Faculty Appointments
Research Assistant Professor of Medicine
Education
M.S., Biostatistics, Vanderbilt University, Nashville, TennesseePh.D., Bioinformatics and computational biology, University of Idaho, Moscow, IdahoM.S., Mathematics, University of Idaho, Moscow, IdahoB.S., Mathematics, Nanjing University, Nanjing, China
Office Address
2525 West End, Suite 730
Nashville, TN 37203
Nashville, TN 37203
Research Description
Dr. Zhong is a Research Assistant Professor in Genetic Medicine at the Vanderbilt University School of Medicine. Trained in mathematics, computational biology and statistics, her expertise spans spatial models and network approaches. Dr. Zhong's current research focuses on integrating multi-modal omics data to identify risk genes for complex diseases including Alzheimer’s Disease. Dr. Zhong has led several projects utilizing electronic health records (EHRs) and biobank data to advance the understanding of the effect of genetic variation on human phenotypic heterogeneity. In recent years, Dr. Zhong has devoted significant efforts to disease risk gene discovery and validation to aid genetics-informed drug discovery and therapeutic development. She is an awardee of an Alzheimer’s Pilot & Feasibility Project from the Vanderbilt Diabetes Research and Training Center studying repurposing of anti-diabetic medicines toward Alzheimer's disease.
Research Keywords
Alzheimer's disease, Genetics-informed therapeutic discovery, drug repurposing, Electronic health records (EHRs), Biobank
Publications
Wang C, Markus H, Diwadkar AR, Khunsriraksakul C, Carrel L, Li B, Zhong X, Wang X, Zhan X, Foulke GT, Olsen NJ, Liu DJ, Jiang B. Integrating electronic health records and GWAS summary statistics to predict the progression of autoimmune diseases from preclinical stages. Nat Commun. 2025 Jan 1/2/2025; 16(1): 180. PMID: 39747168, PMCID: PMC11695684, PII: 10.1038/s41467-024-55636-6, DOI: 10.1038/s41467-024-55636-6, ISSN: 2041-1723.
Lo Faro V, Bhattacharya A, Zhou W, Zhou D, Wang Y, Läll K, Kanai M, Lopera-Maya E, Straub P, Pawar P, Tao R, Zhong X, Namba S, , Sanna S, Nolte IM, Okada Y, Ingold N, MacGregor S, Snieder H, Surakka I, Shortt J, Gignoux C, Rafaels N, Crooks K, Verma A, Verma SS, Guare L, Rader DJ, Willer C, Martin AR, Brantley MA, Gamazon ER, Jansonius NM, Joos K, Cox NJ, Hirbo J. Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation. Cell Rep Med. 2024 Feb 2/20/2024; 5(2): 101430. PMID: 38382466, PMCID: PMC10897632, PII: S2666-3791(24)00053-3, DOI: 10.1016/j.xcrm.2024.101430, ISSN: 2666-3791.
Jia G, Li Y, Zhong X, Wang K, Pividori M, Alomairy R, Esposito A, Ltaief H, Terao C, Akiyama M, Matsuda K, Keyes DE, Im HK, Gojobori T, Kamatani Y, Kubo M, Cox NJ, Evans J, Gao X, Rzhetsky A. The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci. Nat Comput Sci [print-electronic]. 2023 May; 3(5): 403-17. PMID: 38177845, PMCID: PMC10766526, PII: 10.1038/s43588-023-00453-y, DOI: 10.1038/s43588-023-00453-y, ISSN: 2662-8457.
Khunsriraksakul C, Li Q, Markus H, Patrick MT, Sauteraud R, McGuire D, Wang X, Wang C, Wang L, Chen S, Shenoy G, Li B, Zhong X, Olsen NJ, Carrel L, Tsoi LC, Jiang B, Liu DJ. Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus. Nat Commun. 2023 Feb 2/7/2023; 14(1): 668. PMID: 36750564, PMCID: PMC9905560, PII: 10.1038/s41467-023-36306-5, DOI: 10.1038/s41467-023-36306-5, ISSN: 2041-1723.
Coral DE, Fernandez-Tajes J, Tsereteli N, Pomares-Millan H, Fitipaldi H, Mutie PM, Atabaki-Pasdar N, Kalamajski S, Poveda A, Miller-Fleming TW, Zhong X, Giordano GN, Pearson ER, Cox NJ, Franks PW. A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes. Nat Metab [print-electronic]. 2023 Feb; 5(2): 237-47. PMID: 36703017, PMCID: PMC9970876, PII: 10.1038/s42255-022-00731-5, DOI: 10.1038/s42255-022-00731-5, ISSN: 2522-5812.
Wang Y, Namba S, Lopera E, Kerminen S, Tsuo K, Läll K, Kanai M, Zhou W, Wu KH, Favé MJ, Bhatta L, Awadalla P, Brumpton B, Deelen P, Hveem K, Lo Faro V, Mägi R, Murakami Y, Sanna S, Smoller JW, Uzunovic J, Wolford BN, , Willer C, Gamazon ER, Cox NJ, Surakka I, Okada Y, Martin AR, Hirbo J. Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts. Cell Genom. 2023 Jan 1/11/2023; 3(1): 100241. PMID: 36777179, PMCID: PMC9903818, PII: S2666-979X(22)00204-X, DOI: 10.1016/j.xgen.2022.100241, ISSN: 2666-979X.
Kanai M, Elzur R, Zhou W, , Daly MJ, Finucane HK. Meta-analysis fine-mapping is often miscalibrated at single-variant resolution. Cell Genom [print-electronic]. 2022 Dec 12/14/2022; 2(12): PMID: 36643910, PMCID: PMC9839193, PII: 100210, DOI: 10.1016/j.xgen.2022.100210, ISSN: 2666-979X.
Jia G, Zhong X, Im HK, Schoettler N, Pividori M, Hogarth DK, Sperling AI, White SR, Naureckas ET, Lyttle CS, Terao C, Kamatani Y, Akiyama M, Matsuda K, Kubo M, Cox NJ, Ober C, Rzhetsky A, Solway J. Discerning asthma endotypes through comorbidity mapping. Nat Commun. 2022 Nov 11/7/2022; 13(1): 6712. PMID: 36344522, PMCID: PMC9640644, PII: 10.1038/s41467-022-33628-8, DOI: 10.1038/s41467-022-33628-8, ISSN: 2041-1723.
Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN, Lo Faro V, Lopera-Maya EA, Läll K, Favé MJ, Partanen JJ, Chapman SB, Karjalainen J, Kurki M, Maasha M, Brumpton BM, Chavan S, Chen TT, Daya M, Ding Y, Feng YA, Guare LA, Gignoux CR, Graham SE, Hornsby WE, Ingold N, Ismail SI, Johnson R, Laisk T, Lin K, Lv J, Millwood IY, Moreno-Grau S, Nam K, Palta P, Pandit A, Preuss MH, Saad C, Setia-Verma S, Thorsteinsdottir U, Uzunovic J, Verma A, Zawistowski M, Zhong X, Afifi N, Al-Dabhani KM, Al Thani A, Bradford Y, Campbell A, Crooks K, de Bock GH, Damrauer SM, Douville NJ, Finer S, Fritsche LG, Fthenou E, Gonzalez-Arroyo G, Griffiths CJ, Guo Y, Hunt KA, Ioannidis A, Jansonius NM, Konuma T, Lee MTM, Lopez-Pineda A, Matsuda Y, Marioni RE, Moatamed B, Nava-Aguilar MA, Numakura K, Patil S, Rafaels N, Richmond A, Rojas-Muñoz A, Shortt JA, Straub P, Tao R, Vanderwerff B, Vernekar M, Veturi Y, Barnes KC, Boezen M, Chen Z, Chen CY, Cho J, Smith GD, Finucane HK, Franke L, Gamazon ER, Ganna A, Gaunt TR, Ge T, Huang H, Huffman J, Katsanis N, Koskela JT, Lajonchere C, Law MH, Li L, Lindgren CM, Loos RJF, MacGregor S, Matsuda K, Olsen CM, Porteous DJ, Shavit JA, Snieder H, Takano T, Trembath RC, Vonk JM, Whiteman DC, Wicks SJ, Wijmenga C, Wright J, Zheng J, Zhou X, Awadalla P, Boehnke M, Bustamante CD, Cox NJ, Fatumo S, Geschwind DH, Hayward C, Hveem K, Kenny EE, Lee S, Lin YF, Mbarek H, Mägi R, Martin HC, Medland SE, Okada Y, Palotie AV, Pasaniuc B, Rader DJ, Ritchie MD, Sanna S, Smoller JW, Stefansson K, van Heel DA, Walters RG, Zöllner S, , , , , , , , , , , , , , , , , , , , , , , , , Martin AR, Willer CJ, Daly MJ, Neale BM. Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease. Cell Genom. 2022 Oct 10/12/2022; 2(10): 100192. PMID: 36777996, PMCID: PMC9903716, PII: S2666-979X(22)00141-0, DOI: 10.1016/j.xgen.2022.100192, ISSN: 2666-979X.
Vysotskiy M, Zhong X, Miller-Fleming TW, Zhou D, , , , Cox NJ, Weiss LA. Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes. Genome Med. 2021 Oct 10/29/2021; 13(1): 172. PMID: 34715901, PMCID: PMC8557010, PII: 10.1186/s13073-021-00972-1, DOI: 10.1186/s13073-021-00972-1, ISSN: 1756-994X.
Mikhaylova AV, McHugh CP, Polfus LM, Raffield LM, Boorgula MP, Blackwell TW, Brody JA, Broome J, Chami N, Chen MH, Conomos MP, Cox C, Curran JE, Daya M, Ekunwe L, Glahn DC, Heard-Costa N, Highland HM, Hobbs BD, Ilboudo Y, Jain D, Lange LA, Miller-Fleming TW, Min N, Moon JY, Preuss MH, Rosen J, Ryan K, Smith AV, Sun Q, Surendran P, de Vries PS, Walter K, Wang Z, Wheeler M, Yanek LR, Zhong X, Abecasis GR, Almasy L, Barnes KC, Beaty TH, Becker LC, Blangero J, Boerwinkle E, Butterworth AS, Chavan S, Cho MH, Choquet H, Correa A, Cox N, DeMeo DL, Faraday N, Fornage M, Gerszten RE, Hou L, Johnson AD, Jorgenson E, Kaplan R, Kooperberg C, Kundu K, Laurie CA, Lettre G, Lewis JP, Li B, Li Y, Lloyd-Jones DM, Loos RJF, Manichaikul A, Meyers DA, Mitchell BD, Morrison AC, Ngo D, Nickerson DA, Nongmaithem S, North KE, O'Connell JR, Ortega VE, Pankratz N, Perry JA, Psaty BM, Rich SS, Soranzo N, Rotter JI, Silverman EK, Smith NL, Tang H, Tracy RP, Thornton TA, Vasan RS, Zein J, Mathias RA, , Reiner AP, Auer PL. Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program. Am J Hum Genet [print-electronic]. 2021 Oct 10/7/2021; 108(10): 1836-51. PMID: 34582791, PMCID: PMC8546043, PII: S0002-9297(21)00306-2, DOI: 10.1016/j.ajhg.2021.08.007, ISSN: 1537-6605.
Zhou D, Jiang Y, Zhong X, Cox NJ, Liu C, Gamazon ER. A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis. Nat Genet [print-electronic]. 2020 Nov; 52(11): 1239-46. PMID: 33020666, PMCID: PMC7606598, PII: 10.1038/s41588-020-0706-2, DOI: 10.1038/s41588-020-0706-2, ISSN: 1546-1718.
Chen MH, Raffield LM, Mousas A, Sakaue S, Huffman JE, Moscati A, Trivedi B, Jiang T, Akbari P, Vuckovic D, Bao EL, Zhong X, Manansala R, Laplante V, Chen M, Lo KS, Qian H, Lareau CA, Beaudoin M, Hunt KA, Akiyama M, Bartz TM, Ben-Shlomo Y, Beswick A, Bork-Jensen J, Bottinger EP, Brody JA, van Rooij FJA, Chitrala K, Cho K, Choquet H, Correa A, Danesh J, Di Angelantonio E, Dimou N, Ding J, Elliott P, Esko T, Evans MK, Floyd JS, Broer L, Grarup N, Guo MH, Greinacher A, Haessler J, Hansen T, Howson JMM, Huang QQ, Huang W, Jorgenson E, Kacprowski T, Kähönen M, Kamatani Y, Kanai M, Karthikeyan S, Koskeridis F, Lange LA, Lehtimäki T, Lerch MM, Linneberg A, Liu Y, Lyytikäinen LP, Manichaikul A, Martin HC, Matsuda K, Mohlke KL, Mononen N, Murakami Y, Nadkarni GN, Nauck M, Nikus K, Ouwehand WH, Pankratz N, Pedersen O, Preuss M, Psaty BM, Raitakari OT, Roberts DJ, Rich SS, Rodriguez BAT, Rosen JD, Rotter JI, Schubert P, Spracklen CN, Surendran P, Tang H, Tardif JC, Trembath RC, Ghanbari M, Völker U, Völzke H, Watkins NA, Zonderman AB, , Wilson PWF, Li Y, Butterworth AS, Gauchat JF, Chiang CWK, Li B, Loos RJF, Astle WJ, Evangelou E, van Heel DA, Sankaran VG, Okada Y, Soranzo N, Johnson AD, Reiner AP, Auer PL, Lettre G. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. Cell. 2020 Sep 9/3/2020; 182(5): 1198-1213.e14-1213.e14. PMID: 32888493, PMCID: PMC7480402, PII: S0092-8674(20)30822-9, DOI: 10.1016/j.cell.2020.06.045, ISSN: 1097-4172.
Zhong X, Yin Z, Jia G, Zhou D, Wei Q, Faucon A, Evans P, Gamazon ER, Li B, Tao R, Rzhetsky A, Bastarache L, Cox NJ. Electronic health record phenotypes associated with genetically regulated expression of CFTR and application to cystic fibrosis. Genet. Med [print-electronic]. 2020 Apr 4/16/2020; PMID: 32296164, PII: 10.1038/s41436-020-0786-5, DOI: 10.1038/s41436-020-0786-5, ISSN: 1530-0366.
Raffield LM, Iyengar AK, Wang B, Gaynor SM, Spracklen CN, Zhong X, Kowalski MH, Salimi S, Polfus LM, Benjamin EJ, Bis JC, Bowler R, Cade BE, Choi WJ, Comellas AP, Correa A, Cruz P, Doddapaneni H, Durda P, Gogarten SM, Jain D, Kim RW, Kral BG, Lange LA, Larson MG, Laurie C, Lee J, Lee S, Lewis JP, Metcalf GA, Mitchell BD, Momin Z, Muzny DM, Pankratz N, Park CJ, Rich SS, Rotter JI, Ryan K, Seo D, Tracy RP, Viaud-Martinez KA, Yanek LR, Zhao LP, Lin X, Li B, Li Y, Dupuis J, Reiner AP, Mohlke KL, Auer PL, , . Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts. Am. J. Hum. Genet [print-electronic]. 2020 Jan 1/2/2020; 106(1): 112-20. PMID: 31883642, PMCID: PMC7042494, PII: S0002-9297(19)30466-5, DOI: 10.1016/j.ajhg.2019.12.002, ISSN: 1537-6605.
Feng Q, Wei WQ, Chaugai S, Carranza Leon BG, Kawai V, Carranza Leon DA, Jiang L, Zhong X, Liu G, Ihegword A, Shaffer CM, Linton MF, Chung CP, Stein CM. A Genetic Approach to the Association Between PCSK9 and Sepsis. JAMA Netw Open. 2019 Sep 9/4/2019; 2(9): e1911130. PMID: 31509211, PMCID: PMC6739725, PII: 2749565, DOI: 10.1001/jamanetworkopen.2019.11130, ISSN: 2574-3805.
Wang Q, Chen R, Cheng F, Wei Q, Ji Y, Yang H, Zhong X, Tao R, Wen Z, Sutcliffe JS, Liu C, Cook EH, Cox NJ, Li B. A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data. Nat. Neurosci [print-electronic]. 2019 May; 22(5): 691-9. PMID: 30988527, PMCID: PMC6646046, PII: 10.1038/s41593-019-0382-7, DOI: 10.1038/s41593-019-0382-7, ISSN: 1546-1726.
Unlu G, Gamazon ER, Qi X, Levic DS, Bastarache L, Denny JC, Roden DM, Mayzus I, Breyer M, Zhong X, Konkashbaev AI, Rzhetsky A, Knapik EW, Cox NJ. GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish. Am. J. Hum. Genet [print-electronic]. 2019 Mar 3/7/2019; 104(3): 503-19. PMID: 30827500, PMCID: PMC6407495, PII: S0002-9297(19)30017-5, DOI: 10.1016/j.ajhg.2019.01.017, ISSN: 1537-6605.
Polfus LM, Raffield LM, Wheeler MM, Tracy RP, Lange LA, Lettre G, Miller A, Correa A, Bowler RP, Bis JC, Salimi S, Jenny NS, Pankratz N, Wang B, Preuss MH, Zhou L, Moscati A, Nadkarni GN, Loos RJF, Zhong X, Li B, Johnsen JM, Nickerson DA, Reiner AP, Auer PL, . Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans. Hum. Mol. Genet. 2019 Feb 2/1/2019; 28(3): 515-23. PMID: 30307499, PMCID: PMC6337694, PII: 5126494, DOI: 10.1093/hmg/ddy360, ISSN: 1460-2083.
Laroumanie F, Korneva A, Bersi MR, Alexander MR, Xiao L, Zhong X, Van Beusecum JP, Chen Y, Saleh MA, McMaster WG, Gavulic KA, Dale BL, Zhao S, Guo Y, Shyr Y, Perrien DS, Cox NJ, Curci JA, Humphrey JD, Madhur MS. LNK deficiency promotes acute aortic dissection and rupture. JCI Insight. 2018 Oct 10/18/2018; 3(20): PMID: 30333305, PMCID: PMC6237478, PII: 122558, DOI: 10.1172/jci.insight.122558, ISSN: 2379-3708.
Hu Y, Raffield LM, Polfus LM, Moscati A, Nadkarni G, Preuss MH, Zhong X, Wei Q, Rich SS, Li Y, Wilson JG, Correa A, Loos RJF, Li B, Auer PL, Reiner AP, . A common TCN1 loss-of-function variant is associated with lower vitamin B12 concentration in African Americans [letter]. Blood [print-electronic]. 2018 Jun 6/21/2018; 131(25): 2859-63. PMID: 29764838, PMCID: PMC6014360, PII: blood-2018-03-841023, DOI: 10.1182/blood-2018-03-841023, ISSN: 1528-0020.
Wei Q, Ye Z, Zhong X, Li L, Wang C, Myers RE, Palazzo JP, Fortuna D, Yan A, Waldman SA, Chen X, Posey JA, Basu-Mallick A, Jiang BH, Hou L, Shu J, Sun Y, Xing J, Li B, Yang H. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis. Ann. Oncol. 2017 Sep 9/1/2017; 28(9): 2135-41. PMID: 28911083, PMCID: PMC5834069, PII: S0923-7534(19)35240-8, DOI: 10.1093/annonc/mdx278, ISSN: 1569-8041.
Yang H, Wei Q, Zhong X, Yang H, Li B. Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework. Bioinformatics. 2017 Feb 2/15/2017; 33(4): 483-90. PMID: 27797769, PMCID: PMC6075201, PII: btw662, DOI: 10.1093/bioinformatics/btw662, ISSN: 1367-4811.
Liu Q, Zhong X, Madison BB, Rustgi AK, Shyr Y. Assessing Computational Steps for CLIP-Seq Data Analysis. Biomed Res Int. 2015 Oct 10/11/2015; 2015: 196082. PMID: 26539468, PMCID: PMC4619761, DOI: 10.1155/2015/196082, ISSN: 2314-6141.
Zhong X, Yang H, Zhao S, Shyr Y, Li B. Network-based stratification analysis of 13 major cancer types using mutations in panels of cancer genes. BMC Genomics. 2015 Jun 6/11/2015; 16(Suppl 7):S7.
Li B, Wei Q, Zhan X, Zhong X, Chen W, Li C, Haines J. Leveraging Identity-by-Descent for Accurate Genotype Inference in Family Sequencing Data. PLoS Genet. 2015 Jun; 11(6): e1005271. PMID: 26043085, PMCID: PMC4456389, PII: PGENETICS-D-14-01420, DOI: 10.1371/journal.pgen.1005271, ISSN: 1553-7404.
Chen R, Wei Q, Zhan X, Zhong X, Sutcliffe JS, Cox NJ, Cook EH, Li C, Chen W, Li B. A haplotype-based framework for group-wise transmission/disequilibrium tests for rare variant association analysis. Bioinformatics [print-electronic]. 2015 May 5/1/2015; 31(9): 1452-9. PMID: 25568282, PMCID: PMC4410665, PII: btu860, DOI: 10.1093/bioinformatics/btu860, ISSN: 1367-4811.
Wei Q, Zhan X, Zhong X, Liu Y, Han Y, Chen W, Li B. A Bayesian framework for de novo mutation calling in parents-offspring trios. Bioinformatics [print-electronic]. 2015 May 5/1/2015; 31(9): 1375-81. PMID: 25535243, PMCID: PMC4410659, PII: btu839, DOI: 10.1093/bioinformatics/btu839, ISSN: 1367-4811.
Guo Y, He J, Zhao S, Wu H, Zhong X, Sheng Q, Samuels DC, Shyr Y, Long J. Illumina human exome genotyping array clustering and quality control. Nat Protoc [print-electronic]. 2014 Nov; 9(11): 2643-62. PMID: 25321409, PMCID: PMC4441213, PII: nprot.2014.174, DOI: 10.1038/nprot.2014.174, ISSN: 1750-2799.
Guo Y, Bosompem A, Zhong X, Clark T, Shyr Y, Kim AS. A comparison of microRNA sequencing reproducibility and noise reduction using mirVana and TRIzol isolation methods. Int J Comput Biol Drug Des [print-electronic]. 2014; 7(2-3): 102-12. PMID: 24878723, PMCID: PMC5798231, PII: IJCBDD.2014.061642, DOI: 10.1504/IJCBDD.2014.061642, ISSN: 1756-0756.
Hou D, Zhou X, Zhong X, Settles ML, Herring J, Wang L, Abdo Z, Forney LJ, Xu C. Microbiota of the seminal fluid from healthy and infertile men. Fertil. Steril [print-electronic]. 2013 Nov; 100(5): 1261-9. PMID: 23993888, PMCID: PMC3888793, PII: S0015-0282(13)02777-5, DOI: 10.1016/j.fertnstert.2013.07.1991, ISSN: 1556-5653.
Madison BB, Liu Q, Zhong X, Hahn CM, Lin N, Emmett MJ, Stanger BZ, Lee JS, Rustgi AK. LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev. 2013 Oct 10/15/2013; 27(20): 2233-45. PMID: 24142874, PMCID: PMC3814644, PII: 27/20/2233, DOI: 10.1101/gad.224659.113, ISSN: 1549-5477.
Gajer P, Brotman RM, Bai G, Sakamoto J, Schütte UM, Zhong X, Koenig SS, Fu L, Ma ZS, Zhou X, Abdo Z, Forney LJ, Ravel J. Temporal dynamics of the human vaginal microbiota. Sci Transl Med. 2012 May 5/2/2012; 4(132): 132ra52. PMID: 22553250, PMCID: PMC3722878, PII: 4/132/132ra52, DOI: 10.1126/scitranslmed.3003605, ISSN: 1946-6242.
Zhong X, Droesch J, Fox R, Top EM, Krone SM. On the meaning and estimation of plasmid transfer rates for surface-associated and well-mixed bacterial populations. J. Theor. Biol [print-electronic]. 2012 Feb 2/7/2012; 294: 144-52. PMID: 22085738, PMCID: PMC3346278, PII: S0022-5193(11)00557-1, DOI: 10.1016/j.jtbi.2011.10.034, ISSN: 1095-8541.
Rohani P, Zhong X, King AA. Contact network structure explains the changing epidemiology of pertussis. Science. 2010 Nov 11/12/2010; 330(6006): 982-5. PMID: 21071671, PII: 330/6006/982, DOI: 10.1126/science.1194134, ISSN: 1095-9203.
Zhong X, Krol JE, Top EM, Krone SM. Accounting for mating pair formation in plasmid population dynamics. J. Theor. Biol [print-electronic]. 2010 Feb 2/21/2010; 262(4): 711-9. PMID: 19835890, PMCID: PMC2821984, PII: S0022-5193(09)00488-3, DOI: 10.1016/j.jtbi.2009.10.013, ISSN: 1095-8541.
Fox RE, Zhong X, Krone SM, Top EM. Spatial structure and nutrients promote invasion of IncP-1 plasmids in bacterial populations. ISME J [print-electronic]. 2008 Oct; 2(10): 1024-39. PMID: 18528415, PMCID: PMC2605096, PII: ismej200853, DOI: 10.1038/ismej.2008.53, ISSN: 1751-7370.
Lo Faro V, Bhattacharya A, Zhou W, Zhou D, Wang Y, Läll K, Kanai M, Lopera-Maya E, Straub P, Pawar P, Tao R, Zhong X, Namba S, , Sanna S, Nolte IM, Okada Y, Ingold N, MacGregor S, Snieder H, Surakka I, Shortt J, Gignoux C, Rafaels N, Crooks K, Verma A, Verma SS, Guare L, Rader DJ, Willer C, Martin AR, Brantley MA, Gamazon ER, Jansonius NM, Joos K, Cox NJ, Hirbo J. Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation. Cell Rep Med. 2024 Feb 2/20/2024; 5(2): 101430. PMID: 38382466, PMCID: PMC10897632, PII: S2666-3791(24)00053-3, DOI: 10.1016/j.xcrm.2024.101430, ISSN: 2666-3791.
Jia G, Li Y, Zhong X, Wang K, Pividori M, Alomairy R, Esposito A, Ltaief H, Terao C, Akiyama M, Matsuda K, Keyes DE, Im HK, Gojobori T, Kamatani Y, Kubo M, Cox NJ, Evans J, Gao X, Rzhetsky A. The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci. Nat Comput Sci [print-electronic]. 2023 May; 3(5): 403-17. PMID: 38177845, PMCID: PMC10766526, PII: 10.1038/s43588-023-00453-y, DOI: 10.1038/s43588-023-00453-y, ISSN: 2662-8457.
Khunsriraksakul C, Li Q, Markus H, Patrick MT, Sauteraud R, McGuire D, Wang X, Wang C, Wang L, Chen S, Shenoy G, Li B, Zhong X, Olsen NJ, Carrel L, Tsoi LC, Jiang B, Liu DJ. Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus. Nat Commun. 2023 Feb 2/7/2023; 14(1): 668. PMID: 36750564, PMCID: PMC9905560, PII: 10.1038/s41467-023-36306-5, DOI: 10.1038/s41467-023-36306-5, ISSN: 2041-1723.
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