Jere Palmer Segrest, M.D., Ph.D.

Professor

j.segrest@vanderbilt.edu
Faculty Appointments
Professor of Medicine
Education
Ph.D., Biochemistry, Vanderbilt University, Nashville, TennesseeM.D., Vanderbilt University, Nashville, TennesseeB.A., Chemistry, Vanderbilt University, Nashville, Tennessee
Publications
Pourmousa M, Song HD, He Y, Heinecke JW, Segrest JP, Pastor RW. Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2018 Apr 4/30/2018; PMID: 29712830, PII: 1721181115, DOI: 10.1073/pnas.1721181115, ISSN: 1091-6490.

Melchior JT, Walker RG, Cooke AL, Morris J, Castleberry M, Thompson TB, Jones MK, Song HD, Rye KA, Oda MN, Sorci-Thomas MG, Thomas MJ, Heinecke JW, Mei X, Atkinson D, Segrest JP, Lund-Katz S, Phillips MC, Davidson WS. A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state. Nat. Struct. Mol. Biol [print-electronic]. 2017 Dec; 24(12): 1093-9. PMID: 29131142, PMCID: PMC5749415, PII: nsmb.3501, DOI: 10.1038/nsmb.3501, ISSN: 1545-9985.

Manchekar M, Kapil R, Sun Z, Segrest JP, Dashti N. Relationship between Amphipathic ß Structures in the ß1 Domain of Apolipoprotein B and the Properties of the Secreted Lipoprotein Particles in McA-RH7777 Cells. Biochemistry [print-electronic]. 2017 Aug 8/8/2017; 56(31): 4084-94. PMID: 28702990, DOI: 10.1021/acs.biochem.6b01174, ISSN: 1520-4995.

Pan L, Segrest JP. Computational studies of plasma lipoprotein lipids. Biochim. Biophys. Acta [print-electronic]. 2016 Oct; 1858(10): 2401-20. PMID: 26969087, PII: S0005-2736(16)30087-6, DOI: 10.1016/j.bbamem.2016.03.010, ISSN: 0006-3002.

Melchior JT, Walker RG, Morris J, Jones MK, Segrest JP, Lima DB, Carvalho PC, Gozzo FC, Castleberry M, Thompson TB, Davidson WS. An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding. J. Biol. Chem [print-electronic]. 2016 Mar 3/4/2016; 291(10): 5439-51. PMID: 26755744, PMCID: PMC4777873, PII: M115.706093, DOI: 10.1074/jbc.M115.706093, ISSN: 1083-351X.

Segrest JP, Jones MK, Catte A, Manchekar M, Datta G, Zhang L, Zhang R, Li L, Patterson JC, Palgunachari MN, Oram JF, Ren G. Surface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly. Structure [print-electronic]. 2015 Jul 7/7/2015; 23(7): 1214-26. PMID: 26095027, PMCID: PMC4496276, PII: S0969-2126(15)00190-2, DOI: 10.1016/j.str.2015.05.010, ISSN: 1878-4186.

Segrest JP, Jones MK, Catte A, Thirumuruganandham SP. A robust all-atom model for LCAT generated by homology modeling. J. Lipid Res [print-electronic]. 2015 Mar; 56(3): 620-34. PMID: 25589508, PMCID: PMC4340309, PII: jlr.M056382, DOI: 10.1194/jlr.M056382, ISSN: 1539-7262.

Segrest JP, Jones MK, Shao B, Heinecke JW. An experimentally robust model of monomeric apolipoprotein A-I created from a chimera of two X-ray structures and molecular dynamics simulations. Biochemistry [print-electronic]. 2014 Dec 12/9/2014; 53(48): 7625-40. PMID: 25423138, PMCID: PMC4263436, DOI: 10.1021/bi501111j, ISSN: 1520-4995.

Walker RG, Deng X, Melchior JT, Morris J, Tso P, Jones MK, Segrest JP, Thompson TB, Davidson WS. The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering. J. Biol. Chem [print-electronic]. 2014 Feb 2/28/2014; 289(9): 5596-608. PMID: 24425874, PMCID: PMC3937636, PII: M113.541037, DOI: 10.1074/jbc.M113.541037, ISSN: 1083-351X.

Gursky O, Jones MK, Mei X, Segrest JP, Atkinson D. Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I. J. Lipid Res [print-electronic]. 2013 Dec; 54(12): 3244-57. PMID: 24038317, PMCID: PMC3826673, PII: jlr.R037911, DOI: 10.1194/jlr.R037911, ISSN: 1539-7262.

Segrest JP, Cheung MC, Jones MK. Volumetric determination of apolipoprotein stoichiometry of circulating HDL subspecies. J. Lipid Res [print-electronic]. 2013 Oct; 54(10): 2733-44. PMID: 23883582, PMCID: PMC3770086, PII: jlr.M039172, DOI: 10.1194/jlr.M039172, ISSN: 1539-7262.

Segrest JP, Jones MK, Catte A. MD simulations suggest important surface differences between reconstituted and circulating spherical HDL. J. Lipid Res [print-electronic]. 2013 Oct; 54(10): 2718-32. PMID: 23856070, PMCID: PMC3770085, PII: jlr.M039206, DOI: 10.1194/jlr.M039206, ISSN: 1539-7262.

Smith LE, Segrest JP, Davidson WS. Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II. J. Lipid Res [print-electronic]. 2013 Jul; 54(7): 1939-48. PMID: 23620136, PMCID: PMC3679395, PII: jlr.M037903, DOI: 10.1194/jlr.M037903, ISSN: 1539-7262.

Segrest JP, Jones MK, Catte A, Thirumuruganandham SP. Validation of previous computer models and MD simulations of discoidal HDL by a recent crystal structure of apoA-I. J. Lipid Res [print-electronic]. 2012 Sep; 53(9): 1851-63. PMID: 22773698, PMCID: PMC3413226, PII: jlr.M026229, DOI: 10.1194/jlr.M026229, ISSN: 1539-7262.

Nayyar G, Mishra VK, Handattu SP, Palgunachari MN, Shin R, McPherson DT, Deivanayagam CC, Garber DW, Segrest JP, Anantharamaiah GM. Sidedness of interfacial arginine residues and anti-atherogenicity of apolipoprotein A-I mimetic peptides. J. Lipid Res [print-electronic]. 2012 May; 53(5): 849-58. PMID: 22377531, PMCID: PMC3329384, PII: jlr.M019844, DOI: 10.1194/jlr.M019844, ISSN: 1539-7262.

Li L, Li S, Jones MK, Segrest JP. Rotational and hinge dynamics of discoidal high density lipoproteins probed by interchain disulfide bond formation. Biochim. Biophys. Acta [print-electronic]. 2012 Mar; 1821(3): 481-9. PMID: 22063273, PMCID: PMC3666556, PII: S1388-1981(11)00217-4, DOI: 10.1016/j.bbalip.2011.10.013, ISSN: 0006-3002.

Jones MK, Gu F, Catte A, Li L, Segrest JP. "Sticky" and "promiscuous", the yin and yang of apolipoprotein A-I termini in discoidal high-density lipoproteins: a combined computational-experimental approach. Biochemistry [print-electronic]. 2011 Mar 3/29/2011; 50(12): 2249-63. PMID: 21329368, PMCID: PMC3119339, DOI: 10.1021/bi101301g, ISSN: 1520-4995.

Bashtovyy D, Jones MK, Anantharamaiah GM, Segrest JP. Sequence conservation of apolipoprotein A-I affords novel insights into HDL structure-function. J. Lipid Res [print-electronic]. 2011 Mar; 52(3): 435-50. PMID: 21159667, PMCID: PMC3035680, PII: jlr.R012658, DOI: 10.1194/jlr.R012658, ISSN: 1539-7262.

Jones MK, Zhang L, Catte A, Li L, Oda MN, Ren G, Segrest JP. Assessment of the validity of the double superhelix model for reconstituted high density lipoproteins: a combined computational-experimental approach. J. Biol. Chem [print-electronic]. 2010 Dec 12/24/2010; 285(52): 41161-71. PMID: 20974855, PMCID: PMC3003414, PII: M110.187799, DOI: 10.1074/jbc.M110.187799, ISSN: 1083-351X.

Gu F, Jones MK, Chen J, Patterson JC, Catte A, Jerome WG, Li L, Segrest JP. Structures of discoidal high density lipoproteins: a combined computational-experimental approach. J. Biol. Chem [print-electronic]. 2010 Feb 2/12/2010; 285(7): 4652-65. PMID: 19948731, PMCID: PMC2836071, PII: M109.069914, DOI: 10.1074/jbc.M109.069914, ISSN: 1083-351X.

Jones MK, Catte A, Li L, Segrest JP. Dynamics of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I. Biochemistry. 2009 Dec 12/1/2009; 48(47): 11196-210. PMID: 19860440, PMCID: PMC2814595, DOI: 10.1021/bi901242k, ISSN: 1520-4995.

Jones MK, Catte A, Patterson JC, Gu F, Chen J, Li L, Segrest JP. Thermal stability of apolipoprotein A-I in high-density lipoproteins by molecular dynamics. Biophys. J. 2009 Jan; 96(2): 354-71. PMID: 19167289, PMCID: PMC2716522, PII: S0006-3495(08)00051-9, DOI: 10.1016/j.bpj.2008.09.041, ISSN: 1542-0086.

Mishra VK, Palgunachari MN, Krishna R, Glushka J, Segrest JP, Anantharamaiah GM. Effect of leucine to phenylalanine substitution on the nonpolar face of a class A amphipathic helical peptide on its interaction with lipid: high resolution solution NMR studies of 4F-dimyristoylphosphatidylcholine discoidal complex. J. Biol. Chem [print-electronic]. 2008 Dec 12/5/2008; 283(49): 34393-402. PMID: 18845546, PMCID: PMC2590695, PII: M806384200, DOI: 10.1074/jbc.M806384200, ISSN: 0021-9258.

Manchekar M, Richardson PE, Sun Z, Liu Y, Segrest JP, Dashti N. Charged amino acid residues 997-1000 of human apolipoprotein B100 are critical for the initiation of lipoprotein assembly and the formation of a stable lipidated primordial particle in McA-RH7777 cells. J. Biol. Chem [print-electronic]. 2008 Oct 10/24/2008; 283(43): 29251-65. PMID: 18725409, PMCID: PMC2570877, PII: M804912200, DOI: 10.1074/jbc.M804912200, ISSN: 0021-9258.

Sulkes D, Brown BG, Krauss RM, Segrest JP, Sniderman AD, Roberts WC. The editor's roundtable: expanded versus standard lipid panels in assessing and managing cardiovascular risk. Am. J. Cardiol. 2008 Mar 3/15/2008; 101(6): 828-42. PMID: 18328849, PII: S0002-9149(07)02412-5, DOI: 10.1016/j.amjcard.2007.12.006, ISSN: 0002-9149.

Catte A, Patterson JC, Bashtovyy D, Jones MK, Gu F, Li L, Rampioni A, Sengupta D, Vuorela T, Niemelä P, Karttunen M, Marrink SJ, Vattulainen I, Segrest JP. Structure of spheroidal HDL particles revealed by combined atomistic and coarse-grained simulations. Biophys. J [print-electronic]. 2008 Mar 3/15/2008; 94(6): 2306-19. PMID: 18065479, PMCID: PMC2257918, PII: S0006-3495(08)70575-7, DOI: 10.1529/biophysj.107.115857, ISSN: 1542-0086.

Dashti N, Manchekar M, Liu Y, Sun Z, Segrest JP. Microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein B-containing lipoprotein assembly in McA-RH7777 cells. J. Biol. Chem [print-electronic]. 2007 Sep 9/28/2007; 282(39): 28597-608. PMID: 17690102, PII: M700229200, DOI: 10.1074/jbc.M700229200, ISSN: 0021-9258.

Anantharamaiah GM, Mishra VK, Garber DW, Datta G, Handattu SP, Palgunachari MN, Chaddha M, Navab M, Reddy ST, Segrest JP, Fogelman AM. Structural requirements for antioxidative and anti-inflammatory properties of apolipoprotein A-I mimetic peptides. J. Lipid Res [print-electronic]. 2007 Sep; 48(9): 1915-23. PMID: 17570869, PII: R700010-JLR200, DOI: 10.1194/jlr.R700010-JLR200, ISSN: 0022-2275.

Catte A, Patterson JC, Jones MK, Jerome WG, Bashtovyy D, Su Z, Gu F, Chen J, Aliste MP, Harvey SC, Li L, Weinstein G, Segrest JP. Novel changes in discoidal high density lipoprotein morphology: a molecular dynamics study. Biophys. J [print-electronic]. 2006 Jun 6/15/2006; 90(12): 4345-60. PMID: 16581834, PMCID: PMC1471865, PII: biophysj.105.071456, DOI: 10.1529/biophysj.105.071456, ISSN: 0006-3495.

Anantharamaiah G, Navab M, Reddy ST, Garber DW, Datta G, Gupta H, White CR, Handattu SP, Palgunachari MN, Chaddha M, Mishra VK, Segrest JP, Fogelman AM. Synthetic peptides: managing lipid disorders. Curr. Opin. Lipidol. 2006 Jun; 17(3): 233-7. PMID: 16680027, PII: 00041433-200606000-00006, DOI: 10.1097/01.mol.0000226114.89812.75, ISSN: 0957-9672.

Mishra VK, Anantharamaiah GM, Segrest JP, Palgunachari MN, Chaddha M, Sham SW, Krishna NR. Association of a model class A (apolipoprotein) amphipathic alpha helical peptide with lipid: high resolution NMR studies of peptide.lipid discoidal complexes. J. Biol. Chem [print-electronic]. 2006 Mar 3/10/2006; 281(10): 6511-9. PMID: 16407255, PII: M511475200, DOI: 10.1074/jbc.M511475200, ISSN: 0021-9258.

Silva RA, Hilliard GM, Li L, Segrest JP, Davidson WS. A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins. Biochemistry. 2005 Jun 6/21/2005; 44(24): 8600-7. PMID: 15952766, DOI: 10.1021/bi050421z, ISSN: 0006-2960.

Richardson PE, Manchekar M, Dashti N, Jones MK, Beigneux A, Young SG, Harvey SC, Segrest JP. Assembly of lipoprotein particles containing apolipoprotein-B: structural model for the nascent lipoprotein particle. Biophys. J [print-electronic]. 2005 Apr; 88(4): 2789-800. PMID: 15653747, PMCID: PMC1305374, PII: S0006-3495(05)73332-4, DOI: 10.1529/biophysj.104.046235, ISSN: 0006-3495.

Li L, Chen J, Mishra VK, Kurtz JA, Cao D, Klon AE, Harvey SC, Anantharamaiah GM, Segrest JP. Double belt structure of discoidal high density lipoproteins: molecular basis for size heterogeneity. J. Mol. Biol. 2004 Nov 11/5/2004; 343(5): 1293-311. PMID: 15491614, PII: S0022-2836(04)01146-5, DOI: 10.1016/j.jmb.2004.09.017, ISSN: 0022-2836.

Manchekar M, Richardson PE, Forte TM, Datta G, Segrest JP, Dashti N. Apolipoprotein B-containing lipoprotein particle assembly: lipid capacity of the nascent lipoprotein particle. J. Biol. Chem [print-electronic]. 2004 Sep 9/17/2004; 279(38): 39757-66. PMID: 15254032, PII: M406302200, DOI: 10.1074/jbc.M406302200, ISSN: 0021-9258.

Datta G, Epand RF, Epand RM, Chaddha M, Kirksey MA, Garber DW, Lund-Katz S, Phillips MC, Hama S, Navab M, Fogelman AM, Palgunachari MN, Segrest JP, Anantharamaiah GM. Aromatic residue position on the nonpolar face of class a amphipathic helical peptides determines biological activity. J. Biol. Chem [print-electronic]. 2004 Jun 6/18/2004; 279(25): 26509-17. PMID: 15075321, PII: M314276200, DOI: 10.1074/jbc.M314276200, ISSN: 0021-9258.

Epand RM, Epand RF, Sayer BG, Melacini G, Palgulachari MN, Segrest JP, Anantharamaiah GM. An apolipoprotein AI mimetic peptide: membrane interactions and the role of cholesterol. Biochemistry. 2004 May 5/4/2004; 43(17): 5073-83. PMID: 15109266, DOI: 10.1021/bi049786u, ISSN: 0006-2960.

Navab M, Anantharamaiah GM, Reddy ST, Van Lenten BJ, Hough G, Wagner A, Nakamura K, Garber DW, Datta G, Segrest JP, Hama S, Fogelman AM. Human apolipoprotein AI mimetic peptides for the treatment of atherosclerosis. Curr Opin Investig Drugs. 2003 Sep; 4(9): 1100-4. PMID: 14582455, ISSN: 1472-4472.

Klon AE, Segrest JP, Harvey SC. Molecular dynamics simulations on discoidal HDL particles suggest a mechanism for rotation in the apo A-I belt model. J. Mol. Biol. 2002 Dec 12/6/2002; 324(4): 703-21. PMID: 12460572, PII: S0022283602011439, ISSN: 0022-2836.

Klon AE, Segrest JP, Harvey SC. Comparative models for human apolipoprotein A-I bound to lipid in discoidal high-density lipoprotein particles. Biochemistry. 2002 Sep 9/10/2002; 41(36): 10895-905. PMID: 12206659, PII: bi020315m, ISSN: 0006-2960.

Flood C, Gustafsson M, Richardson PE, Harvey SC, Segrest JP, Borén J. Identification of the proteoglycan binding site in apolipoprotein B48. J. Biol. Chem [print-electronic]. 2002 Aug 8/30/2002; 277(35): 32228-33. PMID: 12070165, PII: M204053200, DOI: 10.1074/jbc.M204053200, ISSN: 0021-9258.

Dashti N, Gandhi M, Liu X, Lin X, Segrest JP. The N-terminal 1000 residues of apolipoprotein B associate with microsomal triglyceride transfer protein to create a lipid transfer pocket required for lipoprotein assembly. Biochemistry. 2002 Jun 6/4/2002; 41(22): 6978-87. PMID: 12033930, PII: bi011757l, ISSN: 0006-2960.

Segrest JP. The role of non-LDL:non-HDL particles in atherosclerosis. Curr. Diab. Rep. 2002 Jun; 2(3): 282-8. PMID: 12643186, ISSN: 1534-4827.

Srinivasan SR, Segrest JP, Elkasabany AM, Berenson GS. Distribution and correlates of lipoproteins and their subclasses in black and white young adults. The Bogalusa Heart Study. Atherosclerosis. 2001 Dec; 159(2): 391-7. PMID: 11730819, PII: S0021-9150(01)00514-7, ISSN: 0021-9150.

Segrest JP, Jones MK, De Loof H, Dashti N. Structure of apolipoprotein B-100 in low density lipoproteins. J. Lipid Res. 2001 Sep; 42(9): 1346-67. PMID: 11518754, ISSN: 0022-2275.

Polozov IV, Anantharamaiah GM, Segrest JP, Epand RM. Osmotically induced membrane tension modulates membrane permeabilization by class L amphipathic helical peptides: nucleation model of defect formation. Biophys. J. 2001 Aug; 81(2): 949-59. PMID: 11463637, PMCID: PMC1301565, PII: S0006-3495(01)75753-0, DOI: 10.1016/S0006-3495(01)75753-0, ISSN: 0006-3495.

Datta G, Chaddha M, Hama S, Navab M, Fogelman AM, Garber DW, Mishra VK, Epand RM, Epand RF, Lund-Katz S, Phillips MC, Segrest JP, Anantharamaiah GM. Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide. J. Lipid Res. 2001 Jul; 42(7): 1096-104. PMID: 11441137, ISSN: 0022-2275.

Mishraa VK, Palgunachari MN, Anantharamaiah GM, Jones MK, Segrest JP, Krishna NR. Solution NMR structure of a model class A (apolipoprotein) amphipathic alpha helical peptide. Peptides. 2001 Apr; 22(4): 567-73. PMID: 11311725, PII: S0196978101003655, ISSN: 0196-9781.

Garber DW, Datta G, Chaddha M, Palgunachari MN, Hama SY, Navab M, Fogelman AM, Segrest JP, Anantharamaiah GM. A new synthetic class A amphipathic peptide analogue protects mice from diet-induced atherosclerosis. J. Lipid Res. 2001 Apr; 42(4): 545-52. PMID: 11290826, ISSN: 0022-2275.

Klon AE, Jones MK, Segrest JP, Harvey SC. Molecular belt models for the apolipoprotein A-I Paris and Milano mutations. Biophys. J. 2000 Sep; 79(3): 1679-85. PMID: 10969027, PMCID: PMC1301059, PII: S0006-3495(00)76417-4, DOI: 10.1016/S0006-3495(00)76417-4, ISSN: 0006-3495.

Segrest JP, Harvey SC, Zannis V. Detailed molecular model of apolipoprotein A-I on the surface of high-density lipoproteins and its functional implications. Trends Cardiovasc. Med. 2000 Aug; 10(6): 246-52. PMID: 11282302, PII: S1050-1738(00)00078-5, ISSN: 1050-1738.

Segrest JP, Li L, Anantharamaiah GM, Harvey SC, Liadaki KN, Zannis V. Structure and function of apolipoprotein A-I and high-density lipoprotein. Curr. Opin. Lipidol. 2000 Apr; 11(2): 105-15. PMID: 10787171, ISSN: 0957-9672.

Segrest JP, Jones MK, Klon AE, Sheldahl CJ, Hellinger M, De Loof H, Harvey SC. A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein. J. Biol. Chem. 1999 Nov 11/5/1999; 274(45): 31755-8. PMID: 10542194, ISSN: 0021-9258.

Kulkarni KR, Markovitz JH, Nanda NC, Segrest JP. Increased prevalence of smaller and denser LDL particles in Asian Indians. Arterioscler. Thromb. Vasc. Biol. 1999 Nov; 19(11): 2749-55. PMID: 10559021, ISSN: 1079-5642.

Segrest JP, Jones MK, Dashti N. N-terminal domain of apolipoprotein B has structural homology to lipovitellin and microsomal triglyceride transfer protein: a "lipid pocket" model for self-assembly of apob-containing lipoprotein particles. J. Lipid Res. 1999 Aug; 40(8): 1401-16. PMID: 10428976, ISSN: 0022-2275.

Hristova K, Wimley WC, Mishra VK, Anantharamiah GM, Segrest JP, White SH. An amphipathic alpha-helix at a membrane interface: a structural study using a novel X-ray diffraction method. J. Mol. Biol. 1999 Jul 7/2/1999; 290(1): 99-117. PMID: 10388560, PII: S0022-2836(99)92840-1, DOI: 10.1006/jmbi.1999.2840, ISSN: 0022-2836.

Londos C, Brasaemle DL, Schultz CJ, Segrest JP, Kimmel AR. Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells. Semin. Cell Dev. Biol. 1999 Feb; 10(1): 51-8. PMID: 10355028, PII: S1084-9521(98)90275-0, DOI: 10.1006/scdb.1998.0275, ISSN: 1084-9521.

Gillotte KL, Zaiou M, Lund-Katz S, Anantharamaiah GM, Holvoet P, Dhoest A, Palgunachari MN, Segrest JP, Weisgraber KH, Rothblat GH, Phillips MC. Apolipoprotein-mediated plasma membrane microsolubilization. Role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and phospholipid. J. Biol. Chem. 1999 Jan 1/22/1999; 274(4): 2021-8. PMID: 9890960, ISSN: 0021-9258.

Chung BH, Segrest JP, Franklin F. In vitro production of beta-very low density lipoproteins and small, dense low density lipoproteins in mildly hypertriglyceridemic plasma: role of activities of lecithin:cholester acyltransferase, cholesterylester transfer proteins and lipoprotein lipase. Atherosclerosis. 1998 Dec; 141(2): 209-25. PMID: 9862170, PII: S0021-9150(98)00169-5, ISSN: 0021-9150.

Chung BH, Franklin F, Cho BH, Segrest JP, Hart K, Darnell BE. Potencies of lipoproteins in fasting and postprandial plasma to accept additional cholesterol molecules released from cell membranes. Arterioscler. Thromb. Vasc. Biol. 1998 Aug; 18(8): 1217-30. PMID: 9714128, ISSN: 1079-5642.

Mishra VK, Palgunachari MN, Datta G, Phillips MC, Lund-Katz S, Adeyeye SO, Segrest JP, Anantharamaiah GM. Studies of synthetic peptides of human apolipoprotein A-I containing tandem amphipathic alpha-helixes. Biochemistry. 1998 Jul 7/14/1998; 37(28): 10313-24. PMID: 9665740, PII: bi980042o, DOI: 10.1021/bi980042o, ISSN: 0006-2960.

Polozov IV, Polozova AI, Mishra VK, Anantharamaiah GM, Segrest JP, Epand RM. Studies of kinetics and equilibrium membrane binding of class A and class L model amphipathic peptides. Biochim. Biophys. Acta. 1998 Jan 1/19/1998; 1368(2): 343-54. PMID: 9459611, PII: S0005-2736(97)00210-1, ISSN: 0006-3002.

Segrest JP, Jones MK, Mishra VK, Pierotti V, Young SH, Borén J, Innerarity TL, Dashti N. Apolipoprotein B-100: conservation of lipid-associating amphipathic secondary structural motifs in nine species of vertebrates. J. Lipid Res. 1998 Jan; 39(1): 85-102. PMID: 9469589, ISSN: 0022-2275.

Kulkarni KR, Marcovina SM, Krauss RM, Garber DW, Glasscock AM, Segrest JP. Quantification of HDL2 and HDL3 cholesterol by the Vertical Auto Profile-II (VAP-II) methodology. J. Lipid Res. 1997 Nov; 38(11): 2353-64. PMID: 9392433, ISSN: 0022-2275.

Gazzara JA, Phillips MC, Lund-Katz S, Palgunachari MN, Segrest JP, Anantharamaiah GM, Rodrigueza WV, Snow JW. Effect of vesicle size on their interaction with class A amphipathic helical peptides. J. Lipid Res. 1997 Oct; 38(10): 2147-54. PMID: 9374136, ISSN: 0022-2275.

Gazzara JA, Phillips MC, Lund-Katz S, Palgunachari MN, Segrest JP, Anantharamaiah GM, Snow JW. Interaction of class A amphipathic helical peptides with phospholipid unilamellar vesicles. J. Lipid Res. 1997 Oct; 38(10): 2134-46. PMID: 9374135, ISSN: 0022-2275.

McCormick SP, Ng JK, Cham CM, Taylor S, Marcovina SM, Segrest JP, Hammer RE, Young SG. Transgenic mice expressing human ApoB95 and ApoB97. Evidence that sequences within the carboxyl-terminal portion of human apoB100 are important for the assembly of lipoprotein. J. Biol. Chem. 1997 Sep 9/19/1997; 272(38): 23616-22. PMID: 9295301, ISSN: 0021-9258.

Polozov IV, Polozova AI, Tytler EM, Anantharamaiah GM, Segrest JP, Woolley GA, Epand RM. Role of lipids in the permeabilization of membranes by class L amphipathic helical peptides. Biochemistry. 1997 Jul 7/29/1997; 36(30): 9237-45. PMID: 9230057, PII: bi970045l, DOI: 10.1021/bi970045l, ISSN: 0006-2960.

Chung BH, Palgunachari MN, Mishra VK, Chang CH, Segrest JP, Anantharamaiah GM. Probing structure and function of VLDL by synthetic amphipathic helical peptides. J. Lipid Res. 1996 May; 37(5): 1099-112. PMID: 8725161, ISSN: 0022-2275.

Palgunachari MN, Mishra VK, Lund-Katz S, Phillips MC, Adeyeye SO, Alluri S, Anantharamaiah GM, Segrest JP. Only the two end helixes of eight tandem amphipathic helical domains of human apo A-I have significant lipid affinity. Implications for HDL assembly. Arterioscler. Thromb. Vasc. Biol. 1996 Feb; 16(2): 328-38. PMID: 8620350, ISSN: 1079-5642.

Miller M, Burgan RG, Osterlund L, Segrest JP, Garber DW. A prospective, randomized trial of phenytoin in nonepileptic subjects with reduced HDL cholesterol. Arterioscler. Thromb. Vasc. Biol. 1995 Dec; 15(12): 2151-6. PMID: 7489236, ISSN: 1079-5642.

Kulkarni KR, Garber DW, Jones MK, Segrest JP. Identification and cholesterol quantification of low density lipoprotein subclasses in young adults by VAP-II methodology. J. Lipid Res. 1995 Nov; 36(11): 2291-302. PMID: 8656067, ISSN: 0022-2275.

Chung BH, Tallis GA, Cho BH, Segrest JP, Henkin Y. Lipolysis-induced partitioning of free fatty acids to lipoproteins: effect on the biological properties of free fatty acids. J. Lipid Res. 1995 Sep; 36(9): 1956-70. PMID: 8558084, ISSN: 0022-2275.

Allan CM, Walker D, Segrest JP, Taylor JM. Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. Genomics. 1995 Jul 7/20/1995; 28(2): 291-300. PMID: 8530039, PII: S0888-7543(85)71144-5, DOI: 10.1006/geno.1995.1144, ISSN: 0888-7543.

Lund-Katz S, Phillips MC, Mishra VK, Segrest JP, Anantharamaiah GM. Microenvironments of basic amino acids in amphipathic alpha-helices bound to phospholipid: 13C NMR studies using selectively labeled peptides. Biochemistry. 1995 Jul 7/18/1995; 34(28): 9219-26. PMID: 7619823, ISSN: 0006-2960.

Yancey PG, Bielicki JK, Johnson WJ, Lund-Katz S, Palgunachari MN, Anantharamaiah GM, Segrest JP, Phillips MC, Rothblat GH. Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides. Biochemistry. 1995 Jun 6/20/1995; 34(24): 7955-65. PMID: 7794908, ISSN: 0006-2960.

Tytler EM, Anantharamaiah GM, Walker DE, Mishra VK, Palgunachari MN, Segrest JP. Molecular basis for prokaryotic specificity of magainin-induced lysis. Biochemistry. 1995 Apr 4/4/1995; 34(13): 4393-401. PMID: 7703253, ISSN: 0006-2960.

Sparks DL, Anantharamaiah GM, Segrest JP, Phillips MC. Effect of the cholesterol content of reconstituted LpA-I on lecithin:cholesterol acyltransferase activity. J. Biol. Chem. 1995 Mar 3/10/1995; 270(10): 5151-7. PMID: 7890624, ISSN: 0021-9258.

Mishra VK, Palgunachari MN, Lund-Katz S, Phillips MC, Segrest JP, Anantharamaiah GM. Effect of the arrangement of tandem repeating units of class A amphipathic alpha-helixes on lipid interaction. J. Biol. Chem. 1995 Jan 1/27/1995; 270(4): 1602-11. PMID: 7829491, ISSN: 0021-9258.

Epand RM, Shai Y, Segrest JP, Anantharamaiah GM. Mechanisms for the modulation of membrane bilayer properties by amphipathic helical peptides. Biopolymers. 1995; 37(5): 319-38. PMID: 7632881, DOI: 10.1002/bip.360370504, ISSN: 0006-3525.

Epand RM, Stafford A, Leon B, Lock PE, Tytler EM, Segrest JP, Anantharamaiah GM. HDL and apolipoprotein A-I protect erythrocytes against the generation of procoagulant activity. Arterioscler. Thromb. 1994 Nov; 14(11): 1775-83. PMID: 7947603, ISSN: 1049-8834.

Mendez AJ, Anantharamaiah GM, Segrest JP, Oram JF. Synthetic amphipathic helical peptides that mimic apolipoprotein A-I in clearing cellular cholesterol. J. Clin. Invest. 1994 Oct; 94(4): 1698-705. PMID: 7929849, PMCID: PMC295333, DOI: 10.1172/JCI117515, ISSN: 0021-9738.

Segrest JP, Jones MK, Mishra VK, Anantharamaiah GM, Garber DW. ApoB-100 has a pentapartite structure composed of three amphipathic alpha-helical domains alternating with two amphipathic beta-strand domains. Detection by the computer program LOCATE. Arterioscler. Thromb. 1994 Oct; 14(10): 1674-85. PMID: 7918318, ISSN: 1049-8834.

Spuhler P, Anantharamaiah GM, Segrest JP, Seelig J. Binding of apolipoprotein A-I model peptides to lipid bilayers. Measurement of binding isotherms and peptide-lipid headgroup interactions. J. Biol. Chem. 1994 Sep 9/30/1994; 269(39): 23904-10. PMID: 7929037, ISSN: 0021-9258.

Davidson WS, Lund-Katz S, Johnson WJ, Anantharamaiah GM, Palgunachari MN, Segrest JP, Rothblat GH, Phillips MC. The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein. J. Biol. Chem. 1994 Sep 9/16/1994; 269(37): 22975-82. PMID: 8083197, ISSN: 0021-9258.

Polozov IV, Polozova AI, Anantharamaiah GM, Segrest JP, Epand RM. Mixing rates can markedly affect the kinetics of peptide-induced leakage from liposomes. Biochem. Mol. Biol. Int. 1994 Aug; 33(6): 1073-9. PMID: 7804132, ISSN: 1039-9712.

Segrest JP, Anantharamaiah GM. Pathogenesis of atherosclerosis. Curr. Opin. Cardiol. 1994 Jul; 9(4): 404-10. PMID: 7919584, ISSN: 0268-4705.

Chung BH, Tallis G, Yalamoori V, Anantharamaiah GM, Segrest JP. Liposome-like particles isolated from human atherosclerotic plaques are structurally and compositionally similar to surface remnants of triglyceride-rich lipoproteins. Arterioscler. Thromb. 1994 Apr; 14(4): 622-35. PMID: 8148360, ISSN: 1049-8834.

Mishra VK, Palgunachari MN, Segrest JP, Anantharamaiah GM. Interactions of synthetic peptide analogs of the class A amphipathic helix with lipids. Evidence for the snorkel hypothesis. J. Biol. Chem. 1994 Mar 3/11/1994; 269(10): 7185-91. PMID: 8125930, ISSN: 0021-9258.

Segrest JP, Garber DW, Brouillette CG, Harvey SC, Anantharamaiah GM. The amphipathic alpha helix: a multifunctional structural motif in plasma apolipoproteins. Adv. Protein Chem. 1994; 45: 303-69. PMID: 8154372, ISSN: 0065-3233.

Kulkarni KR, Garber DW, Marcovina SM, Segrest JP. Quantification of cholesterol in all lipoprotein classes by the VAP-II method. J. Lipid Res. 1994 Jan; 35(1): 159-68. PMID: 8138718, ISSN: 0022-2275.

Srinivas SK, Srinivas RV, Anantharamaiah GM, Compans RW, Segrest JP. Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins. J. Biol. Chem. 1993 Oct 10/25/1993; 268(30): 22895-9. PMID: 8226798, ISSN: 0021-9258.

Tytler EM, Segrest JP, Epand RM, Nie SQ, Epand RF, Mishra VK, Venkatachalapathi YV, Anantharamaiah GM. Reciprocal effects of apolipoprotein and lytic peptide analogs on membranes. Cross-sectional molecular shapes of amphipathic alpha helixes control membrane stability. J. Biol. Chem. 1993 Oct 10/15/1993; 268(29): 22112-8. PMID: 8408070, ISSN: 0021-9258.

Hazelrig JB, Jones MK, Segrest JP. A mathematically defined motif for the radial distribution of charged residues on apolipoprotein amphipathic alpha helixes. Biophys. J. 1993 Jun; 64(6): 1827-32. PMID: 8369409, PMCID: PMC1262516, PII: S0006-3495(93)81553-4, DOI: 10.1016/S0006-3495(93)81553-4, ISSN: 0006-3495.

Garber DW, Henkin Y, Osterlund LC, Woolley TW, Segrest JP. Thyroid function and other clinical chemistry parameters in subjects eating iodine-enriched eggs. Food Chem. Toxicol. 1993 Apr; 31(4): 247-51. PMID: 8477914, ISSN: 0278-6915.

Venkatachalapathi YV, Phillips MC, Epand RM, Epand RF, Tytler EM, Segrest JP, Anantharamaiah GM. Effect of end group blockage on the properties of a class A amphipathic helical peptide. Proteins. 1993 Apr; 15(4): 349-59. PMID: 8460106, DOI: 10.1002/prot.340150403, ISSN: 0887-3585.

Kulkarni KR, Garber DW, Schmidt CF, Marcovina SM, Ho MH, Wilhite BJ, Beaudrie KR, Segrest JP. Analysis of cholesterol in all lipoprotein classes by single vertical ultracentrifugation of fingerstick blood and controlled-dispersion flow analysis. Clin. Chem. 1992 Sep; 38(9): 1898-905. PMID: 1526031, ISSN: 0009-9147.

Gallaher WR, Segrest JP, Hunter E. Are fusion peptides really "sided" insertional helices? [letter]. Cell. 1992 Aug 8/21/1992; 70(4): 531-2. PMID: 1505021, PII: 0092-8674(92)90423-A, ISSN: 0092-8674.

Garber DW, Venkatachalapathi YV, Gupta KB, Ibdah J, Phillips MC, Hazelrig JB, Segrest JP, Anantharamaiah GM. Turnover of synthetic class A amphipathic peptide analogues of exchangeable apolipoproteins in rats. Correlation with physical properties. Arterioscler. Thromb. 1992 Aug; 12(8): 886-94. PMID: 1637786, ISSN: 1049-8834.

Garber DW, Henkin Y, Osterlund LC, Darnell BE, Segrest JP. Plasma lipoproteins in hyperlipidemic subjects eating iodine-enriched eggs. J Am Coll Nutr. 1992 Jun; 11(3): 294-303. PMID: 1619181, ISSN: 0731-5724.

Srinivas SK, Srinivas RV, Anantharamaiah GM, Segrest JP, Compans RW. Membrane interactions of synthetic peptides corresponding to amphipathic helical segments of the human immunodeficiency virus type-1 envelope glycoprotein. J. Biol. Chem. 1992 Apr 4/5/1992; 267(10): 7121-7. PMID: 1551918, ISSN: 0021-9258.

Jones MK, Anantharamaiah GM, Segrest JP. Computer programs to identify and classify amphipathic alpha helical domains. J. Lipid Res. 1992 Feb; 33(2): 287-96. PMID: 1569380, ISSN: 0022-2275.

Segrest JP, Jones MK, De Loof H, Brouillette CG, Venkatachalapathi YV, Anantharamaiah GM. The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function. J. Lipid Res. 1992 Feb; 33(2): 141-66. PMID: 1569369, ISSN: 0022-2275.