Matthew W. Semler, M.D.

Assistant Professor
Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Biomedical Informatics
M.Sc., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., University of Virginia, Charlottesville, VirginiaB.S., Biological Sciences, University of Virginia, Charlottesville, Virginia
Shinall MC, Martin SF, Nelson J, Miller RS, Semler MW, Zimmerman EE, Noblit CC, Ely EW, Karlekar M. Five-Year Experience of an Inpatient Palliative Care Unit at an Academic Referral Center. Am J Hosp Palliat Care [print-electronic]. 2018 Aug; 35(8): 1057-62. PMID: 29325441, PMCID: PMC6026569, DOI: 10.1177/1049909117751878, ISSN: 1938-2715.

Brown RM, Stollings JL, Semler MW. Making the Medicine Go Down: Salt or Sugar?. Crit. Care Med. 2018 Aug; 46(8): 1370-1. PMID: 30004966, PII: 00003246-201808000-00020, DOI: 10.1097/CCM.0000000000003229, ISSN: 1530-0293.

Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax [print-electronic]. 2018 Jun 6/14/2018; PMID: 29903755, PII: thoraxjnl-2017-211280, DOI: 10.1136/thoraxjnl-2017-211280, ISSN: 1468-3296.

McKown AC, Huerta LE, Rice TW, Semler MW, . Heterogeneity of Treatment Effect by Baseline Risk in a Trial of Balanced Crystalloids versus Saline. Am. J. Respir. Crit. Care Med [print-electronic]. 2018 Jun 6/13/2018; PMID: 29897785, DOI: 10.1164/rccm.201804-0680LE, ISSN: 1535-4970.

Janz DR, Semler MW, Casey JD, Joffe AM, Rice TW. Response [letter]. Chest. 2018 Jun; 153(6): 1506. PMID: 29884260, PII: S0012-3692(18)30411-2, DOI: 10.1016/j.chest.2018.03.004, ISSN: 1931-3543.

Semler MW, Self WH, Rice TW. Balanced Crystalloids versus Saline in Critically Ill Adults [letter]. N. Engl. J. Med. 2018 May 5/17/2018; 378(20): 1951. PMID: 29768150, PII: 10.1056/NEJMc1804294#SA5, DOI: 10.1056/NEJMc1804294, ISSN: 1533-4406.

Semler MW, Self WH, Wang L, Bernard GR, Rice TW, . Reply to Vincent and De Backer: We Do Not Appreciate SALT. Am. J. Respir. Crit. Care Med. 2018 May 5/15/2018; 197(10): 1362. PMID: 29509507, PMCID: PMC5955063, DOI: 10.1164/rccm.201803-0392LE, ISSN: 1535-4970.

Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI, . Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial. Ann Emerg Med [print-electronic]. 2018 May 5/9/2018; PMID: 29753517, PII: S0196-0644(18)30315-9, DOI: 10.1016/j.annemergmed.2018.03.039, ISSN: 1097-6760.

McKown AC, Semler MW, Rice TW. Best PEEP trials are dependent on tidal volume [letter]. Crit Care. 2018 May 5/2/2018; 22(1): 115. PMID: 29720277, PMCID: PMC5930668, PII: 10.1186/s13054-018-2047-4, DOI: 10.1186/s13054-018-2047-4, ISSN: 1466-609X.

Janz DR, Semler MW, Joffe AM, Casey JD, Lentz RJ, deBoisblanc BP, Khan YA, Santanilla JI, Bentov I, Rice TW, , . A Multicenter Randomized Trial of a Checklist for Endotracheal Intubation of Critically Ill Adults. Chest [print-electronic]. 2018 Apr; 153(4): 816-24. PMID: 28917549, PMCID: PMC5989637, PII: S0012-3692(17)32685-5, DOI: 10.1016/j.chest.2017.08.1163, ISSN: 1931-3543.

Janz DR, Semler MW, Casey JD, Joffe AM, Rice TW. Response [letter]. Chest. 2018 Apr; 153(4): 1076-7. PMID: 29626955, PII: S0012-3692(17)33195-1, DOI: 10.1016/j.chest.2017.11.021, ISSN: 1931-3543.

McKown AC, Semler MW, Rice TW. Lung Recruitment and Positive End-Expiratory Pressure Titration in Patients With Acute Respiratory Distress Syndrome [letter]. JAMA. 2018 Mar 3/6/2018; 319(9): 932-3. PMID: 29509861, PII: 2673963, DOI: 10.1001/jama.2017.21856, ISSN: 1538-3598.

Self WH, Semler MW, Wanderer JP, Wang L, Byrne DW, Collins SP, Slovis CM, Lindsell CJ, Ehrenfeld JM, Siew ED, Shaw AD, Bernard GR, Rice TW, . Balanced Crystalloids versus Saline in Noncritically Ill Adults. N. Engl. J. Med [print-electronic]. 2018 Mar 3/1/2018; 378(9): 819-28. PMID: 29485926, PMCID: PMC5846618, DOI: 10.1056/NEJMoa1711586, ISSN: 1533-4406.

Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, Stollings JL, Kumar AB, Hughes CG, Hernandez A, Guillamondegui OD, May AK, Weavind L, Casey JD, Siew ED, Shaw AD, Bernard GR, Rice TW, . Balanced Crystalloids versus Saline in Critically Ill Adults. N. Engl. J. Med [print-electronic]. 2018 Mar 3/1/2018; 378(9): 829-39. PMID: 29485925, PMCID: PMC5846085, DOI: 10.1056/NEJMoa1711584, ISSN: 1533-4406.

Semler MW, Andrews B, Bernard GR. Early Resuscitation for Adults With Sepsis in a Low-income Country-Reply [letter]. JAMA. 2018 Feb 2/13/2018; 319(6): 614-5. PMID: 29450521, PII: 2672627, DOI: 10.1001/jama.2017.20410, ISSN: 1538-3598.

Stollings JL, Landsperger JS, Semler MW, Rice TW. Tranexamic acid for refractory gastrointestinal bleeds: A cohort study. J Crit Care [print-electronic]. 2018 Feb; 43: 128-32. PMID: 28889070, PMCID: PMC5732862, PII: S0883-9441(17)30772-4, DOI: 10.1016/j.jcrc.2017.08.035, ISSN: 1557-8615.

Semler MW, Casey JD, Janz DR, Russell DW, Rice TW. Response [letter]. Chest. 2018 Feb; 153(2): 568-9. PMID: 29406220, PII: S0012-3692(17)33196-3, DOI: 10.1016/j.chest.2017.11.022, ISSN: 1931-3543.

Kawano-Dourado L, Zampieri FG, Azevedo LCP, Corrêa TD, Figueiró M, Semler MW, Kellum JA, Cavalcanti AB. Low- Versus High-Chloride Content Intravenous Solutions for Critically Ill and Perioperative Adult Patients: A Systematic Review and Meta-analysis. Anesth. Analg. 2018 Feb; 126(2): 513-21. PMID: 29189271, DOI: 10.1213/ANE.0000000000002641, ISSN: 1526-7598.

Brown RM, Semler MW. Fluid Management in Sepsis. J Intensive Care Med [print-electronic]. 2018 Jan 1/1/2018; 885066618784861. PMID: 29986619, DOI: 10.1177/0885066618784861, ISSN: 1525-1489.

Semler MW, Janz DR, Casey JD, Russell DW, Rice TW. Response [letter]. Chest. 2017 Dec; 152(6): 1351. PMID: 29223265, PII: S0012-3692(17)32870-2, DOI: 10.1016/j.chest.2017.09.032, ISSN: 1931-3543.

Casey JD, Semler MW, Bastarache JA. Aspirin for Sepsis Prophylaxis: An Ounce of Prevention?. Crit. Care Med. 2017 Nov; 45(11): 1959-60. PMID: 29028704, PMCID: PMC5658041, PII: 00003246-201711000-00028, DOI: 10.1097/CCM.0000000000002669, ISSN: 1530-0293.

Semler MW, Janz DR, Casey JD, Russell DW, Rice TW. Response [letter]. Chest. 2017 Nov; 152(5): 1092-3. PMID: 29126526, PII: S0012-3692(17)31310-7, DOI: 10.1016/j.chest.2017.07.017, ISSN: 1931-3543.

Andrews B, Semler MW, Muchemwa L, Kelly P, Lakhi S, Heimburger DC, Mabula C, Bwalya M, Bernard GR. Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial. JAMA. 2017 Oct 10/3/2017; 318(13): 1233-40. PMID: 28973227, PMCID: PMC5710318, PII: 2654854, DOI: 10.1001/jama.2017.10913, ISSN: 1538-3598.

Semler MW, Janz DR, Russell DW, Casey JD, Lentz RJ, Zouk AN, deBoisblanc BP, Santanilla JI, Khan YA, Joffe AM, Stigler WS, Rice TW, , . A Multicenter, Randomized Trial of Ramped Position vs Sniffing Position During Endotracheal Intubation of Critically Ill Adults. Chest [print-electronic]. 2017 Oct; 152(4): 712-22. PMID: 28487139, PMCID: PMC5812765, PII: S0012-3692(17)30881-4, DOI: 10.1016/j.chest.2017.03.061, ISSN: 1931-3543.

McKown AC, Semler MW. The authors reply. Crit. Care Med. 2017 Oct; 45(10): e1096-e1097. PMID: 28915192, PII: 00003246-201710000-00059, DOI: 10.1097/CCM.0000000000002591, ISSN: 1530-0293.

McKown AC, Wang L, Wanderer JP, Ehrenfeld J, Rice TW, Bernard GR, Semler MW. Predicting Major Adverse Kidney Events among Critically Ill Adults Using the Electronic Health Record. J Med Syst. 2017 Aug 8/31/2017; 41(10): 156. PMID: 28861688, PMCID: PMC5821255, PII: 10.1007/s10916-017-0806-4, DOI: 10.1007/s10916-017-0806-4, ISSN: 1573-689X.

Casey JD, Janz DR, Semler MW. Hypothermia for the Treatment of Acute Respiratory Distress Syndrome? Cool It. Crit. Care Med. 2017 Jul; 45(7): 1244-5. PMID: 28622220, PII: 00003246-201707000-00021, DOI: 10.1097/CCM.0000000000002359, ISSN: 1530-0293.

McKown AC, McGuinn EM, Ware LB, Wang L, Janz DR, Rice TW, Semler MW. Preadmission Oral Corticosteroids Are Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults With Sepsis. Crit. Care Med. 2017 May; 45(5): 774-80. PMID: 28257336, PMCID: PMC5392158, DOI: 10.1097/CCM.0000000000002286, ISSN: 1530-0293.

Self WH, Semler MW, Wanderer JP, Ehrenfeld JM, Byrne DW, Wang L, Atchison L, Felbinger M, Jones ID, Russ S, Shaw AD, Bernard GR, Rice TW. Saline versus balanced crystalloids for intravenous fluid therapy in the emergency department: study protocol for a cluster-randomized, multiple-crossover trial. Trials. 2017 Apr 4/13/2017; 18(1): 178. PMID: 28407811, PMCID: PMC5390477, PII: 10.1186/s13063-017-1923-6, DOI: 10.1186/s13063-017-1923-6, ISSN: 1745-6215.

Janz DR, Semler MW, Rice TW. The authors reply. Crit. Care Med. 2017 Apr; 45(4): e463. PMID: 28291113, PMCID: PMC5358806, PII: 00003246-201704000-00052, DOI: 10.1097/CCM.0000000000002270, ISSN: 1530-0293.

Janz DR, Semler MW, Rice TW. The authors reply. Crit. Care Med. 2017 Apr; 45(4): e461. PMID: 28291111, PMCID: PMC5358803, PII: 00003246-201704000-00050, DOI: 10.1097/CCM.0000000000002271, ISSN: 1530-0293.

Semler MW, Self WH, Wang L, Byrne DW, Wanderer JP, Ehrenfeld JM, Stollings JL, Kumar AB, Hernandez A, Guillamondegui OD, May AK, Siew ED, Shaw AD, Bernard GR, Rice TW, , . Balanced crystalloids versus saline in the intensive care unit: study protocol for a cluster-randomized, multiple-crossover trial. Trials. 2017 Mar 3/16/2017; 18(1): 129. PMID: 28302179, PMCID: PMC5356286, PII: 10.1186/s13063-017-1871-1, DOI: 10.1186/s13063-017-1871-1, ISSN: 1745-6215.

Semler MW, Mikkelsen ME. If at First You Don't Succeed: Patient Characteristics Associated with First-Attempt Failure of Video Laryngoscopy in the Intensive Care Unit. Ann Am Thorac Soc. 2017 Mar; 14(3): 305-6. PMID: 28248582, PMCID: PMC5427726, DOI: 10.1513/AnnalsATS.201612-1029ED, ISSN: 2325-6621.

Janz DR, Semler MW, Rice TW. The authors reply. Crit. Care Med. 2017 Mar; 45(3): e326-e327. PMID: 28212228, PMCID: PMC5347467, PII: 00003246-201703000-00034, DOI: 10.1097/CCM.0000000000002216, ISSN: 1530-0293.

Upchurch CP, Grijalva CG, Russ S, Collins SP, Semler MW, Rice TW, Liu D, Ehrenfeld JM, High K, Barrett TW, McNaughton CD, Self WH. Comparison of Etomidate and Ketamine for Induction During Rapid Sequence Intubation of Adult Trauma Patients. Ann Emerg Med. 2017 Jan; 69(1): 24-33.e2. PMID: 27993308, PMCID: PMC5180365, PII: S0196-0644(16)30467-X, DOI: 10.1016/j.annemergmed.2016.08.009, ISSN: 1097-6760.

Janz DR, Khan YA, Mooney JL, Semler MW, Rice TW, Johnson JL, deBoisblanc BP, . Effect of Interhospital ICU Relocation on Patient Physiology and Clinical Outcomes. J Intensive Care Med [print-electronic]. 2017 Jan 1/1/2017; 885066617726754. PMID: 28820040, DOI: 10.1177/0885066617726754, ISSN: 1525-1489.

Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS. Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries. Trauma Surg Acute Care Open. 2017; 2(1): e000121. PMID: 29766112, PMCID: PMC5887582, PII: tsaco-2017-000121, DOI: 10.1136/tsaco-2017-000121, ISSN: 2397-5776.

Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nat. Med [print-electronic]. 2016 Nov; 22(11): 1330-4. PMID: 27668938, PMCID: PMC5101143, PII: nm.4174, DOI: 10.1038/nm.4174, ISSN: 1546-170X.

Semler MW, Wanderer JP, Ehrenfeld JM, Stollings JL, Self WH, Siew ED, Wang L, Byrne DW, Shaw AD, Bernard GR, Rice TW, . Balanced Crystalloids versus Saline in the Intensive Care Unit: The SALT Randomized Trial. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Oct 10/17/2016; PMID: 27749094, DOI: 10.1164/rccm.201607-1345OC, ISSN: 1535-4970.

Wu JY, Stollings JL, Wheeler AP, Semler MW, Rice TW. Efficacy and Outcomes After Vasopressin Guideline Implementation in Septic Shock. Ann Pharmacother [print-electronic]. 2016 Sep 9/14/2016; PMID: 27630192, PII: 1060028016669163, DOI: 10.1177/1060028016669163, ISSN: 1542-6270.

Landsperger JS, Semler MW. Response [letter]. Chest. 2016 Sep; 150(3): 746-7. PMID: 27613978, PII: S0012-3692(16)50329-8, DOI: 10.1016/j.chest.2016.06.015, ISSN: 1931-3543.

Semler MW, Rice TW. Saline Is Not the First Choice for Crystalloid Resuscitation Fluids. Crit. Care Med. 2016 Aug; 44(8): 1541-4. PMID: 27428117, PMCID: PMC4955703, PII: 00003246-201608000-00013, DOI: 10.1097/CCM.0000000000001941, ISSN: 1530-0293.

Semler MW, Rice TW, Shaw AD, Siew ED, Self WH, Kumar AB, Byrne DW, Ehrenfeld JM, Wanderer JP. Identification of Major Adverse Kidney Events Within the Electronic Health Record. J Med Syst [print-electronic]. 2016 Jul; 40(7): 167. PMID: 27234478, PII: 10.1007/s10916-016-0528-z, DOI: 10.1007/s10916-016-0528-z, ISSN: 1573-689X.

Semler MW, Marney AM, Rice TW, Nian H, Yu C, Wheeler AP, Brown NJ, . B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS. Chest [print-electronic]. 2016 Jul; 150(1): 102-11. PMID: 27018313, PII: S0012-3692(16)45714-4, DOI: 10.1016/j.chest.2016.03.017, ISSN: 1931-3543.

Janz DR, Semler MW, Lentz RJ, Matthews DT, Assad TR, Norman BC, Keriwala RD, Ferrell BA, Noto MJ, Shaver CM, Richmond BW, Zinggeler Berg J, Rice TW, . Randomized Trial of Video Laryngoscopy for Endotracheal Intubation of Critically Ill Adults. Crit. Care Med [print-electronic]. 2016 Jun 6/28/2016; PMID: 27355526, DOI: 10.1097/CCM.0000000000001841, ISSN: 1530-0293.

Semler MW, Janz DR, Rice TW. Reply: Apneic Oxygenation Has Not Been Disproven. Am. J. Respir. Crit. Care Med. 2016 Jun 6/1/2016; 193(11): 1316-7. PMID: 27248595, PMCID: PMC4910906, DOI: 10.1164/rccm.201603-0604LE, ISSN: 1535-4970.

Semler MW, Rice TW. Sepsis Resuscitation: Fluid Choice and Dose. Clin. Chest Med [print-electronic]. 2016 Jun; 37(2): 241-50. PMID: 27229641, PMCID: PMC4884304, PII: S0272-5231(16)30006-5, DOI: 10.1016/j.ccm.2016.01.007, ISSN: 1557-8216.

Landsperger JS, Semler MW, Wang L, Byrne DW, Wheeler AP. Outcomes of Nurse Practitioner-Delivered Critical Care: A Prospective Cohort Study. Chest [print-electronic]. 2016 May; 149(5): 1146-54. PMID: 26836900, PII: S0012-3692(15)00344-X, DOI: 10.1016/j.chest.2015.12.015, ISSN: 1931-3543.

Semler MW, Wheeler AP, Thompson BT, Bernard GR, Wiedemann HP, Rice TW, . Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome. Crit. Care Med. 2016 Apr; 44(4): 782-9. PMID: 26741580, PMCID: PMC4792704, DOI: 10.1097/CCM.0000000000001555, ISSN: 1530-0293.

Semler MW, Janz DR, Lentz RJ, Matthews DT, Norman BC, Assad TR, Keriwala RD, Ferrell BA, Noto MJ, McKown AC, Kocurek EG, Warren MA, Huerta LE, Rice TW, , . Randomized Trial of Apneic Oxygenation during Endotracheal Intubation of the Critically Ill. Am. J. Respir. Crit. Care Med. 2016 Feb 2/1/2016; 193(3): 273-80. PMID: 26426458, PMCID: PMC4803060, DOI: 10.1164/rccm.201507-1294OC, ISSN: 1535-4970.

Semler MW, Wheeler AP. Slow and Study: Support for a Randomized Trial of ß-Blockade in Sepsis-Associated Atrial Fibrillation [editorial]. Chest [print-electronic]. 2016 Jan; 149(1): 9-10. PMID: 26757282, PII: S0012-3692(15)00041-0, DOI: 10.1016/j.chest.2015.08.020, ISSN: 1931-3543.

Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, Tatem G, Salem D, Moore S, Boka K, Gill JK, Gardner-Gray J, Pflaum J, Domecq JP, Hurst G, Belsky JB, Fowkes R, Elkin RB, Simpson SQ, Falk JL, Singer DJ, Rivers EP. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care. 2016; 20(1): 160. PMID: 27364620, PMCID: PMC4929762, PII: 10.1186/s13054-016-1288-3, DOI: 10.1186/s13054-016-1288-3, ISSN: 1466-609X.

Semler MW, Shashaty MG. Walking on Water: Volume Overload and Ambulation in Survivors of Septic Shock [editorial]. Ann Am Thorac Soc. 2015 Dec; 12(12): 1745-6. PMID: 26653186, DOI: 10.1513/AnnalsATS.201509-616ED, ISSN: 2325-6621.

Semler MW, Rice TW, Ehrenfeld JM. Leveraging Clinical Informatics in the Conduct of Clinical Trials. J Med Syst. 2015 Oct; 39(10): 112. PMID: 26276019, DOI: 10.1007/s10916-015-0317-0, ISSN: 1573-689X.

Semler MW, Weavind L, Hooper MH, Rice TW, Gowda SS, Nadas A, Song Y, Martin JB, Bernard GR, Wheeler AP. An Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU: A Randomized Controlled Trial. Crit. Care Med. 2015 Aug; 43(8): 1595-602. PMID: 25867906, PMCID: PMC4506222, DOI: 10.1097/CCM.0000000000001020, ISSN: 1530-0293.

Semler MW, Wheeler AP. Systemic inflammatory response syndrome after cardiac surgery: time for a change [editorial]. Chest. 2014 Jun; 145(6): 1181-2. PMID: 24889425, PII: S0012-3692(15)34780-2, DOI: 10.1378/chest.14-0438, ISSN: 1931-3543.

Shibao C, Muppa P, Semler MW, Peltier AC, Biaggioni I. A standing dilemma: autonomic failure preceding Hodgkin's lymphoma. Am. J. Med [print-electronic]. 2014 Apr; 127(4): 284-7. PMID: 24333616, PMCID: PMC4099002, PII: S0002-9343(13)01026-7, DOI: 10.1016/j.amjmed.2013.12.002, ISSN: 1555-7162.

Watson GT, Huaman MA, Semler MW, Manners J, Woron AM, Carpenter LR, Christman BW. When nature meets nurture: persistent Yersinia infection. Am. J. Med [print-electronic]. 2013 Jul; 126(7): 578-80. PMID: 23664165, PII: S0002-9343(13)00268-4, DOI: 10.1016/j.amjmed.2013.03.006, ISSN: 1555-7162.

Semler MW, Stover DG, Copland AP, Hong G, Johnson MJ, Kriss MS, Otepka H, Wang L, Christman BW, Rice TW. Flash mob research: a single-day, multicenter, resident-directed study of respiratory rate. Chest. 2013 Jun; 143(6): 1740-4. PMID: 23197319, PMCID: PMC3747725, PII: S0012-3692(13)60406-7, DOI: 10.1378/chest.12-1837, ISSN: 1931-3543.