Patrick J. Hu, M.D., Ph.D.

Associate Professor

patrick.j.hu@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine Associate Professor of Cell & Developmental Biology
Education
Ph.D., Biochemistry, New York University, New York, New YorkM.D., New York University, New York, New YorkA.B., Biology, Harvard University, Cambridge, Massachusetts
Office Address
552B Preston Research Building
2220 Pierce Avenue
Nashville, TN 37232
Research Description
My lab studies the role of insulin-like growth factor signaling in development, metabolism, and aging, using the nematode C. elegans and mice as model systems.
Publications
Delaney CE, Chen AT, Graniel JV, Dumas KJ, Hu PJ. A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity. Development [print-electronic]. 2017 Apr 4/1/2017; 144(7): 1273-82. PMID: 28209779, PMCID: PMC5399626, PII: dev.145722, DOI: 10.1242/dev.145722, ISSN: 1477-9129.

Itani OA, Flibotte S, Dumas KJ, Guo C, Blumenthal T, Hu PJ. N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3' Splice Site Function in Vivo. G3 (Bethesda). 2016 Jun; 6(6): 1751-6. PMID: 27172199, PMCID: PMC4889670, PII: g3.116.028662, DOI: 10.1534/g3.116.028662, ISSN: 2160-1836.

Itani OA, Flibotte S, Dumas KJ, Moerman DG, Hu PJ. Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans. G3 (Bethesda). 2016 Feb; 6(2): 351-6. PMID: 26628482, PMCID: PMC4751554, PII: g3.115.024257, DOI: 10.1534/g3.115.024257, ISSN: 2160-1836.

Chen AT, Guo C, Itani OA, Budaitis BG, Williams TW, Hopkins CE, McEachin RC, Pande M, Grant AR, Yoshina S, Mitani S, Hu PJ. Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans. Genetics [print-electronic]. 2015 Oct; 201(2): 613-29. PMID: 26219299, PMCID: PMC4596673, PII: genetics.115.177998, DOI: 10.1534/genetics.115.177998, ISSN: 1943-2631.

Hu PJ. Whole genome sequencing and the transformation of C. elegans forward genetics. Methods [print-electronic]. 2014 Aug 8/1/2014; 68(3): 437-40. PMID: 24874788, PII: S1046-2023(14)00196-0, DOI: 10.1016/j.ymeth.2014.05.008, ISSN: 1095-9130.

Mahanti P, Bose N, Bethke A, Judkins JC, Wollam J, Dumas KJ, Zimmerman AM, Campbell SL, Hu PJ, Antebi A, Schroeder FC. Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Cell Metab. 2014 Jan 1/7/2014; 19(1): 73-83. PMID: 24411940, PMCID: PMC3924769, PII: S1550-4131(13)00499-3, DOI: 10.1016/j.cmet.2013.11.024, ISSN: 1932-7420.

Murphy CT, Hu PJ. Insulin/insulin-like growth factor signaling in C. elegans. WormBook. 2013 Dec; 1-43. PMID: 24395814, PMCID: PMC4780952, DOI: 10.1895/wormbook.1.164.1, ISSN: 1551-8507.

Ferguson AA, Roy S, Kormanik KN, Kim Y, Dumas KJ, Ritov VB, Matern D, Hu PJ, Fisher AL. TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans. PLoS Genet. 2013 Dec; 9(12): e1004020. PMID: 24385923, PMCID: PMC3868569, PII: PGENETICS-D-13-00168, DOI: 10.1371/journal.pgen.1004020, ISSN: 1553-7404.

Chen AT, Guo C, Dumas KJ, Ashrafi K, Hu PJ. Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell [print-electronic]. 2013 Oct; 12(5): 932-40. PMID: 23786484, PMCID: PMC3824081, DOI: 10.1111/acel.12120, ISSN: 1474-9726.

Dumas KJ, Delaney CE, Flibotte S, Moerman DG, Csankovszki G, Hu PJ. Unexpected role for dosage compensation in the control of dauer arrest, insulin-like signaling, and FoxO transcription factor activity in Caenorhabditis elegans. Genetics [print-electronic]. 2013 Jul; 194(3): 619-29. PMID: 23733789, PMCID: PMC3697968, PII: genetics.113.149948, DOI: 10.1534/genetics.113.149948, ISSN: 1943-2631.

Dumas KJ, Guo C, Shih HJ, Hu PJ. Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling. G3 (Bethesda). 2013 May; 3(5): 841-50. PMID: 23550118, PMCID: PMC3656731, PII: g3.112.005116, DOI: 10.1534/g3.112.005116, ISSN: 2160-1836.

Hu PJ, Knoepp SM, Wu R, Cho KR. Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis. Genes Chromosomes Cancer [print-electronic]. 2012 Mar; 51(3): 283-9. PMID: 22120905, DOI: 10.1002/gcc.20953, ISSN: 1098-2264.

Williams TW, Dumas KJ, Hu PJ. EAK proteins: novel conserved regulators of C. elegans lifespan. Aging (Albany NY). 2010 Oct; 2(10): 742-7. PMID: 20975207, PMCID: PMC2993804, PII: 100214, DOI: 10.18632/aging.100214, ISSN: 1945-4589.

Alam H, Williams TW, Dumas KJ, Guo C, Yoshina S, Mitani S, Hu PJ. EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Cell Metab. 2010 Jul 7/7/2010; 12(1): 30-41. PMID: 20620993, PMCID: PMC2907918, PII: S1550-4131(10)00157-9, DOI: 10.1016/j.cmet.2010.05.004, ISSN: 1932-7420.

Dumas KJ, Guo C, Wang X, Burkhart KB, Adams EJ, Alam H, Hu PJ. Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. Dev. Biol [print-electronic]. 2010 Apr 4/15/2010; 340(2): 605-12. PMID: 20178781, PMCID: PMC4511482, PII: S0012-1606(10)00107-7, DOI: 10.1016/j.ydbio.2010.02.022, ISSN: 1095-564X.

Hu PJ, Sherman DH. DANSing with Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2009 May 5/12/2009; 106(19): 7685-6. PMID: 19416852, PMCID: PMC2683097, PII: 0903021106, DOI: 10.1073/pnas.0903021106, ISSN: 1091-6490.

Zhang Y, Xu J, Puscau C, Kim Y, Wang X, Alam H, Hu PJ. Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Dev. Biol [print-electronic]. 2008 Mar 3/15/2008; 315(2): 290-302. PMID: 18241854, PMCID: PMC2350227, PII: S0012-1606(07)01605-3, DOI: 10.1016/j.ydbio.2007.12.032, ISSN: 1095-564X.

Hu PJ. Dauer. WormBook. 2007 Aug; 1-19. PMID: 17988074, PMCID: PMC2890228, DOI: 10.1895/wormbook.1.144.1, ISSN: 1551-8507.

Hu PJ, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet [print-electronic]. 2006 Jul; 2(7): e99. PMID: 16839187, PMCID: PMC1487177, PII: 05-PLGE-RA-0239R2, DOI: 10.1371/journal.pgen.0020099, ISSN: 1553-7404.

Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol. Cell. 2004 Feb 2/27/2004; 13(4): 469-82. PMID: 14992718, PII: S1097276504000334, ISSN: 1097-2765.

Logan SK, Falasca M, Hu P, Schlessinger J. Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway. Mol. Cell. Biol. 1997 Oct; 17(10): 5784-90. PMID: 9315636, PMCID: PMC232426, ISSN: 0270-7306.

Hu PJ, Shih IM, Hutchins GM, Hellmann DB. Polyarteritis nodosa of the pericardium: antemortem diagnosis in a pericardiectomy specimen. J. Rheumatol. 1997 Oct; 24(10): 2042-4. PMID: 9330952, ISSN: 0315-162X.

Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I. Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells. J. Biol. Chem. 1994 May 5/20/1994; 269(20): 14419-23. PMID: 7514169, ISSN: 0021-9258.

Hu P, Schlessinger J. Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta. Mol. Cell. Biol. 1994 Apr; 14(4): 2577-83. PMID: 8139559, PMCID: PMC358625, ISSN: 0270-7306.

Hu P, Mondino A, Skolnik EY, Schlessinger J. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol. Cell. Biol. 1993 Dec; 13(12): 7677-88. PMID: 8246984, PMCID: PMC364839, ISSN: 0270-7306.

Piccione E, Case RD, Domchek SM, Hu P, Chaudhuri M, Backer JM, Schlessinger J, Shoelson SE. Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. Biochemistry. 1993 Apr 4/6/1993; 32(13): 3197-202. PMID: 8384875, ISSN: 0006-2960.

Felder S, Zhou M, Hu P, UreƱa J, Ullrich A, Chaudhuri M, White M, Shoelson SE, Schlessinger J. SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Mol. Cell. Biol. 1993 Mar; 13(3): 1449-55. PMID: 7680095, PMCID: PMC359455, ISSN: 0270-7306.

Hu P, Margolis B, Schlessinger J. Vav: a potential link between tyrosine kinases and ras-like GTPases in hematopoietic cell signaling. Bioessays. 1993 Mar; 15(3): 179-83. PMID: 8489524, DOI: 10.1002/bies.950150306, ISSN: 0265-9247.

Shoelson SE, Sivaraja M, Williams KP, Hu P, Schlessinger J, Weiss MA. Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation. EMBO J. 1993 Feb; 12(2): 795-802. PMID: 8382612, PMCID: PMC413268, ISSN: 0261-4189.

Li W, Hu P, Skolnik EY, Ullrich A, Schlessinger J. The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors. Mol. Cell. Biol. 1992 Dec; 12(12): 5824-33. PMID: 1333047, PMCID: PMC360522, ISSN: 0270-7306.

Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proc. Natl. Acad. Sci. U.S.A. 1992 Nov 11/1/1992; 89(21): 10350-4. PMID: 1332046, PMCID: PMC50336, ISSN: 0027-8424.

Backer JM, Myers MG, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, et al. Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 1992 Sep; 11(9): 3469-79. PMID: 1380456, PMCID: PMC556882, ISSN: 0261-4189.

Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature. 1992 Mar 3/5/1992; 356(6364): 71-4. PMID: 1531699, DOI: 10.1038/356071a0, ISSN: 0028-0836.

Hu P, Margolis B, Skolnik EY, Lammers R, Ullrich A, Schlessinger J. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol. Cell. Biol. 1992 Mar; 12(3): 981-90. PMID: 1372091, PMCID: PMC369530, ISSN: 0270-7306.