Colin D McKnight, M.D.

Associate Professor

colin.d.mcknight@vumc.org
Faculty Appointments
Associate Professor of Radiology & Radiological Sciences
Education
M.D., Oregon Health & Science University, Portland, OregonB.S., Biology, Duke University, Durham, North Carolina
Clinical Description
Dr. McKnight is an Assistant Professor of Radiology and Radiological Sciences within the division of Neuroradiology at Vanderbilt University Medical Center and Medical Director of Inpatient Radiology for Vanderbilt University Hospital. He joined the VUMC faculty in 2016.

Dr. McKnight attended Duke University where he received a B.S. in biology with distinction in 2004. He also obtained minors in economics and chemistry. He received an intramural research training award where he conducted neurogenetics research for one year at the National Institutes of Health. He subsequently returned to Oregon and attended Oregon Health and Sciences University where he obtained his M.D., graduated cum laude and received Alpha Omega Alpha membership.

Dr. McKnight received his diagnostic radiology and neuroradiology fellowship at the University of Michigan, where he received awards for Outstanding House Officer Research Excellence in 2014, the Radiological Society of North America Fellowship grant in 2015 and the Roentgen Research Award in 2016.

Since joining the faculty at Vanderbilt University Medical Center, Dr. McKnight has focused his research efforts on advanced imaging of the glympatic system (Glial LYMPHATIC system) which is a collection of emerging concepts pertaining to how cerebrospinal fluid functions to clear central nervous system waste products. He is a Co-Investigator on numerous related grants funded through the National Institutes of Health, the Department of Defense and the National Multiple Sclerosis Society. Dr. McKnight was awarded the VUMC Catalyst Research award in 2020. He received the 2021 Radiological Society of North America Research Scholar Award and is the primary investigator on a grant entitled: Magnetization Transfer Imaging of the Human Spinal Cord and Cerebrospinal fluid to Characterize Myelin Metabolism in Mulitple Sclerosis.

Dr. McKnight serves on the Vanderbilt Radiology Resident Selection Committee and the Department or Radiology Amplifying innovation Committee. He is a member of the International Hydrocephalus Imaging Working Group, the Radiological Society of North America, the America Society of Neuroradiologists and the Association of University Radiologists.

Section: Neuroradiology

VUMC email: colin.d.mcknight@vumc.org
Publications
Schilling KG, Rheault F, Petit L, Hansen CB, Nath V, Yeh FC, Girard G, Barakovic M, Rafael-Patino J, Yu T, Fischi-Gomez E, Pizzolato M, Ocampo-Pineda M, Schiavi S, Canales-Rodríguez EJ, Daducci A, Granziera C, Innocenti G, Thiran JP, Mancini L, Wastling S, Cocozza S, Petracca M, Pontillo G, Mancini M, Vos SB, Vakharia VN, Duncan JS, Melero H, Manzanedo L, Sanz-Morales E, Peña-Melián Á, Calamante F, Attyé A, Cabeen RP, Korobova L, Toga AW, Vijayakumari AA, Parker D, Verma R, Radwan A, Sunaert S, Emsell L, De Luca A, Leemans A, Bajada CJ, Haroon H, Azadbakht H, Chamberland M, Genc S, Tax CMW, Yeh PH, Srikanchana R, Mcknight CD, Yang JY, Chen J, Kelly CE, Yeh CH, Cochereau J, Maller JJ, Welton T, Almairac F, Seunarine KK, Clark CA, Zhang F, Makris N, Golby A, Rathi Y, O'Donnell LJ, Xia Y, Aydogan DB, Shi Y, Fernandes FG, Raemaekers M, Warrington S, Michielse S, Ramírez-Manzanares A, Concha L, Aranda R, Meraz MR, Lerma-Usabiaga G, Roitman L, Fekonja LS, Calarco N, Joseph M, Nakua H, Voineskos AN, Karan P, Grenier G, Legarreta JH, Adluru N, Nair VA, Prabhakaran V, Alexander AL, Kamagata K, Saito Y, Uchida W, Andica C, Abe M, Bayrak RG, Wheeler-Kingshott CAMG, D'Angelo E, Palesi F, Savini G, Rolandi N, Guevara P, Houenou J, López-López N, Mangin JF, Poupon C, Román C, Vázquez A, Maffei C, Arantes M, Andrade JP, Silva SM, Calhoun VD, Caverzasi E, Sacco S, Lauricella M, Pestilli F, Bullock D, Zhan Y, Brignoni-Perez E, Lebel C, Reynolds JE, Nestrasil I, Labounek R, Lenglet C, Paulson A, Aulicka S, Heilbronner SR, Heuer K, Chandio BQ, Guaje J, Tang W, Garyfallidis E, Raja R, Anderson AW, Landman BA, Descoteaux M. Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?. Neuroimage [print-electronic]. 2021 Nov; 243: 118502. PMID: 34433094, PII: S1053-8119(21)00775-8, DOI: 10.1016/j.neuroimage.2021.118502, ISSN: 1095-9572.

Johnson SE, McKnight CD, Jordan LC, Claassen DO, Waddle S, Lee C, Garza M, Patel NJ, Davis LT, Pruthi S, Trujillo P, Chitale R, Fusco M, Donahue MJ. Choroid plexus perfusion in sickle cell disease and moyamoya vasculopathy: Implications for glymphatic flow. J Cereb Blood Flow Metab [print-electronic]. 2021 Oct; 41(10): 2699-711. PMID: 33906512, PMCID: PMC8504961, DOI: 10.1177/0271678X211010731, ISSN: 1559-7016.

Spilseth B, McKnight CD, Li MD, Park CJ, Fried JG, Yi PH, Brian JM, Lehman CD, Wang XJ, Phalke V, Pakkal M, Baruah D, Khine PP, Fajardo LL. AUR-RRA Review: Logistics of Academic-Industry Partnerships in Artificial Intelligence. Acad Radiol [print-electronic]. 2021 Sep 9/21/2021; PMID: 34561163, PII: S1076-6332(21)00355-X, DOI: 10.1016/j.acra.2021.08.002, ISSN: 1878-4046.

McKnight CD, Trujillo P, Lopez AM, Petersen K, Considine C, Lin YC, Yan Y, Kang H, Donahue MJ, Claassen DO. Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease. Parkinsonism Relat Disord [print-electronic]. 2021 Aug; 89: 98-104. PMID: 34271425, PMCID: PMC8429254, PII: S1353-8020(21)00215-7, DOI: 10.1016/j.parkreldis.2021.06.004, ISSN: 1873-5126.

McKnight CD, Rouleau RM, Donahue MJ, Claassen DO. The Regulation of Cerebral Spinal Fluid Flow and Its Relevance to the Glymphatic System. Curr Neurol Neurosci Rep. 2020 Oct 10/19/2020; 20(12): 58. PMID: 33074399, PII: 10.1007/s11910-020-01077-9, DOI: 10.1007/s11910-020-01077-9, ISSN: 1534-6293.

Herr KD, George E, Agarwal V, McKnight CD, Jiang L, Jawahar A, Pakkal M, Ulano A, Ganeshan D. Aligning the Implicit Curriculum with the Explicit Curriculum in Radiology. Acad Radiol [print-electronic]. 2020 Sep; 27(9): 1268-73. PMID: 32061468, PII: S1076-6332(20)30027-1, DOI: 10.1016/j.acra.2019.12.028, ISSN: 1878-4046.

Johnson SE, McKnight CD, Lants SK, Juttukonda MR, Fusco M, Chitale R, Donahue PC, Claassen DO, Donahue MJ. Choroid plexus perfusion and intracranial cerebrospinal fluid changes after angiogenesis. J Cereb Blood Flow Metab [print-electronic]. 2020 Aug; 40(8): 1658-71. PMID: 31500523, PMCID: PMC7370367, DOI: 10.1177/0271678X19872563, ISSN: 1559-7016.

McKnight CD, Motuzas CL, Srinivasan A. Approach to Brain Neoplasms: What the Oncologist Wants to Know. Semin Roentgenol. 2018 Jan; 53(1): 6-22. PMID: 29405956, PII: S0037-198X(17)30077-9, DOI: 10.1053/j.ro.2017.11.002, ISSN: 1558-4658.

McKnight CD, Kelly AM, Petrou M, Nidecker AE, Lorincz MT, Altaee DK, Gebarski SS, Foerster B. A Simplified Approach to Encephalitis and Its Mimics: Key Clinical Decision Points in the Setting of Specific Imaging Abnormalities. Acad Radiol [print-electronic]. 2017 Jun; 24(6): 667-76. PMID: 28258904, PII: S1076-6332(17)30048-X, DOI: 10.1016/j.acra.2016.04.013, ISSN: 1878-4046.

McKnight CD, Parmar HA, Watcharotone K, Mukherji SK. Reassessing the Anatomic Origin of the Juvenile Nasopharyngeal Angiofibroma. J Comput Assist Tomogr. 2016 Dec; 41(4): 559-64. PMID: 28632604, DOI: 10.1097/RCT.0000000000000566, ISSN: 1532-3145.

McKnight CD, Glastonbury CM, Ibrahim M, Rivas-Rodriguez F, Srinivasan A. Techniques and Approaches for Safe, High-Yield CT-Guided Suprahyoid Head and Neck Biopsies. AJR Am J Roentgenol [print-electronic]. 2017 Jan; 208(1): 76-83. PMID: 27657741, DOI: 10.2214/AJR.16.16558, ISSN: 1546-3141.

Baer AH, McKnight CD, Ibrahim M, Parmar HA. Imaging of the Spinal Cord: Classic Syndromes and Non-neoplastic Lesions. Neurographics. 2015 Nov 11/1/2015; 5(7): 238.

McKnight CD, Watcharotone K, Ibrahim M, Christodoulou E, Baer AH, Parmar HA. Adaptive statistical iterative reconstruction: reducing dose while preserving image quality in the pediatric head CT examination. Pediatr Radiol [print-electronic]. 2014 Aug; 44(8): 997-1003. PMID: 24696285, DOI: 10.1007/s00247-014-2943-y, ISSN: 1432-1998.

Baer AH, Parmar HA, McKnight CD, Gemmete JJ, DiPietro MA, Kasten SJ, Mukherji SK. Head and Neck Vascular Anomalies in the Pediatric Population. Neurographics (March 2014). 2014 Mar 3/1/2014; 4(1): 2.

McKnight CD, Winn SR, Gong X, Hansen JE, Wax MK. Revascularization of rat fasciocutaneous flap using CROSSEAL with VEGF protein or plasmid DNA expressing VEGF. Otolaryngol Head Neck Surg. 2008 Aug; 139(2): 245-9. PMID: 18656723, PII: S0194-5998(08)00286-6, DOI: 10.1016/j.otohns.2008.04.014, ISSN: 0194-5998.

Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA. Alcoholism is associated with GALR3 but not two other galanin receptor genes. Genes Brain Behav [print-electronic]. 2007 Jul; 6(5): 473-81. PMID: 17083333, PII: GBB275, DOI: 10.1111/j.1601-183X.2006.00275.x, ISSN: 1601-1848.

Max MB, Wu T, Atlas SJ, Edwards RR, Haythornthwaite JA, Bollettino AF, Hipp HS, McKnight CD, Osman IA, Crawford EN, Pao M, Nejim J, Kingman A, Aisen DC, Scully MA, Keller RB, Goldman D, Belfer I. A clinical genetic method to identify mechanisms by which pain causes depression and anxiety. Mol Pain. 2006 Apr 4/19/2006; 2: 14. PMID: 16623937, PMCID: PMC1488826, PII: 1744-8069-2-14, DOI: 10.1186/1744-8069-2-14, ISSN: 1744-8069.

Belfer I, Hipp H, McKnight C, Evans C, Buzas B, Bollettino A, Albaugh B, Virkkunen M, Yuan Q, Max MB, Goldman D, Enoch MA. Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations. Mol Psychiatry. 2006 Mar; 11(3): 301-11. PMID: 16314872, PMCID: PMC2748409, PII: 4001768, DOI: 10.1038/sj.mp.4001768, ISSN: 1359-4184.