Joesph Wiencek, Ph.D.

Associate Professor

joe.wiencek@vumc.org
Faculty Appointments
Associate Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Cleveland State University, Cleveland, OhioB.A., Chemistry, Ohio State University, Columbus, Ohio
Clinical Research Keywords
Clinical Chemistry, Pediatric Clinical Chemistry, Preanalytical Variation, Sustainability, Point of Care Testing
Publications
Glover RT, Connelly J, Gammie A, Kilcoyne J, Ozben T, Santos A, Wiencek JR. Sustainability in Laboratory Medicine. Clin Chem [print-electronic]. 2023 Oct 10/5/2023; PMID: 37795568, PII: 7289393, DOI: 10.1093/clinchem/hvad156, ISSN: 1530-8561.

Hart SA, Wiencek JR, Booth GS. The healthcare price transparency illusion: does anyone know what laboratory tests cost? [letter]. J Pediatr [print-electronic]. 2023 Sep 9/20/2023; 264: 113755. PMID: 37739059, PII: S0022-3476(23)00618-2, DOI: 10.1016/j.jpeds.2023.113755, ISSN: 1097-6833.

Laryea ET, Mitchell K, Hernández J, Stanford E, Twum K, Wiencek JR. Analytical performance evaluation and consumable waste reduction strategies using a tube-based quality control material [letter]. Clin Chem Lab Med [print-electronic]. 2023 Jul 7/12/2023; PMID: 37433060, PII: cclm-2023-0483, DOI: 10.1515/cclm-2023-0483, ISSN: 1437-4331.

Hart SA, Wiencek JR. The Ethical Dilemma of a Patient's Immediate Access to Test Results. Clin Chem. 2023 Jul 7/5/2023; 69(7): 773-4. PMID: 37403308, PII: 7218474, DOI: 10.1093/clinchem/hvad057, ISSN: 1530-8561.

Hart S, Wiencek JR. Global Heatwaves Threaten Integrity of Patient Test Results: A Dire Warning for the Lab Medicine Community. J Appl Lab Med [print-electronic]. 2023 Jun 6/13/2023; PMID: 37310070, PII: 7195122, DOI: 10.1093/jalm/jfad040, ISSN: 2576-9456.

Wiencek JR. Genomic Newborn Screening: Baby Steps into the Future. Clinical chemistry. 2023 Apr 4/28/2023; 69(5) Sect. 542,543.

Wiencek JR, Das S, Beheshti A, Crucian BE, Karouia F, Trudel G, McMonigal KA. Lab Medicine in Space. Clin Chem [print-electronic]. 2023 Apr 4/11/2023; PMID: 37038963, PII: 7113323, DOI: 10.1093/clinchem/hvad035, ISSN: 1530-8561.

Glover RT, Booth GS, Wiencek JR. Opportunities for recycling in an automated clinical chemistry laboratory produced by the comprehensive metabolic panel. Am J Clin Pathol [print-electronic]. 2023 Apr 4/8/2023; PMID: 37029539, PII: 7111063, DOI: 10.1093/ajcp/aqad031, ISSN: 1943-7722.

Tolan NV, Krasowski MD, Mathias PC, Wiencek JR, Babic N, Chai PR, Chambliss AB, Choucair I, Demetriou CA, Erickson TB, Feldhammer M, French D, Hayes BD, Kang P, El-Khoury JM, Knezevic CE, Monte A, Nerenz RD, Okorodudu AO, Roper SM, Saitman A, Thiriveedhi V, Uljon SN, Vest A, Woodworth A, Yu M, Melanson SEF. Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization. Clin Toxicol (Phila). 2023 Apr; 61(4): 248-59. PMID: 37129223, DOI: 10.1080/15563650.2023.2177552, ISSN: 1556-9519.

Wiencek JR, Pierre CC, Füzéry AK. Environmental Factors in the Preanalytical Phase of Laboratory Testing [editorial]. Clin Biochem [print-electronic]. 2023 Mar 3/9/2023; PMID: 36898622, PII: S0009-9120(23)00053-X, DOI: 10.1016/j.clinbiochem.2023.03.006, ISSN: 1873-2933.

Zhao Z, Kumanovics A, Love T, Melanson SEF, Meng QH, Wu AHB, Wiencek J, Apple FS, Ondracek CR, Koch DD, Christenson RH, Zhang YV. T Cell Responses Correlate with Self-Reported Disease Severity and Neutralizing Antibody Responses Predict Protection against SARS-CoV-2 Breakthrough Infection. Viruses. 2023 Mar 3/9/2023; 15(3): PMID: 36992418, PMCID: PMC10058409, PII: v15030709, DOI: 10.3390/v15030709, ISSN: 1999-4915.

Pierre CC, Wiencek JR. The impact of environmental factors on external and internal specimen transport. Clin Biochem [print-electronic]. 2022 Nov 11/13/2022; PMID: 36379239, PII: S0009-9120(22)00242-9, DOI: 10.1016/j.clinbiochem.2022.11.005, ISSN: 1873-2933.

Nedelcu E, Wiencek JR, Pierre CC. A Pediatric Patient with a Complicated History of Sickle Cell Trait. Clin Chem. 2022 Oct 10/6/2022; 68(10): 1245-8. PMID: 36201643, PII: 6749984, DOI: 10.1093/clinchem/hvac139, ISSN: 1530-8561.

Wiencek JR, Chambliss AB, Bertholf RL, Cotten SW, Ellervik C, Kreuter JD, Mirza KM, Shajani-Yi Z. A Paradigm Shift: Engagement of Clinical Chemistry and Laboratory Medicine Trainees by Innovative Teaching Methods. Clin Chem [print-electronic]. 2022 Mar 3/15/2022; PMID: 35288727, PII: 6548427, DOI: 10.1093/clinchem/hvac036, ISSN: 1530-8561.

Hart S, Wiencek JR. Temperature Optimization Within 2 Uniquely Designed Courier Lockboxes During Extreme Summer Temperatures. Am J Clin Pathol [print-electronic]. 2022 Jan 1/17/2022; PMID: 35038739, PII: 6509537, DOI: 10.1093/ajcp/aqab216, ISSN: 1943-7722.

Melanson SEF, Zhao Z, Kumanovics A, Love T, Meng QH, Wu AHB, Apple F, Ondracek CR, Schulz KM, Wiencek JR, Koch D, Christenson R, Zhang YV. Tolerance for three commonly administered COVID-19 vaccines by healthcare professionals. Front Public Health. 2022; 10: 975781. PMID: 36238255, PMCID: PMC9553122, DOI: 10.3389/fpubh.2022.975781, ISSN: 2296-2565.

Ford V, Frischtak H, Wiencek JR, Parsons AS. A High-Value Care Curriculum Using Individual and Group Structured Reflection. South Med J. 2021 Dec; 114(12): 797-800. PMID: 34853857, PII: SMJ_210124, DOI: 10.14423/SMJ.0000000000001325, ISSN: 1541-8243.

Zhang YV, Wiencek J, Meng QH, Theel ES, Babic N, Sepiashvili L, Pecora ND, Slev P, Cameron A, Konforte D. AACC Practical Recommendations for Implementing and Interpreting SARS-CoV-2 Emergency Use Authorization and Laboratory-Developed Test Serologic Testing in Clinical Laboratories. Clin Chem. 2021 Sep 9/1/2021; 67(9): 1188-200. PMID: 34470034, PMCID: PMC8083777, PII: 6178192, DOI: 10.1093/clinchem/hvab051.

Dibbern ME, Pierre CC, Wiencek JR. Outdoor Courier Lockboxes in Summer Are a Significant Source of Preanalytical Error. Am J Clin Pathol [print-electronic]. 2021 Jun 6/21/2021; PMID: 34151359, PII: 6306986, DOI: 10.1093/ajcp/aqab037, ISSN: 1943-7722.

Wiencek JR, Bachmann LM, Dinwiddie K, Miller GW, Bazydlo LAL. Cross-Institutional Evaluation of the Abbott ARCHITECT SARS-CoV-2 IgG Immunoassay. Lab Med [print-electronic]. 2021 Apr 4/30/2021; PMID: 33929022, PII: 6260095, DOI: 10.1093/labmed/lmab011, ISSN: 1943-7730.

Pierre CC, Wiencek JR. Lactate Dehydrogenase Variation in a Patient with History of Giant Cell Tumor. J Appl Lab Med [print-electronic]. 2021 Jan 1/9/2021; PMID: 33421063, PII: 6076715, DOI: 10.1093/jalm/jfaa224, ISSN: 2576-9456.

Keshavarz B, Wiencek JR, Workman LJ, Straesser MD, Muehling LM, Canderan G, Drago F, Bonham CA, Sturek JM, Ramani C, McNamara CA, Woodfolk JA, Kadl A, Platts-Mills TAE, Wilson JM. Quantitative Measurement of IgG to Severe Acute Respiratory Syndrome Coronavirus-2 Proteins Using ImmunoCAP. Int Arch Allergy Immunol [print-electronic]. 2021; 182(5): 417-24. PMID: 33621972, PMCID: PMC8018212, PII: 000514203, DOI: 10.1159/000514203, ISSN: 1423-0097.

Wiencek JR, Head CL, Sifri CD, Parsons AS. Clinical Ordering Practices of the SARS-CoV-2 Antibody Test at a Large Academic Medical Center. Open Forum Infect Dis. 2020 Oct; 7(10): ofaa406. PMID: 33072813, PMCID: PMC7553244, PII: ofaa406, DOI: 10.1093/ofid/ofaa406, ISSN: 2328-8957.

Yang J, Wiencek JR. Biotin sulfoxide is an interferent in several Roche cobas e411 immunoassays [letter]. Clin. Chim. Acta [print-electronic]. 2020 Jul 7/3/2020; 510: 12-4. PMID: 32628921, PII: S0009-8981(20)30314-4, DOI: 10.1016/j.cca.2020.06.050, ISSN: 1873-3492.

Ju JY, Wiencek JR. A Deep C Dive. Clin. Chem. 2020 Jun 6/1/2020; 66(6): 860-1. PMID: 32470123, PII: 5848610, DOI: 10.1093/clinchem/hvaa034, ISSN: 1530-8561.

Yang J, Wiencek JR. Mitigating biotin interference in two Roche immunoassays by premixing biotinylated capturing molecules with streptavidin coated beads. Clin. Chim. Acta [print-electronic]. 2020 Jun; 505: 130-5. PMID: 32084383, PII: S0009-8981(20)30076-0, DOI: 10.1016/j.cca.2020.02.021, ISSN: 1873-3492.

Wiencek JR, Gehrie EA, Keiser AM, Szklarski PC, Johnson-Davis KL, Booth GS. Detection of Nicotine and Nicotine Metabolites in Units of Banked Blood. Am. J. Clin. Pathol. 2019 Apr 4/2/2019; 151(5): 516-21. PMID: 30715103, PMCID: PMC7179511, PII: 5306140, DOI: 10.1093/ajcp/aqy176, ISSN: 1943-7722.

Wiencek JR, McCartney CR, Chang AY, Straseski JA, Auchus RJ, Woodworth A. Challenges in the Assessment and Diagnosis of Polycystic Ovary Syndrome. Clin. Chem [print-electronic]. 2019 Mar; 65(3): 370-7. PMID: 30606725, PII: clinchem.2017.284331, DOI: 10.1373/clinchem.2017.284331, ISSN: 1530-8561.

Wiencek JR, Dietzen DJ, Murray T, Dawling S, Colby JM, Nichols JH. Persistently Increased Alloisoleucine in a Patient with Seizures. Clin. Chem. 2018 Oct; 64(10): 1433-7. PMID: 30266717, PII: 64/10/1433, DOI: 10.1373/clinchem.2017.278804, ISSN: 1530-8561.

Wiencek JR, Lo SF. Advances in the Diagnosis and Management of Cystic Fibrosis in the Genomic Era. Clin. Chem [print-electronic]. 2018 Jun; 64(6): 898-908. PMID: 29436379, PII: clinchem.2017.274670, DOI: 10.1373/clinchem.2017.274670, ISSN: 1530-8561.

Wiencek JR, Nichols JH. Impact of Ambient Seasonal Temperature on Specimens Stored in Courier Lockboxes. J Appl Lab Med. 2018 May 5/1/2018; 2(6): 973-6. PMID: 33636831, PII: 5587562, DOI: 10.1373/jalm.2017.025247, ISSN: 2576-9456.

Campbell ST, Wiencek JR. DNA Sequencing in the Clinical Laboratory: A Ladder to the Future. Clin. Chem. 2018 Apr 4/1/2018; 64(4): 757. PMID: 32100832, PII: 5608817, DOI: 10.1373/clinchem.2017.285221, ISSN: 1530-8561.

Wiencek JR, Booth GS, Nichols JH. A Primed Hemoglobinopathy Screen. Clin. Chem. 2017 Aug; 63(8): 1423-4. PMID: 28751324, PII: 63/8/1423, DOI: 10.1373/clinchem.2016.270496, ISSN: 1530-8561.

Wiencek JR, Bowman C, Adams B, Sussman C, Sephel G, Linton MF, Nichols JH, Woodworth A. Falsely Decreased Carbon Dioxide in Patients with Hypertriglyceridemia. J Appl Lab Med. 2017 Jul 7/1/2017; 2(1): 123-5. PMID: 33636953, PII: 5587472, DOI: 10.1373/jalm.2017.023234, ISSN: 2576-9456.

Wiencek JR, Booth GS. Sickle Cell Trait in the Blood Supply. J Appl Lab Med. 2017 May 5/1/2017; 1(6): 773-5. PMID: 33379832, PII: 5587398, DOI: 10.1373/jalm.2016.022608, ISSN: 2576-9456.

Wiencek JR, Colby JM, Nichols JH. Rapid Assessment of Drugs of Abuse. Adv Clin Chem [print-electronic]. 2017; 80: 193-225. PMID: 28431640, PII: S0065-2423(16)30099-3, DOI: 10.1016/bs.acc.2016.11.003, ISSN: 0065-2423.

Wiencek JR, Hirbawi J, Yee VC, Kalafatis M. The Dual Regulatory Role of Amino Acids Leu480 and Gln481 of Prothrombin. J. Biol. Chem [print-electronic]. 2016 Jan 1/22/2016; 291(4): 1565-81. PMID: 26601957, PMCID: PMC4722440, PII: M115.691956, DOI: 10.1074/jbc.M115.691956, ISSN: 1083-351X.

Wiencek J, Nichols J. Issues in the practical implementation of POCT: overcoming challenges. Expert Rev. Mol. Diagn [print-electronic]. 2016; 16(4): 415-22. PMID: 26783053, DOI: 10.1586/14737159.2016.1141678, ISSN: 1744-8352.

Wiencek JR, Na M, Hirbawi J, Kalafatis M. Amino acid region 1000-1008 of factor V is a dynamic regulator for the emergence of procoagulant activity. J. Biol. Chem [print-electronic]. 2013 Dec 12/27/2013; 288(52): 37026-38. PMID: 24178294, PMCID: PMC3873559, PII: M113.462374, DOI: 10.1074/jbc.M113.462374, ISSN: 1083-351X.