Jaclyn C Watkins, M.D.

Assistant Professor

jaclyn.c.watkins@vanderbilt.edu
Faculty Appointments
Assistant Professor of Pathology, Microbiology and Immunology
Education
M.D., University of California, San Francisco, CaliforniaM.S., University of California, Berkeley, CaliforniaB.S., Cornell University, Ithaca, New York
Research Description
I am primarily interested in translational research pertaining to the gynecologic tract. My work includes research on vulvar neoplasia, including unusual variants of differentiated vulvar intraepithelial neoplasia and other precursor lesions. I am additionally interested in uterine malignancies and precursors to maligancy (endometrial intraepithelial neoplasia) as well as the environmental, genetic, and epigenetic factors involved in their pathogenesis. My work aims to be multidisciplinary, often in collaboration with epidemiologists.
Clinical Description
Chief of Gynecologic Pathology
Research Keywords
Endometrial cancer, familial tumor syndromes, cervical cancer, vulvar neoplasia, ovarian cancer
Clinical Research Keywords
Gynecologic pathology, anatomic pathology
Publications
Watkins JC. Human Papillomavirus-Independent Squamous Lesions of the Vulva. Surg Pathol Clin [print-electronic]. 2019 Jun; 12(2): 249-61. PMID: 31097103, PII: S1875-9181(19)30003-0, DOI: 10.1016/j.path.2019.01.001, ISSN: 1875-9157.

Glass CH, Christakis A, Fishbein GA, Watkins JC, Strickland KC, Mitchell RN, Padera RF. Thrombus on the inflow cannula of the HeartWare HVAD: an update. Cardiovasc. Pathol [print-electronic]. 2019 Jan; 38: 14-20. PMID: 30399526, PII: S1054-8807(18)30157-1, DOI: 10.1016/j.carpath.2018.09.002, ISSN: 1879-1336.

Stonko DP, Liang J, Weeks AG, Redline RW, Boyd TK, Watkins JC, Kovach AE. Ectopic Fetal Hepatic Tissue in the Placenta. Int. J. Gynecol. Pathol [print-electronic]. 2018 Jun 6/12/2018; PMID: 29901524, DOI: 10.1097/PGP.0000000000000531, ISSN: 1538-7151.

Watkins JC, Yang E, Crum CP, Herfs M, Gheit T, Tommasino M, Nucci MR. Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia. Int. J. Gynecol. Pathol [print-electronic]. 2018 May 5/10/2018; PMID: 29750709, DOI: 10.1097/PGP.0000000000000509, ISSN: 1538-7151.

Nitecki R, Davis M, Watkins JC, Wu YE, Vitonis AF, Muto MG, Berkowitz RS, Horowitz NS, Feltmate CM. Extramammary Paget Disease of the Vulva: A Case Series Examining Treatment, Recurrence, and Malignant Transformation. Int. J. Gynecol. Cancer [print-electronic]. 2018 Jan 1/10/2018; PMID: 29324542, DOI: 10.1097/IGC.0000000000001189, ISSN: 1525-1438.

Watkins Jaclyn, Nucci Marisa, Nasciemento Alessandra. Disorders of the Peritoneum. In: Crum Christopher, Nucci Marisa, Howitt Brooke, Granter Scott, Parast Mana, Boyd Theonia, editors. Diagnostic Gynecologic and Obstetric Pathology. 3rd. Philadelphia (United States): Elsevier; 2017 Oct 10/13/2017.Chapter; p. 800-43. ISBN-13: 9780323447324.

Watkins Jaclyn. Obesity and Endometrial Cancer Precursors. In: Berger Nathan, Ann Klopp, Lu Karen, editors. Focus on Gynecologic Malignancies. 1st. [place unknown]: Springer; 2017 Oct. Chapter; p. 63-71. ISBN-13: 978-3-319-63483-8.

Hung YP, Dong F, Watkins JC, Nardi V, Bueno R, Dal Cin P, Godleski JJ, Crum CP, Chirieac LR. Identification of ALK Rearrangements in Malignant Peritoneal Mesothelioma. JAMA Oncol [print-electronic]. 2017 Sep 9/14/2017; PMID: 28910456, PII: 2653897, DOI: 10.1001/jamaoncol.2017.2918, ISSN: 2374-2445.

Watkins JC, Howitt BE, Horowitz NS, Ritterhouse LL, Dong F, MacConaill LE, Garcia E, Lindeman NI, Lee LJ, Berkowitz RS, Nucci MR, Crum CP. Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA. Mod. Pathol [print-electronic]. 2017 Mar; 30(3): 448-58. PMID: 27834349, PII: modpathol2016187, DOI: 10.1038/modpathol.2016.187, ISSN: 1530-0285.

Watkins JC, Yang EJ, Muto MG, Feltmate CM, Berkowitz RS, Horowitz NS, Syngal S, Yurgelun MB, Chittenden A, Hornick JL, Crum CP, Sholl LM, Howitt BE. Universal Screening for Mismatch-Repair Deficiency in Endometrial Cancers to Identify Patients With Lynch Syndrome and Lynch-like Syndrome. Int. J. Gynecol. Pathol. 2017 Mar; 36(2): 115-27. PMID: 27556954, DOI: 10.1097/PGP.0000000000000312, ISSN: 1538-7151.

Watkins JC, Nucci MR, Ritterhouse LL, Howitt BE, Sholl LM. Unusual Mismatch Repair Immunohistochemical Patterns in Endometrial Carcinoma. Am. J. Surg. Pathol. 2016 Jul; 40(7): 909-16. PMID: 27186853, DOI: 10.1097/PAS.0000000000000663, ISSN: 1532-0979.

Strickland KC, Watkins JC, Couper GS, Givertz MM, Padera RF. Thrombus around the redesigned HeartWare HVAD inflow cannula: A pathologic case series [letter]. J. Heart Lung Transplant [print-electronic]. 2016 Jul; 35(7): 926-30. PMID: 27021277, PII: S1053-2498(16)01284-5, DOI: 10.1016/j.healun.2016.01.1230, ISSN: 1557-3117.

Hinchcliff EM, Esselen KM, Watkins JC, Oduyebo T, Rauh-Hain JA, Del Carmen MG, Quade BJ, Muto MG. The Role of Endometrial Biopsy in the Preoperative Detection of Uterine Leiomyosarcoma. J Minim Invasive Gynecol [print-electronic]. 2016 May; 23(4): 567-72. PMID: 26851414, PII: S1553-4650(16)00070-4, DOI: 10.1016/j.jmig.2016.01.022, ISSN: 1553-4669.

Howitt BE, Shukla SA, Sholl LM, Ritterhouse LL, Watkins JC, Rodig S, Stover E, Strickland KC, D'Andrea AD, Wu CJ, Matulonis UA, Konstantinopoulos PA. Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1. JAMA Oncol. 2015 Dec; 1(9): 1319-23. PMID: 26181000, PII: 2383137, DOI: 10.1001/jamaoncol.2015.2151, ISSN: 2374-2445.