Heather K. Kroh, Ph.D.

Research Instructor

heather.k.kroh@vanderbilt.edu
Faculty Appointments
Research Instructor in Pathology, Microbiology and Immunology
Education
B.S., Biology, Tennessee Technological University, Cookeville, TennesseePh.D., Vanderbilt University, Nashville, Tennessee
Publications
Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB. A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells. J. Biol. Chem [print-electronic]. 2018 Jan 1/19/2018; 293(3): 941-52. PMID: 29180448, PMCID: PMC5777265, PII: M117.813428, DOI: 10.1074/jbc.M117.813428, ISSN: 1083-351X.

Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA. Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants. J. Biol. Chem [print-electronic]. 2017 Oct 10/20/2017; 292(42): 17290-301. PMID: 28842504, PMCID: PMC5655507, PII: M117.806687, DOI: 10.1074/jbc.M117.806687, ISSN: 1083-351X.

Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB. Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface. J. Biol. Chem [print-electronic]. 2017 Sep 9/1/2017; 292(35): 14401-12. PMID: 28705932, PMCID: PMC5582835, PII: M117.781112, DOI: 10.1074/jbc.M117.781112, ISSN: 1083-351X.

Hernandez LD, Kroh HK, Hsieh E, Yang X, Beaumont M, Sheth PR, DiNunzio E, Rutherford SA, Ohi MD, Ermakov G, Xiao L, Secore S, Karczewski J, Racine F, Mayhood T, Fischer P, Sher X, Gupta P, Lacy DB, Therien AG. Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab. J. Mol. Biol [print-electronic]. 2017 Apr 4/7/2017; 429(7): 1030-44. PMID: 28232034, PII: S0022-2836(17)30085-2, DOI: 10.1016/j.jmb.2017.02.010, ISSN: 1089-8638.

Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E. Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities. Infect. Immun. 2016 Jan 1/11/2016; 84(3): 856-65. PMID: 26755157, PMCID: PMC4771349, PII: IAI.01291-15, DOI: 10.1128/IAI.01291-15, ISSN: 1098-5522.

Kroh HK, Bock PE. Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein. J. Biol. Chem [print-electronic]. 2012 Nov 11/9/2012; 287(46): 39149-57. PMID: 23012355, PMCID: PMC3493955, PII: M112.415562, DOI: 10.1074/jbc.M112.415562, ISSN: 1083-351X.

Kroh HK, Panizzi P, Bock PE. Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2009 May 5/12/2009; 106(19): 7786-91. PMID: 19416890, PMCID: PMC2683071, PII: 0811750106, DOI: 10.1073/pnas.0811750106, ISSN: 1091-6490.