Danxia Yu, Ph.D.

Assistant Professor

danxia.yu@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine
Education
Ph.D., Biochemistry and Molecular Biology, Chinese Academy of Sciences, Beijing, ChinaB.S., Chemistry, Beijing Normal University, Beijing, China
Office Address
2525 West End Ave
Nashville, TN 37203
Research Description
Dr. Yu’s major research interests include (1) epidemiology and prevention of chronic diseases through healthy diets and lifestyles; (2) biomarkers and metabolomics in type 2 diabetes and cardiovascular disease; and (3) diet-gut microbiota interactions and host cardio-metabolic health. Dr. Yu has identified several dietary factors and novel biomarkers in relation to the risk and mortality of major chronic diseases by using resources from large prospective cohort studies of multi-ethnic populations, including the Shanghai Women’s Health Study, the Shanghai Men’s Health Study, and the Southern Community Cohort Study. She has also played a leading role in multiple international consortium-based projects involving study participants from the US, Europe, and Asia. Dr. Yu’s current research projects focus on diet, gut microbial metabolism, and host cardiometabolic health by integrating advanced metagenomics and metabolomics technology into epidemiologic studies.
Research Keywords
Nutritional Epidemiology Cardiometabolic Diseases Gut Microbiota Metabolomics Cohort Consortium
Publications
Yang JJ, Yu D, Shu XO, Freedman ND, Wen W, Rahman S, Abe SK, Saito E, Gupta PC, He J, Tsugane S, Gao YT, Xiang YB, Yuan JM, Tomata Y, Tsuji I, Sugawara Y, Matsuo K, Ahn YO, Park SK, Chen Y, Pan WH, Pednekar M, Gu D, Sawada N, Cai H, Li HL, Koh WP, Wang R, Zhang S, Kanemura S, Ito H, Shin MH, Wu PE, Yoo KY, Ahsan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W. Quantifying the association of low-intensity and late initiation of tobacco smoking with total and cause-specific mortality in Asia. Tob Control [print-electronic]. 2021 May; 30(3): 328-35. PMID: 32546664, PII: tobaccocontrol-2019-055412, DOI: 10.1136/tobaccocontrol-2019-055412, ISSN: 1468-3318.

Yang JJ, Shu XO, Herrington DM, Moore SC, Meyer KA, Ose J, Menni C, Palmer ND, Eliassen H, Harada S, Tzoulaki I, Zhu H, Albanes D, Wang TJ, Zheng W, Cai H, Ulrich CM, Guasch-Ferré M, Karaman I, Fornage M, Cai Q, Matthews CE, Wagenknecht LE, Elliott P, Gerszten RE, Yu D. Circulating trimethylamine N-oxide in association with diet and cardiometabolic biomarkers: an international pooled analysis. Am J Clin Nutr [print-electronic]. 2021 Apr 4/7/2021; PMID: 33826706, PII: 6214421, DOI: 10.1093/ajcn/nqaa430, ISSN: 1938-3207.

Yu D, Nguyen SM, Yang Y, Xu W, Cai H, Wu J, Cai Q, Long J, Zheng W, Shu XO. Long-term diet quality is associated with gut microbiome diversity and composition among urban Chinese adults. Am J Clin Nutr. 2021 Mar 3/11/2021; 113(3): 684-94. PMID: 33471054, PMCID: PMC7948864, PII: 6104801, DOI: 10.1093/ajcn/nqaa350, ISSN: 1938-3207.

Fan L, Yu D, Zhu X, Huang X, Murff HJ, Azcarate-Peril MA, Shrubsole MJ, Dai Q. Magnesium and imidazole propionate. Clin Nutr ESPEN [print-electronic]. 2021 Feb; 41: 436-8. PMID: 33487303, PMCID: PMC7835418, PII: S2405-4577(20)31117-7, DOI: 10.1016/j.clnesp.2020.12.011, ISSN: 2405-4577.

Chen S, Jiang PP, Yu D, Liao GC, Wu SL, Fang AP, Chen PY, Wang XY, Luo Y, Long JA, Zhong RH, Liu ZY, Li CL, Zhang DM, Zhu HL. Effects of probiotic supplementation on serum trimethylamine-N-oxide level and gut microbiota composition in young males: a double-blinded randomized controlled trial. Eur J Nutr [print-electronic]. 2020 May 5/21/2020; PMID: 32440731, PII: 10.1007/s00394-020-02278-1, DOI: 10.1007/s00394-020-02278-1, ISSN: 1436-6215.

Yang JJ, Yu D, Shu XO. Association of Dietary Fiber and Yogurt Consumption With Lung Cancer Risk-Reply. JAMA Oncol. 2020 May 5/1/2020; 6(5): 788-9. PMID: 32191280, PII: 2762588, DOI: 10.1001/jamaoncol.2020.0270, ISSN: 2374-2445.

Yoon HS, Jeong Yang J, Rivera ES, Shu XO, Xiang YB, Calcutt MW, Cai Q, Zhang X, Li H, Gao YT, Zheng W, Yu D. Urinary metabolites and risk of coronary heart disease: A prospective investigation among urban Chinese adults. Nutr Metab Cardiovasc Dis [print-electronic]. 2020 Mar 3/9/2020; 30(3): 467-73. PMID: 31831367, PMCID: PMC7044070, PII: S0939-4753(19)30410-7, DOI: 10.1016/j.numecd.2019.10.011, ISSN: 1590-3729.

Yang JJ, Lipworth LP, Shu XO, Blot WJ, Xiang YB, Steinwandel MD, Li H, Gao YT, Zheng W, Yu D. Associations of choline-related nutrients with cardiometabolic and all-cause mortality: results from 3 prospective cohort studies of blacks, whites, and Chinese. Am J Clin Nutr. 2020 Mar 3/1/2020; 111(3): 644-56. PMID: 31915809, PMCID: PMC7049525, PII: 5698394, DOI: 10.1093/ajcn/nqz318, ISSN: 1938-3207.

Wang F, Cai H, Gu K, Shi L, Yu D, Zhang M, Zheng W, Zheng Y, Bao P, Shu XO. Adherence to Dietary Recommendations among Long-Term Breast Cancer Survivors and Cancer Outcome Associations. Cancer Epidemiol Biomarkers Prev [print-electronic]. 2020 Feb; 29(2): 386-95. PMID: 31871105, PMCID: PMC7007374, PII: 1055-9965.EPI-19-0872, DOI: 10.1158/1055-9965.EPI-19-0872, ISSN: 1538-7755.

Yang JJ, Yu D, Xiang YB, Blot W, White E, Robien K, Sinha R, Park Y, Takata Y, Lazovich D, Gao YT, Zhang X, Lan Q, Bueno-de-Mesquita B, Johansson I, Tumino R, Riboli E, Tjønneland A, Skeie G, Quirós JR, Johansson M, Smith-Warner SA, Zheng W, Shu XO. Association of Dietary Fiber and Yogurt Consumption With Lung Cancer Risk: A Pooled Analysis. JAMA Oncol [print-electronic]. 2019 Oct 10/24/2019; PMID: 31647500, PMCID: PMC6813596, PII: 2753175, DOI: 10.1001/jamaoncol.2019.4107, ISSN: 2374-2445.

Liu N, Yang JJ, Meng R, Pan XF, Zhang X, He M, Li H, Gao YT, Xiang YB, Shu XO, Zheng W, Wu T, Yu D, Pan A. Associations of blood pressure categories defined by 2017 ACC/AHA guidelines with mortality in China: Pooled results from three prospective cohorts. Eur J Prev Cardiol [print-electronic]. 2019 Jul 7/9/2019; 2047487319862066. PMID: 31288541, DOI: 10.1177/2047487319862066, ISSN: 2047-4881.

Nguyen S, Li H, Yu D, Gao J, Gao Y, Tran H, Xiang YB, Zheng W, Shu XO. Adherence to dietary recommendations and colorectal cancer risk: results from two prospective cohort studies. Int J Epidemiol [print-electronic]. 2019 Jun 6/15/2019; PMID: 31203367, PII: 5519365, DOI: 10.1093/ije/dyz118, ISSN: 1464-3685.

Yang JJ, Yu D, Wen W, Saito E, Rahman S, Shu XO, Chen Y, Gupta PC, Gu D, Tsugane S, Xiang YB, Gao YT, Yuan JM, Tamakoshi A, Irie F, Sadakane A, Tomata Y, Kanemura S, Tsuji I, Matsuo K, Nagata C, Chen CJ, Koh WP, Shin MH, Park SK, Wu PE, Qiao YL, Pednekar MS, He J, Sawada N, Li HL, Gao J, Cai H, Wang R, Sairenchi T, Grant E, Sugawara Y, Zhang S, Ito H, Wada K, Shen CY, Pan WH, Ahn YO, You SL, Fan JH, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W. Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants. JAMA Netw Open. 2019 Apr 4/5/2019; 2(4): e192696. PMID: 31002328, PMCID: PMC6481439, PII: 2730789, DOI: 10.1001/jamanetworkopen.2019.2696, ISSN: 2574-3805.

Yang JJ, Yu D, Wen W, Shu XO, Saito E, Rahman S, Gupta PC, He J, Tsugane S, Xiang YB, Gao YT, Koh WP, Tamakoshi A, Irie F, Sadakane A, Tsuji I, Kanemura S, Matsuo K, Nagata C, Chen CJ, Yuan JM, Shin MH, Park SK, Pan WH, Qiao YL, Pednekar MS, Gu D, Sawada N, Li HL, Gao J, Cai H, Grant E, Tomata Y, Sugawara Y, Ito H, Wada K, Shen CY, Wang R, Ahn YO, You SL, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W. Tobacco Smoking and Mortality in Asia: A Pooled Meta-analysis. JAMA Netw Open. 2019 Mar 3/1/2019; 2(3): e191474. PMID: 30924901, PMCID: PMC6450311, PII: 2729479, DOI: 10.1001/jamanetworkopen.2019.1474, ISSN: 2574-3805.

Yu D, Shu XO, Rivera ES, Zhang X, Cai Q, Calcutt MW, Xiang YB, Li H, Gao YT, Wang TJ, Zheng W. Urinary Levels of Trimethylamine-N-Oxide and Incident Coronary Heart Disease: A Prospective Investigation Among Urban Chinese Adults. J Am Heart Assoc. 2019 Jan 1/8/2019; 8(1): e010606. PMID: 30606084, PMCID: PMC6405718, DOI: 10.1161/JAHA.118.010606, ISSN: 2047-9980.

Shu X, Zheng W, Yu D, Li HL, Lan Q, Yang G, Cai H, Ma X, Rothman N, Gao YT, Jia W, Xiang YB, Shu XO. Prospective metabolomics study identifies potential novel blood metabolites associated with pancreatic cancer risk. Int J Cancer [print-electronic]. 2018 Nov 11/1/2018; 143(9): 2161-7. PMID: 29717485, PMCID: PMC6195470, DOI: 10.1002/ijc.31574, ISSN: 1097-0215.

Yu D, Zheng W, Cai H, Xiang YB, Li H, Gao YT, Shu XO. Long-term Diet Quality and Risk of Type 2 Diabetes Among Urban Chinese Adults. Diabetes Care [print-electronic]. 2018 Apr; 41(4): 723-30. PMID: 29269510, PMCID: PMC5860845, PII: dc17-1626, DOI: 10.2337/dc17-1626, ISSN: 1935-5548.

Yu D, Zheng W, Johansson M, Lan Q, Park Y, White E, Matthews CE, Sawada N, Gao YT, Robien K, Sinha R, Langhammer A, Kaaks R, Giovannucci EL, Liao LM, Xiang YB, Lazovich D, Peters U, Zhang X, Bueno-de-Mesquita B, Willett WC, Tsugane S, Takata Y, Smith-Warner SA, Blot W, Shu XO. Overall and Central Obesity and Risk of Lung Cancer: A Pooled Analysis. J. Natl. Cancer Inst [print-electronic]. 2018 Mar 3/6/2018; PMID: 29518203, PII: 4923348, DOI: 10.1093/jnci/djx286, ISSN: 1460-2105.

Shu X, Xiang YB, Rothman N, Yu D, Li HL, Yang G, Cai H, Ma X, Lan Q, Gao YT, Jia W, Shu XO, Zheng W. Prospective study of blood metabolites associated with colorectal cancer risk. Int. J. Cancer [print-electronic]. 2018 Feb 2/26/2018; PMID: 29479691, DOI: 10.1002/ijc.31341, ISSN: 1097-0215.

Yang JJ, Yu D, Takata Y, Smith-Warner SA, Blot W, White E, Robien K, Park Y, Xiang YB, Sinha R, Lazovich D, Stampfer M, Tumino R, Aune D, Overvad K, Liao L, Zhang X, Gao YT, Johansson M, Willett W, Zheng W, Shu XO. Dietary Fat Intake and Lung Cancer Risk: A Pooled Analysis. J. Clin. Oncol [print-electronic]. 2017 Sep 9/10/2017; 35(26): 3055-64. PMID: 28742456, PMCID: PMC5590804, DOI: 10.1200/JCO.2017.73.3329, ISSN: 1527-7755.

Yu D, Takata Y, Smith-Warner SA, Blot W, Sawada N, White E, Freedman N, Robien K, Giovannucci E, Zhang X, Park Y, Gao YT, Chlebowski RT, Langhammer A, Yang G, Severi G, Manjer J, Khaw KT, Weiderpass E, Liao LM, Caporaso N, Krokstad S, Hveem K, Sinha R, Ziegler R, Tsugane S, Xiang YB, Johansson M, Zheng W, Shu XO. Prediagnostic Calcium Intake and Lung Cancer Survival: A Pooled Analysis of 12 Cohort Studies. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2017 Jul; 26(7): 1060-70. PMID: 28264875, PMCID: PMC5500413, PII: 1055-9965.EPI-16-0863, DOI: 10.1158/1055-9965.EPI-16-0863, ISSN: 1538-7755.

Yu D, Zhang X, Shu XO, Cai H, Li H, Ding D, Hong Z, Xiang YB, Gao YT, Zheng W, Yang G. Dietary glycemic index, glycemic load, and refined carbohydrates are associated with risk of stroke: a prospective cohort study in urban Chinese women. Am. J. Clin. Nutr [print-electronic]. 2016 Nov; 104(5): 1345-51. PMID: 27733400, PMCID: PMC5081713, PII: ajcn.115.129379, DOI: 10.3945/ajcn.115.129379, ISSN: 1938-3207.

Warren Andersen S, Zheng W, Sonderman J, Shu XO, Matthews CE, Yu D, Steinwandel M, McLaughlin JK, Hargreaves MK, Blot WJ. Combined Impact of Health Behaviors on Mortality in Low-Income Americans. Am J Prev Med [print-electronic]. 2016 Sep; 51(3): 344-55. PMID: 27180031, PMCID: PMC4992598, PII: S0749-3797(16)30076-9, DOI: 10.1016/j.amepre.2016.03.018, ISSN: 1873-2607.

Yu D, Moore SC, Matthews CE, Xiang YB, Zhang X, Gao YT, Zheng W, Shu XO. Plasma metabolomic profiles in association with type 2 diabetes risk and prevalence in Chinese adults. Metabolomics [print-electronic]. 2016 Jan; 12: PMID: 27840598, PMCID: PMC5102259, DOI: 10.1007/s11306-015-0890-8, ISSN: 1573-3882.

Yu D, Shu XO, Li H, Yang G, Cai Q, Xiang YB, Ji BT, Franke AA, Gao YT, Zheng W, Zhang X. Dietary isoflavones, urinary isoflavonoids, and risk of ischemic stroke in women. Am. J. Clin. Nutr [print-electronic]. 2015 Sep; 102(3): 680-6. PMID: 26245809, PMCID: PMC4548177, PII: ajcn.115.111591, DOI: 10.3945/ajcn.115.111591, ISSN: 1938-3207.

Yu D, Sonderman J, Buchowski MS, McLaughlin JK, Shu XO, Steinwandel M, Signorello LB, Zhang X, Hargreaves MK, Blot WJ, Zheng W. Healthy Eating and Risks of Total and Cause-Specific Death among Low-Income Populations of African-Americans and Other Adults in the Southeastern United States: A Prospective Cohort Study. PLoS Med. 2015 May; 12(5): e1001830; discussion e1001830. PMID: 26011727, PMCID: PMC4444091, PII: PMEDICINE-D-14-03590, DOI: 10.1371/journal.pmed.1001830, ISSN: 1549-1676.

Yu D, Shu XO, Xiang YB, Li H, Yang G, Gao YT, Zheng W, Zhang X. Higher dietary choline intake is associated with lower risk of nonalcoholic fatty liver in normal-weight Chinese women. J. Nutr [print-electronic]. 2014 Dec; 144(12): 2034-40. PMID: 25320186, PMCID: PMC4230213, PII: jn.114.197533, DOI: 10.3945/jn.114.197533, ISSN: 1541-6100.

Yu D, Zhang X, Xiang YB, Yang G, Li H, Gao YT, Zheng W, Shu XO. Adherence to dietary guidelines and mortality: a report from prospective cohort studies of 134,000 Chinese adults in urban Shanghai. Am. J. Clin. Nutr [print-electronic]. 2014 Aug; 100(2): 693-700. PMID: 24944055, PMCID: PMC4095665, PII: ajcn.113.079194, DOI: 10.3945/ajcn.113.079194, ISSN: 1938-3207.

Yu D, Zhang X, Xiang YB, Yang G, Li H, Fazio S, Linton M, Cai Q, Zheng W, Gao YT, Shu XO. Association of soy food intake with risk and biomarkers of coronary heart disease in Chinese men [letter]. Int. J. Cardiol [print-electronic]. 2014 Mar 3/15/2014; 172(2): e285-7. PMID: 24438928, PMCID: PMC3947738, PII: S0167-5273(14)00060-6, DOI: 10.1016/j.ijcard.2013.12.200, ISSN: 1874-1754.

Yu D, Zhang X, Gao YT, Li H, Yang G, Huang J, Zheng W, Xiang YB, Shu XO. Fruit and vegetable intake and risk of CHD: results from prospective cohort studies of Chinese adults in Shanghai. Br. J. Nutr [print-electronic]. 2014 Jan 1/28/2014; 111(2): 353-62. PMID: 23866068, PMCID: PMC3947047, PII: S0007114513002328, DOI: 10.1017/S0007114513002328, ISSN: 1475-2662.