN: 1550-6606.

Richmond BW, Ploetze K, Isom J, Chambers-Harris I, Braun NA, Taylor T, Abraham S, Mageto Y, Culver DA, Oswald-Richter KA, Drake WP. Sarcoidosis Th17 cells are ESAT-6 antigen specific but demonstrate reduced IFN-¿ expression. J. Clin. Immunol [print-electronic]. 2013 Feb; 33(2): 446-55. PMID: 23073617, PMCID: PMC3850764, DOI: 10.1007/s10875-012-9817-6, ISSN: 1573-2592.

Richmond BW, Cole MB, Dash A, Eyler A, Boomershine CS. A tale of two rashes. Am. J. Med. 2011 May; 124(5): 414-7. PMID: 21531230, PII: S0002-9343(11)00063-5, DOI: 10.1016/j.amjmed.2011.01.003, ISSN: 1555-7162.

Richmond BW, Drake WP. Vitamin D, innate immunity, and sarcoidosis granulomatous inflammation: insights from mycobacterial research. Curr Opin Pulm Med. 2010 Sep; 16(5): 461-4. PMID: 20473167, DOI: 10.1097/MCP.0b013e32833af7e8, ISSN: 1531-6971.

Available Postdoctoral Position Details
Posted: 11/6/2017

Job Description

A postdoctoral position is immediately available to study the role of the airway epithelium in mucosal defense in health and in chronic airway diseases such as chronic obstructive pulmonary disease (COPD). Our growing lab investigates how airborne irritants such as cigarette smoke alter epithelial structure in the airways and the implications of altered epithelial structure on mucosal immunity. Fellows would have an opportunity to train in multiple model systems including human lung tissue, a variety of in vivo models, and primary murine and human airway epithelial cells.

Qualifications

Candidates must have a PhD or MD/PhD in stem cell/developmental biology, cell biology, immunology, or a related field. Proficiency in basic molecular biology and cell culture techniques is required; preference will be given to applicants with experience in stem cell/developmental biology of the lung, viral transduction systems, CRISPR/Cas9-based gene editing, and/or advanced microscopy. Applicants should have a demonstrated ability to work both independently and collaboratively, possess excellent oral and written communication skills, and have a record of productivity as evidenced by publication history. A successful fellow will leave the program with a broad knowledge of epithelial biology in the lung and the role of the epithelium in host defense, a robust scientific skillset, and opportunities for presentation and publication. Interested applicants should send their curriculum vitae, a brief statement of interest, and 2-3 references to Bradley Richmond at bradley.richmond@vanderbilt.edu.