Zahra Shajani Yi, Ph.D.

Assistant Professor
Faculty Appointments
Assistant Professor of Pathology, Microbiology and Immunology
Ph.D., Chemistry, University of Washington, Seattle, WashingtonB.S., Chemistry, University of British Columbia, Vancouver, Canada
Clinical Description
Dr. Zahra Shajani Yi is an assistant professor in the department of Pathology, Microbiology, and Immunology at Vanderbilt University School of Medicine, Associate Director of the Clinical Chemistry laboratory and Director of Esoteric Chemistry. Dr. Yi earned her BSc in chemistry from the University of British Columbia and PhD in chemistry from the University of Washington. She completed a postdoctoral fellowship at the Scripps Research Institute (TSRI) followed by a clinical fellowship in Clinical Chemistry at Dartmouth-Hitchcock Medical Center in New Hampshire. Dr. Yi’s research and clinical interests are primarily in endocrinology, developing best practices and laboratory test utilization. She is committed to teaching and mentoring pathology residents. Outside of work, she enjoys running, reading baking and spending time with her family. She has published as Dr. Shajani and currently publishes under Dr. Shajani-Yi.
Research Keywords
Endocrinology, Adrenal, PCOS, Reproductive Endocrinology
Clinical Research Keywords
Endocrinology, Clinical Chemistry, Test Utilization, Personalized Medicine and Resident Education
Rutherford NJ, Booth GS, Shajani-Yi Z. Where Did That Peak Come From?. Clin. Chem. 2018 Sep; 64(9): 1408-9. PMID: 30154200, PII: 64/9/1408, DOI: 10.1373/clinchem.2017.284620, ISSN: 1530-8561.

Shajani-Yi Z, Johnston AA, Casella SJ, Cervinski MA. Low serum alkaline phosphatase activity due to asymptomatic hypophosphatasia in a teenage girl. Clin. Biochem [print-electronic]. 2018 Jun 6/27/2018; PMID: 29958879, PII: S0009-9120(18)30345-X, DOI: 10.1016/j.clinbiochem.2018.06.018, ISSN: 1873-2933.

Cotten SW, Shajani-Yi Z, Cervinski MA, Voorhees T, Tuchman SA, Korpi-Steiner N. Reference intervals and diagnostic ranges for serum free ¿ and free ¿ immunoglobulin light chains vary by instrument platform: Implications for classification of patient results in a multi-center study. Clin. Biochem [print-electronic]. 2018 Jun 6/6/2018; PMID: 29885308, PII: S0009-9120(18)30233-9, DOI: 10.1016/j.clinbiochem.2018.06.003, ISSN: 1873-2933.

Rutherford NJ, Thoren KL, Shajani-Yi Z, Colby JM. Voxelotor (GBT440) produces interference in measurements of hemoglobin S [letter]. Clin. Chim. Acta. 2018 Mar 3/27/2018; 482(July 2018): 57-9. PMID: 29601794, PII: S0009-8981(18)30148-7, DOI: 10.1016/j.cca.2018.03.032, ISSN: 1873-3492. *Joint senior author.

Shajani-Yi Z, de Abreu FB, Peterson JD, Tsongalis GJ. Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing. Neoplasia [print-electronic]. 2018 Mar; 20(3): 256-62. PMID: 29454261, PII: S1476-5586(17)30316-0, DOI: 10.1016/j.neo.2017.12.005, ISSN: 1476-5586.

Shajani-Yi Z, Brunelle AA, Nerenz RD. Ready to Settle. Clin. Chem. 2017 Sep; 63(9): 1546-7. PMID: 28848031, PII: 63/9/1546, DOI: 10.1373/clinchem.2017.273045, ISSN: 1530-8561.

Shajani-Yi Z, Martin IW, Brunelle AA, Cervinski MA, et al. Method validation of human chorionic gonadotropin and a-fetoprotein in cerebral spinal fluid: Aiding the diagnosis of intracranial germ cell tumors. JALM. 2017 Jul; 2(1): 65-75.

Olson NJ, Shajani-Yi Z, Cervinski MA, Ornstein DL. Prolonged Bleeding in a 34-Year-Old Man following Oral Surgery. Clin. Chem. 2016 Dec; 62(12): 1676-7. PMID: 27899461, PII: 62/12/1676, DOI: 10.1373/clinchem.2016.264069, ISSN: 1530-8561.

Shajani-Yi Z, Lee HK, Cervinski MA. Hyponatremia, Hypokalemia, Hypochloremia, and Other Abnormalities. Clin. Chem. 2016 Jun; 62(6): 898. PMID: 27235468, PII: 62/6/898, DOI: 10.1373/clinchem.2015.249292, ISSN: 1530-8561.

Brunelle AA, Shajani-Yi Zahra, Cervinski MA, et al. Lithium therapy and adverse effects. ASCP Case reports: Clinical Chemistry. 2016.

Shoji S, Dambacher CM, Shajani Z, Williamson JR, Schultz PG. Systematic chromosomal deletion of bacterial ribosomal protein genes. J. Mol. Biol [print-electronic]. 2011 Nov 11/4/2011; 413(4): 751-61. PMID: 21945294, PMCID: PMC3694390, PII: S0022-2836(11)00993-4, DOI: 10.1016/j.jmb.2011.09.004, ISSN: 1089-8638.

Shajani Z, Sykes MT, Williamson JR. Assembly of bacterial ribosomes. Annu. Rev. Biochem. 2011; 80: 501-26. PMID: 21529161, DOI: 10.1146/annurev-biochem-062608-160432, ISSN: 1545-4509.

Sykes MT, Shajani Z, Sperling E, Beck AH, Williamson JR. Quantitative proteomic analysis of ribosome assembly and turnover in vivo. J. Mol. Biol. 2010 Oct 10/29/2010; 403(3): 331-45. PMID: 20709079, PMCID: PMC2953596, PII: S0022-2836(10)00853-3, DOI: 10.1016/j.jmb.2010.08.005, ISSN: 1089-8638. *Joint first author.

Bardaro MF, Shajani Z, Patora-Komisarska K, Robinson JA, Varani G. How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape. Nucleic Acids Res [print-electronic]. 2009 Apr; 37(5): 1529-40. PMID: 19139066, PMCID: PMC2655691, PII: gkn1074, DOI: 10.1093/nar/gkn1074, ISSN: 1362-4962.

Echodu D, Goobes G, Shajani Z, Pederson K, Meints G, Varani G, Drobny G. Furanose dynamics in the HhaI methyltransferase target DNA studied by solution and solid-state NMR relaxation. J Phys Chem B [print-electronic]. 2008 Nov 11/6/2008; 112(44): 13934-44. PMID: 18844399, PMCID: PMC2735271, DOI: 10.1021/jp801723x, ISSN: 1520-6106.

Gherghe CM, Shajani Z, Wilkinson KA, Varani G, Weeks KM. Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. J. Am. Chem. Soc [print-electronic]. 2008 Sep 9/17/2008; 130(37): 12244-5. PMID: 18710236, PMCID: PMC2712629, DOI: 10.1021/ja804541s, ISSN: 1520-5126.

Shajani Z, Varani G. 13C relaxation studies of the DNA target sequence for hhai methyltransferase reveal unique motional properties. Biochemistry [print-electronic]. 2008 Jul 7/22/2008; 47(29): 7617-25. PMID: 18578505, DOI: 10.1021/bi7020469, ISSN: 1520-4995.

Pederson K, Meints GA, Shajani Z, Miller PA, Drobny GP. Backbone dynamics in the DNA HhaI protein binding site. J. Am. Chem. Soc [print-electronic]. 2008 Jul 7/16/2008; 130(28): 9072-9. PMID: 18570423, PMCID: PMC2710389, DOI: 10.1021/ja801243d, ISSN: 1520-5126.

Meints GA, Miller PA, Pederson K, Shajani Z, Drobny G. Solid-state nuclear magnetic resonance spectroscopy studies of furanose ring dynamics in the DNA HhaI binding site. J. Am. Chem. Soc [print-electronic]. 2008 Jun 6/11/2008; 130(23): 7305-14. PMID: 18489097, DOI: 10.1021/ja075775n, ISSN: 1520-5126.

Olsen GL, Echodu DC, Shajani Z, Bardaro MF, Varani G, Drobny GP. Solid-state deuterium NMR studies reveal micros-ns motions in the HIV-1 transactivation response RNA recognition site. J. Am. Chem. Soc [print-electronic]. 2008 Mar 3/12/2008; 130(10): 2896-7. PMID: 18275190, PMCID: PMC2743919, DOI: 10.1021/ja0778803, ISSN: 1520-5126.

Shajani Z, Varani G. NMR studies of dynamics in RNA and DNA by 13C relaxation. Biopolymers. 2007 Aug 8/5/2007; 86(5-6): 348-59. PMID: 17154290, DOI: 10.1002/bip.20650, ISSN: 0006-3525.

Shajani Z, Drobny G, Varani G. Binding of U1A protein changes RNA dynamics as observed by 13C NMR relaxation studies. Biochemistry [print-electronic]. 2007 May 5/22/2007; 46(20): 5875-83. PMID: 17469848, DOI: 10.1021/bi602658x, ISSN: 0006-2960.

Miller PA, Shajani Z, Meints GA, Caplow D, Goobes G, Varani G, Drobny GP. Contrasting views of the internal dynamics of the HhaI methyltransferase target DNA reported by solution and solid-state NMR spectroscopy. J. Am. Chem. Soc. 2006 Dec 12/20/2006; 128(50): 15970-1. PMID: 17165714, DOI: 10.1021/ja066329n, ISSN: 0002-7863.

Shajani Z, Deka P, Varani G. Decoding RNA motional codes. Trends Biochem. Sci [print-electronic]. 2006 Aug; 31(8): 421-4. PMID: 16815707, PII: S0968-0004(06)00146-0, DOI: 10.1016/j.tibs.2006.06.002, ISSN: 0968-0004.

Shajani Z, Varani G. 13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. J. Mol. Biol [print-electronic]. 2005 Jun 6/17/2005; 349(4): 699-715. PMID: 15890361, PII: S0022-2836(05)00411-0, DOI: 10.1016/j.jmb.2005.04.012, ISSN: 0022-2836.