Yike Li, M.D., Ph.D.

Research Assistant Professor

yike.li.1@vumc.org
Faculty Appointments
Research Assistant Professor of Otolaryngology - Head and Neck Surgery
Education
Ph.D., Vanderbilt University, Nashville, TennesseeM.D., Medicine, Fudan University, Shanghai, China
Office Address
1161 21st Avenue South, Medical Center North, Rm. S2211
Nashville, TN 37232
Research Description
Dr. Li is a Research Assistant Professor in the Department of Otolaryngology–Head and Neck Surgery at Vanderbilt University Medical Center. He earned his M.D. from Fudan University in China and his Ph.D. in Hearing and Speech Sciences from Vanderbilt University. He also completed his residency training in Otolaryngology at the Shanghai Eye and ENT Hospital.

With over a decade of experience in otolaryngology, Dr. Li’s research encompasses neurophysiology, voice disorders, hearing loss, and the integration of artificial intelligence in medicine. His recent work focuses on translational medicine and AI-driven approaches to head and neck diseases. He is currently involved in two NIH-funded clinical studies investigating novel neurostimulation therapies for airway disorders, including bilateral vocal fold paralysis and obstructive sleep apnea, and is expanding this research to include facial paralysis.

In parallel, Dr. Li leads several projects applying machine learning and big data analytics to challenges in otolaryngology and broader healthcare. He serves as the principal investigator of a recent NIH-sponsored study examining long-term risks and healthcare disparities in obstructive sleep apnea using big data. Additionally, he is spearheading the development of an AI-assisted system for automatic clinical coding—an innovation designed to enhance efficiency, accuracy, and cost-effectiveness in medical documentation and billing.
Research Keywords
Vocal fold paralysis; Dysphonia; Facial paralysis; Hearing loss; Obstructive sleep apnea; Neurostimulation; Artificial intelligence; Deep learning; Machine learning; Large language model
Publications
Zhang R., Chiron S., Tyree R., Carson K., Raber L., Ramadass K., Gao C., Kim M. E., Zuo L., Li Y, Wan Z., Harris P. A., Liu Q., Lau K. S., Coburn L. A., Wilson K. T., Huo Y., Landman B. A., Bao S.. Enhancing Clinical Data Management through Barcode Integration and REDCap: Innovations in Scalability and Adaptability. JMIR Form Res. 2025 Jul 7/15/2025; DOI: 10.2196/70016.

Li Y, Schwartz AR, Zealear D, Hall ME, Shotwell MS, Lindsell CJ, Bellotto S, Estes KE, Wells CL, Kent DT. Ansa Cervicalis Stimulation During Non-REM Sleep in a Patient with Obstructive Sleep Apnea. Am J Respir Crit Care Med [print-electronic]. 2025 Jun 6/2/2025; PMID: 40455798, PII: 10.1164/rccm.202411-2122IM, ISSN: 1535-4970.

Song Q, Li Y, Malin BA, Yin Z. Exploring the Potential of GPT-4 in Creating Billing Codes from Clinic Notes. Stud Health Technol Inform. 2025 May 5/15/2025; 327: 882-3. PMID: 40380598, PII: SHTI250490, DOI: 10.3233/SHTI250490, ISSN: 1879-8365.

Huang N, Li X, Ren Q, Li Y, Kang J, Ge P. A Surgical Technique of Inner Capsule Vaporization With CO2 Laser for Vocal Fold Cysts. J Voice [print-electronic]. 2025 May 5/5/2025; PMID: 40328555, PII: S0892-1997(25)00161-4, DOI: 10.1016/j.jvoice.2025.04.014, ISSN: 1873-4588.

Wei J, Kim Y, Li Y, Zhang D, Crump C. Incident Hearing Loss and Subsequent Risk of Dementia: The Health and Retirement Study 2010-2018. J Geriatr Psychiatry Neurol [print-electronic]. 2025 Apr 4/18/2025; 8919887251336461. PMID: 40249958, DOI: 10.1177/08919887251336461, ISSN: 0891-9887.

Kent DT, Ceremsak JJ, Li Y, Yalamanchi P, Mannion K, Zealear D, Shotwell MS, Hall ME, Lindsell CJ, Budnick HA, Bellotto S, Estes KE, Wells CL, Schwartz AR. Glossopharyngeal Nerve Stimulation Stabilizes the Lateral Pharyngeal Wall and Ventilation in OSA: A Pilot Study. Chest [print-electronic]. 2025 Feb 2/18/2025; PMID: 39978725, PII: S0012-3692(25)00166-7, DOI: 10.1016/j.chest.2025.02.009, ISSN: 1931-3543.

Li Y, Schwartz AR, Zealear D, Shotwell MS, Hall ME, Lindsell CJ, Budnick HA, Bellotto S, Kent DT. Ansa Cervicalis Stimulation Effects on Upper Airway Patency: A Structure-Based Analysis. Eur Respir J [print-electronic]. 2024 Oct 10/10/2024; PMID: 39401858, PII: 13993003.00901-2024, DOI: 10.1183/13993003.00901-2024, ISSN: 1399-3003.

Wang VH, Li Y, Kent DT, Pagán JA, Arabadjian M, Divers J, Zhang D. Racial and ethnic differences in the receipt of continuous positive airway pressure treatment for obstructive sleep apnea. Sleep Med [print-electronic]. 2024 Sep 9/11/2024; 124: 42-9. PMID: 39276697, PII: S1389-9457(24)00432-5, DOI: 10.1016/j.sleep.2024.09.011, ISSN: 1878-5506.

Li K, Ghosal R, Zhang D, Li Y, Lohman MC, Brown MJ, Merchant AT, Yang CH, Neils-Strunjas J, Friedman DB, Wei J. The Associations of Sensory Impairment With 10-Year Risk of Dementia and Alzheimer's Disease: The Health and Retirement Study, 2010-2020. J Geriatr Psychiatry Neurol [print-electronic]. 2024 Aug 8/26/2024; 8919887241275042. PMID: 39185851, DOI: 10.1177/08919887241275042, ISSN: 0891-9887.

Chen B, Li Y, Sun Y, Sun H, Wang Y, Lyu J, Guo J, Bao S, Cheng Y, Niu X, Yang L, Xu J, Yang J, Huang Y, Chi F, Liang B, Ren D. A 3D and Explainable Artificial Intelligence Model for Evaluation of Chronic Otitis Media Based on Temporal Bone Computed Tomography: Model Development, Validation, and Clinical Application. J Med Internet Res. 2024 Aug 8/8/2024; 26: e51706. PMID: 39116439, PII: v26i1e51706, DOI: 10.2196/51706, ISSN: 1438-8871.

Kent DT, Li Y. Percutaneous Approaches to Hypoglossal Nerve Stimulation: A Pilot Study During Drug-Induced Sleep Endoscopy. Otolaryngol Head Neck Surg [print-electronic]. 2024 Jun 6/29/2024; PMID: 38943442, DOI: 10.1002/ohn.880, ISSN: 1097-6817.

Bao S, Guo J, Lee HH, Deng R, Cui C, Remedios LW, Liu Q, Yang Q, Xu K, Yu X, Li J, Li Y, Roland JT, Liu Q, Lau KS, Wilson KT, Coburn LA, Landman BA, Huo Y. MITIGATING OVER-SATURATED FLUORESCENCE IMAGES THROUGH A SEMI-SUPERVISED GENERATIVE ADVERSARIAL NETWORK. Proc IEEE Int Symp Biomed Imaging [print-electronic]. 2024 May; 2024: PMID: 39867569, PMCID: PMC11756911, DOI: 10.1109/isbi56570.2024.10635687, ISSN: 1945-7928.

Bao S, Zhu S, Kolachala VL, Remedios LW, Hwang Y, Sun Y, Deng R, Cui C, Zhang R, Li Y, Li J, Roland JT, Liu Q, Lau KS, Kugathasan S, Qiu P, Wilson KT, Coburn LA, Landman BA, Huo Y. Cell Spatial Analysis in Crohn's Disease: Unveiling Local Cell Arrangement Pattern with Graph-based Signatures. Proc SPIE Int Soc Opt Eng [print-electronic]. 2024 Feb; 12933: PMID: 39309687, PMCID: PMC11415268, PII: 1293314, DOI: 10.1117/12.3006675, ISSN: 0277-786X.

Liang Q, Qi Z, Li Y. Machine learning to predict the occurrence of thyroid nodules: towards a quantitative approach for judicious utilization of thyroid ultrasonography. Front Endocrinol (Lausanne). 2024; 15: 1385836. PMID: 38774231, PMCID: PMC11106422, DOI: 10.3389/fendo.2024.1385836, ISSN: 1664-2392.

Bao S, Lee HH, Yang Q, Remedios LW, Deng R, Cui C, Cai LY, Xu K, Yu X, Chiron S, Li Y, Patterson NH, Wang Y, Li J, Liu Q, Lau KS, Roland JT, Coburn LA, Wilson KT, Landman BA, Huo Y. Alleviating tiling effect by random walk sliding window in high-resolution histological whole slide image synthesis. Proc Mach Learn Res. 2024; 227: 1406-22. PMID: 38993526, PMCID: PMC11238901, ISSN: 2640-3498.

Guo Jiajie, Liu Yuchao, Guo Chuxuan, Liu Zijie, Li Yike, Wu Xuan, Wang Qining, Xiong Caihua. Wearable Sensing for Breaststroke Phase Monitoring with Lower Limb Muscle-Joint Synergy. IEEE Transactions on Instrumentation and Measurement. 2023 Dec 12/18/2023; 73: 1-12. DOI: 10.1109/TIM.2023.3343771.

Zhang Y, Zhang L, Li B, Ye T, Zhang Y, Yu Y, Ma Y, Sun Y, Xiang J, Li Y, Chen H. Machine learning to predict occult metastatic lymph nodes along the recurrent laryngeal nerves in thoracic esophageal squamous cell carcinoma. BMC Cancer. 2023 Mar 3/2/2023; 23(1): 197. PMID: 36864444, PMCID: PMC9979471, PII: 10.1186/s12885-023-10670-3, DOI: 10.1186/s12885-023-10670-3, ISSN: 1471-2407.

Li Y, Richard KE, Schwartz AR, Zealear D, Lindsell CJ, Budnick HA, Kent DT. Quantitative Effects of Ansa Cervicalis Stimulation in Obstructive Sleep Apnea. Am J Respir Crit Care Med [print-electronic]. 2023 Jan 1/19/2023; PMID: 36656553, DOI: 10.1164/rccm.202212-2318LE, ISSN: 1535-4970.

Zhang D, Li Y, Kalbaugh CA, Shi L, Divers J, Islam S, Annex BH. Machine Learning Approach to Predict In-Hospital Mortality in Patients Admitted for Peripheral Artery Disease in the United States. J Am Heart Assoc [print-electronic]. 2022 Oct 10/10/2022; e026987. PMID: 36216437, DOI: 10.1161/JAHA.122.026987, ISSN: 2047-9980.

Chen Z, Zhu P, Qiu W, Guo J, Li Y. Deep learning in automatic detection of dysphonia: Comparing acoustic features and developing a generalizable framework. Int J Lang Commun Disord [print-electronic]. 2022 Sep 9/18/2022; PMID: 36117378, DOI: 10.1111/1460-6984.12783, ISSN: 1460-6984.

Bai Q, Su C, Tang W, Li Y. Machine learning to predict end stage kidney disease in chronic kidney disease. Sci Rep. 2022 May 5/19/2022; 12(1): 8377. PMID: 35589908, PII: 10.1038/s41598-022-12316-z, DOI: 10.1038/s41598-022-12316-z, ISSN: 2045-2322.

Li Y, Guo J, Yang P. Developing an Image-Based Deep Learning Framework for Automatic Scoring of the Pentagon Drawing Test. J Alzheimers Dis. 2022 Jan 1/4/2022; 85(1): 129-39. PMID: 34776440, PII: JAD210714, DOI: 10.3233/JAD-210714, ISSN: 1875-8908.

Li H, He Y, Zhuo X, Yue Z, Rong X, Li Y, Li Y, He L, Cheng J, Pan D, Xue R, Cai J, Jiang J, Xu Y, Tang Y. Establishment and Validation of a Predictive Model for Radiation-Associated Aspiration Pneumonia in Patients with Radiation-Induced Dysphagia after Nasopharyngeal Carcinoma. Behav Neurol. 2022; 2022: 6307804. PMID: 36039334, PMCID: PMC9418526, DOI: 10.1155/2022/6307804, ISSN: 1875-8584.

Pang J, Wang Y, Cheng Y, Chi F, Li Y, Ni G, Ren D. Conductive hearing loss in large vestibular aqueduct syndrome -clinical observations and proof-of-concept predictive modeling by a biomechanical approach. Int J Pediatr Otorhinolaryngol [print-electronic]. 2021 Jul; 146: 110752. PMID: 33964673, PII: S0165-5876(21)00145-2, DOI: 10.1016/j.ijporl.2021.110752, ISSN: 1872-8464.

Powell ME, Zealear DL, Li Y, Garrett CG, Von Wahlde K, Netterville J. Unilateral and Bilateral Laryngeal Pacing for Bilateral Vocal Fold Paralysis. Curr Otorhinolaryngol Rep [print-electronic]. 2020 Dec; 8(4): 395-401. PMID: 34084663, PMCID: PMC8171271, DOI: 10.1007/s40136-020-00313-7, ISSN: 2167-583X.

Zealear D, Li Y, Huang S. An Implantable System For Chronic In Vivo Electromyography. J Vis Exp. 2020 Apr 4/21/2020; (158): PMID: 32391811, DOI: 10.3791/60345, ISSN: 1940-087X.

Zhao M, Chen BJ, Zhao WD, Li Y, Du Q, Yu J, Wang XW, Qian XQ, Yuan YS, Yang JM, Chi FL, Ren DD. Concurrent Occurrence of Congenital Ossicular Anomaly and Localized Cholesteatoma: Series of 10 Cases. ORL J. Otorhinolaryngol. Relat. Spec [print-electronic]. 2020 Mar 3/23/2020; 1-11. PMID: 32203956, PII: 000506206, DOI: 10.1159/000506206, ISSN: 1423-0275.

Wang YM, Li Y, Cheng YS, He ZY, Yang JM, Xu JH, Chi ZC, Chi FL, Ren DD. Deep Learning in Automated Region Proposal and Diagnosis of Chronic Otitis Media Based on Computed Tomography. Ear Hear [print-electronic]. 2019 Sep 9/19/2019; PMID: 31567561, DOI: 10.1097/AUD.0000000000000794, ISSN: 1538-4667.

Li Y, Zealear D. Publication delays in peer-reviewed journals of otolaryngology, audiology and speech language pathology. Journal of Postdoctoral Research. 2018 May; 6(5): 1-24.

Li Y, Garrett G, Zealear D. Current Treatment Options for Bilateral Vocal Fold Paralysis: A State-of-the-Art Review. Clin Exp Otorhinolaryngol [print-electronic]. 2017 Sep; 10(3): 203-12. PMID: 28669149, PMCID: PMC5545703, PII: ceo.2017.00199, DOI: 10.21053/ceo.2017.00199, ISSN: 1976-8710.

Li Y. Interventions in management of blood viscosity for idiopathic sudden sensorineural hearing loss: A meta-analysis. J Health Res Rev. 2017 Jun 6/15/2017; 4(2): 50-61.

Li Y, Huang S, Zealear D. An implantable system for In Vivo chronic electromyographic study in the larynx. Muscle Nerve [print-electronic]. 2017 May; 55(5): 706-14. PMID: 27543847, DOI: 10.1002/mus.25384, ISSN: 1097-4598.

Li Y. To understand the brain - the 2016 annual meeting of society for neurosciences: a conference report. Neural Regen Res. 2016 Dec; 11(12): 1912-3. PMID: 28197179, PMCID: PMC5270421, PII: NRR-11-1912, DOI: 10.4103/1673-5374.197126, ISSN: 1673-5374.

Li Y, Yang JM, Huang YB, Ren DD, Chi FL. Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection. Neural Regen Res. 2015 Jun; 10(6): 989-95. PMID: 26199619, PMCID: PMC4498364, PII: NRR-10-989, DOI: 10.4103/1673-5374.158366, ISSN: 1673-5374.

Zealear DL, Mainthia R, Li Y, Kunibe I, Katada A, Billante C, Nomura K. Stimulation of denervated muscle promotes selective reinnervation, prevents synkinesis, and restores function. Laryngoscope [print-electronic]. 2014 May; 124(5): E180-7. PMID: 24254367, DOI: 10.1002/lary.24454, ISSN: 1531-4995.

Li Y, Pearce EC, Mainthia R, Athavale SM, Dang J, Ashmead DH, Garrett CG, Rousseau B, Billante CR, Zealear DL. Comparison of ventilation and voice outcomes between unilateral laryngeal pacing and unilateral cordotomy for the treatment of bilateral vocal fold paralysis. ORL J. Otorhinolaryngol. Relat. Spec [print-electronic]. 2013; 75(2): 68-73. PMID: 23736349, PMCID: PMC3798066, PII: 000345501, DOI: 10.1159/000345501, ISSN: 1423-0275.

Yang JM, Chi FL, Han Z, Huang YB, Li Y. Clinical characteristics of patients with labyrinthine fistulae caused by middle ear cholesteatoma. Chin. Med. J. 2013; 126(11): 2116-9. PMID: 23769568, ISSN: 0366-6999.

Li Y, Rentmeester LA, Wang H, et al. Antioxidants for idiopathic sudden sensorineural hearing loss. Cochrane Systematic Review. 2012 Sep 9/12/2012; DOI: https://doi.org/10.1002/14651858.CD010058.

Li Y, Chi FL, Wang SY, Wang WQ, Yang JM, Huang YB. Cutaneous neuroendocrine carcinoma of the external auditory canal: a case report and review of the literature. Case Rep Otolaryngol. 2012; 2012: PMID: 22928140, PMCID: PMC3420451, DOI: 10.1155/2012/941065, ISSN: 2090-6773.

Athavale S, Li Y, Dang J, et al. Voice and Ventilation: Unilateral Laryngeal Pacing Versus Unilateral Cordotomy for the Treatment of Iatrogenic Bilateral Vocal Fold Paralysis. Laryngoscope (Supplement: Poster Presentations from the Triological Society's 2011 Annual Meeting). 2011 Aug 8/15/2011; 121(55): 303. DOI: https://doi.org/10.1002/lary.22259.

Huang Y, Chi F, Han Z, Yang J, Gao W, Li Y. New ectopic vestibular hair cell-like cells induced by Math1 gene transfer in postnatal rats. Brain Res [print-electronic]. 2009 Jun 6/18/2009; 1276: 31-8. PMID: 19397899, PII: S0006-8993(09)00787-2, DOI: 10.1016/j.brainres.2009.04.036, ISSN: 1872-6240.

Li Y, Chi F. History and Development of ear deformity and total auricular reconstruction [in Chinese]. Chinese Journal of Ophthalmology and Otorhinolaryngology. 2009; 9(2): 125-7.

Li Y, Liang Q, Chi F. Huge postauricular sebaceous cyst: A case report [in Chinese]. Chinese Journal of Ophthalmology and Otorhinolaryngology. 2008; 8(3): 147.