Brian Richard Lindman, M.D.

Associate Professor

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Faculty Appointments
Associate Professor of Medicine
M.D., Medicine, Vanderbilt University, Nashville, TennesseeM.A., Theological Studies, Reformed Theological Seminary, Orlando, FloridaB.S., Biology and Public Policy, Duke University, Durham, North Carolina
Research Description
My research is centered on calcific aortic stenosis, including several clinical and translational projects related to biomarker discovery, risk prediction, and elucidating pathophysiology to identify adjunctive interventions to improve patient-centered outcomes. Our group uses various imaging techniques and a biobank of specimens to perform biomarker discovery and understand the pathobiology of aortic stenosis and the effects of pressure overload on the left ventricle and pulmonary vasculature. We have a particular interest in how diabetes affects these processes and aim to identify novel targets for adjunctive medical therapy to improve clinical outcomes in patients with aortic stenosis. Novel rehabilitation strategies targeting frailty are also an area of interest.
Clinical Description
I am actively involved in our heart valve team, evaluating patients clinically and performing the transesophageal echocardiograms for transcatheter valve procedures. I see patients with all types of valve disease to determine the optimal timing of and approach to valve repair or replacement. As a heart valve center, we seek to integrate a clinical and research mission in an innovative way that informs disease paradigms and influences management guidelines in valvular heart disease.
Redfors B, Pibarot P, Gillam LD, Burkhoff D, Bax JJ, Lindman BR, Bonow RO, O'Gara PT, Leon MB, Généreux P. Stress Testing in Asymptomatic Aortic Stenosis. Circulation. 2017 May 5/16/2017; 135(20): 1956-76. PMID: 28507251, PII: CIRCULATIONAHA.116.025457, DOI: 10.1161/CIRCULATIONAHA.116.025457, ISSN: 1524-4539.

Lindman BR, Tong CW, Carlson DE, Balke CW, Jackson EA, Madhur MS, Barac A, Abdalla M, Brittain EL, Desai N, Kates AM, Freeman AM, Mann DL. National Institutes of Health Career Development Awards for Cardiovascular Physician-Scientists: Recent Trends and Strategies for Success. J. Am. Coll. Cardiol. 2015 Oct 10/20/2015; 66(16): 1816-27. PMID: 26483107, PMCID: PMC4615587, PII: S0735-1097(15)05882-9, DOI: 10.1016/j.jacc.2015.08.858, ISSN: 1558-3597.

Lindman BR, Breyley JG, Schilling JD, Vatterott AM, Zajarias A, Maniar HS, Damiano RJ, Moon MR, Lawton JS, Gage BF, Sintek MA, Aquino A, Holley CL, Patel NM, Lawler C, Lasala JM, Novak E. Prognostic utility of novel biomarkers of cardiovascular stress in patients with aortic stenosis undergoing valve replacement. Heart [print-electronic]. 2015 Sep; 101(17): 1382-8. PMID: 26037104, PMCID: PMC4598053, PII: heartjnl-2015-307742, DOI: 10.1136/heartjnl-2015-307742, ISSN: 1468-201X.

Lindman BR, Alexander KP, O'Gara PT, Afilalo J. Futility, benefit, and transcatheter aortic valve replacement. JACC Cardiovasc Interv [print-electronic]. 2014 Jul; 7(7): 707-16. PMID: 24954571, PMCID: PMC4322002, PII: S1936-8798(14)00780-8, DOI: 10.1016/j.jcin.2014.01.167, ISSN: 1876-7605.

Lindman BR, Stewart WJ, Pibarot P, Hahn RT, Otto CM, Xu K, Devereux RB, Weissman NJ, Enriquez-Sarano M, Szeto WY, Makkar R, Miller DC, Lerakis S, Kapadia S, Bowers B, Greason KL, McAndrew TC, Lei Y, Leon MB, Douglas PS. Early regression of severe left ventricular hypertrophy after transcatheter aortic valve replacement is associated with decreased hospitalizations. JACC Cardiovasc Interv. 2014 Jun; 7(6): 662-73. PMID: 24947722, PMCID: PMC4165852, PII: S1936-8798(14)00642-6, DOI: 10.1016/j.jcin.2014.02.011, ISSN: 1876-7605.

Lindman BR, Pibarot P, Arnold SV, Suri RM, McAndrew TC, Maniar HS, Zajarias A, Kodali S, Kirtane AJ, Thourani VH, Tuzcu EM, Svensson LG, Waksman R, Smith CR, Leon MB. Transcatheter versus surgical aortic valve replacement in patients with diabetes and severe aortic stenosis at high risk for surgery: an analysis of the PARTNER Trial (Placement of Aortic Transcatheter Valve). J. Am. Coll. Cardiol [print-electronic]. 2014 Mar 3/25/2014; 63(11): 1090-9. PMID: 24291272, PMCID: PMC3962709, PII: S0735-1097(13)06084-1, DOI: 10.1016/j.jacc.2013.10.057, ISSN: 1558-3597.

Lindman BR, Bonow RO, Otto CM. Current management of calcific aortic stenosis. Circ. Res. 2013 Jul 7/5/2013; 113(2): 223-37. PMID: 23833296, PMCID: PMC4013234, PII: CIRCRESAHA.111.300084, DOI: 10.1161/CIRCRESAHA.111.300084, ISSN: 1524-4571.

Lindman BR, Zajarias A, Madrazo JA, Shah J, Gage BF, Novak E, Johnson SN, Chakinala MM, Hohn TA, Saghir M, Mann DL. Effects of phosphodiesterase type 5 inhibition on systemic and pulmonary hemodynamics and ventricular function in patients with severe symptomatic aortic stenosis. Circulation [print-electronic]. 2012 May 5/15/2012; 125(19): 2353-62. PMID: 22447809, PMCID: PMC3485404, PII: CIRCULATIONAHA.111.081125, DOI: 10.1161/CIRCULATIONAHA.111.081125, ISSN: 1524-4539.