Yike Li, M.D., Ph.D.

Research Assistant Professor

Faculty Appointments
Research Assistant Professor of Otolaryngology - Head and Neck Surgery
M.D., Fudan University, Shanghai, ChinaPh.D., Vanderbilt University, Nashville, Tennessee
Office Address
1161 21st Avenue South, Medical Center North, Rm. S2211
Nashville, TN 37232
Research Description
Dr. Li is currently a research assistant professor in the Department of Otolaryngology-Head and Neck Surgery at Vanderbilt University Medical Center. He obtained his M.D. degree from Fudan University in China, and Ph.D. degree in hearing and speech sciences from Vanderbilt University. He completed his residency training in otolaryngology at Shanghai Eye and ENT hospital. Dr. Li has been working in the field of otolaryngology for over 10 years. His research interests include neurophysiology, voice disorder, hearing loss, and artificial intelligence. Most of his recent research works focus on translational medicine and artificial intelligence in head and neck diseases. He is currently working on two NIH-funded human studies to investigate novel neurostimulation approaches for two airway disorders, including bilateral vocal fold paralysis and obstructive sleep apnea. He is also interested in extending this research line to the management of facial paralysis. In addition, he is leading multiple studies using machine learning and big data techniques in otolaryngology and other areas of medicine. He is the primary investigator in a recent NIH-sponsored study on big data analyses of long-term risks in obstructive sleep apnea.

Research Keywords
Vocal fold paralysis; Dysphonia; Facial paralysis; Hearing loss; Artificial intelligence; Deep learning; Machine learning
Liang Q, Qi Z, Li Y. Machine learning to predict the occurrence of thyroid nodules: towards a quantitative approach for judicious utilization of thyroid ultrasonography. Front Endocrinol (Lausanne). 2024; 15: 1385836. PMID: 38774231, PMCID: PMC11106422, DOI: 10.3389/fendo.2024.1385836, ISSN: 1664-2392.

Guo Jiajie, Liu Yuchao, Guo Chuxuan, Liu Zijie, Li Yike, Wu Xuan, Wang Qining, Xiong Caihua. Wearable Sensing for Breaststroke Phase Monitoring with Lower Limb Muscle-Joint Synergy. IEEE Transactions on Instrumentation and Measurement. 2023 Dec 12/18/2023; 73: 1-12. DOI: 10.1109/TIM.2023.3343771.

Zhang Y, Zhang L, Li B, Ye T, Zhang Y, Yu Y, Ma Y, Sun Y, Xiang J, Li Y, Chen H. Machine learning to predict occult metastatic lymph nodes along the recurrent laryngeal nerves in thoracic esophageal squamous cell carcinoma. BMC Cancer. 2023 Mar 3/2/2023; 23(1): 197. PMID: 36864444, PMCID: PMC9979471, PII: 10.1186/s12885-023-10670-3, DOI: 10.1186/s12885-023-10670-3, ISSN: 1471-2407.

Li Y, Richard KE, Schwartz AR, Zealear D, Lindsell CJ, Budnick HA, Kent DT. Quantitative Effects of Ansa Cervicalis Stimulation in Obstructive Sleep Apnea. Am J Respir Crit Care Med [print-electronic]. 2023 Jan 1/19/2023; PMID: 36656553, DOI: 10.1164/rccm.202212-2318LE, ISSN: 1535-4970.

Zhang D, Li Y, Kalbaugh CA, Shi L, Divers J, Islam S, Annex BH. Machine Learning Approach to Predict In-Hospital Mortality in Patients Admitted for Peripheral Artery Disease in the United States. J Am Heart Assoc [print-electronic]. 2022 Oct 10/10/2022; e026987. PMID: 36216437, DOI: 10.1161/JAHA.122.026987, ISSN: 2047-9980.

Chen Z, Zhu P, Qiu W, Guo J, Li Y. Deep learning in automatic detection of dysphonia: Comparing acoustic features and developing a generalizable framework. Int J Lang Commun Disord [print-electronic]. 2022 Sep 9/18/2022; PMID: 36117378, DOI: 10.1111/1460-6984.12783, ISSN: 1460-6984.

Bai Q, Su C, Tang W, Li Y. Machine learning to predict end stage kidney disease in chronic kidney disease. Sci Rep. 2022 May 5/19/2022; 12(1): 8377. PMID: 35589908, PII: 10.1038/s41598-022-12316-z, DOI: 10.1038/s41598-022-12316-z, ISSN: 2045-2322.

Li Y, Guo J, Yang P. Developing an Image-Based Deep Learning Framework for Automatic Scoring of the Pentagon Drawing Test. J Alzheimers Dis. 2022 Jan 1/4/2022; 85(1): 129-39. PMID: 34776440, PII: JAD210714, DOI: 10.3233/JAD-210714, ISSN: 1875-8908.

Li H, He Y, Zhuo X, Yue Z, Rong X, Li Y, Li Y, He L, Cheng J, Pan D, Xue R, Cai J, Jiang J, Xu Y, Tang Y. Establishment and Validation of a Predictive Model for Radiation-Associated Aspiration Pneumonia in Patients with Radiation-Induced Dysphagia after Nasopharyngeal Carcinoma. Behav Neurol. 2022; 2022: 6307804. PMID: 36039334, PMCID: PMC9418526, DOI: 10.1155/2022/6307804, ISSN: 1875-8584.

Pang J, Wang Y, Cheng Y, Chi F, Li Y, Ni G, Ren D. Conductive hearing loss in large vestibular aqueduct syndrome -clinical observations and proof-of-concept predictive modeling by a biomechanical approach. Int J Pediatr Otorhinolaryngol [print-electronic]. 2021 Jul; 146: 110752. PMID: 33964673, PII: S0165-5876(21)00145-2, DOI: 10.1016/j.ijporl.2021.110752, ISSN: 1872-8464.

Powell ME, Zealear DL, Li Y, Garrett CG, Von Wahlde K, Netterville J. Unilateral and Bilateral Laryngeal Pacing for Bilateral Vocal Fold Paralysis. Curr Otorhinolaryngol Rep [print-electronic]. 2020 Dec; 8(4): 395-401. PMID: 34084663, PMCID: PMC8171271, DOI: 10.1007/s40136-020-00313-7, ISSN: 2167-583X.

Zealear D, Li Y, Huang S. An Implantable System For Chronic In Vivo Electromyography. J Vis Exp. 2020 Apr 4/21/2020; (158): PMID: 32391811, DOI: 10.3791/60345, ISSN: 1940-087X.

Zhao M, Chen BJ, Zhao WD, Li Y, Du Q, Yu J, Wang XW, Qian XQ, Yuan YS, Yang JM, Chi FL, Ren DD. Concurrent Occurrence of Congenital Ossicular Anomaly and Localized Cholesteatoma: Series of 10 Cases. ORL J. Otorhinolaryngol. Relat. Spec [print-electronic]. 2020 Mar 3/23/2020; 1-11. PMID: 32203956, PII: 000506206, DOI: 10.1159/000506206, ISSN: 1423-0275.

Wang YM, Li Y, Cheng YS, He ZY, Yang JM, Xu JH, Chi ZC, Chi FL, Ren DD. Deep Learning in Automated Region Proposal and Diagnosis of Chronic Otitis Media Based on Computed Tomography. Ear Hear [print-electronic]. 2019 Sep 9/19/2019; PMID: 31567561, DOI: 10.1097/AUD.0000000000000794, ISSN: 1538-4667.

Li Y, Zealear D. Publication delays in peer-reviewed journals of otolaryngology, audiology and speech language pathology. Journal of Postdoctoral Research. 2018 May; 6(5): 1-24.

Li Y, Garrett G, Zealear D. Current Treatment Options for Bilateral Vocal Fold Paralysis: A State-of-the-Art Review. Clin Exp Otorhinolaryngol [print-electronic]. 2017 Sep; 10(3): 203-12. PMID: 28669149, PMCID: PMC5545703, PII: ceo.2017.00199, DOI: 10.21053/ceo.2017.00199, ISSN: 1976-8710.

Li Y. Interventions in management of blood viscosity for idiopathic sudden sensorineural hearing loss: A meta-analysis. J Health Res Rev. 2017 Jun 6/15/2017; 4(2): 50-61.

Li Y, Huang S, Zealear D. An implantable system for In Vivo chronic electromyographic study in the larynx. Muscle Nerve [print-electronic]. 2017 May; 55(5): 706-14. PMID: 27543847, DOI: 10.1002/mus.25384, ISSN: 1097-4598.

Li Y. To understand the brain - the 2016 annual meeting of society for neurosciences: a conference report. Neural Regen Res. 2016 Dec; 11(12): 1912-3. PMID: 28197179, PMCID: PMC5270421, PII: NRR-11-1912, DOI: 10.4103/1673-5374.197126, ISSN: 1673-5374.

Li Y, Yang JM, Huang YB, Ren DD, Chi FL. Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection. Neural Regen Res. 2015 Jun; 10(6): 989-95. PMID: 26199619, PMCID: PMC4498364, PII: NRR-10-989, DOI: 10.4103/1673-5374.158366, ISSN: 1673-5374.

Zealear DL, Mainthia R, Li Y, Kunibe I, Katada A, Billante C, Nomura K. Stimulation of denervated muscle promotes selective reinnervation, prevents synkinesis, and restores function. Laryngoscope [print-electronic]. 2014 May; 124(5): E180-7. PMID: 24254367, DOI: 10.1002/lary.24454, ISSN: 1531-4995.

Li Y, Pearce EC, Mainthia R, Athavale SM, Dang J, Ashmead DH, Garrett CG, Rousseau B, Billante CR, Zealear DL. Comparison of ventilation and voice outcomes between unilateral laryngeal pacing and unilateral cordotomy for the treatment of bilateral vocal fold paralysis. ORL J. Otorhinolaryngol. Relat. Spec [print-electronic]. 2013; 75(2): 68-73. PMID: 23736349, PMCID: PMC3798066, PII: 000345501, DOI: 10.1159/000345501, ISSN: 1423-0275.

Yang JM, Chi FL, Han Z, Huang YB, Li Y. Clinical characteristics of patients with labyrinthine fistulae caused by middle ear cholesteatoma. Chin. Med. J. 2013; 126(11): 2116-9. PMID: 23769568, ISSN: 0366-6999.

Li Y, Rentmeester LA, Wang H, et al. Antioxidants for idiopathic sudden sensorineural hearing loss. Cochrane Systematic Review. 2012 Sep 9/12/2012; DOI: https://doi.org/10.1002/14651858.CD010058.

Li Y, Chi FL, Wang SY, Wang WQ, Yang JM, Huang YB. Cutaneous neuroendocrine carcinoma of the external auditory canal: a case report and review of the literature. Case Rep Otolaryngol. 2012; 2012: PMID: 22928140, PMCID: PMC3420451, DOI: 10.1155/2012/941065, ISSN: 2090-6773.

Athavale S, Li Y, Dang J, et al. Voice and Ventilation: Unilateral Laryngeal Pacing Versus Unilateral Cordotomy for the Treatment of Iatrogenic Bilateral Vocal Fold Paralysis. Laryngoscope (Supplement: Poster Presentations from the Triological Society's 2011 Annual Meeting). 2011 Aug 8/15/2011; 121(55): 303. DOI: https://doi.org/10.1002/lary.22259.

Huang Y, Chi F, Han Z, Yang J, Gao W, Li Y. New ectopic vestibular hair cell-like cells induced by Math1 gene transfer in postnatal rats. Brain Res [print-electronic]. 2009 Jun 6/18/2009; 1276: 31-8. PMID: 19397899, PII: S0006-8993(09)00787-2, DOI: 10.1016/j.brainres.2009.04.036, ISSN: 1872-6240.

Li Y, Chi F. History and Development of ear deformity and total auricular reconstruction [in Chinese]. Chinese Journal of Ophthalmology and Otorhinolaryngology. 2009; 9(2): 125-7.

Li Y, Liang Q, Chi F. Huge postauricular sebaceous cyst: A case report [in Chinese]. Chinese Journal of Ophthalmology and Otorhinolaryngology. 2008; 8(3): 147.