J. David Sweatt, Ph.D.

Professor

david.sweatt@vanderbilt.edu

Visit Lab Site


Faculty Appointments
Chair of the Department of Pharmacology Professor of Pharmacology Professor of PsychologyProfessor of Molecular Physiology & BiophysicsAllan D. Bass Professor of Pharmacology
Education
Ph.D., Pharmacology, Vanderbilt University, Nashville, TennesseeB.S., Chemistry, University of South Alabama, Mobile, Alabama
Office Address
2220 Pierce Avenue
442 RRB
Nashville, TN 37232
Research Description
David Sweatt obtained his B.S. in Chemistry from the University of South Alabama before attending Vanderbilt University, where he was awarded a Ph.D. in Pharmacology for studies of intracellular signaling mechanisms. He then did a post-doctoral Fellowship at the Columbia University Center for Neurobiology and Behavior, working on memory mechanisms in the laboratory of Nobel laureate Eric Kandel. From 1989 to 2006 he was a member of the Neuroscience faculty at Baylor College of Medicine in Houston, Texas, rising through the ranks there to Professor and Director of the Neuroscience Ph.D. program. In 2006 he moved to the University of Alabama at Birmingham where he served for ten years as the Evelyn F. McKnight endowed Chairman of the Department of Neurobiology at UAB Medical School, and the Director of the Evelyn F. McKnight Brain Institute at UAB. He is currently the Allan D. Bass endowed Chairman of the Department of Pharmacology at Vanderbilt University.

Dr. Sweatt’s laboratory (Lab URL: https://my.vanderbilt.edu/sweattlab/) studies biochemical mechanisms of learning and memory, most recently focusing on the role of epigenetic mechanisms in memory formation. In addition, his research program also investigates mechanisms of learning and memory disorders, such as intellectual disabilities, Alzheimer’s Disease, and aging-related memory dysfunction. He has expanded his research program to include developing PharmacoEpigenetic approaches to enable new treatments for cognitive dysfunction.

Dr. Sweatt has won numerous awards and honors, including an Ellison Medical Foundation Senior Scholar Award, and election as a Fellow of the American Association for the Advancement of Science. In 2013 he won the Ipsen Foundation International Prize in Neural Plasticity, one of the most prestigious awards in his scientific field. In 2014 he was the recipient of the PROSE Award for the most outstanding reference volume published in 2013, for his book Epigenetic Mechanisms in the Nervous System. The book was also one of five finalists for the 2014 Dawkins Award for the most outstanding academic book published in 2013. In 2014, 2015 and 2016 Thomson-Reuters named him as a “Highly Cited Researcher” and as one of the “World’s Most Influential Scientific Minds”.

From 1998 until 2002 he attended drawing and painting classes at the Glassell School of Art of the Museum of Fine Arts, Houston. As an artist he explores the use of painting as a medium for expressing topics of interest in contemporary biomedical research. In 2009 he published a textbook, Mechanisms of Memory, which is illustrated with original paintings and describes current models for the molecular and cellular basis of memory formation.
Research Keywords
Neuropharmacology
Publications
Cambronero FE, Liu D, Neal JE, Moore EE, Gifford KA, Terry JG, Nair S, Pechman KR, Osborn KE, Hohman TJ, Bell SP, Sweatt JD, Wang TJ, Beckman JA, Carr JJ, Jefferson AL. APOE genotype modifies the association between central arterial stiffening and cognition in older adults. Neurobiol. Aging [print-electronic]. 2018 Jul; 67: 120-7. PMID: 29656011, PII: S0197-4580(18)30051-4, DOI: 10.1016/j.neurobiolaging.2018.02.009, ISSN: 1558-1497.

Bales KL, Ianov L, Kennedy AJ, Sweatt JD, Gross AK. Autosomal dominant retinitis pigmentosa rhodopsin mutant Q344X drives specific alterations in chromatin complex gene transcription. Mol. Vis. 2018; 24: 153-64. PMID: 29463953, PMCID: PMC5815338, ISSN: 1090-0535.

Sweatt JD. Layered-up regulation in the developing brain. Nature. 2017 Nov 11/23/2017; 551(7681): 448-9. PMID: 29168827, PII: d41586-017-07269-7, DOI: 10.1038/d41586-017-07269-7, ISSN: 1476-4687.

Duke CG, Kennedy AJ, Gavin CF, Day JJ, Sweatt JD. Experience-dependent epigenomic reorganization in the hippocampus. Learn. Mem [electronic-print]. 2017 Jul; 24(7): 278-88. PMID: 28620075, PII: 24/7/278, DOI: 10.1101/lm.045112.117, ISSN: 1549-5485.

Ianov L, De Both M, Chawla MK, Rani A, Kennedy AJ, Piras I, Day JJ, Siniard A, Kumar A, Sweatt JD, Barnes CA, Huentelman MJ, Foster TC. Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment. Front Aging Neurosci. 2017; 9: 383. PMID: 29276487, PMCID: PMC5727020, DOI: 10.3389/fnagi.2017.00383, ISSN: 1663-4365.

Sweatt JD. Neural plasticity and behavior - sixty years of conceptual advances. J. Neurochem [print-electronic]. 2016 Oct; 139 Suppl 2: 179-99. PMID: 26875778, DOI: 10.1111/jnc.13580, ISSN: 1471-4159.

Kennedy AJ, Rahn EJ, Paulukaitis BS, Savell KE, Kordasiewicz HB, Wang J, Lewis JW, Posey J, Strange SK, Guzman-Karlsson MC, Phillips SE, Decker K, Motley ST, Swayze EE, Ecker DJ, Michael TP, Day JJ, Sweatt JD. Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function. Cell Rep [print-electronic]. 2016 Sep 9/6/2016; 16(10): 2666-85. PMID: 27568567, PII: S2211-1247(16)31036-1, DOI: 10.1016/j.celrep.2016.08.004, ISSN: 2211-1247.

Kennedy AJ, Rahn EJ, Paulukaitis BS, Savell KE, Kordasiewicz HB, Wang J, Lewis JW, Posey J, Strange SK, Guzman-Karlsson MC, Phillips SE, Decker K, Motley ST, Swayze EE, Ecker DJ, Michael TP, Day JJ, Sweatt JD. Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function. Cell Rep [print-electronic]. 2016 Sep 9/6/2016; 16(10): 2666-85. PMID: 27568567, PII: S2211-1247(16)31036-1, DOI: 10.1016/j.celrep.2016.08.004, ISSN: 2211-1247.

Sweatt JD, Tamminga CA. An epigenomics approach to individual differences and its translation to neuropsychiatric conditions. Dialogues Clin Neurosci. 2016 Sep; 18(3): 289-98. PMID: 27757063, PMCID: PMC5067146, ISSN: 1958-5969.

Sweatt JD, Tamminga CA. An epigenomics approach to individual differences and its translation to neuropsychiatric conditions. Dialogues Clin Neurosci. 2016 Sep; 18(3): 289-98. PMID: 27757063, PMCID: PMC5067146, ISSN: 1958-5969.

Meadows JP, Guzman-Karlsson MC, Phillips S, Brown JA, Strange SK, Sweatt JD, Hablitz JJ. Dynamic DNA methylation regulates neuronal intrinsic membrane excitability. Sci Signal. 2016 Aug 8/23/2016; 9(442): ra83. PMID: 27555660, PII: 9/442/ra83, DOI: 10.1126/scisignal.aaf5642, ISSN: 1937-9145.

Sweatt JD. GENE EXPRESSION. Chromatin controls behavior. Science. 2016 Jul 7/15/2016; 353(6296): 218-9. PMID: 27418488, PII: 353/6296/218, DOI: 10.1126/science.aah4055, ISSN: 1095-9203.

Sweatt JD. GENE EXPRESSION. Chromatin controls behavior. Science. 2016 Jul 7/15/2016; 353(6296): 218-9. PMID: 27418488, PII: 353/6296/218, DOI: 10.1126/science.aah4055, ISSN: 1095-9203.

Savell KE, Gallus NV, Simon RC, Brown JA, Revanna JS, Osborn MK, Song EY, O'Malley JJ, Stackhouse CT, Norvil A, Gowher H, Sweatt JD, Day JJ. Extra-coding RNAs regulate neuronal DNA methylation dynamics. Nat Commun. 2016 Jul 7/7/2016; 7: 12091. PMID: 27384705, PMCID: PMC4941050, PII: ncomms12091, DOI: 10.1038/ncomms12091, ISSN: 2041-1723.

Kennedy AJ, Sweatt JD. Drugging the methylome: DNA methylation and memory. Crit. Rev. Biochem. Mol. Biol [print-electronic]. 2016 May; 51(3): 185-94. PMID: 26915423, DOI: 10.3109/10409238.2016.1150958, ISSN: 1549-7798.

Sweatt JD. Dynamic DNA methylation controls glutamate receptor trafficking and synaptic scaling. J. Neurochem [print-electronic]. 2016 May; 137(3): 312-30. PMID: 26849493, PMCID: PMC4836967, DOI: 10.1111/jnc.13564, ISSN: 1471-4159.

Sweatt JD, Hawkins KE. The molecular neurobiology of the sleep-deprived, fuzzy brain. Sci Signal. 2016 Apr 4/26/2016; 9(425): fs7. PMID: 27117249, PII: 9/425/fs7, DOI: 10.1126/scisignal.aaf6196, ISSN: 1937-9145.

Heyward FD, Gilliam D, Coleman MA, Gavin CF, Wang J, Kaas G, Trieu R, Lewis J, Moulden J, Sweatt JD. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. J. Neurosci. 2016 Jan 1/27/2016; 36(4): 1324-35. PMID: 26818519, PMCID: PMC4728728, PII: 36/4/1324, DOI: 10.1523/JNEUROSCI.1934-15.2016, ISSN: 1529-2401.

Kumar D, Aggarwal M, Kaas GA, Lewis J, Wang J, Ross DL, Zhong C, Kennedy A, Song H, Sweatt JD. Tet1 Oxidase Regulates Neuronal Gene Transcription, Active DNA Hydroxy-methylation, Object Location Memory, and Threat Recognition Memory. Neuroepigenetics. 2015 Oct 10/1/2015; 4: 12-27. PMID: 26644996, PMCID: PMC4669576, DOI: 10.1016/j.nepig.2015.10.002.

Heyward FD, Sweatt JD. DNA Methylation in Memory Formation: Emerging Insights. Neuroscientist [print-electronic]. 2015 Oct; 21(5): 475-89. PMID: 25832671, PMCID: PMC4770785, PII: 1073858415579635, DOI: 10.1177/1073858415579635, ISSN: 1073-8584.

Grubišic V, Kennedy AJ, Sweatt JD, Parpura V. Pitt-Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo. Autism Res [print-electronic]. 2015 Oct; 8(5): 629-33. PMID: 25728630, DOI: 10.1002/aur.1467, ISSN: 1939-3806.

Rumbaugh G, Sillivan SE, Ozkan ED, Rojas CS, Hubbs CR, Aceti M, Kilgore M, Kudugunti S, Puthanveettil SV, Sweatt JD, Rusche J, Miller CA. Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue. Neuropsychopharmacology [print-electronic]. 2015 Sep; 40(10): 2307-16. PMID: 25837283, PMCID: PMC4538358, PII: npp201593, DOI: 10.1038/npp.2015.93, ISSN: 1740-634X.

Zovkic IB, Sweatt JD. Memory-Associated Dynamic Regulation of the "Stable" Core of the Chromatin Particle. Neuron. 2015 Jul 7/1/2015; 87(1): 1-4. PMID: 26139363, PMCID: PMC4765168, PII: S0896-6273(15)00568-1, DOI: 10.1016/j.neuron.2015.06.025, ISSN: 1097-4199.

Meadows JP, Guzman-Karlsson MC, Phillips S, Holleman C, Posey JL, Day JJ, Hablitz JJ, Sweatt JD. DNA methylation regulates neuronal glutamatergic synaptic scaling. Sci Signal. 2015 Jun 6/23/2015; 8(382): ra61. PMID: 26106219, PMCID: PMC4764068, PII: 8/382/ra61, DOI: 10.1126/scisignal.aab0715, ISSN: 1937-9145.

Roth ED, Roth TL, Money KM, SenGupta S, Eason DE, Sweatt JD. DNA methylation regulates neurophysiological spatial representation in memory formation. Neuroepigenetics. 2015 Apr 4/1/2015; 2: 1-8. PMID: 25960947, PMCID: PMC4422108, DOI: 10.1016/j.nepig.2015.03.001.

Yokoi F, Chen HX, Dang MT, Cheetham CC, Campbell SL, Roper SN, Sweatt JD, Li Y. Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice. PLoS ONE. 2015; 10(3): e0120916. PMID: 25799505, PMCID: PMC4370625, PII: PONE-D-14-35621, DOI: 10.1371/journal.pone.0120916, ISSN: 1932-6203.

Day JJ, Kennedy AJ, Sweatt JD. DNA methylation and its implications and accessibility for neuropsychiatric therapeutics. Annu. Rev. Pharmacol. Toxicol [print-electronic]. 2015; 55: 591-611. PMID: 25340930, PMCID: PMC4768530, DOI: 10.1146/annurev-pharmtox-010814-124527, ISSN: 1545-4304.

Zovkic IB, Paulukaitis BS, Day JJ, Etikala DM, Sweatt JD. Histone H2A.Z subunit exchange controls consolidation of recent and remote memory. Nature [print-electronic]. 2014 Nov 11/27/2014; 515(7528): 582-6. PMID: 25219850, PMCID: PMC4768489, PII: nature13707, DOI: 10.1038/nature13707, ISSN: 1476-4687.

Guzman-Karlsson MC, Meadows JP, Gavin CF, Hablitz JJ, Sweatt JD. Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity. Neuropharmacology [print-electronic]. 2014 May; 80: 3-17. PMID: 24418102, PMCID: PMC3984596, PII: S0028-3908(14)00007-0, DOI: 10.1016/j.neuropharm.2014.01.001, ISSN: 1873-7064.

Allison DB, Antoine LH, Ballinger SW, Bamman MM, Biga P, Darley-Usmar VM, Fisher G, Gohlke JM, Halade GV, Hartman JL, Hunter GR, Messina JL, Nagy TR, Plaisance EP, Powell ML, Roth KA, Sandel MW, Schwartz TS, Smith DL, Sweatt JD, Tollefsbol TO, Watts SA, Yang Y, Zhang J, Austad SN. Aging and energetics' 'Top 40' future research opportunities 2010-2013. F1000Res. 2014; 3: 219. PMID: 25324965, PMCID: PMC4197746, DOI: 10.12688/f1000research.5212.1.

Sweatt JD. The emerging field of neuroepigenetics. Neuron. 2013 Oct 10/30/2013; 80(3): 624-32. PMID: 24183015, PMCID: PMC3878295, PII: S0896-6273(13)00927-6, DOI: 10.1016/j.neuron.2013.10.023, ISSN: 1097-4199.

Day JJ, Childs D, Guzman-Karlsson MC, Kibe M, Moulden J, Song E, Tahir A, Sweatt JD. DNA methylation regulates associative reward learning. Nat. Neurosci [print-electronic]. 2013 Oct; 16(10): 1445-52. PMID: 23974711, PMCID: PMC3785567, PII: nn.3504, DOI: 10.1038/nn.3504, ISSN: 1546-1726.

Kaas GA, Zhong C, Eason DE, Ross DL, Vachhani RV, Ming GL, King JR, Song H, Sweatt JD. TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation. Neuron. 2013 Sep 9/18/2013; 79(6): 1086-93. PMID: 24050399, PMCID: PMC3816951, PII: S0896-6273(13)00791-5, DOI: 10.1016/j.neuron.2013.08.032, ISSN: 1097-4199.

Lithner CU, Lacor PN, Zhao WQ, Mustafiz T, Klein WL, Sweatt JD, Hernandez CM. Disruption of neocortical histone H3 homeostasis by soluble Aß: implications for Alzheimer's disease. Neurobiol. Aging [print-electronic]. 2013 Sep; 34(9): 2081-90. PMID: 23582659, PII: S0197-4580(12)00661-6, DOI: 10.1016/j.neurobiolaging.2012.12.028, ISSN: 1558-1497.

Sweatt JD. Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription. Exp. Mol. Med. 2013 May 5/3/2013; 45: e21. PMID: 23640545, PMCID: PMC3674405, PII: emm201332, DOI: 10.1038/emm.2013.32, ISSN: 2092-6413.

Zovkic IB, Guzman-Karlsson MC, Sweatt JD. Epigenetic regulation of memory formation and maintenance. Learn. Mem. 2013 Jan 1/15/2013; 20(2): 61-74. PMID: 23322554, PMCID: PMC3549063, PII: 20/2/61, DOI: 10.1101/lm.026575.112, ISSN: 1549-5485.

Sultan FA, Sweatt JD. The role of the Gadd45 family in the nervous system: a focus on neurodevelopment, neuronal injury, and cognitive neuroepigenetics. Adv. Exp. Med. Biol. 2013; 793: 81-119. PMID: 24104475, DOI: 10.1007/978-1-4614-8289-5_6, ISSN: 0065-2598.

Yokoi F, Cheetham CC, Campbell SL, Sweatt JD, Li Y. Pre-synaptic release deficits in a DYT1 dystonia mouse model. PLoS ONE. 2013; 8(8): e72491. PMID: 23967309, PMCID: PMC3742515, PII: PONE-D-11-22542, DOI: 10.1371/journal.pone.0072491, ISSN: 1932-6203.

Zovkic IB, Meadows JP, Kaas GA, Sweatt JD. Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD. Front Psychiatry. 2013; 4: 60. PMID: 23805109, PMCID: PMC3693073, DOI: 10.3389/fpsyt.2013.00060.

Almonte AG, Qadri LH, Sultan FA, Watson JA, Mount DJ, Rumbaugh G, Sweatt JD. Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity. J. Neurochem [print-electronic]. 2013 Jan; 124(1): 109-22. PMID: 23113835, PMCID: PMC3518655, DOI: 10.1111/jnc.12075, ISSN: 1471-4159.

Zovkic IB, Sweatt JD. Epigenetic mechanisms in learned fear: implications for PTSD. Neuropsychopharmacology [print-electronic]. 2013 Jan; 38(1): 77-93. PMID: 22692566, PMCID: PMC3521992, PII: npp201279, DOI: 10.1038/npp.2012.79, ISSN: 1740-634X.

Sultan FA, Wang J, Tront J, Liebermann DA, Sweatt JD. Genetic deletion of Gadd45b, a regulator of active DNA demethylation, enhances long-term memory and synaptic plasticity. J. Neurosci. 2012 Nov 11/28/2012; 32(48): 17059-66. PMID: 23197699, PMCID: PMC3518911, PII: 32/48/17059, DOI: 10.1523/JNEUROSCI.1747-12.2012, ISSN: 1529-2401.

Heyward FD, Walton RG, Carle MS, Coleman MA, Garvey WT, Sweatt JD. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiol Learn Mem [print-electronic]. 2012 Jul; 98(1): 25-32. PMID: 22542746, PMCID: PMC3389577, PII: S1074-7427(12)00055-X, DOI: 10.1016/j.nlm.2012.04.005, ISSN: 1095-9564.

Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH. Mechanisms of age-related cognitive change and targets for intervention: epigenetics. J. Gerontol. A Biol. Sci. Med. Sci [print-electronic]. 2012 Jun; 67(7): 741-6. PMID: 22522509, PMCID: PMC4009730, PII: gls110, DOI: 10.1093/gerona/gls110, ISSN: 1758-535X.

DeAndrade MP, Zhang L, Doroodchi A, Yokoi F, Cheetham CC, Chen HX, Roper SN, Sweatt JD, Li Y. Enhanced hippocampal long-term potentiation and fear memory in Btbd9 mutant mice. PLoS ONE [print-electronic]. 2012; 7(4): e35518. PMID: 22536397, PMCID: PMC3334925, PII: PONE-D-11-11983, DOI: 10.1371/journal.pone.0035518, ISSN: 1932-6203.

Day JJ, Sweatt JD. Epigenetic treatments for cognitive impairments. Neuropsychopharmacology [print-electronic]. 2012 Jan; 37(1): 247-60. PMID: 21593731, PMCID: PMC3238093, PII: npp201185, DOI: 10.1038/npp.2011.85, ISSN: 1740-634X.

Penner MR, Roth TL, Chawla MK, Hoang LT, Roth ED, Lubin FD, Sweatt JD, Worley PF, Barnes CA. Age-related changes in Arc transcription and DNA methylation within the hippocampus. Neurobiol. Aging [print-electronic]. 2011 Dec; 32(12): 2198-210. PMID: 20189687, PMCID: PMC2888808, PII: S0197-4580(10)00039-4, DOI: 10.1016/j.neurobiolaging.2010.01.009, ISSN: 1558-1497.

Almonte AG, Sweatt JD. Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior. Brain Res [print-electronic]. 2011 Aug 8/17/2011; 1407: 107-22. PMID: 21782155, PMCID: PMC3148282, PII: S0006-8993(11)01169-3, DOI: 10.1016/j.brainres.2011.06.042, ISSN: 1872-6240.

Roth TL, Zoladz PR, Sweatt JD, Diamond DM. Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. J Psychiatr Res [print-electronic]. 2011 Jul; 45(7): 919-26. PMID: 21306736, PMCID: PMC3335738, PII: S0022-3956(11)00014-8, DOI: 10.1016/j.jpsychires.2011.01.013, ISSN: 1879-1379.

Day JJ, Sweatt JD. Cognitive neuroepigenetics: a role for epigenetic mechanisms in learning and memory. Neurobiol Learn Mem [print-electronic]. 2011 Jul; 96(1): 2-12. PMID: 21195202, PMCID: PMC3111867, PII: S1074-7427(10)00228-5, DOI: 10.1016/j.nlm.2010.12.008, ISSN: 1095-9564.

Day JJ, Sweatt JD. Epigenetic mechanisms in cognition. Neuron. 2011 Jun 6/9/2011; 70(5): 813-29. PMID: 21658577, PMCID: PMC3118503, PII: S0896-6273(11)00433-8, DOI: 10.1016/j.neuron.2011.05.019, ISSN: 1097-4199.

Lester BM, Tronick E, Nestler E, Abel T, Kosofsky B, Kuzawa CW, Marsit CJ, Maze I, Meaney MJ, Monteggia LM, Reul JM, Skuse DH, Sweatt JD, Wood MA. Behavioral epigenetics. Ann. N. Y. Acad. Sci. 2011 May; 1226: 14-33. PMID: 21615751, PMCID: PMC3783959, DOI: 10.1111/j.1749-6632.2011.06037.x, ISSN: 1749-6632.

Roth TL, Sweatt JD. Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development. J Child Psychol Psychiatry. 2011 Apr; 52(4): 398-408. PMID: 20626526, PMCID: PMC2965301, PII: JCPP2282, DOI: 10.1111/j.1469-7610.2010.02282.x, ISSN: 1469-7610.

Roth TL, Sweatt JD. Epigenetic marking of the BDNF gene by early-life adverse experiences. Horm Behav [print-electronic]. 2011 Mar; 59(3): 315-20. PMID: 20483357, PMCID: PMC2948595, PII: S0018-506X(10)00138-8, DOI: 10.1016/j.yhbeh.2010.05.005, ISSN: 1095-6867.

Sweatt JD. Neuroscience. Creating stable memories. Science. 2011 Feb 2/18/2011; 331(6019): 869-70. PMID: 21330525, PII: 331/6019/869, DOI: 10.1126/science.1202283, ISSN: 1095-9203.

Day JJ, Sweatt JD. Epigenetic modifications in neurons are essential for formation and storage of behavioral memory. Neuropsychopharmacology. 2011 Jan; 36(1): 357-8. PMID: 21116250, PMCID: PMC3055499, PII: npp2010125, DOI: 10.1038/npp.2010.125, ISSN: 1740-634X.

Xie Z, Cahill ME, Radulovic J, Wang J, Campbell SL, Miller CA, Sweatt JD, Penzes P. Hippocampal phenotypes in kalirin-deficient mice. Mol. Cell. Neurosci [print-electronic]. 2011 Jan; 46(1): 45-54. PMID: 20708080, PMCID: PMC3576140, PII: S1044-7431(10)00196-X, DOI: 10.1016/j.mcn.2010.08.005, ISSN: 1095-9327.

Day JJ, Sweatt JD. DNA methylation and memory formation. Nat. Neurosci. 2010 Nov; 13(11): 1319-23. PMID: 20975755, PMCID: PMC3130618, PII: nn.2666, DOI: 10.1038/nn.2666, ISSN: 1546-1726.

Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, Hepler JR. RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Sep 9/28/2010; 107(39): 16994-8. PMID: 20837545, PMCID: PMC2947872, PII: 1005362107, DOI: 10.1073/pnas.1005362107, ISSN: 1091-6490.

Roth TL, Roth ED, Sweatt JD. Epigenetic regulation of genes in learning and memory. Essays Biochem. 2010 Sep 9/20/2010; 48(1): 263-74. PMID: 20822498, PII: bse0480263, DOI: 10.1042/bse0480263, ISSN: 1744-1358.

Polter A, Beurel E, Yang S, Garner R, Song L, Miller CA, Sweatt JD, McMahon L, Bartolucci AA, Li X, Jope RS. Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. Neuropsychopharmacology [print-electronic]. 2010 Jul; 35(8): 1761-74. PMID: 20357757, PMCID: PMC2891528, PII: npp201043, DOI: 10.1038/npp.2010.43, ISSN: 1740-634X.

Miller CA, Gavin CF, White JA, Parrish RR, Honasoge A, Yancey CR, Rivera IM, Rubio MD, Rumbaugh G, Sweatt JD. Cortical DNA methylation maintains remote memory. Nat. Neurosci [print-electronic]. 2010 Jun; 13(6): 664-6. PMID: 20495557, PMCID: PMC3043549, PII: nn.2560, DOI: 10.1038/nn.2560, ISSN: 1546-1726.

Sweatt JD. Neuroscience. Epigenetics and cognitive aging. Science. 2010 May 5/7/2010; 328(5979): 701-2. PMID: 20448174, PII: 328/5979/701, DOI: 10.1126/science.1189968, ISSN: 1095-9203.

Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat. Neurosci [print-electronic]. 2010 Apr; 13(4): 423-30. PMID: 20228804, PMCID: PMC3060772, PII: nn.2514, DOI: 10.1038/nn.2514, ISSN: 1546-1726.

Gupta S, Kim SY, Artis S, Molfese DL, Schumacher A, Sweatt JD, Paylor RE, Lubin FD. Histone methylation regulates memory formation. J. Neurosci. 2010 Mar 3/10/2010; 30(10): 3589-99. PMID: 20219993, PMCID: PMC2859898, PII: 30/10/3589, DOI: 10.1523/JNEUROSCI.3732-09.2010, ISSN: 1529-2401.

Kilgore M, Miller CA, Fass DM, Hennig KM, Haggarty SJ, Sweatt JD, Rumbaugh G. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology [print-electronic]. 2010 Mar; 35(4): 870-80. PMID: 20010553, PMCID: PMC3055373, PII: npp2009197, DOI: 10.1038/npp.2009.197, ISSN: 1740-634X.

Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT. Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J. Neurosci. 2010 Feb 2/17/2010; 30(7): 2442-53. PMID: 20164328, PMCID: PMC2947456, PII: 30/7/2442, DOI: 10.1523/JNEUROSCI.5038-09.2010, ISSN: 1529-2401.

Yuskaitis CJ, Mines MA, King MK, Sweatt JD, Miller CA, Jope RS. Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome. Biochem. Pharmacol. 2010 Feb 2/15/2010; 79(4): 632-46. PMID: 19799873, PMCID: PMC2810609, PII: S0006-2952(09)00802-8, DOI: 10.1016/j.bcp.2009.09.023, ISSN: 1873-2968.

Penner MR, Roth TL, Barnes CA, Sweatt JD. An epigenetic hypothesis of aging-related cognitive dysfunction. Front Aging Neurosci. 2010; 2: 9. PMID: 20552047, PMCID: PMC2874394, DOI: 10.3389/fnagi.2010.00009, ISSN: 1663-4365.

Yokoi F, Dang MT, Miller CA, Marshall AG, Campbell SL, Sweatt JD, Li Y. Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in Dyt1 DeltaGAG knock-in mice. Neurosci. Res [print-electronic]. 2009 Nov; 65(3): 228-35. PMID: 19619587, PMCID: PMC2757526, PII: S0168-0102(09)00211-9, DOI: 10.1016/j.neures.2009.07.004, ISSN: 1872-8111.

Serrano F, Chang A, Hernandez C, Pautler RG, Sweatt JD, Klann E. NADPH oxidase mediates beta-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures. Mol Brain. 2009 Oct 10/5/2009; 2: 31. PMID: 19804648, PMCID: PMC2762965, PII: 1756-6606-2-31, DOI: 10.1186/1756-6606-2-31, ISSN: 1756-6606.

Cahill ME, Xie Z, Day M, Photowala H, Barbolina MV, Miller CA, Weiss C, Radulovic J, Sweatt JD, Disterhoft JF, Surmeier DJ, Penzes P. Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2009 Aug 8/4/2009; 106(31): 13058-63. PMID: 19625617, PMCID: PMC2722269, PII: 0904636106, DOI: 10.1073/pnas.0904636106, ISSN: 1091-6490.

Roth TL, Sweatt JD. Regulation of chromatin structure in memory formation. Curr. Opin. Neurobiol [print-electronic]. 2009 Jun; 19(3): 336-42. PMID: 19539459, PMCID: PMC2744442, PII: S0959-4388(09)00053-1, DOI: 10.1016/j.conb.2009.05.011, ISSN: 1873-6882.

Guo X, Hamilton PJ, Reish NJ, Sweatt JD, Miller CA, Rumbaugh G. Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia. Neuropsychopharmacology [print-electronic]. 2009 Jun; 34(7): 1659-72. PMID: 19145222, PMCID: PMC3690772, PII: npp2008223, DOI: 10.1038/npp.2008.223, ISSN: 1740-634X.

Roth TL, Lubin FD, Funk AJ, Sweatt JD. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol. Psychiatry [print-electronic]. 2009 May 5/1/2009; 65(9): 760-9. PMID: 19150054, PMCID: PMC3056389, PII: S0006-3223(08)01530-8, DOI: 10.1016/j.biopsych.2008.11.028, ISSN: 1873-2402.

Alexander JC, McDermott CM, Tunur T, Rands V, Stelly C, Karhson D, Bowlby MR, An WF, Sweatt JD, Schrader LA. The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning. Learn. Mem [electronic-print]. 2009 Mar; 16(3): 167-77. PMID: 19223600, PMCID: PMC2661250, PII: 16/3/167, DOI: 10.1101/lm.1261709, ISSN: 1549-5485.

Sweatt JD. Experience-dependent epigenetic modifications in the central nervous system. Biol. Psychiatry [print-electronic]. 2009 Feb 2/1/2009; 65(3): 191-7. PMID: 19006788, PMCID: PMC3090137, PII: S0006-3223(08)01089-5, DOI: 10.1016/j.biopsych.2008.09.002, ISSN: 1873-2402.

Schrader LA, Ren Y, Cheng F, Bui D, Sweatt JD, Anderson AE. Kv4.2 is a locus for PKC and ERK/MAPK cross-talk. Biochem. J. 2009 Feb 2/1/2009; 417(3): 705-15. PMID: 18795890, PMCID: PMC2690529, PII: BJ20081213, DOI: 10.1042/BJ20081213, ISSN: 1470-8728.

Lubin FD, Roth TL, Sweatt JD. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J. Neurosci. 2008 Oct 10/15/2008; 28(42): 10576-86. PMID: 18923034, PMCID: PMC3312036, PII: 28/42/10576, DOI: 10.1523/JNEUROSCI.1786-08.2008, ISSN: 1529-2401.

Roth TL, Sweatt JD. Rhythms of memory. Nat. Neurosci. 2008 Sep; 11(9): 993-4. PMID: 18725902, PII: nn0908-993, DOI: 10.1038/nn0908-993, ISSN: 1546-1726.

Lugo JN, Barnwell LF, Ren Y, Lee WL, Johnston LD, Kim R, Hrachovy RA, Sweatt JD, Anderson AE. Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus. J. Neurochem [print-electronic]. 2008 Aug; 106(4): 1929-40. PMID: 18513371, PMCID: PMC2678944, PII: JNC5508, DOI: 10.1111/j.1471-4159.2008.05508.x, ISSN: 1471-4159.

Samuels IS, Karlo JC, Faruzzi AN, Pickering K, Herrup K, Sweatt JD, Saitta SC, Landreth GE. Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J. Neurosci. 2008 Jul 7/2/2008; 28(27): 6983-95. PMID: 18596172, PMCID: PMC4364995, PII: 28/27/6983, DOI: 10.1523/JNEUROSCI.0679-08.2008, ISSN: 1529-2401.

Ahn HJ, Hernandez CM, Levenson JM, Lubin FD, Liou HC, Sweatt JD. C-Rel, an NF-kappaB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation. Learn. Mem [electronic-print]. 2008 Jul; 15(7): 539-49. PMID: 18626097, PMCID: PMC2505322, PII: 15/7/539, DOI: 10.1101/lm.866408, ISSN: 1549-5485.

Nicholas AP, Lubin FD, Hallett PJ, Vattem P, Ravenscroft P, Bezard E, Zhou S, Fox SH, Brotchie JM, Sweatt JD, Standaert DG. Striatal histone modifications in models of levodopa-induced dyskinesia. J. Neurochem [print-electronic]. 2008 Jul; 106(1): 486-94. PMID: 18410512, PII: JNC5417, DOI: 10.1111/j.1471-4159.2008.05417.x, ISSN: 1471-4159.

Miller CA, Campbell SL, Sweatt JD. DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity. Neurobiol Learn Mem [print-electronic]. 2008 May; 89(4): 599-603. PMID: 17881251, PMCID: PMC2430891, PII: S1074-7427(07)00110-4, DOI: 10.1016/j.nlm.2007.07.016, ISSN: 1095-9564.

Klann E, Sweatt JD. Altered protein synthesis is a trigger for long-term memory formation. Neurobiol Learn Mem [print-electronic]. 2008 Mar; 89(3): 247-59. PMID: 17919940, PMCID: PMC2323606, PII: S1074-7427(07)00123-2, DOI: 10.1016/j.nlm.2007.08.009, ISSN: 1095-9564.

Bracchi-Ricard V, Brambilla R, Levenson J, Hu WH, Bramwell A, Sweatt JD, Green EJ, Bethea JR. Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice. J. Neurochem [print-electronic]. 2008 Feb; 104(3): 611-23. PMID: 17953667, PII: JNC4993, DOI: 10.1111/j.1471-4159.2007.04993.x, ISSN: 1471-4159.

Chwang WB, Arthur JS, Schumacher A, Sweatt JD. The nuclear kinase mitogen- and stress-activated protein kinase 1 regulates hippocampal chromatin remodeling in memory formation. J. Neurosci. 2007 Nov 11/14/2007; 27(46): 12732-42. PMID: 18003853, PII: 27/46/12732, DOI: 10.1523/JNEUROSCI.2522-07.2007, ISSN: 1529-2401.

Lubin FD, Sweatt JD. The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. Neuron. 2007 Sep 9/20/2007; 55(6): 942-57. PMID: 17880897, PMCID: PMC2587178, PII: S0896-6273(07)00585-5, DOI: 10.1016/j.neuron.2007.07.039, ISSN: 0896-6273.

Chan CS, Levenson JM, Mukhopadhyay PS, Zong L, Bradley A, Sweatt JD, Davis RL. Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Learn. Mem [electronic-print]. 2007 Sep; 14(9): 606-15. PMID: 17848500, PMCID: PMC1994082, PII: 14/9/606, DOI: 10.1101/lm.648607, ISSN: 1549-5485.

Sweatt JD. An atomic switch for memory. Cell. 2007 Apr 4/6/2007; 129(1): 23-4. PMID: 17418779, PII: S0092-8674(07)00385-6, DOI: 10.1016/j.cell.2007.03.021, ISSN: 0092-8674.

Kim SY, Levenson JM, Korsmeyer S, Sweatt JD, Schumacher A. Developmental regulation of Eed complex composition governs a switch in global histone modification in brain. J. Biol. Chem [print-electronic]. 2007 Mar 3/30/2007; 282(13): 9962-72. PMID: 17259173, PII: M608722200, DOI: 10.1074/jbc.M608722200, ISSN: 0021-9258.

Miller CA, Sweatt JD. Covalent modification of DNA regulates memory formation. Neuron. 2007 Mar 3/15/2007; 53(6): 857-69. PMID: 17359920, PII: S0896-6273(07)00142-0, DOI: 10.1016/j.neuron.2007.02.022, ISSN: 0896-6273.

Chen X, Yuan LL, Zhao C, Birnbaum SG, Frick A, Jung WE, Schwarz TL, Sweatt JD, Johnston D. Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons. J. Neurosci. 2006 Nov 11/22/2006; 26(47): 12143-51. PMID: 17122039, PII: 26/47/12143, DOI: 10.1523/JNEUROSCI.2667-06.2006, ISSN: 1529-2401.

Nishijima I, Yamagata T, Spencer CM, Weeber EJ, Alekseyenko O, Sweatt JD, Momoi MY, Ito M, Armstrong DL, Nelson DL, Paylor R, Bradley A. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. Hum. Mol. Genet [print-electronic]. 2006 Nov 11/1/2006; 15(21): 3241-50. PMID: 17008357, PMCID: PMC2593392, PII: ddl402, DOI: 10.1093/hmg/ddl402, ISSN: 0964-6906.

Miller CA, Sweatt JD. Amnesia or retrieval deficit? Implications of a molecular approach to the question of reconsolidation. Learn. Mem. 2006 Sep; 13(5): 498-505. PMID: 17015846, PII: 13/5/498, DOI: 10.1101/lm.304606, ISSN: 1072-0502.

Levenson JM, Roth TL, Lubin FD, Miller CA, Huang IC, Desai P, Malone LM, Sweatt JD. Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J. Biol. Chem [print-electronic]. 2006 Jun 6/9/2006; 281(23): 15763-73. PMID: 16606618, PII: M511767200, DOI: 10.1074/jbc.M511767200, ISSN: 0021-9258.

Shalin SC, Hernandez CM, Dougherty MK, Morrison DK, Sweatt JD. Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation. Neuron. 2006 Jun 6/1/2006; 50(5): 765-79. PMID: 16731514, PII: S0896-6273(06)00339-4, DOI: 10.1016/j.neuron.2006.04.029, ISSN: 0896-6273.

O'Riordan KJ, Huang IC, Pizzi M, Spano P, Boroni F, Egli R, Desai P, Fitch O, Malone L, Ahn HJ, Liou HC, Sweatt JD, Levenson JM. Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors. J. Neurosci. 2006 May 5/3/2006; 26(18): 4870-9. PMID: 16672661, PII: 26/18/4870, DOI: 10.1523/JNEUROSCI.4527-05.2006, ISSN: 1529-2401.

Chwang WB, O'Riordan KJ, Levenson JM, Sweatt JD. ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning. Learn. Mem. 2006 May; 13(3): 322-8. PMID: 16741283, PMCID: PMC1475813, PII: 13/3/322, DOI: 10.1101/lm.152906, ISSN: 1072-0502.

Levenson JM, Sweatt JD. Epigenetic mechanisms: a common theme in vertebrate and invertebrate memory formation. Cell. Mol. Life Sci. 2006 May; 63(9): 1009-16. PMID: 16596331, DOI: 10.1007/s00018-006-6026-6, ISSN: 1420-682X.

Schrader LA, Birnbaum SG, Nadin BM, Ren Y, Bui D, Anderson AE, Sweatt JD. ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am. J. Physiol., Cell Physiol [print-electronic]. 2006 Mar; 290(3): C852-61. PMID: 16251476, PII: 00358.2005, DOI: 10.1152/ajpcell.00358.2005, ISSN: 0363-6143.

Beffert U, Durudas A, Weeber EJ, Stolt PC, Giehl KM, Sweatt JD, Hammer RE, Herz J. Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J. Neurosci. 2006 Feb 2/15/2006; 26(7): 2041-52. PMID: 16481437, PII: 26/7/2041, DOI: 10.1523/JNEUROSCI.4566-05.2006, ISSN: 1529-2401.

Moretti P, Levenson JM, Battaglia F, Atkinson R, Teague R, Antalffy B, Armstrong D, Arancio O, Sweatt JD, Zoghbi HY. Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J. Neurosci. 2006 Jan 1/4/2006; 26(1): 319-27. PMID: 16399702, PII: 26/1/319, DOI: 10.1523/JNEUROSCI.2623-05.2006, ISSN: 1529-2401.

Chan CS, Weeber EJ, Zong L, Fuchs E, Sweatt JD, Davis RL. Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. J. Neurosci. 2006 Jan 1/4/2006; 26(1): 223-32. PMID: 16399691, PMCID: PMC2408376, PII: 26/1/223, DOI: 10.1523/JNEUROSCI.4110-05.2006, ISSN: 1529-2401.

Shalin SC, Egli R, Birnbaum SG, Roth TL, Levenson JM, Sweatt JD. Signal transduction mechanisms in memory disorders. Prog. Brain Res. 2006; 157: 25-41. PMID: 17167902, ISSN: 0079-6123.

Beffert U, Weeber EJ, Durudas A, Qiu S, Masiulis I, Sweatt JD, Li WP, Adelmann G, Frotscher M, Hammer RE, Herz J. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron. 2005 Aug 8/18/2005; 47(4): 567-79. PMID: 16102539, PII: S0896-6273(05)00601-X, DOI: 10.1016/j.neuron.2005.07.007, ISSN: 0896-6273.

Winder DG, Sweatt JD. Roles of serine/threonine phosphatases in hippocampal synaptic plasticity. Nat. Rev. Neurosci. 2001 Jul; 2(7): 461-74. PMID: 11433371, PII: 35081514, DOI: 10.1038/35081514, ISSN: 1471-003X.

Winder DG, Sweatt JD. Roles of serine/threonine phosphatases in hippocampal synaptic plasticity. Nat. Rev. Neurosci. 2001 Jul; 2(7): 461-74. PMID: 11433371, PII: 35081514, DOI: 10.1038/35081514, ISSN: 1471-003X.

Sweatt JD, Connolly TM, Baron BM, Limbird LE. Involvement of Na+/H+ exchange in human platelet activation. Prog. Clin. Biol. Res. 1988; 283: 523-57. PMID: 2850577, ISSN: 0361-7742.

Sweatt JD, Connolly TM, Baron BM, Limbird LE. Involvement of Na+/H+ exchange in human platelet activation. Prog. Clin. Biol. Res. 1988; 283: 523-57. PMID: 2850577, ISSN: 0361-7742.

Sweatt JD, Schwartzberg MS, Frazer M, Cragoe EJ, Blair IA, Reed PW, Limbird LE. Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF. Circ. Res. 1987 Nov; 61(5 Pt 2): II6-11. PMID: 2822286, ISSN: 0009-7330.

Sweatt JD, Schwartzberg MS, Frazer M, Cragoe EJ, Blair IA, Reed PW, Limbird LE. Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF. Circ. Res. 1987 Nov; 61(5 Pt 2): II6-11. PMID: 2822286, ISSN: 0009-7330.