Jeremy Allen Goettel, Ph.D.

Assistant Professor
Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Pathology, Microbiology and Immunology
Ph.D., Cell Biology, Vanderbilt University, Nashville, TennesseeB.S., Biology, Missouri State University, Springfield, Missouri
Office Address
2215 Garland Avenue
1075J MRB IV
Nashville, TN 37232
Research Description
Our lab is interested in understanding the mechanisms regulating intestinal immunity and what leads to dysregulation and disease as well as how gut microbes shape the mucosal immune system. In particular the cytokine interleukin-23 (IL23) is required for the development of many experimental models of inflammatory bowel disease (IBD) in mice and mutations in IL23 receptor (IL23R) have been identified as susceptibility or resistance factors for Crohn’s disease. We have developed several murine strains that will facilitate investigations into the role of IL23R signaling in a cell-specific manner using experimental models of IBD and inflammation-associated carcinogenesis. In addition, we have developed several humanized murine systems to model intestinal inflammation driven by human immune cells and new models enabling engraftment of human tumors with autologous immune cells to assess combination therapies and immune activation. We hope that these strategies will be informative for clinical management and pave the way towards precision medicine.
Research Keywords
IBD, Mucosal Immunology, T cells, ILCs, Humanized Mice, Cytokines
Redhu NS, Bakthavatchalu V, Conaway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, Snapper SB, Horwitz BH. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017 Jul 7/5/2017; 6: PMID: 28678006, PMCID: PMC5531923, DOI: 10.7554/eLife.27652, ISSN: 2050-084X.

Lexmond WS, Goettel JA, Sallis BF, McCann K, Rings EHHM, Jensen-Jarolim E, Nurko S, Snapper SB, Fiebiger E. Spontaneous food allergy in Was(-/-) mice occurs independent of FceRI-mediated mast cell activation. Allergy [print-electronic]. 2017 Jun 6/10/2017; PMID: 28600891, DOI: 10.1111/all.13219, ISSN: 1398-9995.

Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature [print-electronic]. 2017 May 5/25/2017; 545(7655): 432-8. PMID: 28514439, PII: nature22370, DOI: 10.1038/nature22370, ISSN: 1476-4687.

Schoellhammer CM, Lauwers GY, Goettel JA, Oberli MA, Cleveland C, Park JY, Minahan D, Chen Y, Anderson DG, Jaklenec A, Snapper SB, Langer R, Traverso G. Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice. Gastroenterology [print-electronic]. 2017 Apr; 152(5): 1151-60. PMID: 28088460, PMCID: PMC5368009, PII: S0016-5085(17)30013-6, DOI: 10.1053/j.gastro.2017.01.002, ISSN: 1528-0012.

Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Jan 1/17/2017; 114(3): 568-73. PMID: 28049834, PMCID: PMC5255594, PII: 1612921114, DOI: 10.1073/pnas.1612921114, ISSN: 1091-6490.

Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Rep. 2016 Oct 10/25/2016; 17(5): 1318-29. PMID: 27783946, PMCID: PMC5106873, PII: S2211-1247(16)31355-9, DOI: 10.1016/j.celrep.2016.09.082, ISSN: 2211-1247.

Lexmond WS, Goettel JA, Lyons JJ, Jacobse J, Deken MM, Lawrence MG, DiMaggio TH, Kotlarz D, Garabedian E, Sackstein P, Nelson CC, Jones N, Stone KD, Candotti F, Rings EH, Thrasher AJ, Milner JD, Snapper SB, Fiebiger E. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J. Clin. Invest [print-electronic]. 2016 Oct 10/3/2016; 126(10): 4030-44. PMID: 27643438, PMCID: PMC5096801, PII: 85129, DOI: 10.1172/JCI85129, ISSN: 1558-8238.

Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 Sep 9/29/2016; 17(1): 201. PMID: 27687735, PMCID: PMC5043525, PII: 10.1186/s13059-016-1062-5, DOI: 10.1186/s13059-016-1062-5, ISSN: 1474-760X.

Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood [print-electronic]. 2015 Jun 6/18/2015; 125(25): 3886-95. PMID: 25833964, PMCID: PMC4473116, PII: blood-2014-12-618363, DOI: 10.1182/blood-2014-12-618363, ISSN: 1528-0020.

Vucovich MM, Cotton RB, Shelton EL, Goettel JA, Ehinger NJ, Poole SD, Brown N, Wynn JL, Paria BC, Slaughter JC, Clark RH, Rojas MA, Reese J. Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): H732-40. PMID: 24993047, PMCID: PMC4187398, PII: ajpheart.00838.2013, DOI: 10.1152/ajpheart.00838.2013, ISSN: 1522-1539.

Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity [print-electronic]. 2014 May 5/15/2014; 40(5): 706-19. PMID: 24792912, PMCID: PMC4513358, PII: S1074-7613(14)00125-3, DOI: 10.1016/j.immuni.2014.03.011, ISSN: 1097-4180.

Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, Muise AM, Snapper SB. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv. Immunol. 2014; 122: 177-210. PMID: 24507158, PMCID: PMC4741283, PII: B978-0-12-800267-4.00005-5, DOI: 10.1016/B978-0-12-800267-4.00005-5, ISSN: 1557-8445.

Nguyen DD, Muthupalani S, Goettel JA, Eston MA, Mobley M, Taylor NS, McCabe A, Marin R, Snapper SB, Fox JG. Colitis and colon cancer in WASP-deficient mice require helicobacter species. Inflamm. Bowel Dis. 2013 Sep; 19(10): 2041-50. PMID: 23820270, PMCID: PMC4082694, DOI: 10.1097/MIB.0b013e318295fd8f, ISSN: 1536-4844.

Lexmond WS, Pardo M, Rooney K, Goettel JA, Snapper SB, Yen EH, Dehlink E, Nurko S, Fiebiger E. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin. Exp. Allergy. 2013 Aug; 43(8): 902-13. PMID: 23889244, PMCID: PMC3728707, DOI: 10.1111/cea.12146, ISSN: 1365-2222.

Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut [print-electronic]. 2013 Jan; 62(1): 73-82. PMID: 22267598, PMCID: PMC3606820, PII: gutjnl-2011-301551, DOI: 10.1136/gutjnl-2011-301551, ISSN: 1468-3288.

Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology [print-electronic]. 2012 Sep; 143(3): 719-729.e2. PMID: 22710191, PMCID: PMC3760724, PII: S0016-5085(12)00824-4, DOI: 10.1053/j.gastro.2012.06.008, ISSN: 1528-0012.

Hobbs SS, Goettel JA, Liang D, Yan F, Edelblum KL, Frey MR, Mullane MT, Polk DB. TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2011 Aug; 301(2): G220-9. PMID: 21566012, PMCID: PMC3154604, PII: ajpgi.00383.2010, DOI: 10.1152/ajpgi.00383.2010, ISSN: 1522-1547.

Zhang Y, Li X, Carpinteiro A, Goettel JA, Soddemann M, Gulbins E. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat. Med [print-electronic]. 2011 Mar; 17(3): 341-6. PMID: 21297617, PII: nm.2296, DOI: 10.1038/nm.2296, ISSN: 1546-170X.

Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB. KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp. Cell Res [print-electronic]. 2011 Feb 2/15/2011; 317(4): 452-63. PMID: 21144847, PMCID: PMC3038243, PII: S0014-4827(10)00547-1, DOI: 10.1016/j.yexcr.2010.11.018, ISSN: 1090-2422.

Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-¿ production. Gastroenterology [print-electronic]. 2011 Jan; 140(1): 265-74. PMID: 20875416, PMCID: PMC3008308, PII: S0016-5085(10)01421-6, DOI: 10.1053/j.gastro.2010.09.041, ISSN: 1528-0012.

Edelblum KL, Goettel JA, Koyama T, McElroy SJ, Yan F, Polk DB. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J. Biol. Chem [print-electronic]. 2008 Oct 10/24/2008; 283(43): 29485-94. PMID: 18713739, PMCID: PMC2570867, PII: M801269200, DOI: 10.1074/jbc.M801269200, ISSN: 0021-9258.

McElroy SJ, Frey MR, Yan F, Edelblum KL, Goettel JA, John S, Polk DB. Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2008 Aug; 295(2): G285-93. PMID: 18467504, PMCID: PMC2519857, PII: 00425.2007, DOI: 10.1152/ajpgi.00425.2007, ISSN: 0193-1857.

Available Postdoctoral Position Details
Posted: 2/13/2018


There is an immediate opening for a post-doctoral fellow position in the laboratory of Dr. Jeremy Goettel in The Department of Medicine in the Division of Gastroenterology, Hepatology, and Nutrition at the Vanderbilt University Medical Center in Nashville Tennessee. The Goettel lab utilizes translational approaches to study mucosal immunity in both murine and humanized murine systems. Specifically, we will characterize the role of IL-23R in intestinal immune homeostasis as well as develop humanized murine systems to assess therapeutic strategies that promote or restore intestinal health. This project involves working with mouse models, primary human immune cells, and established cell lines. Our lab is a member of the Digestive Disease Research Center (DDRC) and the Center for Mucosal Inflammation and Cancer (CMIC) and offers a dynamic, multidisciplinary environment with close interaction with other basic and clinical scientists. This opportunity is for a highly motivated creative individual who can drive projects and ideas forward and offer new insight and approaches that will contribute to our understanding of basic scientific questions.

Requirements and Responsibilities:

• A PhD with strong background in immunology and publication record

• Experience with in vitro and in vivo immunological assays is especially desirable.

• Assist in training new graduate students and lab technicians.

• Proficient in flow cytometry and data analysis, qPCR, molecular biology techniques.

• Present data in lab and departmental meetings as well as national and international conferences.

• Manuscript and grant writing.

To apply:

Please contact Jeremy Goettel with CV, cover letter and references