Faculty Appointments
Assistant Professor of Biological Sciences
Assistant Professor of Pathology, Microbiology and ImmunologyAssistant Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Ecology and Evolutionary Biology, Princeton University, Princeton, New JerseyB.S., Ecology and Evolutionary Biology, Rice University, Houston, Texas
Research Description
We are interested in understanding the impact of parasites on the evolution of immune systems, and the conflicts that arise when organisms need to balance investment in immunity with other life history traits. We couple theoretical approaches with experiments on tractable beetle systems to explore the causes and consequences of variation in both infection and immunity at the molecular, organismal, and population levels of biological organization.
Lab website: https://my.vanderbilt.edu/tatelab/
Lab website: https://my.vanderbilt.edu/tatelab/
Research Keywords
host-microbe interactions, innate immunity, immunology, ecology, evolution, epidemiology, resistance, tolerance, life history evolution, disease dynamics, microbiology, functional genomics, theoretical modeling, computational biology
Publications
Martin RA, Tate AT. Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution. PLoS Comput Biol. 2023 Apr; 19(4): e1010445. PMID: 37022993, PMCID: PMC10079112, PII: PCOMPBIOL-D-22-01155, DOI: 10.1371/journal.pcbi.1010445, ISSN: 1553-7358.
Williams AM, Ngo TM, Figueroa VE, Tate AT. The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes. Genome Biol Evol. 2023 Mar 3/3/2023; 15(3): PMID: 36911982, PMCID: PMC10063218, PII: 7076390, DOI: 10.1093/gbe/evad044, ISSN: 1759-6653.
Chora ÂF, Marques S, Gonçalves JL, Lima P, Gomes da Costa D, Fernandez-Ruiz D, Marreiros MI, Ruivo P, Carvalho T, Ribeiro RM, Serre K, Heath WR, Silva-Santos B, Tate AT, Mota MM. Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via ¿d T cells and IL-17-promoted stress erythropoiesis. Immunity [print-electronic]. 2023 Feb 2/14/2023; PMID: 36804959, PII: S1074-7613(23)00043-2, DOI: 10.1016/j.immuni.2023.01.031, ISSN: 1097-4180.
Lazzaro BP, Tate AT. Balancing sensitivity, risk, and immunopathology in immune regulation. Curr Opin Insect Sci [print-electronic]. 2022 Apr; 50: 100874. PMID: 35051619, PMCID: PMC9133098, PII: S2214-5745(22)00002-5, DOI: 10.1016/j.cois.2022.100874, ISSN: 2214-5753.
Tate AT, Schulz NK. The within-host ecology of insects and their parasites: integrating experiments and mathematical models. Curr Opin Insect Sci [print-electronic]. 2022 Feb; 49: 37-41. PMID: 34793990, PII: S2214-5745(21)00115-2, DOI: 10.1016/j.cois.2021.11.001, ISSN: 2214-5753.
Tate AT, Van Cleve J. Bet-hedging in innate and adaptive immune systems. Evol Med Public Health. 2022; 10(1): 256-65. PMID: 35712085, PMCID: PMC9195227, PII: eoac021, DOI: 10.1093/emph/eoac021, ISSN: 2050-6201.
Gitschlag BL, Tate AT, Patel MR. Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection. Elife. 2020 Sep 9/22/2020; 9: PMID: 32959778, PMCID: PMC7508553, PII: 56686, DOI: 10.7554/eLife.56686, ISSN: 2050-084X.
Greischar MA, Alexander HK, Bashey F, Bento AI, Bhattacharya A, Bushman M, Childs LM, Daversa DR, Day T, Faust CL, Gallagher ME, Gandon S, Glidden CK, Halliday FW, Hanley KA, Kamiya T, Read AF, Schwabl P, Sweeny AR, Tate AT, Thompson RN, Wale N, Wearing HJ, Yeh PJ, Mideo N. Evolutionary consequences of feedbacks between within-host competition and disease control. Evol Med Public Health. 2020; 2020(1): 30-4. PMID: 32099654, PMCID: PMC7027713, PII: eoaa004, DOI: 10.1093/emph/eoaa004, ISSN: 2050-6201.
Jent D, Perry A, Critchlow J, Tate AT. Natural variation in the contribution of microbial density to inducible immune dynamics. Mol. Ecol [print-electronic]. 2019 Nov 11/1/2019; PMID: 31674070, DOI: 10.1111/mec.15293, ISSN: 1365-294X.
Critchlow JT, Norris A, Tate AT. The legacy of larval infection on immunological dynamics over metamorphosis. Philos. Trans. R. Soc. Lond., B, Biol. Sci [print-electronic]. 2019 Oct 10/14/2019; 374(1783): 20190066. PMID: 31438817, DOI: 10.1098/rstb.2019.0066, ISSN: 1471-2970.
Tate AT. Role of Multiple Infections on Immunological Variation in Wild Populations. MSystems. 2019 May 5/7/2019; 4(3): PMID: 31219784, PMCID: PMC6533374, PII: 4/3/e00099-19, DOI: 10.1128/mSystems.00099-19, ISSN: 2379-5077.
The role of multiple infections on immunological variation in wild populations. Msystems. 2019; 4(3): e0009:19.
Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends Immunol [print-electronic]. 2018 Nov; 39(11): 862-73. PMID: 30301592, PMCID: PMC6218297, PII: S1471-4906(18)30168-6, DOI: 10.1016/j.it.2018.09.003, ISSN: 1471-4981.
Graham AL, Tate AT. Are we immune by chance?. Elife. 2017 Nov 11/27/2017; 6: PMID: 29173279, DOI: 10.7554/eLife.32783, ISSN: 2050-084X.
Metcalf CJE, Tate AT, Graham AL. Demographically framing trade-offs between sensitivity and specificity illuminates selection on immunity. Nat Ecol Evol [print-electronic]. 2017 Sep 9/25/2017; PMID: 28963489, PII: 10.1038/s41559-017-0315-3, DOI: 10.1038/s41559-017-0315-3, ISSN: 2397-334X.
Tate AT, Graham AL. Dissecting the contributions of time and microbe density to variation in immune gene expression. Proc. Biol. Sci. 2017 Jul 7/26/2017; 284(1859): PMID: 28747473, PII: rspb.2017.0727, DOI: 10.1098/rspb.2017.0727, ISSN: 1471-2954.
Luu H, Tate AT. Recovery and immune priming modulate the evolutionary trajectory of infection-induced reproductive strategies. J. Evol. Biol [print-electronic]. 2017 Jul 7/1/2017; PMID: 28667661, DOI: 10.1111/jeb.13138, ISSN: 1420-9101.
Tate AT. A general model for the influence of immune priming on disease prevalence. Oikos. 2017 Mar; 126(3): 350-60.
Tate AT, Andolfatto P, Demuth J, Graham AL. The within-host dynamics of infection in trans-generationally primed flour beetles. Molecular Ecology. 2017; 26(14): 3794-807.
Kennedy M, Graham AL, Tate AT. Relative contributions of environmental and maternal factors to trans-generational immune priming in T. castaneum. Ecological Entomology. 2017 Jan; 42(1): 100-4.
Schneider D, Tate AT. Innate Immune Memory: Activation of Macrophage Killing Ability by Developmental Duties. Curr. Biol. 2016 Jun 6/20/2016; 26(12): R503-5. PMID: 27326712, PII: S0960-9822(16)30474-2, DOI: 10.1016/j.cub.2016.05.016, ISSN: 1879-0445.
Torres BY, Oliveira JH, Thomas Tate A, Rath P, Cumnock K, Schneider DS. Tracking Resilience to Infections by Mapping Disease Space. PLoS Biol. 2016 Apr; 14(4): e1002436. PMID: 27088359, PMCID: PMC4835107, PII: PBIOLOGY-D-15-02910, DOI: 10.1371/journal.pbio.1002436, ISSN: 1545-7885.
Louie A, Song KH, Hotson A, Thomas Tate A, Schneider DS. How Many Parameters Does It Take to Describe Disease Tolerance?. PLoS Biol. 2016 Apr; 14(4): e1002435. PMID: 27088212, PMCID: PMC4835111, PII: PBIOLOGY-D-15-02909, DOI: 10.1371/journal.pbio.1002435, ISSN: 1545-7885.
Tate AT. The Interaction of Immune Priming with Different Modes of Disease Transmission. Front Microbiol. 2016; 7: 1102. PMID: 27468283, PMCID: PMC4942476, DOI: 10.3389/fmicb.2016.01102.
Tate AT, Graham AL. Dynamic Patterns of Parasitism and Immunity across Host Development Influence Optimal Strategies of Resource Allocation. Am. Nat [print-electronic]. 2015 Oct; 186(4): 495-512. PMID: 26655573, DOI: 10.1086/682705, ISSN: 1537-5323.
Tate AT, Graham AL, et al. Trans-generational priming of resistance in wild flour beetles reflects the primed phenotypes of laboratory populations and is inhibited by co-infection with a common parasite. Functional Ecology. 2015; 29(8): 1059-69.
Tate AT, Rudolf VW. Impact of life stage – specific immune priming on invertebrate disease dynamics. Oikos. 2012; 121(7): 1083-92.
Thomas AM, Rudolf VW. Challenges of metamorphosis in invertebrate hosts: Maintaining parasite resistance across life-history stages. Ecological Entomology. 2010; 35(2): 200-5.
Abbott AN, Guidry TV, Welsh KJ, Thomas AM, Kling MA, Hunter RL, Actor JK. 11beta-hydroxysteroid dehydrogenases are regulated during the pulmonary granulomatous response to the mycobacterial glycolipid trehalose-6,6'-dimycolate. Neuroimmunomodulation [print-electronic]. 2009; 16(3): 147-54. PMID: 19246936, PII: 000204227, DOI: 10.1159/000204227, ISSN: 1423-0216.
Williams AM, Ngo TM, Figueroa VE, Tate AT. The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes. Genome Biol Evol. 2023 Mar 3/3/2023; 15(3): PMID: 36911982, PMCID: PMC10063218, PII: 7076390, DOI: 10.1093/gbe/evad044, ISSN: 1759-6653.
Chora ÂF, Marques S, Gonçalves JL, Lima P, Gomes da Costa D, Fernandez-Ruiz D, Marreiros MI, Ruivo P, Carvalho T, Ribeiro RM, Serre K, Heath WR, Silva-Santos B, Tate AT, Mota MM. Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via ¿d T cells and IL-17-promoted stress erythropoiesis. Immunity [print-electronic]. 2023 Feb 2/14/2023; PMID: 36804959, PII: S1074-7613(23)00043-2, DOI: 10.1016/j.immuni.2023.01.031, ISSN: 1097-4180.
Lazzaro BP, Tate AT. Balancing sensitivity, risk, and immunopathology in immune regulation. Curr Opin Insect Sci [print-electronic]. 2022 Apr; 50: 100874. PMID: 35051619, PMCID: PMC9133098, PII: S2214-5745(22)00002-5, DOI: 10.1016/j.cois.2022.100874, ISSN: 2214-5753.
Tate AT, Schulz NK. The within-host ecology of insects and their parasites: integrating experiments and mathematical models. Curr Opin Insect Sci [print-electronic]. 2022 Feb; 49: 37-41. PMID: 34793990, PII: S2214-5745(21)00115-2, DOI: 10.1016/j.cois.2021.11.001, ISSN: 2214-5753.
Tate AT, Van Cleve J. Bet-hedging in innate and adaptive immune systems. Evol Med Public Health. 2022; 10(1): 256-65. PMID: 35712085, PMCID: PMC9195227, PII: eoac021, DOI: 10.1093/emph/eoac021, ISSN: 2050-6201.
Gitschlag BL, Tate AT, Patel MR. Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection. Elife. 2020 Sep 9/22/2020; 9: PMID: 32959778, PMCID: PMC7508553, PII: 56686, DOI: 10.7554/eLife.56686, ISSN: 2050-084X.
Greischar MA, Alexander HK, Bashey F, Bento AI, Bhattacharya A, Bushman M, Childs LM, Daversa DR, Day T, Faust CL, Gallagher ME, Gandon S, Glidden CK, Halliday FW, Hanley KA, Kamiya T, Read AF, Schwabl P, Sweeny AR, Tate AT, Thompson RN, Wale N, Wearing HJ, Yeh PJ, Mideo N. Evolutionary consequences of feedbacks between within-host competition and disease control. Evol Med Public Health. 2020; 2020(1): 30-4. PMID: 32099654, PMCID: PMC7027713, PII: eoaa004, DOI: 10.1093/emph/eoaa004, ISSN: 2050-6201.
Jent D, Perry A, Critchlow J, Tate AT. Natural variation in the contribution of microbial density to inducible immune dynamics. Mol. Ecol [print-electronic]. 2019 Nov 11/1/2019; PMID: 31674070, DOI: 10.1111/mec.15293, ISSN: 1365-294X.
Critchlow JT, Norris A, Tate AT. The legacy of larval infection on immunological dynamics over metamorphosis. Philos. Trans. R. Soc. Lond., B, Biol. Sci [print-electronic]. 2019 Oct 10/14/2019; 374(1783): 20190066. PMID: 31438817, DOI: 10.1098/rstb.2019.0066, ISSN: 1471-2970.
Tate AT. Role of Multiple Infections on Immunological Variation in Wild Populations. MSystems. 2019 May 5/7/2019; 4(3): PMID: 31219784, PMCID: PMC6533374, PII: 4/3/e00099-19, DOI: 10.1128/mSystems.00099-19, ISSN: 2379-5077.
The role of multiple infections on immunological variation in wild populations. Msystems. 2019; 4(3): e0009:19.
Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends Immunol [print-electronic]. 2018 Nov; 39(11): 862-73. PMID: 30301592, PMCID: PMC6218297, PII: S1471-4906(18)30168-6, DOI: 10.1016/j.it.2018.09.003, ISSN: 1471-4981.
Graham AL, Tate AT. Are we immune by chance?. Elife. 2017 Nov 11/27/2017; 6: PMID: 29173279, DOI: 10.7554/eLife.32783, ISSN: 2050-084X.
Metcalf CJE, Tate AT, Graham AL. Demographically framing trade-offs between sensitivity and specificity illuminates selection on immunity. Nat Ecol Evol [print-electronic]. 2017 Sep 9/25/2017; PMID: 28963489, PII: 10.1038/s41559-017-0315-3, DOI: 10.1038/s41559-017-0315-3, ISSN: 2397-334X.
Tate AT, Graham AL. Dissecting the contributions of time and microbe density to variation in immune gene expression. Proc. Biol. Sci. 2017 Jul 7/26/2017; 284(1859): PMID: 28747473, PII: rspb.2017.0727, DOI: 10.1098/rspb.2017.0727, ISSN: 1471-2954.
Luu H, Tate AT. Recovery and immune priming modulate the evolutionary trajectory of infection-induced reproductive strategies. J. Evol. Biol [print-electronic]. 2017 Jul 7/1/2017; PMID: 28667661, DOI: 10.1111/jeb.13138, ISSN: 1420-9101.
Tate AT. A general model for the influence of immune priming on disease prevalence. Oikos. 2017 Mar; 126(3): 350-60.
Tate AT, Andolfatto P, Demuth J, Graham AL. The within-host dynamics of infection in trans-generationally primed flour beetles. Molecular Ecology. 2017; 26(14): 3794-807.
Kennedy M, Graham AL, Tate AT. Relative contributions of environmental and maternal factors to trans-generational immune priming in T. castaneum. Ecological Entomology. 2017 Jan; 42(1): 100-4.
Schneider D, Tate AT. Innate Immune Memory: Activation of Macrophage Killing Ability by Developmental Duties. Curr. Biol. 2016 Jun 6/20/2016; 26(12): R503-5. PMID: 27326712, PII: S0960-9822(16)30474-2, DOI: 10.1016/j.cub.2016.05.016, ISSN: 1879-0445.
Torres BY, Oliveira JH, Thomas Tate A, Rath P, Cumnock K, Schneider DS. Tracking Resilience to Infections by Mapping Disease Space. PLoS Biol. 2016 Apr; 14(4): e1002436. PMID: 27088359, PMCID: PMC4835107, PII: PBIOLOGY-D-15-02910, DOI: 10.1371/journal.pbio.1002436, ISSN: 1545-7885.
Louie A, Song KH, Hotson A, Thomas Tate A, Schneider DS. How Many Parameters Does It Take to Describe Disease Tolerance?. PLoS Biol. 2016 Apr; 14(4): e1002435. PMID: 27088212, PMCID: PMC4835111, PII: PBIOLOGY-D-15-02909, DOI: 10.1371/journal.pbio.1002435, ISSN: 1545-7885.
Tate AT. The Interaction of Immune Priming with Different Modes of Disease Transmission. Front Microbiol. 2016; 7: 1102. PMID: 27468283, PMCID: PMC4942476, DOI: 10.3389/fmicb.2016.01102.
Tate AT, Graham AL. Dynamic Patterns of Parasitism and Immunity across Host Development Influence Optimal Strategies of Resource Allocation. Am. Nat [print-electronic]. 2015 Oct; 186(4): 495-512. PMID: 26655573, DOI: 10.1086/682705, ISSN: 1537-5323.
Tate AT, Graham AL, et al. Trans-generational priming of resistance in wild flour beetles reflects the primed phenotypes of laboratory populations and is inhibited by co-infection with a common parasite. Functional Ecology. 2015; 29(8): 1059-69.
Tate AT, Rudolf VW. Impact of life stage – specific immune priming on invertebrate disease dynamics. Oikos. 2012; 121(7): 1083-92.
Thomas AM, Rudolf VW. Challenges of metamorphosis in invertebrate hosts: Maintaining parasite resistance across life-history stages. Ecological Entomology. 2010; 35(2): 200-5.
Abbott AN, Guidry TV, Welsh KJ, Thomas AM, Kling MA, Hunter RL, Actor JK. 11beta-hydroxysteroid dehydrogenases are regulated during the pulmonary granulomatous response to the mycobacterial glycolipid trehalose-6,6'-dimycolate. Neuroimmunomodulation [print-electronic]. 2009; 16(3): 147-54. PMID: 19246936, PII: 000204227, DOI: 10.1159/000204227, ISSN: 1423-0216.