Faculty Appointments
Research Assistant Professor of Medicine
Education
M.S., Biostatistics, Vanderbilt University, Nashville, TennesseePh.D., Bioinformatics and computational biology, University of Idaho, Moscow, IdahoM.S., Mathematics, University of Idaho, Moscow, IdahoB.S., Mathematics, Nanjing University, Nanjing, China
Office Address
515C Light Hall, 2215 Garland Ave.
Nashville, TN 37232
Nashville, TN 37232
Research Description
Dr. Zhong is a Research Assistant Professor in Genetic Medicine at Vanderbilt University Medical Center. Trained in computational biology and biostatistics, Dr. Zhong's early work focused on spatial models and network approaches with applications to predicting population dynamics of pathogenic agents, infectious disease transmission and tumor subtyping. Dr. Zhong's current research focus is to use human genetics and genomics to map risk genes and find new therapeutics. She has led several projects of using biobanks linked to electronic health records (EHR) data to reveal phenotypic patterns associated with genetic instruments constructed for various diseases, including Type 2 diabetes, cystic fibrosis and asthma. Dr. Zhong also collaborate on method development of iRIGS, a Bayesian framework for risk gene identification through integration of genetics and genomic evidence, and JTI, a unified framework of joint-tissue prediction of gene expression and Mendelian randomization analysis. In recent years, Dr. Zhong's research focus is Alzheimer’s disease risk gene identification and drug repurposing.
Research Keywords
Electronic health records (EHRs), Biobank, PheWAS, Alzheimer's disease
Publications
Zhong X, Yin Z, Jia G, Zhou D, Wei Q, Faucon A, Evans P, Gamazon ER, Li B, Tao R, Rzhetsky A, Bastarache L, Cox NJ. Electronic health record phenotypes associated with genetically regulated expression of CFTR and application to cystic fibrosis. Genet. Med [print-electronic]. 2020 Apr 4/16/2020; PMID: 32296164, PII: 10.1038/s41436-020-0786-5, DOI: 10.1038/s41436-020-0786-5, ISSN: 1530-0366.
Raffield LM, Iyengar AK, Wang B, Gaynor SM, Spracklen CN, Zhong X, Kowalski MH, Salimi S, Polfus LM, Benjamin EJ, Bis JC, Bowler R, Cade BE, Choi WJ, Comellas AP, Correa A, Cruz P, Doddapaneni H, Durda P, Gogarten SM, Jain D, Kim RW, Kral BG, Lange LA, Larson MG, Laurie C, Lee J, Lee S, Lewis JP, Metcalf GA, Mitchell BD, Momin Z, Muzny DM, Pankratz N, Park CJ, Rich SS, Rotter JI, Ryan K, Seo D, Tracy RP, Viaud-Martinez KA, Yanek LR, Zhao LP, Lin X, Li B, Li Y, Dupuis J, Reiner AP, Mohlke KL, Auer PL, , . Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts. Am. J. Hum. Genet [print-electronic]. 2020 Jan 1/2/2020; 106(1): 112-20. PMID: 31883642, PMCID: PMC7042494, PII: S0002-9297(19)30466-5, DOI: 10.1016/j.ajhg.2019.12.002, ISSN: 1537-6605.
Feng Q, Wei WQ, Chaugai S, Carranza Leon BG, Kawai V, Carranza Leon DA, Jiang L, Zhong X, Liu G, Ihegword A, Shaffer CM, Linton MF, Chung CP, Stein CM. A Genetic Approach to the Association Between PCSK9 and Sepsis. JAMA Netw Open. 2019 Sep 9/4/2019; 2(9): e1911130. PMID: 31509211, PMCID: PMC6739725, PII: 2749565, DOI: 10.1001/jamanetworkopen.2019.11130, ISSN: 2574-3805.
Wang Q, Chen R, Cheng F, Wei Q, Ji Y, Yang H, Zhong X, Tao R, Wen Z, Sutcliffe JS, Liu C, Cook EH, Cox NJ, Li B. A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data. Nat. Neurosci [print-electronic]. 2019 May; 22(5): 691-9. PMID: 30988527, PMCID: PMC6646046, PII: 10.1038/s41593-019-0382-7, DOI: 10.1038/s41593-019-0382-7, ISSN: 1546-1726.
Unlu G, Gamazon ER, Qi X, Levic DS, Bastarache L, Denny JC, Roden DM, Mayzus I, Breyer M, Zhong X, Konkashbaev AI, Rzhetsky A, Knapik EW, Cox NJ. GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish. Am. J. Hum. Genet [print-electronic]. 2019 Mar 3/7/2019; 104(3): 503-19. PMID: 30827500, PMCID: PMC6407495, PII: S0002-9297(19)30017-5, DOI: 10.1016/j.ajhg.2019.01.017, ISSN: 1537-6605.
Polfus LM, Raffield LM, Wheeler MM, Tracy RP, Lange LA, Lettre G, Miller A, Correa A, Bowler RP, Bis JC, Salimi S, Jenny NS, Pankratz N, Wang B, Preuss MH, Zhou L, Moscati A, Nadkarni GN, Loos RJF, Zhong X, Li B, Johnsen JM, Nickerson DA, Reiner AP, Auer PL, . Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans. Hum. Mol. Genet. 2019 Feb 2/1/2019; 28(3): 515-23. PMID: 30307499, PMCID: PMC6337694, PII: 5126494, DOI: 10.1093/hmg/ddy360, ISSN: 1460-2083.
Laroumanie F, Korneva A, Bersi MR, Alexander MR, Xiao L, Zhong X, Van Beusecum JP, Chen Y, Saleh MA, McMaster WG, Gavulic KA, Dale BL, Zhao S, Guo Y, Shyr Y, Perrien DS, Cox NJ, Curci JA, Humphrey JD, Madhur MS. LNK deficiency promotes acute aortic dissection and rupture. JCI Insight. 2018 Oct 10/18/2018; 3(20): PMID: 30333305, PMCID: PMC6237478, PII: 122558, DOI: 10.1172/jci.insight.122558, ISSN: 2379-3708.
Hu Y, Raffield LM, Polfus LM, Moscati A, Nadkarni G, Preuss MH, Zhong X, Wei Q, Rich SS, Li Y, Wilson JG, Correa A, Loos RJF, Li B, Auer PL, Reiner AP, . A common TCN1 loss-of-function variant is associated with lower vitamin B12 concentration in African Americans [letter]. Blood [print-electronic]. 2018 Jun 6/21/2018; 131(25): 2859-63. PMID: 29764838, PMCID: PMC6014360, PII: blood-2018-03-841023, DOI: 10.1182/blood-2018-03-841023, ISSN: 1528-0020.
Wei Q, Ye Z, Zhong X, Li L, Wang C, Myers RE, Palazzo JP, Fortuna D, Yan A, Waldman SA, Chen X, Posey JA, Basu-Mallick A, Jiang BH, Hou L, Shu J, Sun Y, Xing J, Li B, Yang H. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis. Ann. Oncol. 2017 Sep 9/1/2017; 28(9): 2135-41. PMID: 28911083, PMCID: PMC5834069, PII: S0923-7534(19)35240-8, DOI: 10.1093/annonc/mdx278, ISSN: 1569-8041.
Yang H, Wei Q, Zhong X, Yang H, Li B. Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework. Bioinformatics. 2017 Feb 2/15/2017; 33(4): 483-90. PMID: 27797769, PMCID: PMC6075201, PII: btw662, DOI: 10.1093/bioinformatics/btw662, ISSN: 1367-4811.
Liu Q, Zhong X, Madison BB, Rustgi AK, Shyr Y. Assessing Computational Steps for CLIP-Seq Data Analysis. Biomed Res Int. 2015 Oct 10/11/2015; 2015: 196082. PMID: 26539468, PMCID: PMC4619761, DOI: 10.1155/2015/196082, ISSN: 2314-6141.
Zhong X, Yang H, Zhao S, Shyr Y, Li B. Network-based stratification analysis of 13 major cancer types using mutations in panels of cancer genes. BMC Genomics. 2015 Jun 6/11/2015; 16(Suppl 7):S7.
Li B, Wei Q, Zhan X, Zhong X, Chen W, Li C, Haines J. Leveraging Identity-by-Descent for Accurate Genotype Inference in Family Sequencing Data. PLoS Genet. 2015 Jun; 11(6): e1005271. PMID: 26043085, PMCID: PMC4456389, PII: PGENETICS-D-14-01420, DOI: 10.1371/journal.pgen.1005271, ISSN: 1553-7404.
Chen R, Wei Q, Zhan X, Zhong X, Sutcliffe JS, Cox NJ, Cook EH, Li C, Chen W, Li B. A haplotype-based framework for group-wise transmission/disequilibrium tests for rare variant association analysis. Bioinformatics [print-electronic]. 2015 May 5/1/2015; 31(9): 1452-9. PMID: 25568282, PMCID: PMC4410665, PII: btu860, DOI: 10.1093/bioinformatics/btu860, ISSN: 1367-4811.
Wei Q, Zhan X, Zhong X, Liu Y, Han Y, Chen W, Li B. A Bayesian framework for de novo mutation calling in parents-offspring trios. Bioinformatics [print-electronic]. 2015 May 5/1/2015; 31(9): 1375-81. PMID: 25535243, PMCID: PMC4410659, PII: btu839, DOI: 10.1093/bioinformatics/btu839, ISSN: 1367-4811.
Guo Y, He J, Zhao S, Wu H, Zhong X, Sheng Q, Samuels DC, Shyr Y, Long J. Illumina human exome genotyping array clustering and quality control. Nat Protoc [print-electronic]. 2014 Nov; 9(11): 2643-62. PMID: 25321409, PMCID: PMC4441213, PII: nprot.2014.174, DOI: 10.1038/nprot.2014.174, ISSN: 1750-2799.
Guo Y, Bosompem A, Zhong X, Clark T, Shyr Y, Kim AS. A comparison of microRNA sequencing reproducibility and noise reduction using mirVana and TRIzol isolation methods. Int J Comput Biol Drug Des [print-electronic]. 2014; 7(2-3): 102-12. PMID: 24878723, PMCID: PMC5798231, PII: IJCBDD.2014.061642, DOI: 10.1504/IJCBDD.2014.061642, ISSN: 1756-0756.
Hou D, Zhou X, Zhong X, Settles ML, Herring J, Wang L, Abdo Z, Forney LJ, Xu C. Microbiota of the seminal fluid from healthy and infertile men. Fertil. Steril [print-electronic]. 2013 Nov; 100(5): 1261-9. PMID: 23993888, PMCID: PMC3888793, PII: S0015-0282(13)02777-5, DOI: 10.1016/j.fertnstert.2013.07.1991, ISSN: 1556-5653.
Madison BB, Liu Q, Zhong X, Hahn CM, Lin N, Emmett MJ, Stanger BZ, Lee JS, Rustgi AK. LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev. 2013 Oct 10/15/2013; 27(20): 2233-45. PMID: 24142874, PMCID: PMC3814644, PII: 27/20/2233, DOI: 10.1101/gad.224659.113, ISSN: 1549-5477.
Gajer P, Brotman RM, Bai G, Sakamoto J, Schütte UM, Zhong X, Koenig SS, Fu L, Ma ZS, Zhou X, Abdo Z, Forney LJ, Ravel J. Temporal dynamics of the human vaginal microbiota. Sci Transl Med. 2012 May 5/2/2012; 4(132): 132ra52. PMID: 22553250, PMCID: PMC3722878, PII: 4/132/132ra52, DOI: 10.1126/scitranslmed.3003605, ISSN: 1946-6242.
Zhong X, Droesch J, Fox R, Top EM, Krone SM. On the meaning and estimation of plasmid transfer rates for surface-associated and well-mixed bacterial populations. J. Theor. Biol [print-electronic]. 2012 Feb 2/7/2012; 294: 144-52. PMID: 22085738, PMCID: PMC3346278, PII: S0022-5193(11)00557-1, DOI: 10.1016/j.jtbi.2011.10.034, ISSN: 1095-8541.
Rohani P, Zhong X, King AA. Contact network structure explains the changing epidemiology of pertussis. Science. 2010 Nov 11/12/2010; 330(6006): 982-5. PMID: 21071671, PII: 330/6006/982, DOI: 10.1126/science.1194134, ISSN: 1095-9203.
Zhong X, Krol JE, Top EM, Krone SM. Accounting for mating pair formation in plasmid population dynamics. J. Theor. Biol [print-electronic]. 2010 Feb 2/21/2010; 262(4): 711-9. PMID: 19835890, PMCID: PMC2821984, PII: S0022-5193(09)00488-3, DOI: 10.1016/j.jtbi.2009.10.013, ISSN: 1095-8541.
Fox RE, Zhong X, Krone SM, Top EM. Spatial structure and nutrients promote invasion of IncP-1 plasmids in bacterial populations. ISME J [print-electronic]. 2008 Oct; 2(10): 1024-39. PMID: 18528415, PMCID: PMC2605096, PII: ismej200853, DOI: 10.1038/ismej.2008.53, ISSN: 1751-7370.
Raffield LM, Iyengar AK, Wang B, Gaynor SM, Spracklen CN, Zhong X, Kowalski MH, Salimi S, Polfus LM, Benjamin EJ, Bis JC, Bowler R, Cade BE, Choi WJ, Comellas AP, Correa A, Cruz P, Doddapaneni H, Durda P, Gogarten SM, Jain D, Kim RW, Kral BG, Lange LA, Larson MG, Laurie C, Lee J, Lee S, Lewis JP, Metcalf GA, Mitchell BD, Momin Z, Muzny DM, Pankratz N, Park CJ, Rich SS, Rotter JI, Ryan K, Seo D, Tracy RP, Viaud-Martinez KA, Yanek LR, Zhao LP, Lin X, Li B, Li Y, Dupuis J, Reiner AP, Mohlke KL, Auer PL, , . Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts. Am. J. Hum. Genet [print-electronic]. 2020 Jan 1/2/2020; 106(1): 112-20. PMID: 31883642, PMCID: PMC7042494, PII: S0002-9297(19)30466-5, DOI: 10.1016/j.ajhg.2019.12.002, ISSN: 1537-6605.
Feng Q, Wei WQ, Chaugai S, Carranza Leon BG, Kawai V, Carranza Leon DA, Jiang L, Zhong X, Liu G, Ihegword A, Shaffer CM, Linton MF, Chung CP, Stein CM. A Genetic Approach to the Association Between PCSK9 and Sepsis. JAMA Netw Open. 2019 Sep 9/4/2019; 2(9): e1911130. PMID: 31509211, PMCID: PMC6739725, PII: 2749565, DOI: 10.1001/jamanetworkopen.2019.11130, ISSN: 2574-3805.
Wang Q, Chen R, Cheng F, Wei Q, Ji Y, Yang H, Zhong X, Tao R, Wen Z, Sutcliffe JS, Liu C, Cook EH, Cox NJ, Li B. A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data. Nat. Neurosci [print-electronic]. 2019 May; 22(5): 691-9. PMID: 30988527, PMCID: PMC6646046, PII: 10.1038/s41593-019-0382-7, DOI: 10.1038/s41593-019-0382-7, ISSN: 1546-1726.
Unlu G, Gamazon ER, Qi X, Levic DS, Bastarache L, Denny JC, Roden DM, Mayzus I, Breyer M, Zhong X, Konkashbaev AI, Rzhetsky A, Knapik EW, Cox NJ. GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish. Am. J. Hum. Genet [print-electronic]. 2019 Mar 3/7/2019; 104(3): 503-19. PMID: 30827500, PMCID: PMC6407495, PII: S0002-9297(19)30017-5, DOI: 10.1016/j.ajhg.2019.01.017, ISSN: 1537-6605.
Polfus LM, Raffield LM, Wheeler MM, Tracy RP, Lange LA, Lettre G, Miller A, Correa A, Bowler RP, Bis JC, Salimi S, Jenny NS, Pankratz N, Wang B, Preuss MH, Zhou L, Moscati A, Nadkarni GN, Loos RJF, Zhong X, Li B, Johnsen JM, Nickerson DA, Reiner AP, Auer PL, . Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans. Hum. Mol. Genet. 2019 Feb 2/1/2019; 28(3): 515-23. PMID: 30307499, PMCID: PMC6337694, PII: 5126494, DOI: 10.1093/hmg/ddy360, ISSN: 1460-2083.
Laroumanie F, Korneva A, Bersi MR, Alexander MR, Xiao L, Zhong X, Van Beusecum JP, Chen Y, Saleh MA, McMaster WG, Gavulic KA, Dale BL, Zhao S, Guo Y, Shyr Y, Perrien DS, Cox NJ, Curci JA, Humphrey JD, Madhur MS. LNK deficiency promotes acute aortic dissection and rupture. JCI Insight. 2018 Oct 10/18/2018; 3(20): PMID: 30333305, PMCID: PMC6237478, PII: 122558, DOI: 10.1172/jci.insight.122558, ISSN: 2379-3708.
Hu Y, Raffield LM, Polfus LM, Moscati A, Nadkarni G, Preuss MH, Zhong X, Wei Q, Rich SS, Li Y, Wilson JG, Correa A, Loos RJF, Li B, Auer PL, Reiner AP, . A common TCN1 loss-of-function variant is associated with lower vitamin B12 concentration in African Americans [letter]. Blood [print-electronic]. 2018 Jun 6/21/2018; 131(25): 2859-63. PMID: 29764838, PMCID: PMC6014360, PII: blood-2018-03-841023, DOI: 10.1182/blood-2018-03-841023, ISSN: 1528-0020.
Wei Q, Ye Z, Zhong X, Li L, Wang C, Myers RE, Palazzo JP, Fortuna D, Yan A, Waldman SA, Chen X, Posey JA, Basu-Mallick A, Jiang BH, Hou L, Shu J, Sun Y, Xing J, Li B, Yang H. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis. Ann. Oncol. 2017 Sep 9/1/2017; 28(9): 2135-41. PMID: 28911083, PMCID: PMC5834069, PII: S0923-7534(19)35240-8, DOI: 10.1093/annonc/mdx278, ISSN: 1569-8041.
Yang H, Wei Q, Zhong X, Yang H, Li B. Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework. Bioinformatics. 2017 Feb 2/15/2017; 33(4): 483-90. PMID: 27797769, PMCID: PMC6075201, PII: btw662, DOI: 10.1093/bioinformatics/btw662, ISSN: 1367-4811.
Liu Q, Zhong X, Madison BB, Rustgi AK, Shyr Y. Assessing Computational Steps for CLIP-Seq Data Analysis. Biomed Res Int. 2015 Oct 10/11/2015; 2015: 196082. PMID: 26539468, PMCID: PMC4619761, DOI: 10.1155/2015/196082, ISSN: 2314-6141.
Zhong X, Yang H, Zhao S, Shyr Y, Li B. Network-based stratification analysis of 13 major cancer types using mutations in panels of cancer genes. BMC Genomics. 2015 Jun 6/11/2015; 16(Suppl 7):S7.
Li B, Wei Q, Zhan X, Zhong X, Chen W, Li C, Haines J. Leveraging Identity-by-Descent for Accurate Genotype Inference in Family Sequencing Data. PLoS Genet. 2015 Jun; 11(6): e1005271. PMID: 26043085, PMCID: PMC4456389, PII: PGENETICS-D-14-01420, DOI: 10.1371/journal.pgen.1005271, ISSN: 1553-7404.
Chen R, Wei Q, Zhan X, Zhong X, Sutcliffe JS, Cox NJ, Cook EH, Li C, Chen W, Li B. A haplotype-based framework for group-wise transmission/disequilibrium tests for rare variant association analysis. Bioinformatics [print-electronic]. 2015 May 5/1/2015; 31(9): 1452-9. PMID: 25568282, PMCID: PMC4410665, PII: btu860, DOI: 10.1093/bioinformatics/btu860, ISSN: 1367-4811.
Wei Q, Zhan X, Zhong X, Liu Y, Han Y, Chen W, Li B. A Bayesian framework for de novo mutation calling in parents-offspring trios. Bioinformatics [print-electronic]. 2015 May 5/1/2015; 31(9): 1375-81. PMID: 25535243, PMCID: PMC4410659, PII: btu839, DOI: 10.1093/bioinformatics/btu839, ISSN: 1367-4811.
Guo Y, He J, Zhao S, Wu H, Zhong X, Sheng Q, Samuels DC, Shyr Y, Long J. Illumina human exome genotyping array clustering and quality control. Nat Protoc [print-electronic]. 2014 Nov; 9(11): 2643-62. PMID: 25321409, PMCID: PMC4441213, PII: nprot.2014.174, DOI: 10.1038/nprot.2014.174, ISSN: 1750-2799.
Guo Y, Bosompem A, Zhong X, Clark T, Shyr Y, Kim AS. A comparison of microRNA sequencing reproducibility and noise reduction using mirVana and TRIzol isolation methods. Int J Comput Biol Drug Des [print-electronic]. 2014; 7(2-3): 102-12. PMID: 24878723, PMCID: PMC5798231, PII: IJCBDD.2014.061642, DOI: 10.1504/IJCBDD.2014.061642, ISSN: 1756-0756.
Hou D, Zhou X, Zhong X, Settles ML, Herring J, Wang L, Abdo Z, Forney LJ, Xu C. Microbiota of the seminal fluid from healthy and infertile men. Fertil. Steril [print-electronic]. 2013 Nov; 100(5): 1261-9. PMID: 23993888, PMCID: PMC3888793, PII: S0015-0282(13)02777-5, DOI: 10.1016/j.fertnstert.2013.07.1991, ISSN: 1556-5653.
Madison BB, Liu Q, Zhong X, Hahn CM, Lin N, Emmett MJ, Stanger BZ, Lee JS, Rustgi AK. LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev. 2013 Oct 10/15/2013; 27(20): 2233-45. PMID: 24142874, PMCID: PMC3814644, PII: 27/20/2233, DOI: 10.1101/gad.224659.113, ISSN: 1549-5477.
Gajer P, Brotman RM, Bai G, Sakamoto J, Schütte UM, Zhong X, Koenig SS, Fu L, Ma ZS, Zhou X, Abdo Z, Forney LJ, Ravel J. Temporal dynamics of the human vaginal microbiota. Sci Transl Med. 2012 May 5/2/2012; 4(132): 132ra52. PMID: 22553250, PMCID: PMC3722878, PII: 4/132/132ra52, DOI: 10.1126/scitranslmed.3003605, ISSN: 1946-6242.
Zhong X, Droesch J, Fox R, Top EM, Krone SM. On the meaning and estimation of plasmid transfer rates for surface-associated and well-mixed bacterial populations. J. Theor. Biol [print-electronic]. 2012 Feb 2/7/2012; 294: 144-52. PMID: 22085738, PMCID: PMC3346278, PII: S0022-5193(11)00557-1, DOI: 10.1016/j.jtbi.2011.10.034, ISSN: 1095-8541.
Rohani P, Zhong X, King AA. Contact network structure explains the changing epidemiology of pertussis. Science. 2010 Nov 11/12/2010; 330(6006): 982-5. PMID: 21071671, PII: 330/6006/982, DOI: 10.1126/science.1194134, ISSN: 1095-9203.
Zhong X, Krol JE, Top EM, Krone SM. Accounting for mating pair formation in plasmid population dynamics. J. Theor. Biol [print-electronic]. 2010 Feb 2/21/2010; 262(4): 711-9. PMID: 19835890, PMCID: PMC2821984, PII: S0022-5193(09)00488-3, DOI: 10.1016/j.jtbi.2009.10.013, ISSN: 1095-8541.
Fox RE, Zhong X, Krone SM, Top EM. Spatial structure and nutrients promote invasion of IncP-1 plasmids in bacterial populations. ISME J [print-electronic]. 2008 Oct; 2(10): 1024-39. PMID: 18528415, PMCID: PMC2605096, PII: ismej200853, DOI: 10.1038/ismej.2008.53, ISSN: 1751-7370.