Kristine Phillips, Ph.D., M.D.

Associate Professor

kristine.phillips@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine
Education
M.S., University of Michigan, Ann Arbor, MichiganM.D., Johns Hopkins School of Medicine, Baltimore, MarylandPh.D., Louisiana State University, Baton Rouge, LouisianaB.S., Louisiana State University, Baton Rouge, Louisiana
Publications
Sullivan KM, Goldmuntz EA, Keyes-Elstein L, McSweeney PA, Pinckney A, Welch B, Mayes MD, Nash RA, Crofford LJ, Eggleston B, Castina S, Griffith LM, Goldstein JS, Wallace D, Craciunescu O, Khanna D, Folz RJ, Goldin J, St Clair EW, Seibold JR, Phillips K, Mineishi S, Simms RW, Ballen K, Wener MH, Georges GE, Heimfeld S, Hosing C, Forman S, Kafaja S, Silver RM, Griffing L, Storek J, LeClercq S, Brasington R, Csuka ME, Bredeson C, Keever-Taylor C, Domsic RT, Kahaleh MB, Medsger T, Furst DE, . Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma. N. Engl. J. Med. 2018 Jan 1/4/2018; 378(1): 35-47. PMID: 29298160, PII: 10.1056/NEJMoa1703327, ISSN: 1533-4406.

Tashkin DP, Roth MD, Clements PJ, Furst DE, Khanna D, Kleerup EC, Goldin J, Arriola E, Volkmann ER, Kafaja S, Silver R, Steen V, Strange C, Wise R, Wigley F, Mayes M, Riley DJ, Hussain S, Assassi S, Hsu VM, Patel B, Phillips K, Martinez F, Golden J, Connolly MK, Varga J, Dematte J, Hinchcliff ME, Fischer A, Swigris J, Meehan R, Theodore A, Simms R, Volkov S, Schraufnagel DE, Scholand MB, Frech T, Molitor JA, Highland K, Read CA, Fritzler MJ, Kim GHJ, Tseng CH, Elashoff RM, . Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial. Lancet Respir Med [print-electronic]. 2016 Sep; 4(9): 708-19. PMID: 27469583, PMCID: PMC5014629, PII: S2213-2600(16)30152-7, DOI: 10.1016/S2213-2600(16)30152-7, ISSN: 2213-2619.

Taylor AM, Phillips K, Patel KV, Turk DC, Dworkin RH, Beaton D, Clauw DJ, Gignac MA, Markman JD, Williams DA, Bujanover S, Burke LB, Carr DB, Choy EH, Conaghan PG, Cowan P, Farrar JT, Freeman R, Gewandter J, Gilron I, Goli V, Gover TD, Haddox JD, Kerns RD, Kopecky EA, Lee DA, Malamut R, Mease P, Rappaport BA, Simon LS, Singh JA, Smith SM, Strand V, Tugwell P, Vanhove GF, Veasley C, Walco GA, Wasan AD, Witter J. Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations. Pain. 2016 Sep; 157(9): 1836-50. PMID: 27058676, DOI: 10.1097/j.pain.0000000000000577, ISSN: 1872-6623.

Khanna D, Berrocal VJ, Giannini EH, Seibold JR, Merkel PA, Mayes MD, Baron M, Clements PJ, Steen V, Assassi S, Schiopu E, Phillips K, Simms RW, Allanore Y, Denton CP, Distler O, Johnson SR, Matucci-Cerinic M, Pope JE, Proudman SM, Siegel J, Wong WK, Wells AU, Furst DE. The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis. Arthritis & rheumatology (Hoboken, N.J.). 2016 Feb; 68(2): 299-311. PMID: 26808827, PMCID: PMC4826472, DOI: 10.1002/art.39501, ISSN: 2326-5205.

Khanna D, Berrocal VJ, Giannini EH, Seibold JR, Merkel PA, Mayes MD, Baron M, Clements PJ, Steen V, Assassi S, Schiopu E, Phillips K, Simms RW, Allanore Y, Denton CP, Distler O, Johnson SR, Matucci-Cerinic M, Pope JE, Proudman SM, Siegel J, Wong WK, Wells AU, Furst DE. The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis. Arthritis Care Res (Hoboken). 2016 Feb; 68(2): 167-78. PMID: 26806474, PMCID: PMC4818571, DOI: 10.1002/acr.22804, ISSN: 2151-4658.

Wu M, Assassi S, Salazar GA, Pedroza C, Gorlova OY, Chen WV, Charles J, Taing ML, Liao K, Wigley FM, Hummers LK, Shah AA, Hinchcliff M, Khanna D, Schiopu E, Phillips K, Furst DE, Steen V, Baron M, Hudson M, Zhou X, Pope J, Jones N, Docherty P, Khalidi NA, Robinson D, Simms RW, Silver RM, Frech TM, Fessler BJ, Fritzler MJ, Molitor JA, Segal BM, Movahedian M, Martín J, Varga J, Mayes MD. Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients. Arthritis Res. Ther. 2016 Jan 1/20/2016; 18: 20. PMID: 26792595, PMCID: PMC4719560, PII: 10.1186/s13075-016-0923-3, DOI: 10.1186/s13075-016-0923-3, ISSN: 1478-6362.

Maxwell LJ, Wells GA, Simon LS, Conaghan PG, Grosskleg S, Scrivens K, Beaton DE, Bingham CO, Busse JW, Christensen R, Goel N, Jüni P, Kaiser U, Lyddiatt A, Mease PJ, Ostelo RW, Phillips K, Sapunar D, Singh JA, Strand V, Taylor AM, Terwee CB, Tugwell P. Current State of Reporting Pain Outcomes in Cochrane Reviews of Chronic Musculoskeletal Pain Conditions and Considerations for an OMERACT Research Agenda. J. Rheumatol [print-electronic]. 2015 Oct; 42(10): 1934-42. PMID: 26373562, PII: jrheum.141423, DOI: 10.3899/jrheum.141423, ISSN: 0315-162X.

Phillips K, Taylor A, Mease PJ, Simon LS, Conaghan PG, Choy EH, Singh JA, Strand V, Gossec L, Kaiser U, de Wit M, Ostelo R, Maxwell L, Tugwell PS. Harmonizing Pain Outcome Measures: Results of the Pre-OMERACT Meeting on Partnerships for Consensus on Patient-important Pain Outcome Domains Between the Cochrane Musculoskeletal Group and OMERACT. J. Rheumatol [print-electronic]. 2015 Oct; 42(10): 1943-6. PMID: 26233508, PII: jrheum.141386, DOI: 10.3899/jrheum.141386, ISSN: 0315-162X.

Taylor AM, Phillips K, Taylor JO, Singh JA, Conaghan PG, Choy EH, Tugwell PS, Kaiser U, Strand V, Simon LS, Mease PJ. Is Chronic Pain a Disease in Its Own Right? Discussions from a Pre-OMERACT 2014 Workshop on Chronic Pain. J. Rheumatol [print-electronic]. 2015 Oct; 42(10): 1947-53. PMID: 26136483, PII: jrheum.141328, DOI: 10.3899/jrheum.141328, ISSN: 0315-162X.

Murphy SL, Lyden AK, Kratz AL, Fritz H, Williams DA, Clauw DJ, Gammaitoni AR, Phillips K. Characterizing Pain Flares From the Perspective of Individuals With Symptomatic Knee Osteoarthritis. Arthritis Care Res (Hoboken). 2015 Aug; 67(8): 1103-11. PMID: 25580697, PMCID: PMC4641239, DOI: 10.1002/acr.22545, ISSN: 2151-4658.

Salazar GA, Assassi S, Wigley F, Hummers L, Varga J, Hinchcliff M, Khanna D, Schiopu E, Phillips K, Furst DE, Steen V, Baron M, Hudson M, Taillefer SS, Pope J, Jones N, Docherty P, Khalidi NA, Robinson D, Simms RW, Silver RM, Frech TM, Fessler BJ, Molitor JA, Fritzler MJ, Segal BM, Al-Kassab F, Perry M, Yang J, Zamanian S, Reveille JD, Arnett FC, Pedroza C, Mayes MD. Antinuclear antibody-negative systemic sclerosis. Semin. Arthritis Rheum [print-electronic]. 2015 Jun; 44(6): 680-6. PMID: 25578738, PMCID: PMC4447614, PII: S0049-0172(14)00293-5, DOI: 10.1016/j.semarthrit.2014.11.006, ISSN: 1532-866X.

Morgan R, Endres J, Behbahani-Nejad N, Phillips K, Ruth JH, Friday SC, Edhayan G, Lanigan T, Urquhart A, Chung KC, Fox DA. Expression and function of aminopeptidase N/CD13 produced by fibroblast-like synoviocytes in rheumatoid arthritis: role of CD13 in chemotaxis of cytokine-activated T cells independent of enzymatic activity. Arthritis & rheumatology (Hoboken, N.J.). 2015 Jan; 67(1): 74-85. PMID: 25219368, PMCID: PMC4280337, DOI: 10.1002/art.38878, ISSN: 2326-5205.

Saketkoo LA, Mittoo S, Frankel S, LeSage D, Sarver C, Phillips K, Strand V, Matteson EL, , . Reconciling healthcare professional and patient perspectives in the development of disease activity and response criteria in connective tissue disease-related interstitial lung diseases. J. Rheumatol [print-electronic]. 2014 Apr; 41(4): 792-8. PMID: 24488412, PMCID: PMC4369780, PII: jrheum.131251, DOI: 10.3899/jrheum.131251, ISSN: 0315-162X.

Mayes MD, Bossini-Castillo L, Gorlova O, Martin JE, Zhou X, Chen WV, Assassi S, Ying J, Tan FK, Arnett FC, Reveille JD, Guerra S, Teruel M, Carmona FD, Gregersen PK, Lee AT, López-Isac E, Ochoa E, Carreira P, Simeón CP, Castellví I, González-Gay MÁ, , Zhernakova A, Padyukov L, Alarcón-Riquelme M, Wijmenga C, Brown M, Beretta L, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Voskuyl AE, Schuerwegh AJ, Hesselstrand R, Nordin A, Airó P, Lunardi C, Shiels P, van Laar JM, Herrick A, Worthington J, Denton C, Wigley FM, Hummers LK, Varga J, Hinchcliff ME, Baron M, Hudson M, Pope JE, Furst DE, Khanna D, Phillips K, Schiopu E, Segal BM, Molitor JA, Silver RM, Steen VD, Simms RW, Lafyatis RA, Fessler BJ, Frech TM, Alkassab F, Docherty P, Kaminska E, Khalidi N, Jones HN, Markland J, Robinson D, Broen J, Radstake TR, Fonseca C, Koeleman BP, Martin J. Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. Am. J. Hum. Genet. 2014 Jan 1/2/2014; 94(1): 47-61. PMID: 24387989, PMCID: PMC3882906, PII: S0002-9297(13)00571-5, DOI: 10.1016/j.ajhg.2013.12.002, ISSN: 1537-6605.

Phillips K, Clauw DJ. Central pain mechanisms in the rheumatic diseases: future directions. Arthritis Rheum. 2013 Feb; 65(2): 291-302. PMID: 23045168, PMCID: PMC3610409, DOI: 10.1002/art.37739, ISSN: 1529-0131.

Wagner D, Pasko D, Phillips K, Waldvogel J, Annich G. In vitro clearance of dexmedetomidine in extracorporeal membrane oxygenation. Perfusion [print-electronic]. 2013 Jan; 28(1): 40-6. PMID: 22891035, PII: 0267659112456894, DOI: 10.1177/0267659112456894, ISSN: 1477-111X.

Murphy SL, Phillips K, Williams DA, Clauw DJ. The role of the central nervous system in osteoarthritis pain and implications for rehabilitation. Curr Rheumatol Rep. 2012 Dec; 14(6): 576-82. PMID: 22879060, DOI: 10.1007/s11926-012-0285-z, ISSN: 1534-6307.

Tsou PS, Talia NN, Pinney AJ, Kendzicky A, Piera-Velazquez S, Jimenez SA, Seibold JR, Phillips K, Koch AE. Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts. Arthritis Rheum [print-electronic]. 2012 Jun; 64(6): 1978-89. PMID: 22161819, PMCID: PMC3309078, DOI: 10.1002/art.34336, ISSN: 1529-0131.

Schiopu E, Phillips K, MacDonald PM, Crofford LJ, Somers EC. Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. Arthritis Res. Ther. 2012 Jan 1/27/2012; 14(1): R22. PMID: 22284862, PMCID: PMC3392815, PII: ar3704, DOI: 10.1186/ar3704, ISSN: 1478-6362.

Murphy SL, Lyden AK, Phillips K, Clauw DJ, Williams DA. Association between pain, radiographic severity, and centrally-mediated symptoms in women with knee osteoarthritis. Arthritis Care Res (Hoboken). 2011 Nov; 63(11): 1543-9. PMID: 22034116, PMCID: PMC3205461, DOI: 10.1002/acr.20583, ISSN: 2151-4658.

Murphy SL, Lyden AK, Phillips K, Clauw DJ, Williams DA. Subgroups of older adults with osteoarthritis based upon differing comorbid symptom presentations and potential underlying pain mechanisms. Arthritis Res. Ther. 2011 Aug 8/24/2011; 13(4): R135. PMID: 21864381, PMCID: PMC3239378, PII: ar3449, DOI: 10.1186/ar3449, ISSN: 1478-6362.

Phillips K, Clauw DJ. Central pain mechanisms in chronic pain states--maybe it is all in their head. Best Pract Res Clin Rheumatol. 2011 Apr; 25(2): 141-54. PMID: 22094191, PMCID: PMC3220875, PII: S1521-6942(11)00029-5, DOI: 10.1016/j.berh.2011.02.005, ISSN: 1532-1770.

Rabquer BJ, Tsou PS, Hou Y, Thirunavukkarasu E, Haines GK, Impens AJ, Phillips K, Kahaleh B, Seibold JR, Koch AE. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Arthritis Res. Ther. 2011 Feb 2/8/2011; 13(1): R18. PMID: 21303517, PMCID: PMC3241362, PII: ar3242, DOI: 10.1186/ar3242, ISSN: 1478-6362.

Impens AJ, Phillips K, Schiopu E. PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers: Current Status of Clinical Trials. Int J Rheumatol [print-electronic]. 2011; 2011: 392542. PMID: 22121375, PMCID: PMC3216380, DOI: 10.1155/2011/392542, ISSN: 1687-9279.

Schiopu E, Impens AJ, Phillips K. Digital ischemia in scleroderma spectrum of diseases. Int J Rheumatol [print-electronic]. 2010; 2010: PMID: 20862342, PMCID: PMC2939434, DOI: 10.1155/2010/923743, ISSN: 1687-9279.

Schiopu E, Hsu VM, Impens AJ, Rothman JA, McCloskey DA, Wilson JE, Phillips K, Seibold JR. Randomized placebo-controlled crossover trial of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis. J. Rheumatol [print-electronic]. 2009 Oct; 36(10): 2264-8. PMID: 19755613, PII: jrheum.090270, DOI: 10.3899/jrheum.090270, ISSN: 0315-162X.

Phillips K, Byrne-Dugan C, Batterson E, Seibold JR. Rapidly progressive fatal interstitial lung disease in a patient with systemic sclerosis. Nat Rev Rheumatol. 2009 Apr; 5(4): 225-8. PMID: 19337287, PII: nrrheum.2009.30, DOI: 10.1038/nrrheum.2009.30, ISSN: 1759-4804.

Anderson P, Phillips K, Stoecklin G, Kedersha N. Post-transcriptional regulation of proinflammatory proteins. J. Leukoc. Biol [print-electronic]. 2004 Jul; 76(1): 42-7. PMID: 15075353, PII: jlb.1103536, DOI: 10.1189/jlb.1103536, ISSN: 0741-5400.

Phillips K, Husni ME, Karlson EW, Coblyn JS. Experience with etanercept in an academic medical center: are infection rates increased?. Arthritis Rheum. 2002 Feb; 47(1): 17-21. PMID: 11932873, PII: 10.1002/art1.10243, ISSN: 0004-3591.