Yike Li, M.D., Ph.D.

Research Assistant Professor

yike.li.1@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Otolaryngology - Head and Neck Surgery
Education
M.D., Fudan University, Shanghai, ChinaPh.D., Vanderbilt University, Nashville, Tennessee
Office Address
1161 21st Avenue South, Medical Center North, Rm. S2211
Nashville, TN 37232
Research Description
Dr. Li is currently a research assistant professor in the Department of Otolaryngology at Vanderbilt University Medical Center. He obtained his M.D. degree from Fudan University in China, and Ph.D. degree in hearing and speech sciences from Vanderbilt University. He completed his residency training in otolaryngology in Shanghai Eye and ENT hospital. Dr. Li has been working in the field of otolaryngology for over 10 years. His research interests include neurolaryngology, voice disorder, hearing loss, and artificial intelligence. Most of his recent publications focus on the application of electrical stimulation to the laryngeal muscles as a treatment approach to vocal fold paralysis. He is currently working on an NIH-funded clinical trial to investigate using an implantable electrical stimulator in the treatment of bilateral vocal fold paralysis in humans. He is also interested in exploring a similar approach in the management of facial paralysis. In addition, he is now engaged in applying machine learning techniques in the detection and diagnosis of head and neck diseases.

Research Keywords
Vocal fold paralysis; Dysphonia; Facial paralysis; Hearing loss; Machine learning; Artificial intelligence
Publications
Powell M.E., Zealear D.L., Li Y, Garrett C. G., Von Wahlde K., Netterville J.. Unilateral and Bilateral Laryngeal Pacing for Bilateral Vocal Fold Paralysis. Curr Otorhinolaryngol Rep. 2020 Sep 9/3/2020; DOI: https://doi.org/10.1007/s40136-020-00313-7.

Zealear D, Li Y, Huang S. An Implantable System For Chronic In Vivo Electromyography. J Vis Exp. 2020 Apr 4/21/2020; (158): PMID: 32391811, DOI: 10.3791/60345, ISSN: 1940-087X.

Zhao M, Chen BJ, Zhao WD, Li Y, Du Q, Yu J, Wang XW, Qian XQ, Yuan YS, Yang JM, Chi FL, Ren DD. Concurrent Occurrence of Congenital Ossicular Anomaly and Localized Cholesteatoma: Series of 10 Cases. ORL J. Otorhinolaryngol. Relat. Spec [print-electronic]. 2020 Mar 3/23/2020; 1-11. PMID: 32203956, PII: 000506206, DOI: 10.1159/000506206, ISSN: 1423-0275.

Wang YM, Li Y, Cheng YS, He ZY, Yang JM, Xu JH, Chi ZC, Chi FL, Ren DD. Deep Learning in Automated Region Proposal and Diagnosis of Chronic Otitis Media Based on Computed Tomography. Ear Hear [print-electronic]. 2019 Sep 9/19/2019; PMID: 31567561, DOI: 10.1097/AUD.0000000000000794, ISSN: 1538-4667.

Li Y, Zealear D. Publication delays in peer-reviewed journals of otolaryngology, audiology and speech language pathology. Journal of Postdoctoral Research. 2018 May; 6(5): 1-24.

Li Y, Garrett G, Zealear D. Current Treatment Options for Bilateral Vocal Fold Paralysis: A State-of-the-Art Review. Clin Exp Otorhinolaryngol [print-electronic]. 2017 Sep; 10(3): 203-12. PMID: 28669149, PMCID: PMC5545703, PII: ceo.2017.00199, DOI: 10.21053/ceo.2017.00199, ISSN: 1976-8710.

Li Y. Interventions in management of blood viscosity for idiopathic sudden sensorineural hearing loss: A meta-analysis. J Health Res Rev. 2017 Jun 6/15/2017; 4(2): 50-61.

Li Y, Huang S, Zealear D. An implantable system for In Vivo chronic electromyographic study in the larynx. Muscle Nerve [print-electronic]. 2017 May; 55(5): 706-14. PMID: 27543847, DOI: 10.1002/mus.25384, ISSN: 1097-4598.

Li Y. To understand the brain - the 2016 annual meeting of society for neurosciences: a conference report. Neural Regen Res. 2016 Dec; 11(12): 1912-3. PMID: 28197179, PMCID: PMC5270421, PII: NRR-11-1912, DOI: 10.4103/1673-5374.197126, ISSN: 1673-5374.

Li Y, Yang JM, Huang YB, Ren DD, Chi FL. Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection. Neural Regen Res. 2015 Jun; 10(6): 989-95. PMID: 26199619, PMCID: PMC4498364, PII: NRR-10-989, DOI: 10.4103/1673-5374.158366, ISSN: 1673-5374.

Zealear DL, Mainthia R, Li Y, Kunibe I, Katada A, Billante C, Nomura K. Stimulation of denervated muscle promotes selective reinnervation, prevents synkinesis, and restores function. Laryngoscope [print-electronic]. 2014 May; 124(5): E180-7. PMID: 24254367, DOI: 10.1002/lary.24454, ISSN: 1531-4995.

Li Y, Pearce EC, Mainthia R, Athavale SM, Dang J, Ashmead DH, Garrett CG, Rousseau B, Billante CR, Zealear DL. Comparison of ventilation and voice outcomes between unilateral laryngeal pacing and unilateral cordotomy for the treatment of bilateral vocal fold paralysis. ORL J. Otorhinolaryngol. Relat. Spec [print-electronic]. 2013; 75(2): 68-73. PMID: 23736349, PMCID: PMC3798066, PII: 000345501, DOI: 10.1159/000345501, ISSN: 1423-0275.

Yang JM, Chi FL, Han Z, Huang YB, Li Y. Clinical characteristics of patients with labyrinthine fistulae caused by middle ear cholesteatoma. Chin. Med. J. 2013; 126(11): 2116-9. PMID: 23769568, ISSN: 0366-6999.

Li Y, Rentmeester LA, Wang H, et al. Antioxidants for idiopathic sudden sensorineural hearing loss. Cochrane Systematic Review. 2012 Sep 9/12/2012; DOI: https://doi.org/10.1002/14651858.CD010058.

Li Y, Chi FL, Wang SY, Wang WQ, Yang JM, Huang YB. Cutaneous neuroendocrine carcinoma of the external auditory canal: a case report and review of the literature. Case Rep Otolaryngol. 2012; 2012: PMID: 22928140, PMCID: PMC3420451, DOI: 10.1155/2012/941065, ISSN: 2090-6773.

Athavale S, Li Y, Dang J, et al. Voice and Ventilation: Unilateral Laryngeal Pacing Versus Unilateral Cordotomy for the Treatment of Iatrogenic Bilateral Vocal Fold Paralysis. Laryngoscope (Supplement: Poster Presentations from the Triological Society's 2011 Annual Meeting). 2011 Aug 8/15/2011; 121(55): 303. DOI: https://doi.org/10.1002/lary.22259.

Huang Y, Chi F, Han Z, Yang J, Gao W, Li Y. New ectopic vestibular hair cell-like cells induced by Math1 gene transfer in postnatal rats. Brain Res [print-electronic]. 2009 Jun 6/18/2009; 1276: 31-8. PMID: 19397899, PII: S0006-8993(09)00787-2, DOI: 10.1016/j.brainres.2009.04.036, ISSN: 1872-6240.

Li Y, Chi F. History and Development of ear deformity and total auricular reconstruction [in Chinese]. Chinese Journal of Ophthalmology and Otorhinolaryngology. 2009; 9(2): 125-7.

Li Y, Liang Q, Chi F. Huge postauricular sebaceous cyst: A case report [in Chinese]. Chinese Journal of Ophthalmology and Otorhinolaryngology. 2008; 8(3): 147.