Ana Paula Moreira Serezani, Ph.D.

Research Assistant Professor
Faculty Appointments
Research Assistant Professor of Medicine
Ph.D., Immunology, Universidade de Sao Paulo, Sao Paulo, BrazilM.S., Immunology, Universidade de Sao Paulo, Sao Paulo, BrazilB.S., Biomedicine, Sao Paulo State University, Sao Paulo, Brazil
Research Description
Dr. Ana Serezani is a Research Assistant Professor in the Division of Allergy, Pulmonary, and Critical Care Medicine. She obtained her Ph.D. in Immunology from University of Sao Paulo, Brazil. Dr. Serezani was a Research Assistant Professor in the Pediatrics Department at Indiana University School of Medicine. Her research examines the contribution of adaptive and innate immune responses to the control of pathogens associated with chronic lung diseases, including herpesvirus in idiopathic pulmonary fibrosis (IPF). She is particularly interested in developing therapeutic interventions to prevent chronic inflammation, decreasing risks for disease progression and/or exacerbation
Research Keywords
Immunology, Inflammation, T cells, lung remodeling and fibrosis.
Money KM, Barke TL, Serezani A, Gannon M, Garbett KA, Aronoff DM, Mirnics K. Gestational diabetes exacerbates maternal immune activation effects in the developing brain. Mol. Psychiatry [print-electronic]. 2017 Sep 9/26/2017; PMID: 28948973, PII: mp2017191, DOI: 10.1038/mp.2017.191, ISSN: 1476-5578.

Serezani AP, Bozdogan G, Sehra S, Walsh D, Krishnamurthy P, Sierra Potchanant EA, Nalepa G, Goenka S, Turner MJ, Spandau DF, Kaplan MH. IL-4 impairs wound healing potential in the skin by repressing fibronectin expression. J. Allergy Clin. Immunol [print-electronic]. 2017 Jan; 139(1): 142-151.e5. PMID: 27554818, PMCID: PMC5222746, PII: S0091-6749(16)30794-1, DOI: 10.1016/j.jaci.2016.07.012, ISSN: 1097-6825.

Sehra S, Serezani APM, Ocaña JA, Travers JB, Kaplan MH. Mast Cells Regulate Epidermal Barrier Function and the Development of Allergic Skin Inflammation. J. Invest. Dermatol [print-electronic]. 2016 Jul; 136(7): 1429-37. PMID: 27021404, PMCID: PMC4921316, PII: S0022-202X(16)30980-0, DOI: 10.1016/j.jid.2016.03.019, ISSN: 1523-1747.

Shibata T, Ismailoglu UB, Kittan NA, Moreira AP, Coelho AL, Chupp GL, Kunkel SL, Lukacs NW, Hogaboam CM. Role of growth arrest-specific gene 6 in the development of fungal allergic airway disease in mice. Am. J. Respir. Cell Mol. Biol. 2014 Nov; 51(5): 615-25. PMID: 24810144, PMCID: PMC5455299, DOI: 10.1165/rcmb.2014-0049OC, ISSN: 1535-4989.

Handlogten MW, Serezani AP, Sinn AL, Pollok KE, Kaplan MH, Bilgicer B. A heterobivalent ligand inhibits mast cell degranulation via selective inhibition of allergen-IgE interactions in vivo. J. Immunol [print-electronic]. 2014 Mar 3/1/2014; 192(5): 2035-41. PMID: 24489096, PMCID: PMC3951166, PII: jimmunol.1301371, DOI: 10.4049/jimmunol.1301371, ISSN: 1550-6606.

Ferreira AE, Sisti F, Sônego F, Wang S, Filgueiras LR, Brandt S, Serezani AP, Du H, Cunha FQ, Alves-Filho JC, Serezani CH. PPAR-¿/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis. J. Immunol [print-electronic]. 2014 Mar 3/1/2014; 192(5): 2357-65. PMID: 24489087, PMCID: PMC3943997, PII: jimmunol.1302375, DOI: 10.4049/jimmunol.1302375, ISSN: 1550-6606.

Wang Z, Filgueiras LR, Wang S, Serezani AP, Peters-Golden M, Jancar S, Serezani CH. Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation. J. Immunol [print-electronic]. 2014 Mar 3/1/2014; 192(5): 2349-56. PMID: 24477912, PMCID: PMC3943984, PII: jimmunol.1302982, DOI: 10.4049/jimmunol.1302982, ISSN: 1550-6606.

Handlogten MW, Serezani AP, Kaplan MH, Bilgicer B. What potential do heterobivalent inhibitors have for the treatment of severe allergic reactions? [editorial]. Immunotherapy. 2014; 6(3): 223-5. PMID: 24762067, DOI: 10.2217/imt.14.1, ISSN: 1750-7448.

Handlogten MW, Kiziltepe T, Serezani AP, Kaplan MH, Bilgicer B. Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation. Nat. Chem. Biol [print-electronic]. 2013 Dec; 9(12): 789-95. PMID: 24096304, PMCID: PMC3913000, PII: nchembio.1358, DOI: 10.1038/nchembio.1358, ISSN: 1552-4469.

Tristão FS, Panagio LA, Rocha FA, Cavassani KA, Moreira AP, Rossi MA, Silva JS. B cell-deficient mice display enhanced susceptibility to Paracoccidioides brasiliensis Infection. Mycopathologia [print-electronic]. 2013 Aug; 176(1-2): 1-10. PMID: 23765323, DOI: 10.1007/s11046-013-9671-y, ISSN: 1573-0832.

Tristão FS, Rocha FA, Moreira AP, Cunha FQ, Rossi MA, Silva JS. 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection. Infect. Immun [print-electronic]. 2013 Apr; 81(4): 1256-66. PMID: 23381993, PMCID: PMC3639621, PII: IAI.01209-12, DOI: 10.1128/IAI.01209-12, ISSN: 1098-5522.

Cavassani KA, Moreira AP, Habiel D, Ito T, Coelho AL, Allen RM, Hu B, Raphelson J, Carson WF, Schaller MA, Lukacs NW, Omary MB, Hogaboam CM, Kunkel SL. Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity. PLoS ONE [electronic-print]. 2013; 8(6): e65899. PMID: 23762449, PMCID: PMC3676358, PII: PONE-D-13-03681, DOI: 10.1371/journal.pone.0065899, ISSN: 1932-6203.

Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight DA, Kunkel SL, Uematsu S, Akira S, Hogaboam CM. The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A. J. Clin. Invest [print-electronic]. 2011 Nov; 121(11): 4420-32. PMID: 22005301, PMCID: PMC3204826, PII: 44999, DOI: 10.1172/JCI44999, ISSN: 1558-8238.

Ramaprakash H, Shibata T, Duffy KE, Ismailoglu UB, Bredernitz RM, Moreira AP, Coelho AL, Das AM, Fursov N, Chupp GL, Hogaboam CM. Targeting ST2L potentiates CpG-mediated therapeutic effects in a chronic fungal asthma model. Am. J. Pathol [print-electronic]. 2011 Jul; 179(1): 104-15. PMID: 21640974, PMCID: PMC3123853, PII: S0002-9440(11)00356-7, DOI: 10.1016/j.ajpath.2011.03.032, ISSN: 1525-2191.

Moreira AP, Hogaboam CM. Macrophages in allergic asthma: fine-tuning their pro- and anti-inflammatory actions for disease resolution. J. Interferon Cytokine Res. 2011 Jun; 31(6): 485-91. PMID: 21631355, DOI: 10.1089/jir.2011.0027, ISSN: 1557-7465.

Cavassani KA, Tristao FS, Oliveira LL, Rocha FA, Vancim JO, Moreira AP, Campanelli AP, Panagio LA, Milanezi CM, Martinez R, Rossi MA, Silva JS. Cell-free antigens from Paracoccidioides brasiliensis drive IL-4 production and increase the severity of paracoccidioidomycosis. PLoS ONE [print-electronic]. 2011; 6(6): e21423. PMID: 21731741, PMCID: PMC3120880, PII: PONE-D-11-02370, DOI: 10.1371/journal.pone.0021423, ISSN: 1932-6203.

Moreira AP, Cavassani KA, Hullinger R, Rosada RS, Fong DJ, Murray L, Hesson DP, Hogaboam CM. Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore-induced allergic airway disease. J. Allergy Clin. Immunol [print-electronic]. 2010 Oct; 126(4): 712-721.e7. PMID: 20673988, PII: S0091-6749(10)00967-X, DOI: 10.1016/j.jaci.2010.06.010, ISSN: 1097-6825.

Cavassani KA, Carson WF, Moreira AP, Wen H, Schaller MA, Ishii M, Lindell DM, Dou Y, Lukacs NW, Keshamouni VG, Hogaboam CM, Kunkel SL. The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth. Blood [print-electronic]. 2010 Jun 6/3/2010; 115(22): 4403-11. PMID: 20130237, PMCID: PMC2881495, PII: blood-2009-09-241083, DOI: 10.1182/blood-2009-09-241083, ISSN: 1528-0020.

Murray LA, Rosada R, Moreira AP, Joshi A, Kramer MS, Hesson DP, Argentieri RL, Mathai S, Gulati M, Herzog EL, Hogaboam CM. Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages. PLoS ONE. 2010 Mar 3/12/2010; 5(3): e9683. PMID: 20300636, PMCID: PMC2837381, DOI: 10.1371/journal.pone.0009683, ISSN: 1932-6203.

Rosada RS, Moreira AP, Frantz FG, Puri RK, Rahman A, Standiford TJ, Zárate-Bladés CR, Silva CL, Hogaboam CM. Therapeutic efficacy of Cintredekin Besudotox (IL13-PE38QQR) in murine lung fibrosis is unaffected by immunity to Pseudomonas aeruginosa exotoxin A. PLoS ONE. 2010 Jan 1/15/2010; 5(1): e8721. PMID: 20090941, PMCID: PMC2806906, DOI: 10.1371/journal.pone.0008721, ISSN: 1932-6203.

Moreira AP, Dias-Melicio LA, Soares AM. Interleukin-10 but not Transforming Growth Factor beta inhibits murine activated macrophages Paracoccidioides brasiliensis killing: effect on H2O2 and NO production. Cell. Immunol [print-electronic]. 2010; 263(2): 196-203. PMID: 20417928, PII: S0008-8749(10)00091-2, DOI: 10.1016/j.cellimm.2010.03.016, ISSN: 1090-2163.

Panagio LA, Tristao FS, Moreira AP, Pereira MS, Cavassani KA, Milanezi CM, Rossi MA, Silva JS. Role of interleukin (IL)-18 in experimental paracoccidioidomycosis. Med. Mycol [print-electronic]. 2008 Aug; 46(5): 435-42. PMID: 18608933, PII: 791305146, DOI: 10.1080/13693780801895444, ISSN: 1369-3786.

Moreira AP, Dias-Melicio LA, Peraçoli MT, Calvi SA, Victoriano de Campos Soares AM. Killing of Paracoccidioides brasiliensis yeast cells by IFN-gamma and TNF-alpha activated murine peritoneal macrophages: evidence of H(2)O (2) and NO effector mechanisms. Mycopathologia [print-electronic]. 2008 Jul; 166(1): 17-23. PMID: 18496766, DOI: 10.1007/s11046-007-9046-3, ISSN: 0301-486X.

Cardoso CR, Garlet GP, Moreira AP, Júnior WM, Rossi MA, Silva JS. Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis. J. Leukoc. Biol [print-electronic]. 2008 Jul; 84(1): 311-8. PMID: 18451325, PII: jlb.0108014, DOI: 10.1189/jlb.0108014, ISSN: 0741-5400.

Mariano FS, Gutierrez FR, Pavanelli WR, Milanezi CM, Cavassani KA, Moreira AP, Ferreira BR, Cunha FQ, Cardoso CR, Silva JS. The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection. Microbes Infect [print-electronic]. 2008 Jun; 10(7): 825-33. PMID: 18538611, PII: S1286-4579(08)00113-5, DOI: 10.1016/j.micinf.2008.04.009, ISSN: 1286-4579.

Moreira AP, Cavassani KA, Massafera Tristão FS, Campanelli AP, Martinez R, Rossi MA, Silva JS. CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression. J. Immunol. 2008 Mar 3/1/2008; 180(5): 3049-56. PMID: 18292527, PII: 180/5/3049, ISSN: 0022-1767.

Cavassani KA, Campanelli AP, Moreira AP, Vancim JO, Vitali LH, Mamede RC, Martinez R, Silva JS. Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans. J. Immunol. 2006 Nov 11/1/2006; 177(9): 5811-8. PMID: 17056505, PII: 177/9/5811, ISSN: 0022-1767.

Dal Secco D, Moreira AP, Freitas A, Silva JS, Rossi MA, Ferreira SH, Cunha FQ. Nitric oxide inhibits neutrophil migration by a mechanism dependent on ICAM-1: role of soluble guanylate cyclase. Nitric Oxide [print-electronic]. 2006 Aug; 15(1): 77-86. PMID: 16621629, PII: S1089-8603(06)00035-8, DOI: 10.1016/j.niox.2006.02.004, ISSN: 1089-8603.

Dias-Melicio LA, Moreira AP, Calvi SA, Soares AM. Chloroquine inhibits Paracoccidioides brasiliensis survival within human monocytes by limiting the availability of intracellular iron. Microbiol. Immunol. 2006; 50(4): 307-14. PMID: 16625052, PII: JST.JSTAGE/mandi/50.307, ISSN: 0385-5600.