Ricardo Capone, Dr., Ph.D.

Research Instructor

ricardo.f.capone@vanderbilt.edu
Faculty Appointments
Research Instructor in Biochemistry
Education
Ph.D., Biological Chemistry, Hebrew University of Jerusalem, Jerusalem, IsraelM.S., Biology and Molecular Genetics, State University of Milan, Milan, ItalyB.A., Biology and Molecular Genetics, State University of Milan, Milan, Italy
Publications
Rivera I, Capone R, Cauvi DM, Arispe N, De Maio A. Modulation of Alzheimer's amyloid ß peptide oligomerization and toxicity by extracellular Hsp70. Cell Stress Chaperones [print-electronic]. 2017 Sep 9/27/2017; PMID: 28956268, PII: 10.1007/s12192-017-0839-0, DOI: 10.1007/s12192-017-0839-0, ISSN: 1466-1268.

Gillman AL, Lee J, Ramachandran S, Capone R, Gonzalez T, Wrasidlo W, Masliah E, Lal R. Small molecule NPT-440-1 inhibits ionic flux through Aß1-42 pores: Implications for Alzheimer's disease therapeutics. Nanomedicine [print-electronic]. 2016 Nov; 12(8): 2331-40. PMID: 27335341, PMCID: PMC5116404, PII: S1549-9634(16)30069-7, DOI: 10.1016/j.nano.2016.06.001, ISSN: 1549-9642.

Kagan BL, Jang H, Capone R, Teran Arce F, Ramachandran S, Lal R, Nussinov R. Antimicrobial properties of amyloid peptides. Mol. Pharm [print-electronic]. 2012 Apr 4/2/2012; 9(4): 708-17. PMID: 22081976, PMCID: PMC3297685, DOI: 10.1021/mp200419b, ISSN: 1543-8392.

Capone R, Jang H, Kotler SA, Connelly L, Teran Arce F, Ramachandran S, Kagan BL, Nussinov R, Lal R. All-d-Enantiomer of ß-Amyloid Peptide Forms Ion Channels in Lipid Bilayers. J Chem Theory Comput [print-electronic]. 2012 Mar 3/13/2012; 8(3): 1143-52. PMID: 22423218, PMCID: PMC3302213, DOI: 10.1021/ct200885r, ISSN: 1549-9626.

Allen MJ, Lacroix JJ, Ramachandran S, Capone R, Whitlock JL, Ghadge GD, Arnsdorf MF, Roos RP, Lal R. Mutant SOD1 forms ion channel: implications for ALS pathophysiology. Neurobiol. Dis [print-electronic]. 2012 Mar; 45(3): 831-8. PMID: 21930207, PMCID: PMC3384721, PII: S0969-9961(11)00297-X, DOI: 10.1016/j.nbd.2011.08.031, ISSN: 1095-953X.

Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R. Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's ß-amyloid peptide: relevance to the ion channel mechanism of AD pathology. J Phys Chem B [print-electronic]. 2012 Feb 2/9/2012; 116(5): 1728-35. PMID: 22217000, PMCID: PMC4342054, DOI: 10.1021/jp2108126, ISSN: 1520-5207.

Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R. Probing structural features of Alzheimer's amyloid-ß pores in bilayers using site-specific amino acid substitutions. Biochemistry [print-electronic]. 2012 Jan 1/24/2012; 51(3): 776-85. PMID: 22242635, PMCID: PMC3265145, DOI: 10.1021/bi2017427, ISSN: 1520-4995.

Jang H, Arce FT, Mustata M, Ramachandran S, Capone R, Nussinov R, Lal R. Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link. Biophys. J. 2011 Apr 4/6/2011; 100(7): 1775-83. PMID: 21463591, PMCID: PMC3072611, PII: S0006-3495(11)00242-6, DOI: 10.1016/j.bpj.2011.01.072, ISSN: 1542-0086.

Jang H, Arce FT, Ramachandran S, Capone R, Lal R, Nussinov R. ß-Barrel topology of Alzheimer's ß-amyloid ion channels. J. Mol. Biol [print-electronic]. 2010 Dec 12/17/2010; 404(5): 917-34. PMID: 20970427, PII: S0022-2836(10)01133-2, DOI: 10.1016/j.jmb.2010.10.025, ISSN: 1089-8638.

Jang H, Teran Arce F, Ramachandran S, Capone R, Lal R, Nussinov R. Structural convergence among diverse, toxic beta-sheet ion channels. J Phys Chem B. 2010 Jul 7/29/2010; 114(29): 9445-51. PMID: 20608696, PMCID: PMC2908347, DOI: 10.1021/jp104073k, ISSN: 1520-5207.

Godovikova V, Wang HT, Goetting-Minesky MP, Ning Y, Capone RF, Slater CK, Fenno JC. Treponema denticola PrcB is required for expression and activity of the PrcA-PrtP (dentilisin) complex. J. Bacteriol [print-electronic]. 2010 Jul; 192(13): 3337-44. PMID: 20435733, PMCID: PMC2897659, PII: JB.00274-10, DOI: 10.1128/JB.00274-10, ISSN: 1098-5530.

Capone R, Mustata M, Jang H, Arce FT, Nussinov R, Lal R. Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies. Biophys. J. 2010 Jun 6/2/2010; 98(11): 2644-52. PMID: 20513409, PMCID: PMC2877344, PII: S0006-3495(10)00275-4, DOI: 10.1016/j.bpj.2010.02.024, ISSN: 1542-0086.

Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R. Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Apr 4/6/2010; 107(14): 6538-43. PMID: 20308552, PMCID: PMC2851998, PII: 0914251107, DOI: 10.1073/pnas.0914251107, ISSN: 1091-6490.

Jang H, Arce FT, Capone R, Ramachandran S, Lal R, Nussinov R. Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels. Biophys. J. 2009 Dec 12/2/2009; 97(11): 3029-37. PMID: 19948133, PMCID: PMC2784570, PII: S0006-3495(09)01460-X, DOI: 10.1016/j.bpj.2009.09.014, ISSN: 1542-0086.

Macrae MX, Blake S, Jiang X, Capone R, Estes DJ, Mayer M, Yang J. A semi-synthetic ion channel platform for detection of phosphatase and protease activity. ACS Nano. 2009 Nov 11/24/2009; 3(11): 3567-80. PMID: 19860382, PMCID: PMC2805247, DOI: 10.1021/nn901231h, ISSN: 1936-086X.

Mustata M, Capone R, Jang H, Arce FT, Ramachandran S, Lal R, Nussinov R. K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis. J. Am. Chem. Soc. 2009 Oct 10/21/2009; 131(41): 14938-45. PMID: 19824733, PMCID: PMC2782653, DOI: 10.1021/ja9049299, ISSN: 1520-5126.

Capone R, Quiroz FG, Prangkio P, Saluja I, Sauer AM, Bautista MR, Turner RS, Yang J, Mayer M. Amyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversy. Neurotox Res [print-electronic]. 2009 Jul; 16(1): 1-13. PMID: 19526294, PMCID: PMC2864106, DOI: 10.1007/s12640-009-9033-1, ISSN: 1476-3524.

Horger KS, Estes DJ, Capone R, Mayer M. Films of agarose enable rapid formation of giant liposomes in solutions of physiologic ionic strength. J. Am. Chem. Soc. 2009 Feb 2/11/2009; 131(5): 1810-9. PMID: 19154115, PMCID: PMC2757642, PII: 10.1021/ja805625u, DOI: 10.1021/ja805625u, ISSN: 1520-5126.

Blake S, Capone R, Mayer M, Yang J. Chemically reactive derivatives of gramicidin A for developing ion channel-based nanoprobes. Bioconjug. Chem [print-electronic]. 2008 Aug; 19(8): 1614-24. PMID: 18630940, DOI: 10.1021/bc800180z, ISSN: 1520-4812.

Capone R, Wang HT, Ning Y, Sweier DG, Lopatin DE, Fenno JC. Human serum antibodies recognize Treponema denticola Msp and PrtP protease complex proteins. Oral Microbiol. Immunol. 2008 Apr; 23(2): 165-9. PMID: 18279185, PII: OMI404, DOI: 10.1111/j.1399-302X.2007.00404.x, ISSN: 0902-0055.

Capone RF, Ning Y, Pakulis N, Alhazzazi T, Fenno JC. Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase. FEMS Microbiol. Lett [print-electronic]. 2007 Mar; 268(2): 261-7. PMID: 17187656, PII: FML589, DOI: 10.1111/j.1574-6968.2006.00589.x, ISSN: 0378-1097.

Askari N, Diskin R, Avitzour M, Capone R, Livnah O, Engelberg D. Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription. J. Biol. Chem [print-electronic]. 2007 Jan 1/5/2007; 282(1): 91-9. PMID: 17088247, PII: M608012200, DOI: 10.1074/jbc.M608012200, ISSN: 0021-9258.

Diskin R, Askari N, Capone R, Engelberg D, Livnah O. Active mutants of the human p38alpha mitogen-activated protein kinase. J. Biol. Chem [print-electronic]. 2004 Nov 11/5/2004; 279(45): 47040-9. PMID: 15284239, PII: M404595200, DOI: 10.1074/jbc.M404595200, ISSN: 0021-9258.

Capone R, Tiwari BS, Levine A. Rapid transmission of oxidative and nitrosative stress signals from roots to shoots in Arabidopsis. Plant Physiol. Biochem. 2004 May; 42(5): 425-8. PMID: 15191746, PII: S0981-9428(04)00042-7, DOI: 10.1016/j.plaphy.2004.03.005, ISSN: 0981-9428.

Bell M, Capone R, Pashtan I, Levitzki A, Engelberg D. Isolation of hyperactive mutants of the MAPK p38/Hog1 that are independent of MAPK kinase activation. J. Biol. Chem [print-electronic]. 2001 Jul 7/6/2001; 276(27): 25351-8. PMID: 11309396, PII: M101818200, DOI: 10.1074/jbc.M101818200, ISSN: 0021-9258.

Pozzi C, Faccioli P, Terzi V, Stanca AM, Cerioli S, Castiglioni P, Fink R, Capone R, Müller KJ, Bossinger G, Rohde W, Salamini F. Genetics of mutations affecting the development of a barley floral bract. Genetics. 2000 Mar; 154(3): 1335-46. PMID: 10757774, PMCID: PMC1460976, ISSN: 0016-6731.

Kleinberger-Doron N, Shelah N, Capone R, Gazit A, Levitzki A. Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase. Exp. Cell Res. 1998 Jun 6/15/1998; 241(2): 340-51. PMID: 9637776, PII: S0014-4827(98)94061-7, DOI: 10.1006/excr.1998.4061, ISSN: 0014-4827.

Foiani M, Nadjar-Boger E, Capone R, Sagee S, Hashimshoni T, Kassir Y. A meiosis-specific protein kinase, Ime2, is required for the correct timing of DNA replication and for spore formation in yeast meiosis. Mol. Gen. Genet. 1996 Dec 12/13/1996; 253(3): 278-88. PMID: 9003314, ISSN: 0026-8925.