Faculty Appointments
Associate Professor of Medicine
Associate Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Cell Biology, Vanderbilt University, Nashville, TennesseeB.S., Biology, Missouri State University, Springfield, Missouri
Office Address
2215 Garland Avenue
1075J MRB IV
Nashville, TN 37232
1075J MRB IV
Nashville, TN 37232
Research Description
Our lab is interested in understanding the mechanisms regulating intestinal immunity and what leads to dysregulation and disease as well as how gut microbes shape the mucosal immune system. In particular the cytokine interleukin-23 (IL23) is required for the development of many experimental models of inflammatory bowel disease (IBD) in mice and mutations in IL23 receptor (IL23R) have been identified as susceptibility or resistance factors for Crohn’s disease. We have developed several murine strains that will facilitate investigations into the role of IL23R signaling in a cell-specific manner using experimental models of IBD and inflammation-associated carcinogenesis. In addition, we have developed several humanized murine systems to model intestinal inflammation driven by human immune cells and new models enabling engraftment of human tumors with autologous immune cells to assess combination therapies and immune activation. We hope that these strategies will be informative for clinical management and pave the way towards precision medicine.
Research Keywords
IBD, Mucosal Immunology, T cells, ILCs, Humanized Mice, Cytokines
Publications
Spencer PN, Brown ME, Smith EP, Wang J, Kim W, Spiga L, Tasneem N, Simmons AJ, Kim T, Yang Y, Xu Y, Zheng L, Ro J, Kaur H, Kang SW, Helou MD, Lee MA, Arceneaux D, Mueller KD, Kuddar OS, Harned MH, Li J, Banerjee A, Markham NO, Wilson KT, Coburn LA, Goettel JA, Liu Q, Washington MK, Valdivia RH, Zhu W, Lau KS. Pathobiont-triggered induction of goblet cell response drives regional susceptibility to inflammatory bowel disease. J Clin Invest. 2026 Apr 4/1/2026; 136(7): PMID: 41701533, PMCID: PMC13038202, PII: 201729, DOI: 10.1172/JCI201729, ISSN: 1558-8238.
Spencer PN, Brown ME, Smith EP, Wang J, Kim W, Spiga L, Tasneem N, Simmons AJ, Kim T, Yang Y, Xu Y, Zheng L, Ro J, Kaur H, Kang SW, Helou MD, Lee MA, Arceneaux D, Mueller KD, Kuddar OS, Harned MH, Li J, Banerjee A, Markham NO, Wilson KT, Coburn LA, Goettel JA, Liu Q, Washington MK, Valdivia RH, Zhu W, Lau KS. Pathobiont-triggered induction of goblet cell response drives regional susceptibility to inflammatory bowel disease. J Clin Invest. 2026 Apr 4/1/2026; 136(7): PMID: 41701533, PMCID: PMC13038202, PII: 201729, DOI: 10.1172/JCI201729, ISSN: 1558-8238.
Rusznak M, Toki S, Hao Y, Todd MJC, Malone L, Goodhead JF, DuPuy C, Zhou W, Babin D, Warren CM, Abney M, Stier MT, Thomas CM, Li J, Jacobse J, Pahnke AP, Petrovic MI, Cephus JY, Kuehnle SN, Calcutt MW, Norlander AE, Yan F, Goettel JA, Miller DR, Lynch RM, Cook DP, Newcomb DC, Zou F, Peebles RS. Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming. Nat Commun. 2026 Jan 1/3/2026; 17(1): 1053. PMID: 41484153, PMCID: PMC12847941, PII: 10.1038/s41467-025-67813-2, DOI: 10.1038/s41467-025-67813-2, ISSN: 2041-1723.
Rusznak M, Toki S, Hao Y, Todd MJC, Malone L, Goodhead JF, DuPuy C, Zhou W, Babin D, Warren CM, Abney M, Stier MT, Thomas CM, Li J, Jacobse J, Pahnke AP, Petrovic MI, Cephus JY, Kuehnle SN, Calcutt MW, Norlander AE, Yan F, Goettel JA, Miller DR, Lynch RM, Cook DP, Newcomb DC, Zou F, Peebles RS. Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming. Nat Commun. 2026 Jan 1/3/2026; 17(1): 1053. PMID: 41484153, PMCID: PMC12847941, PII: 10.1038/s41467-025-67813-2, DOI: 10.1038/s41467-025-67813-2, ISSN: 2041-1723.
Tigue ML, Jagarlamudi R, Chi C, Diaz D, Chen HC, Sheng Q, Chen SC, Schwarzkopf A, Goettel JA, Pua HH, Lee E, Weiss VL. Prolonged Wnt3a exposure tolerizes macrophages to inflammatory stimuli. Front Immunol. 2026; 17: 1752131. PMID: 41909666, PMCID: PMC13017329, DOI: 10.3389/fimmu.2026.1752131, ISSN: 1664-3224.
Tigue ML, Jagarlamudi R, Chi C, Diaz D, Chen HC, Sheng Q, Chen SC, Schwarzkopf A, Goettel JA, Pua HH, Lee E, Weiss VL. Prolonged Wnt3a exposure tolerizes macrophages to inflammatory stimuli. Front Immunol. 2026; 17: 1752131. PMID: 41909666, PMCID: PMC13017329, DOI: 10.3389/fimmu.2026.1752131, ISSN: 1664-3224.
Huang Y, Sun Y, Ronda C, Mavros CF, Li J, Jacobse J, Huang LH, Resnick SJ, Giddins M, Freedberg DE, Chavez A, Goettel JA, Wang HH. Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut. Nat Biotechnol [print-electronic]. 2025 Nov 11/17/2025; PMID: 41249836, PMCID: PMC13035107, PII: 10.1038/s41587-025-02894-4, DOI: 10.1038/s41587-025-02894-4, ISSN: 1546-1696.
Huang Y, Sun Y, Ronda C, Mavros CF, Li J, Jacobse J, Huang LH, Resnick SJ, Giddins M, Freedberg DE, Chavez A, Goettel JA, Wang HH. Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut. Nat Biotechnol [print-electronic]. 2025 Nov 11/17/2025; PMID: 41249836, PMCID: PMC13035107, PII: 10.1038/s41587-025-02894-4, DOI: 10.1038/s41587-025-02894-4, ISSN: 1546-1696.
Jacobse J, Pilat JM, Harris AB, Kwag A, Aziz Z, Chi C, Schaefer S, Neely MD, Buendia MA, Pahnke A, Williams CS, Deng W, Washington MK, Rathmell JC, Flynn CR, Rings EHHM, Short SP, Prabhu KS, Samsom JN, Goettel JA, Choksi YA. Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice. BioRxiv. 2025 Sep 9/15/2025; PMID: 41000784, PMCID: PMC12458461, PII: 2025.09.09.675163, DOI: 10.1101/2025.09.09.675163, ISSN: 2692-8205.
Jacobse J, Pilat JM, Harris AB, Kwag A, Aziz Z, Chi C, Schaefer S, Neely MD, Buendia MA, Pahnke A, Williams CS, Deng W, Washington MK, Rathmell JC, Flynn CR, Rings EHHM, Short SP, Prabhu KS, Samsom JN, Goettel JA, Choksi YA. Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice. BioRxiv. 2025 Sep 9/15/2025; PMID: 41000784, PMCID: PMC12458461, PII: 2025.09.09.675163, DOI: 10.1101/2025.09.09.675163, ISSN: 2692-8205.
Li J, Jacobse J, Pilat JM, Kaur H, Gu W, Kang SW, Rusznak M, Huang HI, Barrera J, Oloo PA, Roland JT, Hawkins CV, Pahnke AP, Khalil M, Washington MK, Wilson KT, Williams CS, Peebles RS, Konnikova L, Choksi YA, Hammer GE, Lau KS, Goettel JA. Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice. Mucosal Immunol [print-electronic]. 2025 Jun; 18(3): 643-55. PMID: 39988202, PMCID: PMC12167137, PII: S1933-0219(25)00023-6, DOI: 10.1016/j.mucimm.2025.02.005, ISSN: 1935-3456.
Li J, Jacobse J, Pilat JM, Kaur H, Gu W, Kang SW, Rusznak M, Huang HI, Barrera J, Oloo PA, Roland JT, Hawkins CV, Pahnke AP, Khalil M, Washington MK, Wilson KT, Williams CS, Peebles RS, Konnikova L, Choksi YA, Hammer GE, Lau KS, Goettel JA. Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice. Mucosal Immunol [print-electronic]. 2025 Jun; 18(3): 643-55. PMID: 39988202, PMCID: PMC12167137, PII: S1933-0219(25)00023-6, DOI: 10.1016/j.mucimm.2025.02.005, ISSN: 1935-3456.
Spencer PN, Wang J, Smith EP, Spiga L, Simmons AJ, Kim T, Kim W, Brown ME, Yang Y, Kaur H, Xu Y, Kang SW, Helou MD, Lee MA, Zheng L, Arceneaux D, Tasneem N, Mueller KD, Kuddar OS, Harned MH, Ro J, Li J, Banerjee A, Markham NO, Wilson KT, Coburn LA, Goettel JA, Liu Q, Kay Washington M, Valdivia RH, Zhu W, Lau KS. Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease. BioRxiv. 2025 Jan 1/4/2025; PMID: 39803424, PMCID: PMC11722351, PII: 2025.01.04.630951, DOI: 10.1101/2025.01.04.630951, ISSN: 2692-8205.
Spencer PN, Wang J, Smith EP, Spiga L, Simmons AJ, Kim T, Kim W, Brown ME, Yang Y, Kaur H, Xu Y, Kang SW, Helou MD, Lee MA, Zheng L, Arceneaux D, Tasneem N, Mueller KD, Kuddar OS, Harned MH, Ro J, Li J, Banerjee A, Markham NO, Wilson KT, Coburn LA, Goettel JA, Liu Q, Kay Washington M, Valdivia RH, Zhu W, Lau KS. Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease. BioRxiv. 2025 Jan 1/4/2025; PMID: 39803424, PMCID: PMC11722351, PII: 2025.01.04.630951, DOI: 10.1101/2025.01.04.630951, ISSN: 2692-8205.
Hiremath G, Choksi Y, Correa H, Jacobse J, Das SR, Ma S, Goettel JA, Rajagopala SV. Children with eosinophilic esophagitis non-responsive to combination therapy have distinct esophageal transcriptomic and microbiome profile. Allergy [print-electronic]. 2024 Oct; 79(10): 2798-811. PMID: 38993131, PMCID: PMC11528550, DOI: 10.1111/all.16208, ISSN: 1398-9995.
Diaz D, Bergdorf K, Loberg MA, Phifer CJ, Xu GJ, Sheng Q, Chen SC, Byrant JM, Tigue ML, Hartmann H, Rohde SL, Netterville JL, Baregamian N, Goettel JA, Ye F, Lee E, Weiss VL. Wnt/ß-catenin signaling is a therapeutic target in anaplastic thyroid carcinoma. Endocrine [print-electronic]. 2024 Oct; 86(1): 114-8. PMID: 38806891, PMCID: PMC11444896, PII: 10.1007/s12020-024-03887-0, DOI: 10.1007/s12020-024-03887-0, ISSN: 1559-0100.
Diaz D, Bergdorf K, Loberg MA, Phifer CJ, Xu GJ, Sheng Q, Chen SC, Byrant JM, Tigue ML, Hartmann H, Rohde SL, Netterville JL, Baregamian N, Goettel JA, Ye F, Lee E, Weiss VL. Wnt/ß-catenin signaling is a therapeutic target in anaplastic thyroid carcinoma. Endocrine [print-electronic]. 2024 Oct; 86(1): 114-8. PMID: 38806891, PMCID: PMC11444896, PII: 10.1007/s12020-024-03887-0, DOI: 10.1007/s12020-024-03887-0, ISSN: 1559-0100.
Hiremath G, Choksi Y, Correa H, Jacobse J, Das SR, Ma S, Goettel JA, Rajagopala SV. Children with eosinophilic esophagitis non-responsive to combination therapy have distinct esophageal transcriptomic and microbiome profile. Allergy [print-electronic]. 2024 Oct; 79(10): 2798-811. PMID: 38993131, PMCID: PMC11528550, DOI: 10.1111/all.16208, ISSN: 1398-9995.
Short SP, Brown RE, Chen Z, Pilat JM, McElligott BA, Meenderink LM, Bickart AC, Blunt KM, Jacobse J, Wang J, Simmons AJ, Xu Y, Yang Y, Parang B, Choksi YA, Goettel JA, Lau KS, Hiebert SW, Williams CS. MTGR1 is required to maintain small intestinal stem cell populations. Cell Death Differ [print-electronic]. 2024 Sep; 31(9): 1170-83. PMID: 39048708, PMCID: PMC11369156, PII: 10.1038/s41418-024-01346-x, DOI: 10.1038/s41418-024-01346-x, ISSN: 1476-5403.
Short SP, Brown RE, Chen Z, Pilat JM, McElligott BA, Meenderink LM, Bickart AC, Blunt KM, Jacobse J, Wang J, Simmons AJ, Xu Y, Yang Y, Parang B, Choksi YA, Goettel JA, Lau KS, Hiebert SW, Williams CS. MTGR1 is required to maintain small intestinal stem cell populations. Cell Death Differ [print-electronic]. 2024 Sep; 31(9): 1170-83. PMID: 39048708, PMCID: PMC11369156, PII: 10.1038/s41418-024-01346-x, DOI: 10.1038/s41418-024-01346-x, ISSN: 1476-5403.
Li J, Simmons AJ, Hawkins CV, Chiron S, Ramirez-Solano MA, Tasneem N, Kaur H, Xu Y, Revetta F, Vega PN, Bao S, Cui C, Tyree RN, Raber LW, Conner AN, Pilat JM, Jacobse J, McNamara KM, Allaman MM, Raffa GA, Gobert AP, Asim M, Goettel JA, Choksi YA, Beaulieu DB, Dalal RL, Horst SN, Pabla BS, Huo Y, Landman BA, Roland JT, Scoville EA, Schwartz DA, Washington MK, Shyr Y, Wilson KT, Coburn LA, Lau KS, Liu Q. Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease. Nat Commun. 2024 Aug 8/22/2024; 15(1): 7204. PMID: 39169060, PMCID: PMC11339313, PII: 10.1038/s41467-024-51580-7, DOI: 10.1038/s41467-024-51580-7, ISSN: 2041-1723.
Li J, Simmons AJ, Hawkins CV, Chiron S, Ramirez-Solano MA, Tasneem N, Kaur H, Xu Y, Revetta F, Vega PN, Bao S, Cui C, Tyree RN, Raber LW, Conner AN, Pilat JM, Jacobse J, McNamara KM, Allaman MM, Raffa GA, Gobert AP, Asim M, Goettel JA, Choksi YA, Beaulieu DB, Dalal RL, Horst SN, Pabla BS, Huo Y, Landman BA, Roland JT, Scoville EA, Schwartz DA, Washington MK, Shyr Y, Wilson KT, Coburn LA, Lau KS, Liu Q. Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease. Nat Commun. 2024 Aug 8/22/2024; 15(1): 7204. PMID: 39169060, PMCID: PMC11339313, PII: 10.1038/s41467-024-51580-7, DOI: 10.1038/s41467-024-51580-7, ISSN: 2041-1723.
Jacobse J, Brown R, Revetta F, Vaezi M, Buendia MA, Williams CS, Higginbotham T, Washington MK, Goettel J, Hiremath G, Choksi YA. A synthesis and subgroup analysis of the eosinophilic esophagitis tissue transcriptome. J Allergy Clin Immunol [print-electronic]. 2024 Mar; 153(3): 759-71. PMID: 37852329, PMCID: PMC10939980, PII: S0091-6749(23)01253-8, DOI: 10.1016/j.jaci.2023.10.002, ISSN: 1097-6825.
Latour YL, McNamara KM, Allaman MM, Barry DP, Smith TM, Asim M, Williams KJ, Hawkins CV, Jacobse J, Goettel JA, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT. Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation. Sci Rep. 2023 Dec 12/15/2023; 13(1): 22368. PMID: 38102166, PMCID: PMC10724268, PII: 10.1038/s41598-023-49614-z, DOI: 10.1038/s41598-023-49614-z, ISSN: 2045-2322.
Latour YL, McNamara KM, Allaman MM, Barry DP, Smith TM, Asim M, Williams KJ, Hawkins CV, Jacobse J, Goettel JA, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT. Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation. Sci Rep. 2023 Dec 12/15/2023; 13(1): 22368. PMID: 38102166, PMCID: PMC10724268, PII: 10.1038/s41598-023-49614-z, DOI: 10.1038/s41598-023-49614-z, ISSN: 2045-2322.
Kaur H, Ali SA, Short SP, Williams CS, Goettel JA, Washington MK, Peek RM, Acra SA, Yan F. Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis. Gut Microbes [print-electronic]. 2023 Dec; 15(2): 2264456. PMID: 37815528, PMCID: PMC10566403, DOI: 10.1080/19490976.2023.2264456, ISSN: 1949-0984.
Kaur H, Ali SA, Short SP, Williams CS, Goettel JA, Washington MK, Peek RM, Acra SA, Yan F. Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis. Gut Microbes [print-electronic]. 2023 Dec; 15(2): 2264456. PMID: 37815528, PMCID: PMC10566403, DOI: 10.1080/19490976.2023.2264456, ISSN: 1949-0984.
Williams C, Brown R, Zhao Y, Wang J, Chen Z, Blunt K, Pilat J, Parang B, Choksi Y, Lau K, Hiebert S, Short S, Jacobse J, Xu Y, Yang Y, Goettel J. MTGR1 is required to maintain small intestinal stem cell populations. Res Sq. 2023 Sep 9/21/2023; PMID: 37790452, PMCID: PMC10543309, PII: rs.3.rs-3315071, DOI: 10.21203/rs.3.rs-3315071/v1, ISSN: 2693-5015.
Pilat JM, Brown RE, Chen Z, Berle NJ, Othon AP, Washington MK, Anant SA, Kurokawa S, Ng VH, Thompson JJ, Jacobse J, Goettel JA, Lee E, Choksi YA, Lau KS, Short SP, Williams CS. SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. J Clin Invest. 2023 Jul 7/3/2023; 133(13): PMID: 37166989, PMCID: PMC10313376, PII: 165988, DOI: 10.1172/JCI165988, ISSN: 1558-8238.
Pilat JM, Brown RE, Chen Z, Berle NJ, Othon AP, Washington MK, Anant SA, Kurokawa S, Ng VH, Thompson JJ, Jacobse J, Goettel JA, Lee E, Choksi YA, Lau KS, Short SP, Williams CS. SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. J Clin Invest. 2023 Jul 7/3/2023; 133(13): PMID: 37166989, PMCID: PMC10313376, PII: 165988, DOI: 10.1172/JCI165988, ISSN: 1558-8238.
Jacobse J, Aziz Z, Sun L, Chaparro J, Pilat JM, Kwag A, Buendia M, Wimbiscus M, Nasu M, Saito T, Mine S, Orita H, Revetta F, Short SP, Washington MK, Hiremath G, Gibson MK, Coburn L, Koyama T, Goettel JA, Williams CS, Choksi YA. Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma. BioRxiv. 2023 Jun 6/5/2023; PMID: 37333285, PMCID: PMC10274643, PII: 2023.06.01.543287, DOI: 10.1101/2023.06.01.543287, ISSN: 2692-8205.
Jacobse J, Brown RE, Li J, Pilat JM, Pham L, Short SP, Peek CT, Rolong A, Washington MK, Martinez-Barricarte R, Byndloss MX, Shelton C, Markle JG, Latour YL, Allaman MM, Cassat JE, Wilson KT, Choksi YA, Williams CS, Lau KS, Flynn CR, Casanova JL, Rings EHHM, Samsom JN, Goettel JA. Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells. Cell Rep [print-electronic]. 2023 Feb 2/28/2023; 42(2): 112128. PMID: 36807140, PMCID: PMC10432575, PII: S2211-1247(23)00139-0, DOI: 10.1016/j.celrep.2023.112128, ISSN: 2211-1247.
Jacobse J, Brown RE, Li J, Pilat JM, Pham L, Short SP, Peek CT, Rolong A, Washington MK, Martinez-Barricarte R, Byndloss MX, Shelton C, Markle JG, Latour YL, Allaman MM, Cassat JE, Wilson KT, Choksi YA, Williams CS, Lau KS, Flynn CR, Casanova JL, Rings EHHM, Samsom JN, Goettel JA. Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells. Cell Rep [print-electronic]. 2023 Feb 2/28/2023; 42(2): 112128. PMID: 36807140, PMCID: PMC10432575, PII: S2211-1247(23)00139-0, DOI: 10.1016/j.celrep.2023.112128, ISSN: 2211-1247.
Tigue ML, Loberg MA, Goettel JA, Weiss WA, Lee E, Weiss VL. Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages. Cancer Res. 2023 Jan 1/4/2023; 83(1): 3-11. PMID: 36214645, PMCID: PMC9812914, PII: 711847, DOI: 10.1158/0008-5472.CAN-22-1403, ISSN: 1538-7445.
Tigue ML, Loberg MA, Goettel JA, Weiss WA, Lee E, Weiss VL. Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages. Cancer Res. 2023 Jan 1/4/2023; 83(1): 3-11. PMID: 36214645, PMCID: PMC9812914, PII: 711847, DOI: 10.1158/0008-5472.CAN-22-1403, ISSN: 1538-7445.
Jacobse J, Pilat JM, Li J, Brown RE, Kwag A, Buendia MA, Choksi YA, Washington MK, Williams CS, Markham NO, Short SP, Goettel JA. Distinct roles for interleukin-23 receptor signaling in regulatory T cells in sporadic and inflammation-associated carcinogenesis. Front Oncol. 2023; 13: 1276743. PMID: 38375204, PMCID: PMC10876294, DOI: 10.3389/fonc.2023.1276743, ISSN: 2234-943X.
Rajagopala SV, Shilts MH, Correa H, Das SR, Choksi YA, Jacobse J, Goettel JA, Hiremath G. Proton Pump Inhibitors Modulate Gene Expression Profile in Esophageal Mucosa and Microbiome. J Pediatr Pharmacol Ther [print-electronic]. 2023; 28(6): 504-8. PMID: 38130344, PMCID: PMC10731942, DOI: 10.5863/1551-6776-28.6.504, ISSN: 1551-6776.
Jacobse J, Aziz Z, Sun L, Chaparro J, Pilat JM, Kwag A, Buendia M, Wimbiscus M, Nasu M, Saito T, Mine S, Orita H, Revetta F, Short SP, Kay Washington M, Hiremath G, Gibson MK, Coburn LA, Koyama T, Goettel JA, Williams CS, Choksi YA. Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell Carcinoma. Cell Mol Gastroenterol Hepatol [print-electronic]. 2023; 16(6): 961-83. PMID: 37574015, PMCID: PMC10630122, PII: S2352-345X(23)00149-2, DOI: 10.1016/j.jcmgh.2023.08.005, ISSN: 2352-345X.
Latour YL, Allaman MM, Barry DP, Smith TM, Williams KJ, McNamara KM, Jacobse J, Goettel JA, Delgado AG, Piazuelo MB, Zhao S, Gobert AP, Wilson KT. Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity. Gut Microbes. 2023; 15(1): 2192623. PMID: 36951501, PMCID: PMC10038039, DOI: 10.1080/19490976.2023.2192623, ISSN: 1949-0984.
Latour YL, Allaman MM, Barry DP, Smith TM, Williams KJ, McNamara KM, Jacobse J, Goettel JA, Delgado AG, Piazuelo MB, Zhao S, Gobert AP, Wilson KT. Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity. Gut Microbes. 2023; 15(1): 2192623. PMID: 36951501, PMCID: PMC10038039, DOI: 10.1080/19490976.2023.2192623, ISSN: 1949-0984.
Jacobse J, Aziz Z, Sun L, Chaparro J, Pilat JM, Kwag A, Buendia M, Wimbiscus M, Nasu M, Saito T, Mine S, Orita H, Revetta F, Short SP, Kay Washington M, Hiremath G, Gibson MK, Coburn LA, Koyama T, Goettel JA, Williams CS, Choksi YA. Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell Carcinoma. Cell Mol Gastroenterol Hepatol [print-electronic]. 2023; 16(6): 961-83. PMID: 37574015, PMCID: PMC10630122, PII: S2352-345X(23)00149-2, DOI: 10.1016/j.jcmgh.2023.08.005, ISSN: 2352-345X.
Rajagopala SV, Shilts MH, Correa H, Das SR, Choksi YA, Jacobse J, Goettel JA, Hiremath G. Proton Pump Inhibitors Modulate Gene Expression Profile in Esophageal Mucosa and Microbiome. J Pediatr Pharmacol Ther [print-electronic]. 2023; 28(6): 504-8. PMID: 38130344, PMCID: PMC10731942, DOI: 10.5863/1551-6776-28.6.504, ISSN: 1551-6776.
Jacobse J, Pilat JM, Li J, Brown RE, Kwag A, Buendia MA, Choksi YA, Washington MK, Williams CS, Markham NO, Short SP, Goettel JA. Distinct roles for interleukin-23 receptor signaling in regulatory T cells in sporadic and inflammation-associated carcinogenesis. Front Oncol. 2023; 13: 1276743. PMID: 38375204, PMCID: PMC10876294, DOI: 10.3389/fonc.2023.1276743, ISSN: 2234-943X.
Latour YL, Sierra JC, Finley JL, Asim M, Barry DP, Allaman MM, Smith TM, McNamara KM, Luis PB, Schneider C, Jacobse J, Goettel JA, Calcutt MW, Rose KL, Schey KL, Milne GL, Delgado AG, Piazuelo MB, Paul BD, Snyder SH, Gobert AP, Wilson KT. Cystathionine ¿-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation. JCI Insight. 2022 Jun 6/22/2022; 7(12): PMID: 35579952, PMCID: PMC9309056, PII: 155338, DOI: 10.1172/jci.insight.155338, ISSN: 2379-3708.
Latour YL, Sierra JC, Finley JL, Asim M, Barry DP, Allaman MM, Smith TM, McNamara KM, Luis PB, Schneider C, Jacobse J, Goettel JA, Calcutt MW, Rose KL, Schey KL, Milne GL, Delgado AG, Piazuelo MB, Paul BD, Snyder SH, Gobert AP, Wilson KT. Cystathionine ¿-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation. JCI Insight. 2022 Jun 6/22/2022; 7(12): PMID: 35579952, PMCID: PMC9309056, PII: 155338, DOI: 10.1172/jci.insight.155338, ISSN: 2379-3708.
Brown RE, Jacobse J, Anant SA, Blunt KM, Chen B, Vega PN, Jones CT, Pilat JM, Revetta F, Gorby AH, Stengel KR, Choksi YA, Palin K, Piazuelo MB, Washington MK, Lau KS, Goettel JA, Hiebert SW, Short SP, Williams CS. MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors. JCI Insight. 2022 May 5/23/2022; 7(10): PMID: 35503250, PMCID: PMC9220854, PII: 153045, DOI: 10.1172/jci.insight.153045, ISSN: 2379-3708.
Brown RE, Jacobse J, Anant SA, Blunt KM, Chen B, Vega PN, Jones CT, Pilat JM, Revetta F, Gorby AH, Stengel KR, Choksi YA, Palin K, Piazuelo MB, Washington MK, Lau KS, Goettel JA, Hiebert SW, Short SP, Williams CS. MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors. JCI Insight. 2022 May 5/23/2022; 7(10): PMID: 35503250, PMCID: PMC9220854, PII: 153045, DOI: 10.1172/jci.insight.153045, ISSN: 2379-3708.
Dixon BREA, Lee TJ, Contreras Healey DC, Li J, Goettel JA, Piazuelo MB, Algood HMS. IL-17 Receptor Signaling through IL-17A or IL-17F Is Sufficient to Maintain Innate Response and Control of Helicobacter pylori Immunopathogenesis. Immunohorizons. 2022 Feb 2/10/2022; 6(2): 116-29. PMID: 35144998, PMCID: PMC9364271, PII: immunohorizons.2000072, DOI: 10.4049/immunohorizons.2000072, ISSN: 2573-7732.
Dixon BREA, Lee TJ, Contreras Healey DC, Li J, Goettel JA, Piazuelo MB, Algood HMS. IL-17 Receptor Signaling through IL-17A or IL-17F Is Sufficient to Maintain Innate Response and Control of Helicobacter pylori Immunopathogenesis. Immunohorizons. 2022 Feb 2/10/2022; 6(2): 116-29. PMID: 35144998, PMCID: PMC9364271, PII: immunohorizons.2000072, DOI: 10.4049/immunohorizons.2000072, ISSN: 2573-7732.
Peek CT, Ford CA, Eichelberger KR, Jacobse J, Torres TP, Maseda D, Latour YL, Piazuelo MB, Johnson JR, Byndloss MX, Wilson KT, Rathmell JC, Goettel JA, Cassat JE. Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss. Cell Mol Gastroenterol Hepatol [print-electronic]. 2022; 14(4): 731-50. PMID: 35835390, PMCID: PMC9420375, PII: S2352-345X(22)00160-6, DOI: 10.1016/j.jcmgh.2022.07.002, ISSN: 2352-345X.
Peek CT, Ford CA, Eichelberger KR, Jacobse J, Torres TP, Maseda D, Latour YL, Piazuelo MB, Johnson JR, Byndloss MX, Wilson KT, Rathmell JC, Goettel JA, Cassat JE. Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss. Cell Mol Gastroenterol Hepatol [print-electronic]. 2022; 14(4): 731-50. PMID: 35835390, PMCID: PMC9420375, PII: S2352-345X(22)00160-6, DOI: 10.1016/j.jcmgh.2022.07.002, ISSN: 2352-345X.
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell [print-electronic]. 2021 Dec 12/22/2021; 184(26): 6262-6280.e26-6280.e26. PMID: 34910928, PMCID: PMC8941949, PII: S0092-8674(21)01381-7, DOI: 10.1016/j.cell.2021.11.031, ISSN: 1097-4172.
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell [print-electronic]. 2021 Dec 12/22/2021; 184(26): 6262-6280.e26-6280.e26. PMID: 34910928, PMCID: PMC8941949, PII: S0092-8674(21)01381-7, DOI: 10.1016/j.cell.2021.11.031, ISSN: 1097-4172.
Tsou AM, Goettel JA, Bao B, Biswas A, Kang YH, Redhu NS, Peng K, Putzel GG, Saltzman J, Kelly R, Gringauz J, Barends J, Hatazaki M, Frei SM, Emani R, Huang Y, Shen Z, Fox JG, Glickman JN, Horwitz BH, Snapper SB. Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation. Microbiome. 2021 Nov 11/3/2021; 9(1): 215. PMID: 34732258, PMCID: PMC8565002, PII: 10.1186/s40168-021-01161-3, DOI: 10.1186/s40168-021-01161-3, ISSN: 2049-2618.
Tsou AM, Goettel JA, Bao B, Biswas A, Kang YH, Redhu NS, Peng K, Putzel GG, Saltzman J, Kelly R, Gringauz J, Barends J, Hatazaki M, Frei SM, Emani R, Huang Y, Shen Z, Fox JG, Glickman JN, Horwitz BH, Snapper SB. Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation. Microbiome. 2021 Nov 11/3/2021; 9(1): 215. PMID: 34732258, PMCID: PMC8565002, PII: 10.1186/s40168-021-01161-3, DOI: 10.1186/s40168-021-01161-3, ISSN: 2049-2618.
Jacobse J, Li J, Rings EHHM, Samsom JN, Goettel JA. Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease. Front Immunol. 2021; 12: 716499. PMID: 34421921, PMCID: PMC8371910, DOI: 10.3389/fimmu.2021.716499, ISSN: 1664-3224.
Tyagi RK, Jacobse J, Li J, Allaman MM, Otipoby KL, Sampson ER, Wilson KT, Goettel JA. HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice. Front Immunol. 2021; 12: 630204. PMID: 33717161, PMCID: PMC7945590, DOI: 10.3389/fimmu.2021.630204, ISSN: 1664-3224.
Tyagi RK, Jacobse J, Li J, Allaman MM, Otipoby KL, Sampson ER, Wilson KT, Goettel JA. HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice. Front Immunol. 2021; 12: 630204. PMID: 33717161, PMCID: PMC7945590, DOI: 10.3389/fimmu.2021.630204, ISSN: 1664-3224.
Jacobse J, Li J, Rings EHHM, Samsom JN, Goettel JA. Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease. Front Immunol. 2021; 12: 716499. PMID: 34421921, PMCID: PMC8371910, DOI: 10.3389/fimmu.2021.716499, ISSN: 1664-3224.
Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ, Southard-Smith AN, Allaman MM, White JR, Macedonia MC, Mckinley ET, Ramirez-Solano MA, Scoville EA, Liu Q, Wilson KT, Coffey RJ, Washington MK, Goettel JA, Lau KS. Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation. Gastroenterology [print-electronic]. 2020 Dec; 159(6): 2101-2115.e5-2115.e5. PMID: 32828819, PMCID: PMC7725941, PII: S0016-5085(20)35068-X, DOI: 10.1053/j.gastro.2020.08.029, ISSN: 1528-0012.
Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ, Southard-Smith AN, Allaman MM, White JR, Macedonia MC, Mckinley ET, Ramirez-Solano MA, Scoville EA, Liu Q, Wilson KT, Coffey RJ, Washington MK, Goettel JA, Lau KS. Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation. Gastroenterology [print-electronic]. 2020 Dec; 159(6): 2101-2115.e5-2115.e5. PMID: 32828819, PMCID: PMC7725941, PII: S0016-5085(20)35068-X, DOI: 10.1053/j.gastro.2020.08.029, ISSN: 1528-0012.
Tyagi RK, Li J, Jacobse J, Snapper SB, Shouval DS, Goettel JA. Humanized mouse models of genetic immune disorders and hematological malignancies. Biochem Pharmacol [print-electronic]. 2020 Apr; 174: 113671. PMID: 31634456, PMCID: PMC7050416, PII: S0006-2952(19)30370-3, DOI: 10.1016/j.bcp.2019.113671, ISSN: 1873-2968.
Tyagi RK, Li J, Jacobse J, Snapper SB, Shouval DS, Goettel JA. Humanized mouse models of genetic immune disorders and hematological malignancies. Biochem Pharmacol [print-electronic]. 2020 Apr; 174: 113671. PMID: 31634456, PMCID: PMC7050416, PII: S0006-2952(19)30370-3, DOI: 10.1016/j.bcp.2019.113671, ISSN: 1873-2968.
Goettel JA, Kotlarz D, Emani R, Canavan JB, Konnikova L, Illig D, Frei SM, Field M, Kowalik M, Peng K, Gringauz J, Mitsialis V, Wall SM, Tsou A, Griffith AE, Huang Y, Friedman JR, Towne JE, Plevy SE, O'Hara Hall A, Snapper SB. Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model [letter]. Cell Mol Gastroenterol Hepatol [print-electronic]. 2019; 8(2): 193-5. PMID: 31078723, PMCID: PMC6661391, PII: S2352-345X(19)30062-1, DOI: 10.1016/j.jcmgh.2019.05.001, ISSN: 2352-345X.
Ryzhakov G, West NR, Franchini F, Clare S, Ilott NE, Sansom SN, Bullers SJ, Pearson C, Costain A, Vaughan-Jackson A, Goettel JA, Ermann J, Horwitz BH, Buti L, Lu X, Mukhopadhyay S, Snapper SB, Powrie F. Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nat Commun. 2018 Sep 9/18/2018; 9(1): 3797. PMID: 30228258, PMCID: PMC6143560, PII: 10.1038/s41467-018-06085-5, DOI: 10.1038/s41467-018-06085-5, ISSN: 2041-1723.
Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 May 5/3/2018; 9(1): 1779. PMID: 29725003, PMCID: PMC5934380, PII: 10.1038/s41467-018-03670-6, DOI: 10.1038/s41467-018-03670-6, ISSN: 2041-1723.
Shouval DS, Konnikova L, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, Yanagi T, Beier R, Conklin LS, Ebens CL, Santos FGMS, Sherlock M, Goldsmith JD, Kotlarz D, Glover SC, Shah N, Bousvaros A, Uhlig HH, Muise AM, Klein C, Snapper SB. Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. Inflamm Bowel Dis. 2017 Nov; 23(11): 1950-61. PMID: 29023267, DOI: 10.1097/MIB.0000000000001270, ISSN: 1536-4844.
Redhu NS, Bakthavatchalu V, Conaway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, Snapper SB, Horwitz BH. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017 Jul 7/5/2017; 6: PMID: 28678006, PMCID: PMC5531923, DOI: 10.7554/eLife.27652, ISSN: 2050-084X.
Lexmond WS, Goettel JA, Sallis BF, McCann K, Rings EHHM, Jensen-Jarolim E, Nurko S, Snapper SB, Fiebiger E. Spontaneous food allergy in Was(-/-) mice occurs independent of FceRI-mediated mast cell activation. Allergy [print-electronic]. 2017 Jun 6/10/2017; PMID: 28600891, DOI: 10.1111/all.13219, ISSN: 1398-9995.
Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature [print-electronic]. 2017 May 5/25/2017; 545(7655): 432-8. PMID: 28514439, PII: nature22370, DOI: 10.1038/nature22370, ISSN: 1476-4687.
Schoellhammer CM, Lauwers GY, Goettel JA, Oberli MA, Cleveland C, Park JY, Minahan D, Chen Y, Anderson DG, Jaklenec A, Snapper SB, Langer R, Traverso G. Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice. Gastroenterology [print-electronic]. 2017 Apr; 152(5): 1151-60. PMID: 28088460, PMCID: PMC5368009, PII: S0016-5085(17)30013-6, DOI: 10.1053/j.gastro.2017.01.002, ISSN: 1528-0012.
Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Jan 1/17/2017; 114(3): 568-73. PMID: 28049834, PMCID: PMC5255594, PII: 1612921114, DOI: 10.1073/pnas.1612921114, ISSN: 1091-6490.
Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Rep. 2016 Oct 10/25/2016; 17(5): 1318-29. PMID: 27783946, PMCID: PMC5106873, PII: S2211-1247(16)31355-9, DOI: 10.1016/j.celrep.2016.09.082, ISSN: 2211-1247.
Lexmond WS, Goettel JA, Lyons JJ, Jacobse J, Deken MM, Lawrence MG, DiMaggio TH, Kotlarz D, Garabedian E, Sackstein P, Nelson CC, Jones N, Stone KD, Candotti F, Rings EH, Thrasher AJ, Milner JD, Snapper SB, Fiebiger E. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J. Clin. Invest [print-electronic]. 2016 Oct 10/3/2016; 126(10): 4030-44. PMID: 27643438, PMCID: PMC5096801, PII: 85129, DOI: 10.1172/JCI85129, ISSN: 1558-8238.
Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 Sep 9/29/2016; 17(1): 201. PMID: 27687735, PMCID: PMC5043525, PII: 10.1186/s13059-016-1062-5, DOI: 10.1186/s13059-016-1062-5, ISSN: 1474-760X.
Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood [print-electronic]. 2015 Jun 6/18/2015; 125(25): 3886-95. PMID: 25833964, PMCID: PMC4473116, PII: blood-2014-12-618363, DOI: 10.1182/blood-2014-12-618363, ISSN: 1528-0020.
Vucovich MM, Cotton RB, Shelton EL, Goettel JA, Ehinger NJ, Poole SD, Brown N, Wynn JL, Paria BC, Slaughter JC, Clark RH, Rojas MA, Reese J. Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): H732-40. PMID: 24993047, PMCID: PMC4187398, PII: ajpheart.00838.2013, DOI: 10.1152/ajpheart.00838.2013, ISSN: 1522-1539.
Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity [print-electronic]. 2014 May 5/15/2014; 40(5): 706-19. PMID: 24792912, PMCID: PMC4513358, PII: S1074-7613(14)00125-3, DOI: 10.1016/j.immuni.2014.03.011, ISSN: 1097-4180.
Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, Muise AM, Snapper SB. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv. Immunol. 2014; 122: 177-210. PMID: 24507158, PMCID: PMC4741283, PII: B978-0-12-800267-4.00005-5, DOI: 10.1016/B978-0-12-800267-4.00005-5, ISSN: 1557-8445.
Nguyen DD, Muthupalani S, Goettel JA, Eston MA, Mobley M, Taylor NS, McCabe A, Marin R, Snapper SB, Fox JG. Colitis and colon cancer in WASP-deficient mice require helicobacter species. Inflamm. Bowel Dis. 2013 Sep; 19(10): 2041-50. PMID: 23820270, PMCID: PMC4082694, DOI: 10.1097/MIB.0b013e318295fd8f, ISSN: 1536-4844.
Lexmond WS, Pardo M, Rooney K, Goettel JA, Snapper SB, Yen EH, Dehlink E, Nurko S, Fiebiger E. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin. Exp. Allergy. 2013 Aug; 43(8): 902-13. PMID: 23889244, PMCID: PMC3728707, DOI: 10.1111/cea.12146, ISSN: 1365-2222.
Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut [print-electronic]. 2013 Jan; 62(1): 73-82. PMID: 22267598, PMCID: PMC3606820, PII: gutjnl-2011-301551, DOI: 10.1136/gutjnl-2011-301551, ISSN: 1468-3288.
Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology [print-electronic]. 2012 Sep; 143(3): 719-729.e2. PMID: 22710191, PMCID: PMC3760724, PII: S0016-5085(12)00824-4, DOI: 10.1053/j.gastro.2012.06.008, ISSN: 1528-0012.
Hobbs SS, Goettel JA, Liang D, Yan F, Edelblum KL, Frey MR, Mullane MT, Polk DB. TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2011 Aug; 301(2): G220-9. PMID: 21566012, PMCID: PMC3154604, PII: ajpgi.00383.2010, DOI: 10.1152/ajpgi.00383.2010, ISSN: 1522-1547.
Zhang Y, Li X, Carpinteiro A, Goettel JA, Soddemann M, Gulbins E. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat. Med [print-electronic]. 2011 Mar; 17(3): 341-6. PMID: 21297617, PII: nm.2296, DOI: 10.1038/nm.2296, ISSN: 1546-170X.
Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB. KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp. Cell Res [print-electronic]. 2011 Feb 2/15/2011; 317(4): 452-63. PMID: 21144847, PMCID: PMC3038243, PII: S0014-4827(10)00547-1, DOI: 10.1016/j.yexcr.2010.11.018, ISSN: 1090-2422.
Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-¿ production. Gastroenterology [print-electronic]. 2011 Jan; 140(1): 265-74. PMID: 20875416, PMCID: PMC3008308, PII: S0016-5085(10)01421-6, DOI: 10.1053/j.gastro.2010.09.041, ISSN: 1528-0012.
Edelblum KL, Goettel JA, Koyama T, McElroy SJ, Yan F, Polk DB. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J. Biol. Chem [print-electronic]. 2008 Oct 10/24/2008; 283(43): 29485-94. PMID: 18713739, PMCID: PMC2570867, PII: M801269200, DOI: 10.1074/jbc.M801269200, ISSN: 0021-9258.
McElroy SJ, Frey MR, Yan F, Edelblum KL, Goettel JA, John S, Polk DB. Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2008 Aug; 295(2): G285-93. PMID: 18467504, PMCID: PMC2519857, PII: 00425.2007, DOI: 10.1152/ajpgi.00425.2007, ISSN: 0193-1857.
Spencer PN, Brown ME, Smith EP, Wang J, Kim W, Spiga L, Tasneem N, Simmons AJ, Kim T, Yang Y, Xu Y, Zheng L, Ro J, Kaur H, Kang SW, Helou MD, Lee MA, Arceneaux D, Mueller KD, Kuddar OS, Harned MH, Li J, Banerjee A, Markham NO, Wilson KT, Coburn LA, Goettel JA, Liu Q, Washington MK, Valdivia RH, Zhu W, Lau KS. Pathobiont-triggered induction of goblet cell response drives regional susceptibility to inflammatory bowel disease. J Clin Invest. 2026 Apr 4/1/2026; 136(7): PMID: 41701533, PMCID: PMC13038202, PII: 201729, DOI: 10.1172/JCI201729, ISSN: 1558-8238.
Rusznak M, Toki S, Hao Y, Todd MJC, Malone L, Goodhead JF, DuPuy C, Zhou W, Babin D, Warren CM, Abney M, Stier MT, Thomas CM, Li J, Jacobse J, Pahnke AP, Petrovic MI, Cephus JY, Kuehnle SN, Calcutt MW, Norlander AE, Yan F, Goettel JA, Miller DR, Lynch RM, Cook DP, Newcomb DC, Zou F, Peebles RS. Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming. Nat Commun. 2026 Jan 1/3/2026; 17(1): 1053. PMID: 41484153, PMCID: PMC12847941, PII: 10.1038/s41467-025-67813-2, DOI: 10.1038/s41467-025-67813-2, ISSN: 2041-1723.
Rusznak M, Toki S, Hao Y, Todd MJC, Malone L, Goodhead JF, DuPuy C, Zhou W, Babin D, Warren CM, Abney M, Stier MT, Thomas CM, Li J, Jacobse J, Pahnke AP, Petrovic MI, Cephus JY, Kuehnle SN, Calcutt MW, Norlander AE, Yan F, Goettel JA, Miller DR, Lynch RM, Cook DP, Newcomb DC, Zou F, Peebles RS. Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming. Nat Commun. 2026 Jan 1/3/2026; 17(1): 1053. PMID: 41484153, PMCID: PMC12847941, PII: 10.1038/s41467-025-67813-2, DOI: 10.1038/s41467-025-67813-2, ISSN: 2041-1723.
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Dixon BREA, Lee TJ, Contreras Healey DC, Li J, Goettel JA, Piazuelo MB, Algood HMS. IL-17 Receptor Signaling through IL-17A or IL-17F Is Sufficient to Maintain Innate Response and Control of Helicobacter pylori Immunopathogenesis. Immunohorizons. 2022 Feb 2/10/2022; 6(2): 116-29. PMID: 35144998, PMCID: PMC9364271, PII: immunohorizons.2000072, DOI: 10.4049/immunohorizons.2000072, ISSN: 2573-7732.
Peek CT, Ford CA, Eichelberger KR, Jacobse J, Torres TP, Maseda D, Latour YL, Piazuelo MB, Johnson JR, Byndloss MX, Wilson KT, Rathmell JC, Goettel JA, Cassat JE. Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss. Cell Mol Gastroenterol Hepatol [print-electronic]. 2022; 14(4): 731-50. PMID: 35835390, PMCID: PMC9420375, PII: S2352-345X(22)00160-6, DOI: 10.1016/j.jcmgh.2022.07.002, ISSN: 2352-345X.
Peek CT, Ford CA, Eichelberger KR, Jacobse J, Torres TP, Maseda D, Latour YL, Piazuelo MB, Johnson JR, Byndloss MX, Wilson KT, Rathmell JC, Goettel JA, Cassat JE. Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss. Cell Mol Gastroenterol Hepatol [print-electronic]. 2022; 14(4): 731-50. PMID: 35835390, PMCID: PMC9420375, PII: S2352-345X(22)00160-6, DOI: 10.1016/j.jcmgh.2022.07.002, ISSN: 2352-345X.
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell [print-electronic]. 2021 Dec 12/22/2021; 184(26): 6262-6280.e26-6280.e26. PMID: 34910928, PMCID: PMC8941949, PII: S0092-8674(21)01381-7, DOI: 10.1016/j.cell.2021.11.031, ISSN: 1097-4172.
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell [print-electronic]. 2021 Dec 12/22/2021; 184(26): 6262-6280.e26-6280.e26. PMID: 34910928, PMCID: PMC8941949, PII: S0092-8674(21)01381-7, DOI: 10.1016/j.cell.2021.11.031, ISSN: 1097-4172.
Tsou AM, Goettel JA, Bao B, Biswas A, Kang YH, Redhu NS, Peng K, Putzel GG, Saltzman J, Kelly R, Gringauz J, Barends J, Hatazaki M, Frei SM, Emani R, Huang Y, Shen Z, Fox JG, Glickman JN, Horwitz BH, Snapper SB. Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation. Microbiome. 2021 Nov 11/3/2021; 9(1): 215. PMID: 34732258, PMCID: PMC8565002, PII: 10.1186/s40168-021-01161-3, DOI: 10.1186/s40168-021-01161-3, ISSN: 2049-2618.
Tsou AM, Goettel JA, Bao B, Biswas A, Kang YH, Redhu NS, Peng K, Putzel GG, Saltzman J, Kelly R, Gringauz J, Barends J, Hatazaki M, Frei SM, Emani R, Huang Y, Shen Z, Fox JG, Glickman JN, Horwitz BH, Snapper SB. Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation. Microbiome. 2021 Nov 11/3/2021; 9(1): 215. PMID: 34732258, PMCID: PMC8565002, PII: 10.1186/s40168-021-01161-3, DOI: 10.1186/s40168-021-01161-3, ISSN: 2049-2618.
Jacobse J, Li J, Rings EHHM, Samsom JN, Goettel JA. Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease. Front Immunol. 2021; 12: 716499. PMID: 34421921, PMCID: PMC8371910, DOI: 10.3389/fimmu.2021.716499, ISSN: 1664-3224.
Tyagi RK, Jacobse J, Li J, Allaman MM, Otipoby KL, Sampson ER, Wilson KT, Goettel JA. HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice. Front Immunol. 2021; 12: 630204. PMID: 33717161, PMCID: PMC7945590, DOI: 10.3389/fimmu.2021.630204, ISSN: 1664-3224.
Tyagi RK, Jacobse J, Li J, Allaman MM, Otipoby KL, Sampson ER, Wilson KT, Goettel JA. HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice. Front Immunol. 2021; 12: 630204. PMID: 33717161, PMCID: PMC7945590, DOI: 10.3389/fimmu.2021.630204, ISSN: 1664-3224.
Jacobse J, Li J, Rings EHHM, Samsom JN, Goettel JA. Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease. Front Immunol. 2021; 12: 716499. PMID: 34421921, PMCID: PMC8371910, DOI: 10.3389/fimmu.2021.716499, ISSN: 1664-3224.
Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ, Southard-Smith AN, Allaman MM, White JR, Macedonia MC, Mckinley ET, Ramirez-Solano MA, Scoville EA, Liu Q, Wilson KT, Coffey RJ, Washington MK, Goettel JA, Lau KS. Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation. Gastroenterology [print-electronic]. 2020 Dec; 159(6): 2101-2115.e5-2115.e5. PMID: 32828819, PMCID: PMC7725941, PII: S0016-5085(20)35068-X, DOI: 10.1053/j.gastro.2020.08.029, ISSN: 1528-0012.
Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ, Southard-Smith AN, Allaman MM, White JR, Macedonia MC, Mckinley ET, Ramirez-Solano MA, Scoville EA, Liu Q, Wilson KT, Coffey RJ, Washington MK, Goettel JA, Lau KS. Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation. Gastroenterology [print-electronic]. 2020 Dec; 159(6): 2101-2115.e5-2115.e5. PMID: 32828819, PMCID: PMC7725941, PII: S0016-5085(20)35068-X, DOI: 10.1053/j.gastro.2020.08.029, ISSN: 1528-0012.
Tyagi RK, Li J, Jacobse J, Snapper SB, Shouval DS, Goettel JA. Humanized mouse models of genetic immune disorders and hematological malignancies. Biochem Pharmacol [print-electronic]. 2020 Apr; 174: 113671. PMID: 31634456, PMCID: PMC7050416, PII: S0006-2952(19)30370-3, DOI: 10.1016/j.bcp.2019.113671, ISSN: 1873-2968.
Tyagi RK, Li J, Jacobse J, Snapper SB, Shouval DS, Goettel JA. Humanized mouse models of genetic immune disorders and hematological malignancies. Biochem Pharmacol [print-electronic]. 2020 Apr; 174: 113671. PMID: 31634456, PMCID: PMC7050416, PII: S0006-2952(19)30370-3, DOI: 10.1016/j.bcp.2019.113671, ISSN: 1873-2968.
Goettel JA, Kotlarz D, Emani R, Canavan JB, Konnikova L, Illig D, Frei SM, Field M, Kowalik M, Peng K, Gringauz J, Mitsialis V, Wall SM, Tsou A, Griffith AE, Huang Y, Friedman JR, Towne JE, Plevy SE, O'Hara Hall A, Snapper SB. Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model [letter]. Cell Mol Gastroenterol Hepatol [print-electronic]. 2019; 8(2): 193-5. PMID: 31078723, PMCID: PMC6661391, PII: S2352-345X(19)30062-1, DOI: 10.1016/j.jcmgh.2019.05.001, ISSN: 2352-345X.
Ryzhakov G, West NR, Franchini F, Clare S, Ilott NE, Sansom SN, Bullers SJ, Pearson C, Costain A, Vaughan-Jackson A, Goettel JA, Ermann J, Horwitz BH, Buti L, Lu X, Mukhopadhyay S, Snapper SB, Powrie F. Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nat Commun. 2018 Sep 9/18/2018; 9(1): 3797. PMID: 30228258, PMCID: PMC6143560, PII: 10.1038/s41467-018-06085-5, DOI: 10.1038/s41467-018-06085-5, ISSN: 2041-1723.
Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 May 5/3/2018; 9(1): 1779. PMID: 29725003, PMCID: PMC5934380, PII: 10.1038/s41467-018-03670-6, DOI: 10.1038/s41467-018-03670-6, ISSN: 2041-1723.
Shouval DS, Konnikova L, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, Yanagi T, Beier R, Conklin LS, Ebens CL, Santos FGMS, Sherlock M, Goldsmith JD, Kotlarz D, Glover SC, Shah N, Bousvaros A, Uhlig HH, Muise AM, Klein C, Snapper SB. Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. Inflamm Bowel Dis. 2017 Nov; 23(11): 1950-61. PMID: 29023267, DOI: 10.1097/MIB.0000000000001270, ISSN: 1536-4844.
Redhu NS, Bakthavatchalu V, Conaway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, Snapper SB, Horwitz BH. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017 Jul 7/5/2017; 6: PMID: 28678006, PMCID: PMC5531923, DOI: 10.7554/eLife.27652, ISSN: 2050-084X.
Lexmond WS, Goettel JA, Sallis BF, McCann K, Rings EHHM, Jensen-Jarolim E, Nurko S, Snapper SB, Fiebiger E. Spontaneous food allergy in Was(-/-) mice occurs independent of FceRI-mediated mast cell activation. Allergy [print-electronic]. 2017 Jun 6/10/2017; PMID: 28600891, DOI: 10.1111/all.13219, ISSN: 1398-9995.
Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature [print-electronic]. 2017 May 5/25/2017; 545(7655): 432-8. PMID: 28514439, PII: nature22370, DOI: 10.1038/nature22370, ISSN: 1476-4687.
Schoellhammer CM, Lauwers GY, Goettel JA, Oberli MA, Cleveland C, Park JY, Minahan D, Chen Y, Anderson DG, Jaklenec A, Snapper SB, Langer R, Traverso G. Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice. Gastroenterology [print-electronic]. 2017 Apr; 152(5): 1151-60. PMID: 28088460, PMCID: PMC5368009, PII: S0016-5085(17)30013-6, DOI: 10.1053/j.gastro.2017.01.002, ISSN: 1528-0012.
Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Jan 1/17/2017; 114(3): 568-73. PMID: 28049834, PMCID: PMC5255594, PII: 1612921114, DOI: 10.1073/pnas.1612921114, ISSN: 1091-6490.
Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Rep. 2016 Oct 10/25/2016; 17(5): 1318-29. PMID: 27783946, PMCID: PMC5106873, PII: S2211-1247(16)31355-9, DOI: 10.1016/j.celrep.2016.09.082, ISSN: 2211-1247.
Lexmond WS, Goettel JA, Lyons JJ, Jacobse J, Deken MM, Lawrence MG, DiMaggio TH, Kotlarz D, Garabedian E, Sackstein P, Nelson CC, Jones N, Stone KD, Candotti F, Rings EH, Thrasher AJ, Milner JD, Snapper SB, Fiebiger E. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J. Clin. Invest [print-electronic]. 2016 Oct 10/3/2016; 126(10): 4030-44. PMID: 27643438, PMCID: PMC5096801, PII: 85129, DOI: 10.1172/JCI85129, ISSN: 1558-8238.
Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 Sep 9/29/2016; 17(1): 201. PMID: 27687735, PMCID: PMC5043525, PII: 10.1186/s13059-016-1062-5, DOI: 10.1186/s13059-016-1062-5, ISSN: 1474-760X.
Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood [print-electronic]. 2015 Jun 6/18/2015; 125(25): 3886-95. PMID: 25833964, PMCID: PMC4473116, PII: blood-2014-12-618363, DOI: 10.1182/blood-2014-12-618363, ISSN: 1528-0020.
Vucovich MM, Cotton RB, Shelton EL, Goettel JA, Ehinger NJ, Poole SD, Brown N, Wynn JL, Paria BC, Slaughter JC, Clark RH, Rojas MA, Reese J. Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): H732-40. PMID: 24993047, PMCID: PMC4187398, PII: ajpheart.00838.2013, DOI: 10.1152/ajpheart.00838.2013, ISSN: 1522-1539.
Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity [print-electronic]. 2014 May 5/15/2014; 40(5): 706-19. PMID: 24792912, PMCID: PMC4513358, PII: S1074-7613(14)00125-3, DOI: 10.1016/j.immuni.2014.03.011, ISSN: 1097-4180.
Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, Muise AM, Snapper SB. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv. Immunol. 2014; 122: 177-210. PMID: 24507158, PMCID: PMC4741283, PII: B978-0-12-800267-4.00005-5, DOI: 10.1016/B978-0-12-800267-4.00005-5, ISSN: 1557-8445.
Nguyen DD, Muthupalani S, Goettel JA, Eston MA, Mobley M, Taylor NS, McCabe A, Marin R, Snapper SB, Fox JG. Colitis and colon cancer in WASP-deficient mice require helicobacter species. Inflamm. Bowel Dis. 2013 Sep; 19(10): 2041-50. PMID: 23820270, PMCID: PMC4082694, DOI: 10.1097/MIB.0b013e318295fd8f, ISSN: 1536-4844.
Lexmond WS, Pardo M, Rooney K, Goettel JA, Snapper SB, Yen EH, Dehlink E, Nurko S, Fiebiger E. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin. Exp. Allergy. 2013 Aug; 43(8): 902-13. PMID: 23889244, PMCID: PMC3728707, DOI: 10.1111/cea.12146, ISSN: 1365-2222.
Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut [print-electronic]. 2013 Jan; 62(1): 73-82. PMID: 22267598, PMCID: PMC3606820, PII: gutjnl-2011-301551, DOI: 10.1136/gutjnl-2011-301551, ISSN: 1468-3288.
Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology [print-electronic]. 2012 Sep; 143(3): 719-729.e2. PMID: 22710191, PMCID: PMC3760724, PII: S0016-5085(12)00824-4, DOI: 10.1053/j.gastro.2012.06.008, ISSN: 1528-0012.
Hobbs SS, Goettel JA, Liang D, Yan F, Edelblum KL, Frey MR, Mullane MT, Polk DB. TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2011 Aug; 301(2): G220-9. PMID: 21566012, PMCID: PMC3154604, PII: ajpgi.00383.2010, DOI: 10.1152/ajpgi.00383.2010, ISSN: 1522-1547.
Zhang Y, Li X, Carpinteiro A, Goettel JA, Soddemann M, Gulbins E. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat. Med [print-electronic]. 2011 Mar; 17(3): 341-6. PMID: 21297617, PII: nm.2296, DOI: 10.1038/nm.2296, ISSN: 1546-170X.
Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB. KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp. Cell Res [print-electronic]. 2011 Feb 2/15/2011; 317(4): 452-63. PMID: 21144847, PMCID: PMC3038243, PII: S0014-4827(10)00547-1, DOI: 10.1016/j.yexcr.2010.11.018, ISSN: 1090-2422.
Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-¿ production. Gastroenterology [print-electronic]. 2011 Jan; 140(1): 265-74. PMID: 20875416, PMCID: PMC3008308, PII: S0016-5085(10)01421-6, DOI: 10.1053/j.gastro.2010.09.041, ISSN: 1528-0012.
Edelblum KL, Goettel JA, Koyama T, McElroy SJ, Yan F, Polk DB. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J. Biol. Chem [print-electronic]. 2008 Oct 10/24/2008; 283(43): 29485-94. PMID: 18713739, PMCID: PMC2570867, PII: M801269200, DOI: 10.1074/jbc.M801269200, ISSN: 0021-9258.
McElroy SJ, Frey MR, Yan F, Edelblum KL, Goettel JA, John S, Polk DB. Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2008 Aug; 295(2): G285-93. PMID: 18467504, PMCID: PMC2519857, PII: 00425.2007, DOI: 10.1152/ajpgi.00425.2007, ISSN: 0193-1857.
Available Postdoctoral Position Details
Posted: 2/13/2018
Description:
There is an immediate opening for a post-doctoral fellow position in the laboratory of Dr. Jeremy Goettel in The Department of Medicine in the Division of Gastroenterology, Hepatology, and Nutrition at the Vanderbilt University Medical Center in Nashville Tennessee. The Goettel lab utilizes translational approaches to study mucosal immunity in both murine and humanized murine systems. Specifically, we will characterize the role of IL-23R in intestinal immune homeostasis as well as develop humanized murine systems to assess therapeutic strategies that promote or restore intestinal health. This project involves working with mouse models, primary human immune cells, and established cell lines. Our lab is a member of the Digestive Disease Research Center (DDRC) and the Center for Mucosal Inflammation and Cancer (CMIC) and offers a dynamic, multidisciplinary environment with close interaction with other basic and clinical scientists. This opportunity is for a highly motivated creative individual who can drive projects and ideas forward and offer new insight and approaches that will contribute to our understanding of basic scientific questions.
Requirements and Responsibilities:
• A PhD with strong background in immunology and publication record
• Experience with in vitro and in vivo immunological assays is especially desirable.
• Assist in training new graduate students and lab technicians.
• Proficient in flow cytometry and data analysis, qPCR, molecular biology techniques.
• Present data in lab and departmental meetings as well as national and international conferences.
• Manuscript and grant writing.
To apply:
Please contact Jeremy Goettel jeremy.goettel@vanderbilt.edu with CV, cover letter and references