Suman Ranjan Das, Ph.D.

Associate Professor

suman.r.das@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine
Education
Ph.D., Molecular Biology, Banaras Hindu University, Varanaisi, India
Office Address
9704 Medical Center Drive
Rockville, MD 20850
Research Description
Dr. Suman R. Das, Ph.D. is a Associate Professor of Medicine at the Vanderbilt University Medical Center in the Division of Infectious Diseases. Prior to joining Vanderbilt, Dr. Das was an Associate Professor in the Infectious Diseases Group at J. Craig Venter Institute, Rockville MD. Using genomics tools, his group is trying to understand the underlying mechanisms that contribute to evolution of RNA viruses (i.e., influenza, RSV, rotavirus EEEV, and enterovirus). For the past four years, his lab is also interested in understanding virus, host and microbiome interactions, to identify if the host microbiota contributes to disease severity and long-term outcomes. Further, employing a two-pronged research approach, his lab is currently developing in vitro and in vivo models to understand the underlying mechanisms that contribute to antigenic evolution of influenza virus to escape the host immune response. By combining bioinformatics and synthetic genomics, his lab is evaluating the experimental data to better predict the future evolutionary path of influenza virus.

Dr. Das received PhD in virology from the International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India, where he studied molecular pathogenesis of HIV-1 subtype C Indian isolates.  After a short postdoctoral fellowship at the University of Massachusetts Medical School in Worcester, MA, he joined the Laboratory of Viral Diseases in NIAID to work with Drs. Yewdell and Bennink as a Fogarty International fellow, where his research was focused on understanding the antigenic evolution influenza A virus. Prior to joining JCVI, he studied human B-cell response to influenza infection and vaccination at Emory Vaccine Center, in Atlanta.
Research Keywords
Viral genomics of Influenza, RSV, Rotavirus, Norovirus, EEEV, VEEV, West Nile virus, Chikungunya, Zika, Ebola, and Enterovirus, synthetic genomics, virus-host microbiome interactions, modeling of evolution of RNA viruses using in vitro, in vivo and computational tools.
Publications
Brown DM, Hixon AM, Oldfield LM, Zhang Y, Novotny M, Wang W, Das SR, Shabman RS, Tyler KL, Scheuermann RH. Contemporary Circulating Enterovirus D68 Strains Have Acquired the Capacity for Viral Entry and Replication in Human Neuronal Cells. MBio. 2018 Oct 10/16/2018; 9(5): PMID: 30327438, PMCID: PMC6191546, PII: mBio.01954-18, DOI: 10.1128/mBio.01954-18, ISSN: 2150-7511.

Hickman HD, Mays JW, Gibbs J, Kosik I, Magádan JG, Takeda K, Das S, Reynoso GV, Ngudiankama BF, Wei J, Shannon JP, McManus D, Yewdell JW. Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance. J. Immunol [print-electronic]. 2018 Aug 8/15/2018; 201(4): 1222-8. PMID: 30012850, PMCID: PMC6082381, PII: jimmunol.1800586, DOI: 10.4049/jimmunol.1800586, ISSN: 1550-6606.

Rajagopala SV, Singh H, Patel MC, Wang W, Tan Y, Shilts MH, Hartert TV, Boukhvalova MS, Blanco JCG, Das SR. Cotton rat lung transcriptome reveals host immune response to Respiratory Syncytial Virus infection. Sci Rep. 2018 Jul 7/27/2018; 8(1): 11318. PMID: 30054492, PMCID: PMC6063970, PII: 10.1038/s41598-018-29374-x, DOI: 10.1038/s41598-018-29374-x, ISSN: 2045-2322.

Nyaga MM, Tan Y, Seheri ML, Halpin RA, Akopov A, Stucker KM, Fedorova NB, Shrivastava S, Duncan Steele A, Mwenda JM, Pickett BE, Das SR, Jeffery Mphahlele M. Whole-genome sequencing and analyses identify high genetic heterogeneity and diversity of rotavirus genotype P[6] strains circulating in Africa. Infect. Genet. Evol [print-electronic]. 2018 May 5/18/2018; PMID: 29782933, PII: S1567-1348(18)30286-7, DOI: 10.1016/j.meegid.2018.05.013, ISSN: 1567-7257.

Turi KN, Shankar J, Anderson LJ, Rajan D, Gaston K, Gebretsadik T, Das SR, Stone C, Larkin EK, Rosas-Salazar C, Brunwasser SM, Moore ML, Peebles RS, Hartert TV. Infant Viral Respiratory Infection Nasal-Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze. Am. J. Respir. Crit. Care Med [print-electronic]. 2018 May 5/7/2018; PMID: 29733679, DOI: 10.1164/rccm.201711-2348OC, ISSN: 1535-4970.

Tan Y, Tsan-Yuk Lam T, Heberlein-Larson LA, Smole SC, Auguste AJ, Hennigan S, Halpin RA, Fedorova N, Puri V, Stockwell TB, Shilts MH, Andreadis T, Armstrong PM, Tesh RB, Weaver SC, Unnasch TR, Ciota AT, Kramer LD, Das SR. Large scale complete genome sequencing and phylodynamic analysis of eastern equine encephalitis virus reveal source-sink transmission dynamics in the United States. J. Virol [print-electronic]. 2018 Apr 4/4/2018; PMID: 29618651, PII: JVI.00074-18, DOI: 10.1128/JVI.00074-18, ISSN: 1098-5514.

Tan Y, Tsan-Yuk Lam T, Heberlein-Larson LA, Smole SC, Auguste AJ, Hennigan S, Halpin RA, Fedorova N, Puri V, Stockwell TB, Shilts MH, Andreadis T, Armstrong PM, Tesh RB, Weaver SC, Unnasch TR, Ciota AT, Kramer LD, Das SR. Large scale complete genome sequencing and phylodynamic analysis of eastern equine encephalitis virus reveal source-sink transmission dynamics in the United States. J. Virol [print-electronic]. 2018 Apr 4/4/2018; PMID: 29618651, PII: JVI.00074-18, DOI: 10.1128/JVI.00074-18, ISSN: 1098-5514.

Cobey S, Gouma S, Parkhouse K, Chambers BS, Ertl HC, Schmader KE, Halpin RA, Lin X, Stockwell TB, Das SR, Landon E, Tesic V, Youngster I, Pinsky BA, Wentworth DE, Hensley SE, Grad YH. Poor immunogenicity, not vaccine strain egg adaptation, may explain the low H3N2 influenza vaccine effectiveness in 2012-13. Clin. Infect. Dis [print-electronic]. 2018 Feb 2/20/2018; PMID: 29471464, PII: 4846904, DOI: 10.1093/cid/ciy097, ISSN: 1537-6591.

Rosas-Salazar C, Shilts MH, Tovchigrechko A, Schobel S, Chappell JD, Larkin EK, Gebretsadik T, Halpin RA, Nelson KE, Moore ML, Anderson LJ, Peebles RS, Das SR, Hartert TV. Nasopharyngeal Lactobacillus is Associated with Childhood Wheezing Illnesses Following Acute Respiratory Syncytial Virus Infection in Infancy. J. Allergy Clin. Immunol [print-electronic]. 2018 Jan 1/9/2018; PMID: 29330010, PII: S0091-6749(18)30031-9, DOI: 10.1016/j.jaci.2017.10.049, ISSN: 1097-6825.

Pollett S, Trovão NS, Tan Y, Eden JS, Halpin RA, Bera J, Das SR, Wentworth D, Ocaña V, Mendocilla SM, Álvarez C, Calisto ME, Garcia J, Halsey E, Ampuero JS, Nelson MI, Leguia M. The transmission dynamics and diversity of human metapneumovirus in Peru. Influenza Other Respir Viruses [print-electronic]. 2017 Dec 12/29/2017; PMID: 29288526, DOI: 10.1111/irv.12537, ISSN: 1750-2659.

Nelson MI, Culhane MR, Trovão NS, Patnayak DP, Halpin RA, Lin X, Shilts MH, Das SR, Detmer SE. The emergence and evolution of influenza A (H1a) viruses in swine in Canada and the United States. J. Gen. Virol [print-electronic]. 2017 Oct 10/23/2017; PMID: 29058649, DOI: 10.1099/jgv.0.000924, ISSN: 1465-2099.

Forrester NL, Wertheim JO, Dugan VG, Auguste AJ, Lin D, Adams AP, Chen R, Gorchakov R, Leal G, Estrada-Franco JG, Pandya J, Halpin RA, Hari K, Jain R, Stockwell TB, Das SR, Wentworth DE, Smith MD, Kosakovsky Pond SL, Weaver SC. Evolution and spread of Venezuelan equine encephalitis complex alphavirus in the Americas. PLoS Negl Trop Dis. 2017 Aug; 11(8): e0005693. PMID: 28771475, PMCID: PMC5557581, PII: PNTD-D-16-01990, DOI: 10.1371/journal.pntd.0005693, ISSN: 1935-2735.

Hill NJ, Hussein IT, Davis KR, Ma EJ, Spivey TJ, Ramey AM, Puryear WB, Das SR, Halpin RA, Lin X, Fedorova NB, Suarez DL, Boyce WM, Runstadler JA. Reassortment of Influenza A Viruses in Wild Birds in Alaska before H5 Clade 2.3.4.4 Outbreaks. Emerging Infect. Dis. 2017 Apr; 23(4): 654-7. PMID: 28322698, DOI: 10.3201/eid2304.161668, ISSN: 1080-6059.

Angeletti D, Gibbs JS, Angel M, Kosik I, Hickman HD, Frank GM, Das SR, Wheatley AK, Prabhakaran M, Leggat DJ, McDermott AB, Yewdell JW. Defining B cell immunodominance to viruses. Nat. Immunol [print-electronic]. 2017 Feb 2/13/2017; PMID: 28192417, PII: ni.3680, DOI: 10.1038/ni.3680, ISSN: 1529-2916.

Sobel Leonard A, McClain MT, Smith GJ, Wentworth DE, Halpin RA, Lin X, Ransier A, Stockwell TB, Das SR, Gilbert AS, Lambkin-Williams R, Ginsburg GS, Woods CW, Koelle K, Illingworth CJ. The effective rate of influenza reassortment is limited during human infection. PLoS Pathog. 2017 Feb; 13(2): e1006203. PMID: 28170438, PII: PPATHOGENS-D-16-02333, DOI: 10.1371/journal.ppat.1006203, ISSN: 1553-7374.

Rosas-Salazar C, Shilts MH, Tovchigrechko A, Schobel S, Chappell JD, Larkin EK, Shankar J, Yooseph S, Nelson KE, Halpin RA, Moore ML, Anderson LJ, Peebles RS, Das SR, Hartert TV. Differences in the Nasopharyngeal Microbiome During Acute Respiratory Tract Infection With Human Rhinovirus and Respiratory Syncytial Virus in Infancy. J. Infect. Dis. 2016 Dec 12/15/2016; 214(12): 1924-8. PMID: 27923952, PMCID: PMC5142087, PII: jiw456, DOI: 10.1093/infdis/jiw456, ISSN: 1537-6613.

Sobel Leonard A, McClain MT, Smith GJ, Wentworth DE, Halpin RA, Lin X, Ransier A, Stockwell TB, Das SR, Gilbert AS, Lambkin-Williams R, Ginsburg GS, Woods CW, Koelle K. Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification. J. Virol [electronic-print]. 2016 Dec 12/15/2016; 90(24): 11247-58. PMID: 27707932, PMCID: PMC5126380, PII: JVI.01657-16, DOI: 10.1128/JVI.01657-16, ISSN: 1098-5514.

Nelson MI, Stucker KM, Schobel SA, Trovão NS, Das SR, Dugan VG, Nelson SW, Sreevatsan S, Killian ML, Nolting JM, Wentworth DE, Bowman AS. Introduction, Evolution, and Dissemination of Influenza A Viruses in Exhibition Swine in the United States during 2009 to 2013. J. Virol [electronic-print]. 2016 Dec 12/1/2016; 90(23): 10963-71. PMID: 27681134, PMCID: PMC5110178, PII: JVI.01457-16, DOI: 10.1128/JVI.01457-16, ISSN: 1098-5514.

Chen R, Puri V, Fedorova N, Lin D, Hari KL, Jain R, Rodas JD, Das SR, Shabman RS, Weaver SC. Comprehensive Genome-Scale Phylogenetic Study Provides New Insights on the Global Expansion of Chikungunya Virus. J. Virol [print-electronic]. 2016 Sep 9/21/2016; PMID: 27654297, PII: JVI.01166-16, DOI: 10.1128/JVI.01166-16, ISSN: 1098-5514.

Rosas-Salazar C, Shilts MH, Tovchigrechko A, Chappell JD, Larkin EK, Nelson KE, Moore ML, Anderson LJ, Das SR, Hartert TV. Nasopharyngeal Microbiome in Respiratory Syncytial Virus Resembles Profile Associated with Increased Childhood Asthma Risk. Am. J. Respir. Crit. Care Med. 2016 May 5/15/2016; 193(10): 1180-3. PMID: 27174483, PMCID: PMC4872668, DOI: 10.1164/rccm.201512-2350LE, ISSN: 1535-4970.

Tan Y, Hassan F, Schuster JE, Simenauer A, Selvarangan R, Halpin RA, Lin X, Fedorova N, Stockwell TB, Lam TT, Chappell JD, Hartert TV, Holmes EC, Das SR. Molecular Evolution and Intraclade Recombination of Enterovirus D68 during the 2014 Outbreak in the United States. J. Virol. 2016 Feb; 90(4): 1997-2007. PMID: 26656685, PMCID: PMC4733988, PII: JVI.02418-15, DOI: 10.1128/JVI.02418-15, ISSN: 1098-5514.

Nelson MI, Wentworth DE, Das SR, Sreevatsan S, Killian ML, Nolting JM, Slemons RD, Bowman AS. Evolutionary Dynamics of Influenza A Viruses in US Exhibition Swine. J. Infect. Dis [print-electronic]. 2016 Jan 1/15/2016; 213(2): 173-82. PMID: 26243317, PMCID: PMC4690152, PII: jiv399, DOI: 10.1093/infdis/jiv399, ISSN: 1537-6613.

Schobel SA, Stucker KM, Moore ML, Anderson LJ, Larkin EK, Shankar J, Bera J, Puri V, Shilts MH, Rosas-Salazar C, Halpin RA, Fedorova N, Shrivastava S, Stockwell TB, Peebles RS, Hartert TV, Das SR. Respiratory Syncytial Virus whole-genome sequencing identifies convergent evolution of sequence duplication in the C-terminus of the G gene. Sci Rep. 2016; 6: 26311. PMID: 27212633, PMCID: PMC4876326, PII: srep26311, DOI: 10.1038/srep26311, ISSN: 2045-2322.

Shilts MH, Rosas-Salazar C, Tovchigrechko A, Larkin EK, Torralba M, Akopov A, Halpin R, Peebles RS, Moore ML, Anderson LJ, Nelson KE, Hartert TV, Das SR. Minimally Invasive Sampling Method Identifies Differences in Taxonomic Richness of Nasal Microbiomes in Young Infants Associated with Mode of Delivery. Microb. Ecol [print-electronic]. 2016 Jan; 71(1): 233-42. PMID: 26370110, PMCID: PMC4688197, PII: 10.1007/s00248-015-0663-y, DOI: 10.1007/s00248-015-0663-y, ISSN: 1432-184X.

Wu P, Feldman AS, Rosas-Salazar C, James K, Escobar G, Gebretsadik T, Li SX, Carroll KN, Walsh E, Mitchel E, Das S, Kumar R, Yu C, Dupont WD, Hartert TV. Relative Importance and Additive Effects of Maternal and Infant Risk Factors on Childhood Asthma. PLoS ONE. 2016; 11(3): e0151705. PMID: 27002979, PMCID: PMC4803347, PII: PONE-D-15-54345, DOI: 10.1371/journal.pone.0151705, ISSN: 1932-6203.

Duong V, Mey C, Eloit M, Zhu H, Danet L, Huang Z, Zou G, Tarantola A, Cheval J, Perot P, Laurent D, Richner B, Ky S, Heng S, Touch S, Sovann L, van Doorn R, Tan Tran T, Farrar JJ, Wentworth DE, Das SR, Stockwell TB, Manuguerra JC, Delpeyroux F, Guan Y, Altmeyer R, Buchy P. Molecular epidemiology of human enterovirus 71 at the origin of an epidemic of fatal hand, foot and mouth disease cases in Cambodia. Emerg Microbes Infect. 2016; 5(9): e104. PMID: 27651091, PII: emi2016101, DOI: 10.1038/emi.2016.101, ISSN: 2222-1751.

Patel MC, Wang W, Pletneva LM, Rajagopala SV, Tan Y, Hartert TV, Boukhvalova MS, Vogel SN, Das SR, Blanco JC. Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus). PLoS ONE. 2016; 11(11): e0166336. PMID: 27814404, PMCID: PMC5096705, PII: PONE-D-16-36002, DOI: 10.1371/journal.pone.0166336, ISSN: 1932-6203.

Lakdawala SS, Jayaraman A, Halpin RA, Lamirande EW, Shih AR, Stockwell TB, Lin X, Simenauer A, Hanson CT, Vogel L, Paskel M, Minai M, Moore I, Orandle M, Das SR, Wentworth DE, Sasisekharan R, Subbarao K. The soft palate is an important site of adaptation for transmissible influenza viruses. Nature [print-electronic]. 2015 Oct 10/1/2015; 526(7571): 122-5. PMID: 26416728, PMCID: PMC4592815, PII: nature15379, DOI: 10.1038/nature15379, ISSN: 1476-4687.

Geoghegan JL, Tan le V, Kühnert D, Halpin RA, Lin X, Simenauer A, Akopov A, Das SR, Stockwell TB, Shrivastava S, Ngoc NM, Uyen le TT, Tuyen NT, Thanh TT, Hang VT, Qui PT, Hung NT, Khanh TH, Thinh le Q, Nhan le NT, Van HM, Viet do C, Tuan HM, Viet HL, Hien TT, Chau NV, Thwaites G, Grenfell BT, Stadler T, Wentworth DE, Holmes EC, Van Doorn HR. Phylodynamics of Enterovirus A71-Associated Hand, Foot, and Mouth Disease in Viet Nam. J. Virol [print-electronic]. 2015 Sep; 89(17): 8871-9. PMID: 26085170, PMCID: PMC4524079, PII: JVI.00706-15, DOI: 10.1128/JVI.00706-15, ISSN: 1098-5514.

Lee AJ, Das SR, Wang W, Fitzgerald T, Pickett BE, Aevermann BD, Topham DJ, Falsey AR, Scheuermann RH. Diversifying Selection Analysis Predicts Antigenic Evolution of 2009 Pandemic H1N1 Influenza A Virus in Humans. J. Virol [print-electronic]. 2015 May; 89(10): 5427-40. PMID: 25741011, PMCID: PMC4442545, PII: JVI.03636-14, DOI: 10.1128/JVI.03636-14, ISSN: 1098-5514.

Fries AC, Nolting JM, Bowman AS, Lin X, Halpin RA, Wester E, Fedorova N, Stockwell TB, Das SR, Dugan VG, Wentworth DE, Gibbs HL, Slemons RD. Spread and persistence of influenza A viruses in waterfowl hosts in the North American Mississippi migratory flyway. J. Virol [print-electronic]. 2015 May; 89(10): 5371-81. PMID: 25741003, PMCID: PMC4442537, PII: JVI.03249-14, DOI: 10.1128/JVI.03249-14, ISSN: 1098-5514.

Larkin EK, Gebretsadik T, Moore ML, Anderson LJ, Dupont WD, Chappell JD, Minton PA, Peebles RS, Moore PE, Valet RS, Arnold DH, Rosas-Salazar C, Das SR, Polack FP, Hartert TV, . Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE). BMC Pulm Med. 2015; 15: 45. PMID: 26021723, PMCID: PMC4506623, PII: 10.1186/s12890-015-0040-0, DOI: 10.1186/s12890-015-0040-0, ISSN: 1471-2466.

Stockwell TB, Heberlein-Larson LA, Tan Y, Halpin RA, Fedorova N, Katzel DA, Smole S, Unnasch TR, Kramer LD, Das SR. First Complete Genome Sequences of Two Keystone Viruses from Florida. Genome Announc. 2015; 3(5): PMID: 26514762, PMCID: PMC4626608, PII: 3/5/e01255-15, DOI: 10.1128/genomeA.01255-15, ISSN: 2169-8287.

Stucker KM, Schobel SA, Olsen RJ, Hodges HL, Lin X, Halpin RA, Fedorova N, Stockwell TB, Tovchigrechko A, Das SR, Wentworth DE, Musser JM. Haemagglutinin mutations and glycosylation changes shaped the 2012/13 influenza A(H3N2) epidemic, Houston, Texas. Euro Surveill. 2015; 20(18): PMID: 25990233, ISSN: 1560-7917.

Krauss S, Stucker KM, Schobel SA, Danner A, Friedman K, Knowles JP, Kayali G, Niles LJ, Dey AD, Raven G, Pryor P, Lin X, Das SR, Stockwell TB, Wentworth DE, Webster RG. Long-term surveillance of H7 influenza viruses in American wild aquatic birds: are the H7N3 influenza viruses in wild birds the precursors of highly pathogenic strains in domestic poultry?. Emerg Microbes Infect. 2015; 4: e35. PMID: 26954883, PMCID: PMC4773044, PII: emi201535, DOI: 10.1038/emi.2015.35, ISSN: 2222-1751.

Magadán JG, Khurana S, Das SR, Frank GM, Stevens J, Golding H, Bennink JR, Yewdell JW. Influenza A virus hemagglutinin trimerization completes monomer folding and antigenicity. J. Virol [print-electronic]. 2013 Sep; 87(17): 9742-53. PMID: 23824811, PMCID: PMC3754138, PII: JVI.00471-13, DOI: 10.1128/JVI.00471-13, ISSN: 1098-5514.

Serquiña AK, Das SR, Popova E, Ojelabi OA, Roy CK, Göttlinger HG. UPF1 is crucial for the infectivity of human immunodeficiency virus type 1 progeny virions. J. Virol [print-electronic]. 2013 Aug; 87(16): 8853-61. PMID: 23785196, PMCID: PMC3754033, PII: JVI.00925-13, DOI: 10.1128/JVI.00925-13, ISSN: 1098-5514.

Harris AK, Meyerson JR, Matsuoka Y, Kuybeda O, Moran A, Bliss D, Das SR, Yewdell JW, Sapiro G, Subbarao K, Subramaniam S. Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2013 Mar 3/19/2013; 110(12): 4592-7. PMID: 23460696, PMCID: PMC3607006, PII: 1214913110, DOI: 10.1073/pnas.1214913110, ISSN: 1091-6490.

Das SR, Hensley SE, Ince WL, Brooke CB, Subba A, Delboy MG, Russ G, Gibbs JS, Bennink JR, Yewdell JW. Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection. Cell Host Microbe. 2013 Mar 3/13/2013; 13(3): 314-23. PMID: 23498956, PMCID: PMC3747226, PII: S1931-3128(13)00074-7, DOI: 10.1016/j.chom.2013.02.008, ISSN: 1934-6069.

Li GM, Chiu C, Wrammert J, McCausland M, Andrews SF, Zheng NY, Lee JH, Huang M, Qu X, Edupuganti S, Mulligan M, Das SR, Yewdell JW, Mehta AK, Wilson PC, Ahmed R. Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2012 Jun 6/5/2012; 109(23): 9047-52. PMID: 22615367, PMCID: PMC3384143, PII: 1118979109, DOI: 10.1073/pnas.1118979109, ISSN: 1091-6490.

O'Donnell CD, Vogel L, Wright A, Das SR, Wrammert J, Li GM, McCausland M, Zheng NY, Yewdell JW, Ahmed R, Wilson PC, Subbarao K. Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice. MBio [electronic-print]. 2012; 3(3): PMID: 22647789, PMCID: PMC3372962, PII: mBio.00120-12, DOI: 10.1128/mBio.00120-12, ISSN: 2150-7511.

David A, Das SR, Gibbs JS, Bennink JR, Yewdell JW. Cysteinyl-tRNA deacylation can be uncoupled from protein synthesis. PLoS ONE [print-electronic]. 2012; 7(3): e33072. PMID: 22427952, PMCID: PMC3302863, PII: PONE-D-11-13499, DOI: 10.1371/journal.pone.0033072, ISSN: 1932-6203.

Das SR, Hensley SE, David A, Schmidt L, Gibbs JS, Puigbò P, Ince WL, Bennink JR, Yewdell JW. Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Dec 12/20/2011; 108(51): E1417-22. PMID: 22106257, PMCID: PMC3251056, PII: 1108754108, DOI: 10.1073/pnas.1108754108, ISSN: 1091-6490.

Leysath CE, Chen KH, Moayeri M, Crown D, Fattah R, Chen Z, Das SR, Purcell RH, Leppla SH. Mouse monoclonal antibodies to anthrax edema factor protect against infection. Infect. Immun [print-electronic]. 2011 Nov; 79(11): 4609-16. PMID: 21911463, PMCID: PMC3257937, PII: IAI.05314-11, DOI: 10.1128/IAI.05314-11, ISSN: 1098-5522.

David A, Netzer N, Strader MB, Das SR, Chen CY, Gibbs J, Pierre P, Bennink JR, Yewdell JW. RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes. J. Biol. Chem [print-electronic]. 2011 Jun 6/10/2011; 286(23): 20688-700. PMID: 21460219, PMCID: PMC3121505, PII: M110.209452, DOI: 10.1074/jbc.M110.209452, ISSN: 1083-351X.

Wrammert J, Koutsonanos D, Li GM, Edupuganti S, Sui J, Morrissey M, McCausland M, Skountzou I, Hornig M, Lipkin WI, Mehta A, Razavi B, Del Rio C, Zheng NY, Lee JH, Huang M, Ali Z, Kaur K, Andrews S, Amara RR, Wang Y, Das SR, O'Donnell CD, Yewdell JW, Subbarao K, Marasco WA, Mulligan MJ, Compans R, Ahmed R, Wilson PC. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J. Exp. Med [print-electronic]. 2011 Jan 1/17/2011; 208(1): 181-93. PMID: 21220454, PMCID: PMC3023136, PII: jem.20101352, DOI: 10.1084/jem.20101352, ISSN: 1540-9538.

Hensley SE, Das SR, Gibbs JS, Bailey AL, Schmidt LM, Bennink JR, Yewdell JW. Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance. PLoS ONE. 2011; 6(2): e15190. PMID: 21364978, PMCID: PMC3043005, DOI: 10.1371/journal.pone.0015190, ISSN: 1932-6203.

Das SR, Puigbò P, Hensley SE, Hurt DE, Bennink JR, Yewdell JW. Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain. PLoS Pathog. 2010; 6(11): e1001211. PMID: 21124818, PMCID: PMC2991263, DOI: 10.1371/journal.ppat.1001211, ISSN: 1553-7374.

Netzer N, Goodenbour JM, David A, Dittmar KA, Jones RB, Schneider JR, Boone D, Eves EM, Rosner MR, Gibbs JS, Embry A, Dolan B, Das S, Hickman HD, Berglund P, Bennink JR, Yewdell JW, Pan T. Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature. 2009 Nov 11/26/2009; 462(7272): 522-6. PMID: 19940929, PMCID: PMC2785853, PII: nature08576, DOI: 10.1038/nature08576, ISSN: 1476-4687.

Hensley SE, Das SR, Bailey AL, Schmidt LM, Hickman HD, Jayaraman A, Viswanathan K, Raman R, Sasisekharan R, Bennink JR, Yewdell JW. Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift. Science. 2009 Oct 10/30/2009; 326(5953): 734-6. PMID: 19900932, PMCID: PMC2784927, PII: 326/5953/734, DOI: 10.1126/science.1178258, ISSN: 1095-9203.

Lev A, Dimberu P, Das SR, Maynard JC, Nicchitta CV, Bennink JR, Yewdell JW. Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent. J. Immunol [print-electronic]. 2009 Oct 10/1/2009; 183(7): 4205-10. PMID: 19752220, PMCID: PMC2749969, PII: jimmunol.0901828, DOI: 10.4049/jimmunol.0901828, ISSN: 1550-6606.

Chaudhry A, Verghese DA, Das SR, Jameel S, George A, Bal V, Mayor S, Rath S. HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway. J. Immunol [print-electronic]. 2009 Aug 8/15/2009; 183(4): 2415-24. PMID: 19620308, PII: jimmunol.0804014, DOI: 10.4049/jimmunol.0804014, ISSN: 1550-6606.

Chaudhry A, Das SR, Jameel S, George A, Bal V, Mayor S, Rath S. HIV-1 Nef induces a Rab11-dependent routing of endocytosed immune costimulatory proteins CD80 and CD86 to the Golgi. Traffic [print-electronic]. 2008 Nov; 9(11): 1925-35. PMID: 18764822, PII: TRA802, DOI: 10.1111/j.1600-0854.2008.00802.x, ISSN: 1600-0854.

Chaudhry A, Das SR, Jameel S, George A, Bal V, Mayor S, Rath S. A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86. Cell Host Microbe. 2007 Mar 3/15/2007; 1(1): 37-49. PMID: 18005680, PII: S1931-3128(07)00003-0, DOI: 10.1016/j.chom.2007.01.001, ISSN: 1934-6069.

Sundaravaradan V, Das SR, Ramakrishnan R, Sehgal S, Gopalan S, Ahmad N, Jameel S. Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages. Virol. J. 2007; 4: 126. PMID: 18036244, PMCID: PMC2216014, PII: 1743-422X-4-126, DOI: 10.1186/1743-422X-4-126, ISSN: 1743-422X.

Hussain A, Das SR, Tanwar C, Jameel S. Oligomerization of the human immunodeficiency virus type 1 (HIV-1) Vpu protein--a genetic, biochemical and biophysical analysis. Virol. J. 2007; 4: 81. PMID: 17727710, PMCID: PMC2042504, PII: 1743-422X-4-81, DOI: 10.1186/1743-422X-4-81, ISSN: 1743-422X.

Sarrami-Forooshani R, Das SR, Sabahi F, Adeli A, Esmaeili R, Wahren B, Mohraz M, Haji-Abdolbaghi M, Rasoolinejad M, Jameel S, Mahboudi F. Molecular analysis and phylogenetic characterization of HIV in Iran. J. Med. Virol. 2006 Jul; 78(7): 853-63. PMID: 16721846, DOI: 10.1002/jmv.20634, ISSN: 0146-6615.

Chaudhry A, Das SR, Hussain A, Mayor S, George A, Bal V, Jameel S, Rath S. The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. J. Immunol. 2005 Oct 10/1/2005; 175(7): 4566-74. PMID: 16177101, PII: 175/7/4566, ISSN: 0022-1767.

Das SR, Jameel S. Biology of the HIV Nef protein. Indian J. Med. Res. 2005 Apr; 121(4): 315-32. PMID: 15817946, ISSN: 0971-5916.

Korkaya H, Jameel S, Gupta D, Tyagi S, Kumar R, Zafrullah M, Mazumdar M, Lal SK, Xiaofang L, Sehgal D, Das SR, Sahal D. The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. J. Biol. Chem [print-electronic]. 2001 Nov 11/9/2001; 276(45): 42389-400. PMID: 11518702, PII: M101546200, DOI: 10.1074/jbc.M101546200, ISSN: 0021-9258.