Mingfeng Bai, Ph.D.

Assistant Professor

Faculty Appointments
Assistant Professor of Radiology and Radiological Sciences
Ph.D., Chemistry/Molecular Imaging, Vanderbilt University, Nashville, TennesseeM.S., Analytical Chemistry, Vanderbilt University, Nashville, TennesseeB.S., Chemistry, Nankai University, Tianjin, China
Research Description
Mingfeng Bai, Ph.D., earned a M.S. in Analytical Chemistry and a Ph.D. in Organic Chemistry/Molecular Imaging from Vanderbilt University. He completed a postdoctoral fellowship in Organic Chemistry/Molecular Imaging at Washington University School of Medicine. After working at the University of Pittsburgh as an Assistant Professor for 6 years, he joined the Vanderbilt faculty in 2017 as Assistant Professor. His research is mainly focused on the syntheses, biological characterizations and in vivo evaluation of targeted fluorescence imaging probes and photodynamic therapy agents. He is a frequent panel reviewer for the National Institute of Health (NIH), Department of Defense (DOD), National Science Foundation (NSF) and other national and international foundations, and manuscript reviewer for over 40 journals.

Section: Vanderbilt University Institute of Imaging Science
Yang L, Zhang S, Ling X, Shao P, Jia N, Bai M. Multilayer Photodynamic Therapy for Highly Effective and Safe Cancer Treatment. Acta Biomater [print-electronic]. 2017 Mar 3/8/2017; PMID: 28285077, PII: S1742-7061(17)30174-5, DOI: 10.1016/j.actbio.2017.03.012, ISSN: 1878-7568.

Li B, Wang A, Liu J, Qi Z, Liu X, Yu K, Wu H, Chen C, Hu C, Wang W, Wu J, Hu Z, Ye L, Zou F, Liu F, Wang B, Wang L, Ren T, Zhang S, Bai M, Zhang S, Liu J, Liu Q. Discovery of N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase. J. Med. Chem [print-electronic]. 2016 Sep 9/22/2016; 59(18): 8456-72. PMID: 27545040, DOI: 10.1021/acs.jmedchem.6b00902, ISSN: 1520-4804.

Zhang S, Yang L, Ling X, Shao P, Wang X, Edwards WB, Bai M. Tumor mitochondria-targeted photodynamic therapy with a translocator protein (TSPO)-specific photosensitizer. Acta Biomater [print-electronic]. 2015 Dec; 28: 160-70. PMID: 26432436, PMCID: PMC4648641, PII: S1742-7061(15)30126-4, DOI: 10.1016/j.actbio.2015.09.033, ISSN: 1878-7568.

Ling X, Zhang S, Shao P, Wang P, Ma X, Bai M. Synthesis of a reactive oxygen species responsive heterobifunctional thioketal linker. Tetrahedron Lett. 2015 Sep 9/9/2015; 56(37): 5242-4. PMID: 26309336, PMCID: PMC4545510, DOI: 10.1016/j.tetlet.2015.07.059, ISSN: 0040-4039.

Ling X, Zhang S, Shao P, Li W, Yang L, Ding Y, Xu C, Stella N, Bai M. A novel near-infrared fluorescence imaging probe that preferentially binds to cannabinoid receptors CB2R over CB1R. Biomaterials [print-electronic]. 2015 Jul; 57: 169-78. PMID: 25916505, PMCID: PMC4426855, PII: S0142-9612(15)00365-8, DOI: 10.1016/j.biomaterials.2015.04.018, ISSN: 1878-5905.

Zeng Y, Liu Y, Shang J, Ma J, Wang R, Deng L, Guo Y, Zhong F, Bai M, Zhang S, Wu D. Phosphorescence monitoring of hypoxic microenvironment in solid-tumors to evaluate chemotherapeutic effects using the hypoxia-sensitive iridium (III) coordination compound. PLoS ONE. 2015; 10(3): e0121293. PMID: 25786221, PMCID: PMC4365010, PII: PONE-D-14-54129, DOI: 10.1371/journal.pone.0121293, ISSN: 1932-6203.

Zhang S, Shao P, Ling X, Yang L, Hou W, Thorne SH, Beaino W, Anderson CJ, Ding Y, Bai M. In vivo inflammation imaging using a CB2R-targeted near infrared fluorescent probe. Am J Nucl Med Mol Imaging. 2015; 5(3): 246-58. PMID: 26069858, PMCID: PMC4446393.

Wen Y, Liu W, Bagia C, Zhang S, Bai M, Janjic JM, Giannoukakis N, Gawalt ES, Meng WS. Antibody-functionalized peptidic membranes for neutralization of allogeneic skin antigen-presenting cells. Acta Biomater [print-electronic]. 2014 Nov; 10(11): 4759-67. PMID: 25117952, PMCID: PMC4186902, PII: S1742-7061(14)00339-0, DOI: 10.1016/j.actbio.2014.08.003, ISSN: 1878-7568.

Available Postdoctoral Position Details
Posted: 3/29/2017

Description: A post-doctoral/RA-3 position is available for motivated researcher in the Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center. The primary focus of the group is to develop, characterize and evaluate targeting molecular agents for cancer imaging and therapy. The candidate will be responsible for biological characterization, fluorescence microscopy and in vivo imaging/therapy of such agents.

Qualifications: The desired candidate should have expertise and publication in biology and molecular imaging. Technical skills with cell culture, genetic manipulation of cancer cells, western blotting, PCR, binding study, fluorescence microscopy, animal model development, in vivo/ex vivo imaging, and statistical analysis are essential to this position.A candidate with experience in bioconjugate chemistry and therapeutic effect monitoring is preferred. The candidate must have a Ph.D. degree in biology or related fields. Applicants should be fluent in English and possess good written and verbal communication skills.

To be considered, applicants should send curriculum vitae, along with names and contact information for three references to: Mingfeng Bai, Ph.D. Email: mingfeng.bai@vanderbilt.edu