Michael James Noto, M.D., Ph.D.

Assistant Professor


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Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Pathology, Microbiology and Immunology
Ph.D., Microbiology, Virginia Commonwealth University, Richmond, VirginiaM.D., Virginia Commonwealth University, Richmond, VirginiaB.S., Biology, James Madison University, Harrisonburg, Virginia
Research Description
The Noto lab is focused on studying innate host defenses against acute bacterial lung infection. We are particularly interested in ways to augment host immunity as an antibiotic-independent approach to pneumonia therapy as well as understanding how combinations of bacterial pathogens present in the polymicrobial lung infections alter host immunity to promote the survival of the bacterial community.
Research Keywords
Bacterial infection, pneumonia, sepsis, host-defense, innate immunity, macrophage biology
Noto MJ, Burns WJ, Beavers WN, Skaar EP. Mechanisms of pyocyanin toxicity and genetic determinants of resistance in Staphylococcus aureus. J. Bacteriol [print-electronic]. 2017 Jun 6/12/2017; PMID: 28607159, PMCID: PMC5553028, PII: JB.00221-17, DOI: 10.1128/JB.00221-17, ISSN: 1098-5530.

Noto MJ, Becker KW, Boyd KL, Schmidt AM, Skaar EP. RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis. Infect. Immun [electronic-print]. 2017 Mar; 85(3): PMID: 28052995, PMCID: PMC5328494, PII: IAI.00954-16, DOI: 10.1128/IAI.00954-16, ISSN: 1098-5522.

Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nat. Med [print-electronic]. 2016 Nov; 22(11): 1330-4. PMID: 27668938, PMCID: PMC5101143, PII: nm.4174, DOI: 10.1038/nm.4174, ISSN: 1546-170X.

Janz DR, Semler MW, Lentz RJ, Matthews DT, Assad TR, Norman BC, Keriwala RD, Ferrell BA, Noto MJ, Shaver CM, Richmond BW, Zinggeler Berg J, Rice TW, . Randomized Trial of Video Laryngoscopy for Endotracheal Intubation of Critically Ill Adults. Crit. Care Med [print-electronic]. 2016 Jun 6/28/2016; PMID: 27355526, DOI: 10.1097/CCM.0000000000001841, ISSN: 1530-0293.

Spraggins JM, Rizzo DG, Moore JL, Noto MJ, Skaar EP, Caprioli RM. Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis. Proteomics [print-electronic]. 2016 Jun; 16(11-12): 1678-89. PMID: 27060368, DOI: 10.1002/pmic.201600003, ISSN: 1615-9861.

Semler MW, Janz DR, Lentz RJ, Matthews DT, Norman BC, Assad TR, Keriwala RD, Ferrell BA, Noto MJ, McKown AC, Kocurek EG, Warren MA, Huerta LE, Rice TW, , . Randomized Trial of Apneic Oxygenation during Endotracheal Intubation of the Critically Ill. Am. J. Respir. Crit. Care Med. 2016 Feb 2/1/2016; 193(3): 273-80. PMID: 26426458, PMCID: PMC4803060, DOI: 10.1164/rccm.201507-1294OC, ISSN: 1535-4970.

Wakeman CA, Moore JL, Noto MJ, Zhang Y, Singleton MD, Prentice BM, Gilston BA, Doster RS, Gaddy JA, Chazin WJ, Caprioli RM, Skaar EP. The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction. Nat Commun. 2016; 7: 11951. PMID: 27301800, PMCID: PMC4912628, PII: ncomms11951, DOI: 10.1038/ncomms11951, ISSN: 2041-1723.

Noto MJ, Boyd KL, Burns WJ, Varga MG, Peek RM, Skaar EP. Toll-Like Receptor 9 Contributes to Defense against Acinetobacter baumannii Infection. Infect. Immun [print-electronic]. 2015 Oct; 83(10): 4134-41. PMID: 26238713, PMCID: PMC4567622, PII: IAI.00410-15, DOI: 10.1128/IAI.00410-15, ISSN: 1098-5522.

Noto MJ, Wheeler AP. Understanding chlorhexidine decolonization strategies. Intensive Care Med [print-electronic]. 2015 Jul; 41(7): 1351-4. PMID: 26088910, DOI: 10.1007/s00134-015-3846-6, ISSN: 1432-1238.

Noto MJ, Rice TW, Wheeler AP. Chlorhexidine bathing and infections in critically ill patients--reply [letter]. JAMA. 2015 May 5/12/2015; 313(18): 1863-4. PMID: 25965240, PII: 2290631, DOI: 10.1001/jama.2015.3539, ISSN: 1538-3598.

Kyle JM, Stollings JL, White KD, Noto MJ, Wheeler AP. Fosfomycin for multidrug treatment of Klebsiella pneumoniae carbapenemase bacteremia. Ann Pharmacother. 2015 Mar; 49(3): 366-7. PMID: 25691478, PII: 49/3/366, DOI: 10.1177/1060028014564395, ISSN: 1542-6270.

Noto MJ, Domenico HJ, Byrne DW, Talbot T, Rice TW, Bernard GR, Wheeler AP. Chlorhexidine bathing and health care-associated infections: a randomized clinical trial. JAMA. 2015 Jan 1/27/2015; 313(4): 369-78. PMID: 25602496, PMCID: PMC4383133, PII: 2091544, DOI: 10.1001/jama.2014.18400, ISSN: 1538-3598.

Hammer ND, Cassat JE, Noto MJ, Lojek LJ, Chadha AD, Schmitz JE, Creech CB, Skaar EP. Inter- and intraspecies metabolite exchange promotes virulence of antibiotic-resistant Staphylococcus aureus. Cell Host Microbe. 2014 Oct 10/8/2014; 16(4): 531-7. PMID: 25299336, PMCID: PMC4197139, PII: S1931-3128(14)00335-7, DOI: 10.1016/j.chom.2014.09.002, ISSN: 1934-6069.

Noto MJ, Koethe JR, Miller G, Wright PW. Detectable serum tobramycin levels in patients with renal dysfunction and recent placement of antibiotic-impregnated cement knee or hip spacers [letter]. Clin. Infect. Dis [print-electronic]. 2014 Jun; 58(12): 1783-4. PMID: 24633689, PMCID: PMC4064010, PII: ciu159, DOI: 10.1093/cid/ciu159, ISSN: 1537-6591.

Noto MJ, Wheeler AP. Macrolides for acute lung injury [editorial]. Chest. 2012 May; 141(5): 1131-2. PMID: 22553255, PMCID: PMC3342786, PII: S0012-3692(12)60260-8, DOI: 10.1378/chest.11-3245, ISSN: 1931-3543.