Jacklyn Nikole Hellwege, Ph.D.

Research Instructor

Faculty Appointments
Research Instructor in Medicine
Education
Ph.D., Molecular Genetics and Genomics, Wake Forest University, Winston-Salem, North CarolinaB.S., Biology, Appalachian State University, Boone, North Carolina
Office Address
515A Light Hall
2215 Garland Ave
Nashville, TN 37232
Publications
Wang H, Nandakumar P, Tekola-Ayele F, Tayo BO, Ware EB, Gu CC, Lu Y, Yao J, Zhao W, Smith JA, Hellwege JN, Guo X, Edwards TL, Loos RJF, Arnett DK, Fornage M, Rotimi C, Kardia SLR, Cooper RS, Rao DC, Ehret G, Chakravarti A, Zhu X. Combined linkage and association analysis identifies rare and low frequency variants for blood pressure at 1q31. Eur. J. Hum. Genet [print-electronic]. 2019 Feb; 27(2): 269-77. PMID: 30262922, PMCID: PMC6336803, PII: 10.1038/s41431-018-0277-1, DOI: 10.1038/s41431-018-0277-1, ISSN: 1476-5438.

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP, Sun YV, Wilson OD, Robinson-Cohen C, Roumie CL, Chung CP, Birdwell KA, Damrauer SM, DuVall SL, Klarin D, Cho K, Wang Y, Evangelou E, Cabrera CP, Wain LV, Shrestha R, Mautz BS, Akwo EA, Sargurupremraj M, Debette S, Boehnke M, Scott LJ, Luan J, Zhao JH, Willems SM, Thériault S, Shah N, Oldmeadow C, Almgren P, Li-Gao R, Verweij N, Boutin TS, Mangino M, Ntalla I, Feofanova E, Surendran P, Cook JP, Karthikeyan S, Lahrouchi N, Liu C, Sepúlveda N, Richardson TG, Kraja A, Amouyel P, Farrall M, Poulter NR, , , , Laakso M, Zeggini E, Sever P, Scott RA, Langenberg C, Wareham NJ, Conen D, Palmer CNA, Attia J, Chasman DI, Ridker PM, Melander O, Mook-Kanamori DO, Harst PV, Cucca F, Schlessinger D, Hayward C, Spector TD, Jarvelin MR, Hennig BJ, Timpson NJ, Wei WQ, Smith JC, Xu Y, Matheny ME, Siew EE, Lindgren C, Herzig KH, Dedoussis G, Denny JC, Psaty BM, Howson JMM, Munroe PB, Newton-Cheh C, Caulfield MJ, Elliott P, Gaziano JM, Concato J, Wilson PWF, Tsao PS, Velez Edwards DR, Susztak K, , O'Donnell CJ, Hung AM, Edwards TL. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat. Genet [print-electronic]. 2019 Jan; 51(1): 51-62. PMID: 30578418, PMCID: PMC6365102, PII: 10.1038/s41588-018-0303-9, DOI: 10.1038/s41588-018-0303-9, ISSN: 1546-1718.

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, Elosua R, Enroth S, Erzurumluoglu AM, Ferreira T, Frånberg M, Franco OH, Gandin I, Gasparini P, Giedraitis V, Gieger C, Girotto G, Goel A, Gow AJ, Gudnason V, Guo X, Gyllensten U, Hamsten A, Harris TB, Harris SE, Hartman CA, Havulinna AS, Hicks AA, Hofer E, Hofman A, Hottenga JJ, Huffman JE, Hwang SJ, Ingelsson E, James A, Jansen R, Jarvelin MR, Joehanes R, Johansson Å, Johnson AD, Joshi PK, Jousilahti P, Jukema JW, Jula A, Kähönen M, Kathiresan S, Keavney BD, Khaw KT, Knekt P, Knight J, Kolcic I, Kooner JS, Koskinen S, Kristiansson K, Kutalik Z, Laan M, Larson M, Launer LJ, Lehne B, Lehtimäki T, Liewald DCM, Lin L, Lind L, Lindgren CM, Liu Y, Loos RJF, Lopez LM, Lu Y, Lyytikäinen LP, Mahajan A, Mamasoula C, Marrugat J, Marten J, Milaneschi Y, Morgan A, Morris AP, Morrison AC, Munson PJ, Nalls MA, Nandakumar P, Nelson CP, Niiranen T, Nolte IM, Nutile T, Oldehinkel AJ, Oostra BA, O'Reilly PF, Org E, Padmanabhan S, Palmas W, Palotie A, Pattie A, Penninx BWJH, Perola M, Peters A, Polasek O, Pramstaller PP, Nguyen QT, Raitakari OT, Ren M, Rettig R, Rice K, Ridker PM, Ried JS, Riese H, Ripatti S, Robino A, Rose LM, Rotter JI, Rudan I, Ruggiero D, Saba Y, Sala CF, Salomaa V, Samani NJ, Sarin AP, Schmidt R, Schmidt H, Shrine N, Siscovick D, Smith AV, Snieder H, Sõber S, Sorice R, Starr JM, Stott DJ, Strachan DP, Strawbridge RJ, Sundström J, Swertz MA, Taylor KD, Teumer A, Tobin MD, Tomaszewski M, Toniolo D, Traglia M, Trompet S, Tuomilehto J, Tzourio C, Uitterlinden AG, Vaez A, van der Most PJ, van Duijn CM, Vergnaud AC, Verwoert GC, Vitart V, Völker U, Vollenweider P, Vuckovic D, Watkins H, Wild SH, Willemsen G, Wilson JF, Wright AF, Yao J, Zemunik T, Zhang W, Attia JR, Butterworth AS, Chasman DI, Conen D, Cucca F, Danesh J, Hayward C, Howson JMM, Laakso M, Lakatta EG, Langenberg C, Melander O, Mook-Kanamori DO, Palmer CNA, Risch L, Scott RA, Scott RJ, Sever P, Spector TD, van der Harst P, Wareham NJ, Zeggini E, Levy D, Munroe PB, Newton-Cheh C, Brown MJ, Metspalu A, Hung AM, O'Donnell CJ, Edwards TL, Psaty BM, Tzoulaki I, Barnes MR, Wain LV, Elliott P, Caulfield MJ, . Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat. Genet [print-electronic]. 2018 Oct; 50(10): 1412-25. PMID: 30224653, PMCID: PMC6284793, PII: 10.1038/s41588-018-0205-x, DOI: 10.1038/s41588-018-0205-x, ISSN: 1546-1718.

Keaton JM, Gao C, Guan M, Hellwege JN, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YI, Taylor KD, Rich SS, Wagenknecht LE, Freedman BI, Ng MCY, Bowden DW. Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans. Genet. Epidemiol [print-electronic]. 2018 Sep; 42(6): 559-70. PMID: 29691896, PMCID: PMC6160319, DOI: 10.1002/gepi.22126, ISSN: 1098-2272.

Weigl K, Thomsen H, Balavarca Y, Hellwege JN, Shrubsole MJ, Brenner H. Genetic Risk Score Is Associated With Prevalence of Advanced Neoplasms in a Colorectal Cancer Screening Population. Gastroenterology [print-electronic]. 2018 Jul; 155(1): 88-98.e10. PMID: 29574091, PMCID: PMC6035076, PII: S0016-5085(18)30337-8, DOI: 10.1053/j.gastro.2018.03.030, ISSN: 1528-0012.

Hellwege JN, Russell SB, Williams SM, Edwards TL, Velez Edwards DR. Gene-based evaluation of low-frequency variation and genetically-predicted gene expression impacting risk of keloid formation. Ann. Hum. Genet [print-electronic]. 2018 Jul; 82(4): 206-15. PMID: 29484647, PMCID: PMC5993571, DOI: 10.1111/ahg.12245, ISSN: 1469-1809.

Gao C, Langefeld CD, Ziegler JT, Taylor KD, Norris JM, Chen YI, Hellwege JN, Guo X, Allison MA, Speliotes EK, Rotter JI, Bowden DW, Wagenknecht LE, Palmer ND. Genome-Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex-Specific Adiposity Loci in Mexican Americans. Obesity (Silver Spring) [print-electronic]. 2018 Jan; 26(1): 202-12. PMID: 29178545, PMCID: PMC5740005, DOI: 10.1002/oby.22074, ISSN: 1930-739X.

Hellwege JN, Keaton JM, Giri A, Gao X, Velez Edwards DR, Edwards TL. Population Stratification in Genetic Association Studies. Curr Protoc Hum Genet. 2017 Oct 10/18/2017; 95: 1.22.1-1.22.23. PMID: 29044472, PMCID: PMC6007879, DOI: 10.1002/cphg.48, ISSN: 1934-8258.

Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, Mancuso N, Im HK, Hinds DA, Palmer JR, Rosenberg L, Denny JC, Roden DM, Stewart EA, Morton CC, Kenny EE, Edwards TL, Velez Edwards DR. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum. Genet [print-electronic]. 2017 Oct; 136(10): 1363-73. PMID: 28836065, PMCID: PMC5628188, PII: 10.1007/s00439-017-1836-1, DOI: 10.1007/s00439-017-1836-1, ISSN: 1432-1203.

Mollan KR, Tierney C, Hellwege JN, Eron JJ, Hudgens MG, Gulick RM, Haubrich R, Sax PE, Campbell TB, Daar ES, Robertson KR, Ventura D, Ma Q, Edwards DRV, Haas DW, . Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants. J. Infect. Dis. 2017 Sep 9/1/2017; 216(5): 554-64. PMID: 28931220, PMCID: PMC5853681, PII: 3927196, DOI: 10.1093/infdis/jix248, ISSN: 1537-6613.

Giri A, Hartmann KE, Hellwege JN, Velez Edwards DR, Edwards TL. Obesity and pelvic organ prolapse: a systematic review and meta-analysis of observational studies. Am. J. Obstet. Gynecol [print-electronic]. 2017 Jul; 217(1): 11-26.e3. PMID: 28188775, PII: S0002-9378(17)30174-6, DOI: 10.1016/j.ajog.2017.01.039, ISSN: 1097-6868.

Tabb KL, Hellwege JN, Palmer ND, Dimitrov L, Sajuthi S, Taylor KD, Ng MC, Hawkins GA, Chen YI, Brown WM, McWilliams D, Williams A, Lorenzo C, Norris JM, Long J, Rotter JI, Curran JE, Blangero J, Wagenknecht LE, Langefeld CD, Bowden DW. Analysis of Whole Exome Sequencing with Cardiometabolic Traits Using Family-Based Linkage and Association in the IRAS Family Study. Ann. Hum. Genet [print-electronic]. 2017 Mar; 81(2): 49-58. PMID: 28067407, PMCID: PMC5719883, DOI: 10.1111/ahg.12184, ISSN: 1469-1809.

Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW. Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. J. Hum. Genet [print-electronic]. 2017 Feb; 62(2): 175-84. PMID: 27535031, PMCID: PMC5266668, PII: jhg2016103, DOI: 10.1038/jhg.2016.103, ISSN: 1435-232X.

Hellwege JN, Torstenson ES, Russell SB, Edwards TL, Velez Edwards DR. Evidence of selection as a cause for racial disparities in fibroproliferative disease. PLoS ONE. 2017; 12(8): e0182791. PMID: 28792542, PMCID: PMC5549739, PII: PONE-D-17-27618, DOI: 10.1371/journal.pone.0182791, ISSN: 1932-6203.

Hellwege JN, Velez Edwards DR, Acra S, Chen K, Buchowski MS, Edwards TL. Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults. BMC Obes. 2017; 4: 12. PMID: 28417008, PMCID: PMC5381071, PII: 145, DOI: 10.1186/s40608-017-0145-5, ISSN: 2052-9538.

Keaton JM, Hellwege JN, Ng MCY, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YI, Taylor KD, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW. GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS. Pac Symp Biocomput. 2017; 22: 242-53. PMID: 27896979, PMCID: PMC5146756, PII: 9789813207813_0024, DOI: 10.1142/9789813207813_0024, ISSN: 2335-6936.

Keaton JM, Hellwege JN, Ng MC, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YD, Taylor KD, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW. Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans. PLoS ONE. 2016; 11(7): e0159977. PMID: 27448167, PMCID: PMC4957757, PII: PONE-D-16-20120, DOI: 10.1371/journal.pone.0159977, ISSN: 1932-6203.

Hellwege JN, Palmer ND, Mark Brown W, Ziegler JT, Sandy An S, Guo X, Ida Chen YD, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW. Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hum. Genet [print-electronic]. 2015 Feb; 134(2): 203-13. PMID: 25447270, PMCID: PMC4293344, DOI: 10.1007/s00439-014-1511-8, ISSN: 1432-1203.

Hellwege JN, Palmer ND, Raffield LM, Ng MC, Hawkins GA, Long J, Lorenzo C, Norris JM, Ida Chen YD, Speliotes EK, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW. Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk. Genet. Epidemiol [print-electronic]. 2014 May; 38(4): 345-52. PMID: 24719370, PMCID: PMC4281959, DOI: 10.1002/gepi.21801, ISSN: 1098-2272.

Hellwege JN, Palmer ND, Ziegler JT, Langefeld CD, Lorenzo C, Norris JM, Takamura T, Bowden DW. Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics. Gene [print-electronic]. 2014 Jan 1/15/2014; 534(1): 33-9. PMID: 24161883, PMCID: PMC3856675, PII: S0378-1119(13)01430-3, DOI: 10.1016/j.gene.2013.10.035, ISSN: 1879-0038.

Cooke JN, Bostrom MA, Hicks PJ, Ng MC, Hellwege JN, Comeau ME, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans. Nephrol. Dial. Transplant [print-electronic]. 2012 Apr; 27(4): 1505-11. PMID: 21968013, PMCID: PMC3315672, PII: gfr522, DOI: 10.1093/ndt/gfr522, ISSN: 1460-2385.

Hellwege JN, Hicks PJ, Palmer ND, Ng MC, Freedman BI, Bowden DW. Examination of Rare Variants in HNF4 a in European Americans with Type 2 Diabetes. J Diabetes Metab. 2011 Oct 10/20/2011; 2(145): PMID: 23227446, PMCID: PMC3515062, DOI: 10.4172/2155-6156.1000145, ISSN: 2155-6156.