Ann Thomas Tate, Ph.D.

Assistant Professor
Faculty Appointments
Assistant Professor of Biological Sciences
Ph.D., Ecology and Evolutionary Biology, Princeton University, Princeton, New JerseyB.S., Ecology and Evolutionary Biology, Rice University, Houston, Texas
Research Description
We are interested in understanding the impact of parasites on the evolution of immune systems, and the conflicts that arise when organisms need to balance investment in immunity with other life history traits. We couple theoretical approaches with experiments on tractable beetle systems to explore the causes and consequences of variation in both infection and immunity at the molecular, organismal, and population levels of biological organization.

Lab website:
Research Keywords
host-microbe interactions, innate immunity, immunology, ecology, evolution, epidemiology, resistance, tolerance, life history evolution, disease dynamics, microbiology, functional genomics, theoretical modeling
Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends Immunol [print-electronic]. 2018 Nov; 39(11): 862-73. PMID: 30301592, PMCID: PMC6218297, PII: S1471-4906(18)30168-6, DOI: 10.1016/, ISSN: 1471-4981.

Graham AL, Tate AT. Are we immune by chance?. Elife. 2017 Nov 11/27/2017; 6: PMID: 29173279, DOI: 10.7554/eLife.32783, ISSN: 2050-084X.

Metcalf CJE, Tate AT, Graham AL. Demographically framing trade-offs between sensitivity and specificity illuminates selection on immunity. Nat Ecol Evol [print-electronic]. 2017 Sep 9/25/2017; PMID: 28963489, PII: 10.1038/s41559-017-0315-3, DOI: 10.1038/s41559-017-0315-3, ISSN: 2397-334X.

Tate AT, Graham AL. Dissecting the contributions of time and microbe density to variation in immune gene expression. Proc. Biol. Sci. 2017 Jul 7/26/2017; 284(1859): PMID: 28747473, PII: rspb.2017.0727, DOI: 10.1098/rspb.2017.0727, ISSN: 1471-2954.

Luu H, Tate AT. Recovery and immune priming modulate the evolutionary trajectory of infection-induced reproductive strategies. J. Evol. Biol [print-electronic]. 2017 Jul 7/1/2017; PMID: 28667661, DOI: 10.1111/jeb.13138, ISSN: 1420-9101.

Tate AT. A general model for the influence of immune priming on disease prevalence. Oikos. 2017 Mar; 126(3): 350-60.

Tate AT, Andolfatto P, Demuth J, Graham AL. The within-host dynamics of infection in trans-generationally primed flour beetles. Molecular Ecology. 2017; 26(14): 3794-807.

Kennedy M, Graham AL, Tate AT. Relative contributions of environmental and maternal factors to trans-generational immune priming in T. castaneum. Ecological Entomology. 2017 Jan; 42(1): 100-4.

Schneider D, Tate AT. Innate Immune Memory: Activation of Macrophage Killing Ability by Developmental Duties. Curr. Biol. 2016 Jun 6/20/2016; 26(12): R503-5. PMID: 27326712, PII: S0960-9822(16)30474-2, DOI: 10.1016/j.cub.2016.05.016, ISSN: 1879-0445.

Torres BY, Oliveira JH, Thomas Tate A, Rath P, Cumnock K, Schneider DS. Tracking Resilience to Infections by Mapping Disease Space. PLoS Biol. 2016 Apr; 14(4): e1002436. PMID: 27088359, PMCID: PMC4835107, PII: PBIOLOGY-D-15-02910, DOI: 10.1371/journal.pbio.1002436, ISSN: 1545-7885.

Louie A, Song KH, Hotson A, Thomas Tate A, Schneider DS. How Many Parameters Does It Take to Describe Disease Tolerance?. PLoS Biol. 2016 Apr; 14(4): e1002435. PMID: 27088212, PMCID: PMC4835111, PII: PBIOLOGY-D-15-02909, DOI: 10.1371/journal.pbio.1002435, ISSN: 1545-7885.

Tate AT. The Interaction of Immune Priming with Different Modes of Disease Transmission. Front Microbiol. 2016; 7: 1102. PMID: 27468283, PMCID: PMC4942476, DOI: 10.3389/fmicb.2016.01102.

Tate AT, Graham AL. Dynamic Patterns of Parasitism and Immunity across Host Development Influence Optimal Strategies of Resource Allocation. Am. Nat [print-electronic]. 2015 Oct; 186(4): 495-512. PMID: 26655573, DOI: 10.1086/682705, ISSN: 1537-5323.

Tate AT, Graham AL, et al. Trans-generational priming of resistance in wild flour beetles reflects the primed phenotypes of laboratory populations and is inhibited by co-infection with a common parasite. Functional Ecology. 2015; 29(8): 1059-69.

Tate AT, Rudolf VW. Impact of life stage – specific immune priming on invertebrate disease dynamics. Oikos. 2012; 121(7): 1083-92.

Thomas AM, Rudolf VW. Challenges of metamorphosis in invertebrate hosts: Maintaining parasite resistance across life-history stages. Ecological Entomology. 2010; 35(2): 200-5.

Abbott AN, Guidry TV, Welsh KJ, Thomas AM, Kling MA, Hunter RL, Actor JK. 11beta-hydroxysteroid dehydrogenases are regulated during the pulmonary granulomatous response to the mycobacterial glycolipid trehalose-6,6'-dimycolate. Neuroimmunomodulation [print-electronic]. 2009; 16(3): 147-54. PMID: 19246936, PII: 000204227, DOI: 10.1159/000204227, ISSN: 1423-0216.