Eric Robert Tkaczyk, M.D., Ph.D.

Assistant Professor

eric.tkaczyk@vanderbilt.edu

Visit Lab Site


Faculty Appointments
Assistant Professor of Dermatology Assistant Professor of Biomedical Engineering
Education
M.D., University of Michigan, Ann Arbor, MichiganPh.D., Electrical Engineering, University of Michigan, Ann Arbor, MichiganM.S.E., Electrical Engineering, University of Michigan, Ann Arbor, MichiganB.S.E.E., Purdue University, West Lafayette, IndianaB.S., Purdue University, West Lafayette, Indiana
Office Address
One Hundred Oaks Suite 26300
719 Thompson Lane
Nashville, TN 37204
Research Description
The Vanderbilt Dermatology Translational Research Clinic (https://medsites.mc.vanderbilt.edu/vdtrc/home) was founded in 2016 (then as the Cutaneous Imaging Clinic) as a platform for direct clinical translation of biophotonics for clinical impact in dermatology, oncology, and related specialties. The mission is seamless integration of technology-based patient care and translational research. A major focus is engineering development and clinical investigation of noninvasive methods to assess graft-versus-host disease (GVHD) severity in bone marrow / hematopoietic stem cell transplantation (HCT) patients. Occurring in most patients following allogeneic HCT, chronic GVHD is the leading cause of long-term mortality and morbidity in this population. Current staging relies on physician estimation of involved skin body surface area, which suffers poor intra- and interrater reproducibility and is therefore insensitive to disease changes.

WE CURRENTLY HAVE AN AVAILABLE POST-DOCTORAL FELLOWSHIP POSITION IN CUTANEOUS IMAGE ANALYSIS (and several other positions for all levels)!
Representative publication: DOI: 10.1038/s41409-018-0211-8

Interested candidates should read more on the Translational Research Clinic homepage:
https://medsites.mc.vanderbilt.edu/vdtrc/positions-available

And email us: TranslationalResearchClinic@vumc.org
Research Keywords
biophotonics, imaging, dermatology, translational research, cutaneous, confocal microscopy, machine learning, neural networks, deep learning, artificial intelligence, digital pathology, inflammatory disease, graft-versus-host disease, GVHD
Clinical Research Keywords
Dermatology; Confocal Microscopy; Graft-versus-host disease
Publications
Chen F, Dellalana LE, Gandelman JS, Vain A, Jagasia MH, Tkaczyk ER. Correction: Non-invasive measurement of sclerosis in cutaneous cGVHD patients with the handheld device Myoton: a cross-sectional study. Bone Marrow Transplant [print-electronic]. 2020 Jan 1/17/2020; PMID: 31953531, PII: 10.1038/s41409-020-0780-1, DOI: 10.1038/s41409-020-0780-1, ISSN: 1476-5365.

Vaher H, Runnel T, Urgard E, Aab A, Carreras Badosa G, Maslovskaja J, Abram K, Raam L, Kaldvee B, Annilo T, Tkaczyk ER, Maimets T, Akdis CA, Kingo K, Rebane A. MiR-10a-5p is increased in atopic dermatitis and has capacity to inhibit keratinocyte proliferation. Allergy [print-electronic]. 2019 Nov; 74(11): 2146-56. PMID: 31049964, PMCID: PMC6817370, DOI: 10.1111/all.13849, ISSN: 1398-9995.

Saknite I, Gill M, Alessi-Fox C, Byrne M, Jagasia M, Gonzalez S, Ardigo M, Tkaczyk ER. Features of cutaneous acute graft-versus-host disease by reflectance confocal microscopy [letter]. Br. J. Dermatol [print-electronic]. 2019 Oct; 181(4): 829-31. PMID: 30927259, PMCID: PMC6766422, DOI: 10.1111/bjd.17921, ISSN: 1365-2133.

Tadros J, Chastain CA, Tkaczyk E. Colonic and perianal ulceration exhibiting vacuolar interface dermatitis in the setting of HIV. Clin Case Rep. 2019 Aug; 7(8): 1478-80. PMID: 31428371, PMCID: PMC6692980, PII: CCR32222, DOI: 10.1002/ccr3.2222, ISSN: 2050-0904.

Tkaczyk ER, Coco JR, Wang J, Chen F, Ye C, Jagasia MH, Dawant BM, Fabbri D. Crowdsourcing to delineate skin affected by chronic graft-vs-host disease. Skin Res Technol [print-electronic]. 2019 Feb 2/20/2019; PMID: 30786065, DOI: 10.1111/srt.12688, ISSN: 1600-0846.

Gandelman JS, Zic J, Dewan AK, Lee SJ, Flowers M, Cutler C, Pidala J, Chen H, Jagasia MH, Tkaczyk ER. The Anatomic Distribution of Skin Involvement in Patients with Incident Chronic Graft-versus-Host Disease. Biol. Blood Marrow Transplant [print-electronic]. 2019 Feb; 25(2): 279-86. PMID: 30219700, PII: S1083-8791(18)30564-0, DOI: 10.1016/j.bbmt.2018.09.007, ISSN: 1523-6536.

Dellalana LE, Chen F, Vain A, Gandelman JS, Põldemaa M, Chen H, Tkaczyk ER. Reproducibility of the durometer and myoton devices for skin stiffness measurement in healthy subjects. Skin Res Technol [print-electronic]. 2018 Nov 11/10/2018; PMID: 30414198, DOI: 10.1111/srt.12646, ISSN: 1600-0846.

Chen F, Dellalana LE, Gandelman JS, Vain A, Jagasia MH, Tkaczyk ER. Non-invasive measurement of sclerosis in cutaneous cGVHD patients with the handheld device Myoton: a cross-sectional study [letter]. Bone Marrow Transplant [print-electronic]. 2018 Oct 10/4/2018; PMID: 30287938, PII: 10.1038/s41409-018-0346-7, DOI: 10.1038/s41409-018-0346-7, ISSN: 1476-5365.

Lanevski D, Mauring K, Tkaczyk ER, Jaaniso R. Optical differential temperature measurement with beat frequency phase fluorometry. Appl Opt. 2018 Sep 9/20/2018; 57(27): 8053-9. PMID: 30462078, PMCID: PMC6858842, PII: 398357, DOI: 10.1364/AO.57.008053, ISSN: 1539-4522.

Tadros J, Goodman S, Tkaczyk ER. Subcutaneous scalp nodule as the presenting symptom of systemic light-chain amyloidosis. Dermatol Pract Concept. 2018 Jul; 8(3): 184-7. PMID: 30116661, PMCID: PMC6092069, PII: dp0803a07, DOI: 10.5826/dpc.0803a07, ISSN: 2160-9381.

Tkaczyk ER, Chen F, Wang J, Gandelman JS, Saknite I, Dellalana LE, Jagasia MH, Dawant BM. Overcoming human disagreement assessing erythematous lesion severity on 3D photos of chronic graft-versus-host disease [letter]. Bone Marrow Transplant [print-electronic]. 2018 May 5/8/2018; PMID: 29740182, PII: 10.1038/s41409-018-0211-8, DOI: 10.1038/s41409-018-0211-8, ISSN: 1476-5365.

Riemenschneider K, Diiorio DA, Zic JA, Livingood MR, Fine JD, Powers JG, Zwerner JP, Tkaczyk E. Drug-induced linear IgA bullous dermatosis in a patient with a vancomycin-impregnated cement spacer. Cutis. 2018 Apr; 101(4): 293-6. PMID: 29763476, ISSN: 2326-6929.

Hermann H, Runnel T, Aab A, Baurecht H, Rodriguez E, Magilnick N, Urgard E, Šahmatova L, Prans E, Maslovskaja J, Abram K, Karelson M, Kaldvee B, Reemann P, Haljasorg U, Rückert B, Wawrzyniak P, Weichenthal M, Mrowietz U, Franke A, Gieger C, Barker J, Trembath R, Tsoi LC, Elder JT, Tkaczyk ER, Kisand K, Peterson P, Kingo K, Boldin M, Weidinger S, Akdis CA, Rebane A. MiR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis. J. Invest. Dermatol [print-electronic]. 2017 Sep; 137(9): 1945-54. PMID: 28595995, PII: S0022-202X(17)31551-8, DOI: 10.1016/j.jid.2017.05.012, ISSN: 1523-1747.

Tkaczyk E. Innovations and Developments in Dermatologic Non-invasive Optical Imaging and Potential Clinical Applications. Acta Derm. Venereol [print-electronic]. 2017 Jul 7/5/2017; PMID: 28676880, DOI: 10.2340/00015555-2717, ISSN: 1651-2057.

Dewan AK, Dickerman D, Tkaczyk E, Zwerner JP, Boyd A, Miller JL. A Rapidly Growing Facial Mass: Challenge. Am J Dermatopathol. 2017 Jun; 39(6): 457-8. PMID: 28291134, DOI: 10.1097/DAD.0000000000000472, ISSN: 1533-0311.

Dewan AK, Dickerman D, Tkaczyk E, Zwerner JP, Boyd A, Miller JL. A Rapidly Growing Facial Mass: Answer. Am J Dermatopathol. 2017 Jun; 39(6): e71-e72. PMID: 28291133, DOI: 10.1097/DAD.0000000000000473, ISSN: 1533-0311.

Lanevski D, Mauring K, Tkaczyk E. Interference filter tilting to detect a polycyclic aromatic hydrocarbon at the second harmonic of wavelength modulation frequency. Appl Opt. 2017 Apr 4/10/2017; 56(11): 3155-61. PMID: 28414378, PII: 362845, ISSN: 1539-4522.

Riemenschneider K, Redenius R, Reese J, Fine JD, Weitkamp JH, Tkaczyk E. Erythematous plaques and papules on a premature infant. J. Am. Acad. Dermatol. 2017 Apr; 76(4): e111-e112. PMID: 29081565, PMCID: PMC5563474, DOI: 10.1016/j.jaad.2016.08.038, ISSN: 1097-6787.

Howard HE, Zwerner JP, Byers J, Tkaczyk E. An Erythematous papular eruption in a woman with Crohn disease treated with infliximab. Dermatol. Online J. 2016 Oct 10/15/2016; 22(10): PMID: 28329591, ISSN: 1087-2108.

Urgard E, Lorents A, Klaas M, Padari K, Viil J, Runnel T, Langel K, Kingo K, Tkaczyk E, Langel Ü, Maimets T, Jaks V, Pooga M, Rebane A. Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis. J Control Release [print-electronic]. 2016 Aug 8/10/2016; 235: 195-204. PMID: 27269729, PII: S0168-3659(16)30371-6, DOI: 10.1016/j.jconrel.2016.06.006, ISSN: 1873-4995.

Tkaczyk ER, Mauring K, Tkaczyk AH. Gaussian beam reflection and refraction by a spherical or parabolic surface: comparison of vectorial-law calculation with lens approximation. J Opt Soc Am A Opt Image Sci Vis. 2012 Oct 10/1/2012; 29(10): 2144-53. PMID: 23201662, PII: 241853, ISSN: 1520-8532.

Tkaczyk ER. Vectorial laws of refraction and reflection using the cross product and dot product. Opt Lett. 2012 Mar 3/1/2012; 37(5): 972-4. PMID: 22378456, PII: 229633, ISSN: 1539-4794.

Tkaczyk ER, Mauring T, Pajusalu M, Anijalg A, Tkaczyk AH, Teesalu P, Kikas J, Mauring K. Cataract diagnosis by measurement of backscattered light. Opt Lett. 2011 Dec 12/1/2011; 36(23): 4707-9. PMID: 22139291, PII: 225504, ISSN: 1539-4794.

Tkaczyk ER, Tkaczyk AH. Multiphoton flow cytometry strategies and applications. Cytometry A [print-electronic]. 2011 Oct; 79(10): 775-88. PMID: 21796772, DOI: 10.1002/cyto.a.21110, ISSN: 1552-4930.

Wang AS, Harrison D, Lobastov V, Tkaczyk JE. Pulse pileup statistics for energy discriminating photon counting x-ray detectors. Med Phys. 2011 Jul; 38(7): 4265-75. PMID: 21859028, DOI: 10.1118/1.3592932, ISSN: 0094-2405.

Tkaczyk AH, Tkaczyk ER, Norris TB, Takayama S. Microfluidic Droplet Consistency Monitoring and Cell Detection via Laser Excitation. J Mech Med Biol. 2011 Mar; 11(1): 1-14. PMID: 29755161, PMCID: PMC5943058, DOI: 10.1142/S0219519410003617, ISSN: 0219-5194.

Chang YC, Ye JY, Thomas TP, Cao Z, Kotlyar A, Tkaczyk ER, Baker JR, Norris TB. Fiber-optic multiphoton flow cytometry in whole blood and in vivo. J Biomed Opt. 2010 Jul; 15(4): 47004. PMID: 20799835, PMCID: PMC2924903, DOI: 10.1117/1.3463481, ISSN: 1560-2281.

Cheng J, Waite AL, Tkaczyk ER, Ke K, Richards N, Hunt AJ, Gumucio DL. Kinetic properties of ASC protein aggregation in epithelial cells. J. Cell. Physiol. 2010 Mar; 222(3): 738-47. PMID: 20020448, DOI: 10.1002/jcp.22005, ISSN: 1097-4652.

Tkaczyk ER, Tkaczyk AH, Mauring K, Ye JY, Baker JR, Norris TB. Quantitative differentiation of dyes with overlapping one-photon spectra by femtosecond pulse shaping. J Lumin. 2010 Jan 1/1/2010; 130(1): 29-34. PMID: 20160886, PMCID: PMC2772214, DOI: 10.1016/j.jlumin.2009.07.014, ISSN: 0022-2313.

Tkaczyk ER, Tkaczyk AH, Mauring K, Ye JY, Baker JR, Norris TB. Control of two-photon fluorescence of common dyes and conjugated dyes. J Fluoresc [print-electronic]. 2009 May; 19(3): 517-32. PMID: 19082694, DOI: 10.1007/s10895-008-0441-z, ISSN: 1573-4994.

Chang YC, Ye JY, Thomas TP, Cao Z, Kotlyar A, Tkaczyk ER, Baker JR, Norris TB. Two-photon in vivo flow cytometry using a fiber probe. Proc SPIE Int Soc Opt Eng. 2009 Feb 2/20/2009; 7173: 71730I1-71730I10. PMID: 27182102, PMCID: PMC4866831, DOI: 10.1117/12.808436, ISSN: 0277-786X.

Krasnenko V, Tkaczyk AH, Tkaczyk ER, Mauring K. Physicochemical properties of blue fluorescent protein determined via molecular dynamics simulation. Biopolymers. 2008 Dec; 89(12): 1136-43. PMID: 18690664, DOI: 10.1002/bip.21065, ISSN: 0006-3525.

Tkaczyk ER, Mauring K, Tkaczyk AH, Krasnenko V, Ye JY, Baker JR, Norris TB. Control of the blue fluorescent protein with advanced evolutionary pulse shaping. Biochem. Biophys. Res. Commun [print-electronic]. 2008 Nov 11/28/2008; 376(4): 733-7. PMID: 18817751, PMCID: PMC2600451, PII: S0006-291X(08)01823-8, DOI: 10.1016/j.bbrc.2008.09.075, ISSN: 1090-2104.

Tkaczyk ER, Tkaczyk AH, Katnik S, Ye JY, Luker KE, Luker GD, Myc A, Baker JR, Norris TB. Extended cavity laser enhanced two-photon flow cytometry. J Biomed Opt. 2008 Jul; 13(4): 41319. PMID: 19021327, PMCID: PMC4469470, DOI: 10.1117/1.2967983, ISSN: 1083-3668.

Zhong CF, Tkaczyk ER, Thomas T, Ye JY, Myc A, Bielinska AU, Cao Z, Majoros I, Keszler B, Baker JR, Norris TB. Quantitative two-photon flow cytometry--in vitro and in vivo. J Biomed Opt. 2008 May; 13(3): 34008. PMID: 18601553, DOI: 10.1117/1.2931077, ISSN: 1083-3668.

Tkaczyk ER, Zhong CF, Ye JY, Myc A, Thomas T, Cao Z, Duran-Struuck R, Luker KE, Luker GD, Norris TB, Baker JR. In Vivo Monitoring of Multiple Circulating Cell Populations Using Two-photon Flow Cytometry. Opt Commun. 2008 Feb 2/15/2008; 281(4): 888-94. PMID: 19221581, PMCID: PMC2352153, DOI: 10.1016/j.optcom.2007.10.106, ISSN: 0030-4018.

Krasnenko V, Tkaczyk AH, Tkaczyk ER, Farkas O, Mauring K. Vibrations-determined properties of green fluorescent protein. Biopolymers. 2005 Jun 6/15/2005; 78(3): 140-6. PMID: 15759290, DOI: 10.1002/bip.20264, ISSN: 0006-3525.

Available Postdoctoral Position Details
Posted Position
2/27/2020

Post-doctoral Fellowships in Skin Mechanics and Translational Imaging


Position and project description: Two post-doctoral scholar positions are available at the Vanderbilt Dermatology Translational Research Clinic (VDTRC.org) and the Vanderbilt University School of Engineering to launch translational research careers. We invite motivated candidates to apply their backgrounds in engineering, physics, and/or computer science to medical problems facing oncology patients. The goal is to develop, commercialize, and deploy technologies in our ongoing multicenter trials to track disease progression and response to treatment following stem cell / bone marrow transplantation.


Specific projects are:

1. Skin mechanics. The scholar will develop and validate a novel handheld clinical device to mechanically measure cutaneous sclerosis. This project will involve signal processing of mechanical vibrations, validation with ultrasound tissue phantoms, and clinical measurement. Our prior results:

https://www.nature.com/articles/s41409-018-0346-7

2. Analysis of rash images from smartphone and hyperspectral cameras. The scholar will analyze existing 2D and 3D skin images and advise prospective collection from collaborating centers. Technical approaches may include image registration algorithms, traditional image processing, crowd sourcing, and artificial intelligence such as clustering algorithms and deep learning for segmentation and colorimetric analyses.

Our prior results: https://www.nature.com/articles/s41409-018-0211-8


Selected candidates will take the lead on the funded project and also will be encouraged to formulate their own research ideas. They will be provided infrastructure and mentoring for independent funding. Scholars will interact with a broad range of collaborating experts in clinical medicine and technology as well as several innovative partners in industry. Trainees in this well-funded program will enjoy competitive benefits including NIH rate salary.


Environment: Selected candidates will benefit from a personalized research program catered to their goals utilizing resources and mentoring within Dermatology (Eric Tkaczyk), Computer Science (Benoit Dawant), Bioinformatics (Daniel Fabbri), Biomedical Engineering (Brett Byram and Anita Mahadevan-Jansen), and the Vanderbilt-Ingram Cancer Center (Madan Jagasia). This environment brings together clinicians, basic scientists, engineers and statisticians in close collaboration due to its interdisciplinary research and close physical proximity of the School of Medicine to the School of Engineering (100-200 yards).


Qualifications: Applicants must have a demonstrated record of rigorous & creative contributions and a capacity to communicate effectively with experts from a range of disciplines. Interviews are underway, with the first position to be filled by summer 2020. The Vanderbilt University Medical Center is an equal opportunities employer.


Application and contact: Every applicant should send a CV, a one-page personal statement, and two letters of recommendation with reference phone numbers and email addresses to:

Eric Tkaczyk, M.D., Ph.D. Director, VDTRC (vdtrc.org)

Vanderbilt Dermatology One Hundred Oaks Suite 26300

719 Thompson Lane Nashville, TN 37204

VCICrecruit@gmail.com

5/10/2018

The Vanderbilt Cutaneous Imaging Clinic has a postdoctoral research fellowship available for a motivated individual with interest in image processing, image analysis, signal processing and/or machine learning. Programs/tools that will be used may include Knime, Matlab, R, ImageJ Celltracker, ImageJ Sift, Caffe.


Position: The Vanderbilt University Medical Center (VUMC) in Nashville, Tennessee is seeking motivated post-doctoral candidates to develop their translational research career in biophotonics and imaging of cutaneous manifestations of cancer and its treatments. Multimodal dermatologic imaging techniques including 3D photography, hyperspectral imaging, and confocal microscopy, coupled to image analysis techniques including deep learning neural networks, will be applied in ongoing multicenter clinical trials and basic science research. Initial appointment will be for one year with annual renewal options. 


Environment: Candidates will benefit from a personalized research program catered to their goals utilizing resources and mentoring within the VUMC Division of Oncology and the Division of Dermatology as well as The Biophotonics Center within the Vanderbilt Department of Biomedical Engineering. The renowned Vanderbilt-Ingram Cancer Center brings together clinicians, basic scientists, engineers and statisticians in close collaboration due to its interdisciplinary research and close physical proximity of the School of Medicine to the School of Engineering (100-200 yards). Representative research:

https://www.nature.com/articles/s41409-018-0211-8

https://medsites.mc.vanderbilt.edu/vdtrc/home


Qualifications: Ph.D. or equivalent degree with expertise in at least one of the following: computer science, dermatologic imaging, multivariate data analysis, optical spectroscopy, image processing, optical design, clinical device validation, clinical trials, immunology, or biomarkers. The Vanderbilt University Medical Center is an equal opportunities employer. Application and contact: Interested applicants are requested to mail their CV, a one-page personal statement, and two letters of recommendation with reference phone numbers and email addresses to:


Eric Tkaczyk, M.D., Ph.D.

Director, Cutaneous Imaging Clinic

Vanderbilt Dermatology

One Hundred Oaks Suite 26300

719 Thompson Lane

Nashville, TN 37204

VCICrecruit@gmail.com