Jacklyn N. Hellwege, Ph.D.

Research Assistant Professor

jacklyn.hellwege@vumc.org
Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Molecular Genetics and Genomics, Wake Forest University, Winston-Salem, North CarolinaB.S., Biology, Appalachian State University, Boone, North Carolina
Office Address
2525 West End Avenue
Suite 700
Nashville, TN 37203
Research Description
I am a current Building Interdisciplinary Research Careers in Women’s Heath (BIRCWH) K12 scholar in the Division of Genetic Medicine. My training includes graduate and postgraduate work in human genetics/genomics and genetic epidemiology at Wake Forest and Vanderbilt. My current research program is designed to identify genetic predispositions to cardiovascular and renal diseases, with emphasis on diverse populations overburdened by these diseases. I also have an interest in women’s health and the role of genetics in reproduction-related phenotypes. In general, my work aims to understand the genetic architecture and biological mechanisms underlying disease outcomes with the goal of translating my findings to aid in the development of precision medicine. My current projects extend beyond genome-wide association studies (GWAS) to discover gene-disease relationships using predicted gene expression across tissues, identify comorbid or pleiotropic conditions using clinical phenome-wide association studies (PheWAS), and development of polygenic risk scores.

Full bibliography available here: https://www.ncbi.nlm.nih.gov/myncbi/jacklyn.hellwege.1/bibliography/public/
Publications
Scholz M, Horn K, Pott J, Wuttke M, Kühnapfel A, Nasr MK, Kirsten H, Li Y, Hoppmann A, Gorski M, Ghasemi S, Li M, Tin A, Chai JF, Cocca M, Wang J, Nutile T, Akiyama M, Åsvold BO, Bansal N, Biggs ML, Boutin T, Brenner H, Brumpton B, Burkhardt R, Cai J, Campbell A, Campbell H, Chalmers J, Chasman DI, Chee ML, Chee ML, Chen X, Cheng CY, Cifkova R, Daviglus M, Delgado G, Dittrich K, Edwards TL, Endlich K, Michael Gaziano J, Giri A, Giulianini F, Gordon SD, Gudbjartsson DF, Hallan S, Hamet P, Hartman CA, Hayward C, Heid IM, Hellwege JN, Holleczek B, Holm H, Hutri-Kähönen N, Hveem K, Isermann B, Jonas JB, Joshi PK, Kamatani Y, Kanai M, Kastarinen M, Khor CC, Kiess W, Kleber ME, Körner A, Kovacs P, Krajcoviechova A, Kramer H, Krämer BK, Kuokkanen M, Kähönen M, Lange LA, Lash JP, Lehtimäki T, Li H, Lin BM, Liu J, Loeffler M, Lyytikäinen LP, Magnusson PKE, Martin NG, Matsuda K, Milaneschi Y, Mishra PP, Mononen N, Montgomery GW, Mook-Kanamori DO, Mychaleckyj JC, März W, Nauck M, Nikus K, Nolte IM, Noordam R, Okada Y, Olafsson I, Oldehinkel AJ, Penninx BWJH, Perola M, Pirastu N, Polasek O, Porteous DJ, Poulain T, Psaty BM, Rabelink TJ, Raffield LM, Raitakari OT, Rasheed H, Reilly DF, Rice KM, Richmond A, Ridker PM, Rotter JI, Rudan I, Sabanayagam C, Salomaa V, Schneiderman N, Schöttker B, Sims M, Snieder H, Stark KJ, Stefansson K, Stocker H, Stumvoll M, Sulem P, Sveinbjornsson G, Svensson PO, Tai ES, Taylor KD, Tayo BO, Teren A, Tham YC, Thiery J, Thio CHL, Thomas LF, Tremblay J, Tönjes A, van der Most PJ, Vitart V, Völker U, Wang YX, Wang C, Wei WB, Whitfield JB, Wild SH, Wilson JF, Winkler TW, Wong TY, Woodward M, Sim X, Chu AY, Feitosa MF, Thorsteinsdottir U, Hung AM, Teumer A, Franceschini N, Parsa A, Köttgen A, Schlosser P, Pattaro C. X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements. Nat Commun. 2024 Jan 1/18/2024; 15(1): 586. PMID: 38233393, PMCID: PMC10794254, PII: 10.1038/s41467-024-44709-1, DOI: 10.1038/s41467-024-44709-1, ISSN: 2041-1723.

Piekos JA, Kim J, Keaton JM, Hellwege JN, Edwards TL, Velez Edwards DR. EVALUATING THE RELATIONSHIPS BETWEEN GENETIC ANCESTRY AND THE CLINICAL PHENOME. Pac Symp Biocomput. 2024; 29: 389-403. PMID: 38160294, PMCID: PMC10802858, PII: 9789811286421_0030, ISSN: 2335-6936.

Seagle HM, Hellwege JN, Mautz BS, Li C, Xu Y, Zhang S, Roden DM, McGregor TL, Velez Edwards DR, Edwards TL. Evidence of recent and ongoing admixture in the U.S. and influences on health and disparities. Pac Symp Biocomput. 2024; 29: 374-88. PMID: 38160293, PII: 9789811286421_0029, ISSN: 2335-6936.

Shuey MM, Hellwege JN, Khankari N, Vujkovic M, Edwards TL. Session Introduction: Drug-repurposing and discovery in the era of "big" real-world data: how the incorporation of observational data, genetics, and other -omic technologies can move us forward. Pac Symp Biocomput. 2024; 29: 226-31. PMID: 38160282, PII: 9789811286421_0018, ISSN: 2335-6936.

Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R, Darst BF, Sheng X, Xu Y, Chou AJ, Benlloch S, Dadaev T, Brook MN, Plym A, Sahimi A, Hoffman TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Laisk T, Figuerêdo J, Muir K, Ito S, Liu X, , Uchio Y, Kubo M, Kamatani Y, Lophatananon A, Wan P, Andrews C, Lori A, Choudhury PP, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Rentsch CT, Cho K, Mcmahon BH, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder A, Stroomberg HV, Batra J, Chambers S, Horvath L, Clements JA, Tilly W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordstrom T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein S, Cook MB, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Koutros S, Beane Freeman LE, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Butler EN, Mohler JL, Taylor JA, Kogevinas M, Dierssen-Sotos T, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Pilie P, Yu Y, Bohlender RJ, Gu J, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Brenner H, Chen X, Holleczek B, Schöttker B, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas CM, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Abraham A, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen J, Petrovics G, Casey G, Wang Y, Tettey Y, Lachance J, Tang W, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Yamoah K, Govindasami K, Chokkalingam AP, Keaton JM, Hellwege JN, Clark PE, Jalloh M, Gueye SM, Niang L, Ogunbiyi O, Shittu O, Amodu O, Adebiyi AO, Aisuodionoe-Shadrach OI, Ajibola HO, Jamda MA, Oluwole OP, Nwegbu M, Adusei B, Mante S, Darkwa-Abrahams A, Diop H, Gundell SM, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Kachuri L, Varma R, McKean-Cowdin R, Torres M, Preuss MH, Loos RJF, Zawistowski M, Zöllner S, Lu Z, Van Den Eeden SK, Easton DF, Ambs S, Edwards TL, Mägi R, Rebbeck TR, Fritsche L, Chanock SJ, Berndt SI, Wiklund F, Nakagawa H, Witte JS, Gaziano JM, Justice AC, Mancuso N, Terao C, Eeles RA, Kote-Jarai Z, Madduri RK, Conti DV, Haiman CA. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nat Genet [print-electronic]. 2023 Dec; 55(12): 2065-74. PMID: 37945903, PMCID: PMC10841479, PII: 10.1038/s41588-023-01534-4, DOI: 10.1038/s41588-023-01534-4, ISSN: 1546-1718.

Hampton G, Kim J, Edwards TL, Hellwege JN, Velez Edwards DR. Uterine leiomyomata and keloids fibrosis origins: a mini-review of fibroproliferative diseases. Am J Physiol Cell Physiol [print-electronic]. 2023 Oct 10/1/2023; 325(4): C817-C822-C822. PMID: 37642233, PMCID: PMC10635651, DOI: 10.1152/ajpcell.00181.2023, ISSN: 1522-1563.

Robinson-Cohen C, Triozzi JL, Rowan B, He J, Chen HC, Zheng NS, Wei WQ, Wilson OD, Hellwege JN, Tsao PS, Gaziano JM, Bick A, Matheny ME, Chung CP, Lipworth L, Siew ED, Ikizler TA, Tao R, Hung AM. Genome-Wide Association Study of CKD Progression. J Am Soc Nephrol [print-electronic]. 2023 Sep 9/1/2023; 34(9): 1547-59. PMID: 37261792, PMCID: PMC10482057, PII: 00001751-202309000-00012, DOI: 10.1681/ASN.0000000000000170, ISSN: 1533-3450.

Edwards TL, Greene CA, Piekos JA, Hellwege JN, Hampton G, Jasper EA, Edwards DRV. Challenges and Opportunities for Data Science in Women's Health. Annu Rev Biomed Data Sci [print-electronic]. 2023 Apr 4/11/2023; PMID: 37040736, DOI: 10.1146/annurev-biodatasci-020722-105958, ISSN: 2574-3414.

Hellwege JN, Stallings SC, Piekos JA, Jasper EA, Aronoff DM, Edwards TL, Velez Edwards DR. Association of genetically-predicted placental gene expression with adult blood pressure traits. J Hypertens [print-electronic]. 2023 Apr 4/5/2023; PMID: 37016918, PII: 00004872-990000000-00224, DOI: 10.1097/HJH.0000000000003427, ISSN: 1473-5598.

Chen F, Madduri RK, Rodriguez AA, Darst BF, Chou A, Sheng X, Wang A, Shen J, Saunders EJ, Rhie SK, Bensen JT, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, Sanderson M, John EM, Park JY, Xu J, Wang Y, Berndt SI, Huff CD, Yeboah ED, Tettey Y, Lachance J, Tang W, Rentsch CT, Cho K, Mcmahon BH, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Sellers TA, Yamoah K, Murphy AB, Crawford DC, Patel AV, Bush WS, Aldrich MC, Cussenot O, Petrovics G, Cullen J, Neslund-Dudas CM, Stern MC, Kote-Jarai Z, Govindasami K, Cook MB, Chokkalingam AP, Hsing AW, Goodman PJ, Hoffmann TJ, Drake BF, Hu JJ, Keaton JM, Hellwege JN, Clark PE, Jalloh M, Gueye SM, Niang L, Ogunbiyi O, Idowu MO, Popoola O, Adebiyi AO, Aisuodionoe-Shadrach OI, Ajibola HO, Jamda MA, Oluwole OP, Nwegbu M, Adusei B, Mante S, Darkwa-Abrahams A, Mensah JE, Diop H, Van Den Eeden SK, Blanchet P, Fowke JH, Casey G, Hennis AJ, Lubwama A, Thompson IM, Leach R, Easton DF, Preuss MH, Loos RJ, Gundell SM, Wan P, Mohler JL, Fontham ET, Smith GJ, Taylor JA, Srivastava S, Eeles RA, Carpten JD, Kibel AS, Multigner L, Parent MÉ, Menegaux F, Cancel-Tassin G, Klein EA, Andrews C, Rebbeck TR, Brureau L, Ambs S, Edwards TL, Watya S, Chanock SJ, Witte JS, Blot WJ, Michael Gaziano J, Justice AC, Conti DV, Haiman CA. Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry. Eur Urol [print-electronic]. 2023 Feb 2/27/2023; PMID: 36872133, PII: S0302-2838(23)02561-7, DOI: 10.1016/j.eururo.2023.01.022, ISSN: 1873-7560.

Jasper EA, Hellwege JN, Breeyear JH, Xiao B, Jarvik GP, Stanaway IB, Leppig KA, Chittoor G, Hayes MG, Dikilitas O, Kullo IJ, Holm IA, Verma SS, Edwards TL, Velez Edwards DR. Genetic Predictors of Blood Pressure Traits are Associated with Preeclampsia. MedRxiv. 2023 Feb 2/14/2023; PMID: 36824881, PMCID: PMC9949198, PII: 2023.02.09.23285734, DOI: 10.1101/2023.02.09.23285734.

Jasper EA, Hellwege JN, Piekos JA, Jones SH, Hartmann KE, Mautz B, Aronoff DM, Edwards TL, Edwards DRV. Genetically-predicted placental gene expression is associated with birthweight and adult body mass index. Sci Rep. 2023 Jan 1/6/2023; 13(1): 322. PMID: 36609580, PMCID: PMC9822919, PII: 10.1038/s41598-022-26572-6, DOI: 10.1038/s41598-022-26572-6, ISSN: 2045-2322.

Hellwege JN, Dorn C, Irvin MR, Limdi NA, Cimino J, Beasley TM, Tsao PS, Damrauer SM, Roden DM, Velez Edwards DR, Wei WQ, Edwards TL. Predictive models for abdominal aortic aneurysms using polygenic scores and PheWAS-derived risk factors. Pac Symp Biocomput. 2023; 28: 425-36. PMID: 36540997, PMCID: PMC9782709, PII: 9789811270611_0039, ISSN: 2335-6936.

Armstrong ND, Srinivasasainagendra V, Ammous F, Assimes TL, Beitelshees AL, Brody J, Cade BE, Ida Chen YD, Chen H, de Vries PS, Floyd JS, Franceschini N, Guo X, Hellwege JN, House JS, Hwu CM, Kardia SLR, Lange EM, Lange LA, McDonough CW, Montasser ME, O'Connell JR, Shuey MM, Sun X, Tanner RM, Wang Z, Zhao W, Carson AP, Edwards TL, Kelly TN, Kenny EE, Kooperberg C, Loos RJF, Morrison AC, Motsinger-Reif A, Psaty BM, Rao DC, Redline S, Rich SS, Rotter JI, Smith JA, Smith AV, Irvin MR, Arnett DK. Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program. Front Genet. 2023; 14: 1278215. PMID: 38162683, PMCID: PMC10755672, PII: 1278215, DOI: 10.3389/fgene.2023.1278215, ISSN: 1664-8021.

Hellwege JN, Edwards TL. Translational opportunities emerge from genetic influences on health. Trends Mol Med [print-electronic]. 2022 Dec; 28(12): 1028-9. PMID: 36344332, PII: S1471-4914(22)00271-4, DOI: 10.1016/j.molmed.2022.10.006, ISSN: 1471-499X.

Khan A, Turchin MC, Patki A, Srinivasasainagendra V, Shang N, Nadukuru R, Jones AC, Malolepsza E, Dikilitas O, Kullo IJ, Schaid DJ, Karlson E, Ge T, Meigs JB, Smoller JW, Lange C, Crosslin DR, Jarvik GP, Bhatraju PK, Hellwege JN, Chandler P, Torvik LR, Fedotov A, Liu C, Kachulis C, Lennon N, Abul-Husn NS, Cho JH, Ionita-Laza I, Gharavi AG, Chung WK, Hripcsak G, Weng C, Nadkarni G, Irvin MR, Tiwari HK, Kenny EE, Limdi NA, Kiryluk K. Genome-wide polygenic score to predict chronic kidney disease across ancestries. Nat Med [print-electronic]. 2022 Jul; 28(7): 1412-20. PMID: 35710995, PMCID: PMC9329233, PII: 10.1038/s41591-022-01869-1, DOI: 10.1038/s41591-022-01869-1, ISSN: 1546-170X.

Kelly TN, Sun X, He KY, Brown MR, Taliun SAG, Hellwege JN, Irvin MR, Mi X, Brody JA, Franceschini N, Guo X, Hwang SJ, de Vries PS, Gao Y, Moscati A, Nadkarni GN, Yanek LR, Elfassy T, Smith JA, Chung RH, Beitelshees AL, Patki A, Aslibekyan S, Blobner BM, Peralta JM, Assimes TL, Palmas WR, Liu C, Bress AP, Huang Z, Becker LC, Hwa CM, O'Connell JR, Carlson JC, Warren HR, Das S, Giri A, Martin LW, Craig Johnson W, Fox ER, Bottinger EP, Razavi AC, Vaidya D, Chuang LM, Chang YC, Naseri T, Jain D, Kang HM, Hung AM, Srinivasasainagendra V, Snively BM, Gu D, Montasser ME, Reupena MS, Heavner BD, LeFaive J, Hixson JE, Rice KM, Wang FF, Nielsen JB, Huang J, Khan AT, Zhou W, Nierenberg JL, Laurie CC, Armstrong ND, Shi M, Pan Y, Stilp AM, Emery L, Wong Q, Hawley NL, Minster RL, Curran JE, Munroe PB, Weeks DE, North KE, Tracy RP, Kenny EE, Shimbo D, Chakravarti A, Rich SS, Reiner AP, Blangero J, Redline S, Mitchell BD, Rao DC, Ida Chen YD, Kardia SLR, Kaplan RC, Mathias RA, He J, Psaty BM, Fornage M, Loos RJF, Correa A, Boerwinkle E, Rotter JI, Kooperberg C, Edwards TL, Abecasis GR, Zhu X, Levy D, Arnett DK, Morrison AC, . Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension. Hypertension [print-electronic]. 2022 Jun 6/2/2022; 101161HYPERTENSIONAHA12219324. PMID: 35652341, DOI: 10.1161/HYPERTENSIONAHA.122.19324, ISSN: 1524-4563.

Breeyear JH, Shuey MM, Edwards TL, Hellwege JN. Blood Pressure Polygenic Scores Are Associated With Apparent Treatment-Resistant Hypertension [letter]. Circ Genom Precis Med [print-electronic]. 2022 May 5/6/2022; 101161CIRCGEN121003554. PMID: 35522175, DOI: 10.1161/CIRCGEN.121.003554, ISSN: 2574-8300.

Piekos JA, Hellwege JN, Zhang Y, Torstenson ES, Jarvik GP, Dikilitas O, Kullo IJ, Schaid DJ, Crosslin DR, Pendergrass SA, Lee MTM, Roden D, Denny JC, Edwards TL, Velez Edwards DR. Uterine fibroid polygenic risk score (PRS) associates and predicts risk for uterine fibroid. Hum Genet [print-electronic]. 2022 Feb 2/28/2022; PMID: 35226188, PII: 10.1007/s00439-022-02442-z, DOI: 10.1007/s00439-022-02442-z, ISSN: 1432-1203.

Chaudhary NS, Armstrong ND, Hidalgo BA, Gutiérrez OM, Hellwege JN, Limdi NA, Reynolds RJ, Judd SE, Nadkarni GN, Lange L, Winkler CA, Kopp JB, Arnett DK, Tiwari HK, Irvin MR. SMOC2 gene interacts with APOL1 in the development of end-stage kidney disease: A genome-wide association study. Front Med (Lausanne). 2022; 9: 971297. PMID: 36250097, PMCID: PMC9554233, DOI: 10.3389/fmed.2022.971297, ISSN: 2296-858X.

Guan Y, Liang X, Ma Z, Hu H, Liu H, Miao Z, Linkermann A, Hellwege JN, Voight BF, Susztak K. A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis. Nat Commun. 2021 Aug 8/23/2021; 12(1): 5078. PMID: 34426578, PII: 10.1038/s41467-021-25377-x, DOI: 10.1038/s41467-021-25377-x, ISSN: 2041-1723.

Sheng X, Guan Y, Ma Z, Wu J, Liu H, Qiu C, Vitale S, Miao Z, Seasock MJ, Palmer M, Shin MK, Duffin KL, Pullen SS, Edwards TL, Hellwege JN, Hung AM, Li M, Voight BF, Coffman TM, Brown CD, Susztak K. Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments. Nat Genet [print-electronic]. 2021 Aug 8/12/2021; PMID: 34385711, PII: 10.1038/s41588-021-00909-9, DOI: 10.1038/s41588-021-00909-9, ISSN: 1546-1718.

Akwo EA, Robinson-Cohen C, Chung CP, Shah SC, Brown NJ, Ikizler TA, Wilson OD, Rowan BX, Shuey MM, Siew ED, Luther JM, Giri A, Hellwege JN, Velez Edwards DR, Roumie CL, Tao R, Tsao PS, Gaziano JM, Wilson PWF, O'Donnell CJ, Edwards TL, Kovesdy CP, Hung AM, . Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program. Hypertension [print-electronic]. 2021 Aug; 78(2): 376-86. PMID: 34148359, PMCID: PMC8364328, DOI: 10.1161/HYPERTENSIONAHA.120.16181, ISSN: 1524-4563.

Keaton JM, Jasper EA, Hellwege JN, Jones SH, Torstenson ES, Edwards TL, Velez Edwards DR. Evidence that geographic variation in genetic ancestry associates with uterine fibroids. Hum Genet [print-electronic]. 2021 Jul 7/23/2021; PMID: 34302236, PII: 10.1007/s00439-021-02322-y, DOI: 10.1007/s00439-021-02322-y, ISSN: 1432-1203.

Shi M, Manouchehri AM, Shaffer CM, Vaitinadin NS, Hellwege JN, Salem JE, Davis LK, Simmons JH, Roden DM, Shoemaker MB, Ferguson JF, Mosley JD. Genetic Thyrotropin Regulation of Atrial Fibrillation Risk Is Mediated Through an Effect on Height. J Clin Endocrinol Metab. 2021 Jun 6/16/2021; 106(7): 2124-32. PMID: 33895829, PMCID: PMC8208678, PII: 6250092, DOI: 10.1210/clinem/dgab272, ISSN: 1945-7197.

Levin MG, Klarin D, Walker VM, Gill D, Lynch J, Hellwege JN, Keaton JM, Lee KM, Assimes TL, Natarajan P, Hung AM, Edwards TL, Rader DJ, Gaziano JM, Davies NM, Tsao PS, Chang KM, Voight BF, Damrauer SM, . Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease. Arterioscler Thromb Vasc Biol [print-electronic]. 2021 Jun; 41(6): 2027-34. PMID: 33853351, PMCID: PMC8159880, DOI: 10.1161/ATVBAHA.120.315482, ISSN: 1524-4636.

Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D. Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses. Hypertension [print-electronic]. 2021 Jun; 77(6): 2004-13. PMID: 33813844, PMCID: PMC8115430, DOI: 10.1161/HYPERTENSIONAHA.120.16534, ISSN: 1524-4563.

Hellwege JN, Zhu X, Huang X, Shrubsole MJ, Fan L, Li B, Ness R, Seidner DL, Giovannucci EL, Edwards TL, Dai Q. Blunted PTH response to vitamin D insufficiency/deficiency and colorectal neoplasia risk. Clin Nutr [print-electronic]. 2021 May; 40(5): 3305-13. PMID: 33190990, PMCID: PMC8099932, PII: S0261-5614(20)30603-8, DOI: 10.1016/j.clnu.2020.10.057, ISSN: 1532-1983.

Keaton JM, Hellwege JN, Giri A, Torstenson ES, Kovesdy CP, Sun YV, Wilson PWF, O'Donnell CJ, Edwards TL, Hung AM, Velez Edwards DR, . Associations of biogeographic ancestry with hypertension traits. J Hypertens. 2021 Apr 4/1/2021; 39(4): 633-42. PMID: 33534346, PMCID: PMC8362794, PII: 00004872-202104000-00009, DOI: 10.1097/HJH.0000000000002701, ISSN: 1473-5598.

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Mosley JD, Levinson RT, Farber-Eger E, Edwards TL, Hellwege JN, Hung AM, Giri A, Shuey MM, Shaffer CM, Shi M, Brittain EL, Chung WK, Kullo IJ, Arruda-Olson AM, Jarvik GP, Larson EB, Crosslin DR, Williams MS, Borthwick KM, Hakonarson H, Denny JC, Wang TJ, Stein CM, Roden DM, Wells QS. The polygenic architecture of left ventricular mass mirrors the clinical epidemiology. Sci Rep. 2020 May 5/5/2020; 10(1): 7561. PMID: 32372017, PMCID: PMC7200691, PII: 10.1038/s41598-020-64525-z, DOI: 10.1038/s41598-020-64525-z, ISSN: 2045-2322.

Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Sturmer T, Stewart J, Raffield L, Sun F, Liu CT, Xu H, Cupples AL, Tanner RM, Rossing P, Smith A, Zilhão NR, Launer LJ, Noordam R, Rotter JI, Yao J, Li X, Guo X, Limdi N, Sundaresan A, Lange L, Correa A, Stott DJ, Ford I, Jukema JW, Gudnason V, Mook-Kanamori DO, Trompet S, Palmas W, Warren HR, Hellwege JN, Giri A, O'Donnell C, Hung AM, Edwards TL, Ahluwalia TS, Arnett DK, Avery CL, . Genome wide association study of apparent treatment resistant hypertension in the CHARGE consortium: The CHARGE Pharmacogenetics Working Group. Am. J. Hypertens [print-electronic]. 2019 Sep 9/23/2019; PMID: 31545351, PII: 5572670, DOI: 10.1093/ajh/hpz150, ISSN: 1941-7225.

Hellwege JN, Velez Edwards DR, Giri A, Qiu C, Park J, Torstenson ES, Keaton JM, Wilson OD, Robinson-Cohen C, Chung CP, Roumie CL, Klarin D, Damrauer SM, DuVall SL, Siew E, Akwo EA, Wuttke M, Gorski M, Li M, Li Y, Gaziano JM, Wilson PWF, Tsao PS, O'Donnell CJ, Kovesdy CP, Pattaro C, Köttgen A, Susztak K, Edwards TL, Hung AM. Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. Nat Commun. 2019 Aug 8/26/2019; 10(1): 3842. PMID: 31451708, PMCID: PMC6710266, PII: 10.1038/s41467-019-11704-w, DOI: 10.1038/s41467-019-11704-w, ISSN: 2041-1723.

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Hellwege JN, Stallings S, Torstenson ES, Carroll R, Borthwick KM, Brilliant MH, Crosslin D, Gordon A, Hripcsak G, Jarvik GP, Linneman JG, Devi P, Peissig PL, Sleiman PAM, Hakonarson H, Ritchie MD, Verma SS, Shang N, Denny JC, Roden DM, Velez Edwards DR, Edwards TL. Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network. Sci Rep. 2019 Apr 4/15/2019; 9(1): 6077. PMID: 30988330, PMCID: PMC6465359, PII: 10.1038/s41598-019-42427-z, DOI: 10.1038/s41598-019-42427-z, ISSN: 2045-2322.

Wang H, Nandakumar P, Tekola-Ayele F, Tayo BO, Ware EB, Gu CC, Lu Y, Yao J, Zhao W, Smith JA, Hellwege JN, Guo X, Edwards TL, Loos RJF, Arnett DK, Fornage M, Rotimi C, Kardia SLR, Cooper RS, Rao DC, Ehret G, Chakravarti A, Zhu X. Combined linkage and association analysis identifies rare and low frequency variants for blood pressure at 1q31. Eur. J. Hum. Genet [print-electronic]. 2019 Feb; 27(2): 269-77. PMID: 30262922, PMCID: PMC6336803, PII: 10.1038/s41431-018-0277-1, DOI: 10.1038/s41431-018-0277-1, ISSN: 1476-5438.

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP, Sun YV, Wilson OD, Robinson-Cohen C, Roumie CL, Chung CP, Birdwell KA, Damrauer SM, DuVall SL, Klarin D, Cho K, Wang Y, Evangelou E, Cabrera CP, Wain LV, Shrestha R, Mautz BS, Akwo EA, Sargurupremraj M, Debette S, Boehnke M, Scott LJ, Luan J, Zhao JH, Willems SM, Thériault S, Shah N, Oldmeadow C, Almgren P, Li-Gao R, Verweij N, Boutin TS, Mangino M, Ntalla I, Feofanova E, Surendran P, Cook JP, Karthikeyan S, Lahrouchi N, Liu C, Sepúlveda N, Richardson TG, Kraja A, Amouyel P, Farrall M, Poulter NR, , , , Laakso M, Zeggini E, Sever P, Scott RA, Langenberg C, Wareham NJ, Conen D, Palmer CNA, Attia J, Chasman DI, Ridker PM, Melander O, Mook-Kanamori DO, Harst PV, Cucca F, Schlessinger D, Hayward C, Spector TD, Jarvelin MR, Hennig BJ, Timpson NJ, Wei WQ, Smith JC, Xu Y, Matheny ME, Siew EE, Lindgren C, Herzig KH, Dedoussis G, Denny JC, Psaty BM, Howson JMM, Munroe PB, Newton-Cheh C, Caulfield MJ, Elliott P, Gaziano JM, Concato J, Wilson PWF, Tsao PS, Velez Edwards DR, Susztak K, , O'Donnell CJ, Hung AM, Edwards TL. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat. Genet [print-electronic]. 2019 Jan; 51(1): 51-62. PMID: 30578418, PMCID: PMC6365102, PII: 10.1038/s41588-018-0303-9, DOI: 10.1038/s41588-018-0303-9, ISSN: 1546-1718.

Edwards TL, Giri A, Hellwege JN, Hartmann KE, Stewart EA, Jeff JM, Bray MJ, Pendergrass SA, Torstenson ES, Keaton JM, Jones SH, Gogoi RP, Kuivaniemi H, Jackson KL, Kho AN, Kullo IJ, McCarty CA, Im HK, Pacheco JA, Pathak J, Williams MS, Tromp G, Kenny EE, Peissig PL, Denny JC, Roden DM, Velez Edwards DR. A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids. Front Genet. 2019; 10: 511. PMID: 31249589, PMCID: PMC6582231, DOI: 10.3389/fgene.2019.00511, ISSN: 1664-8021.

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, Elosua R, Enroth S, Erzurumluoglu AM, Ferreira T, Frånberg M, Franco OH, Gandin I, Gasparini P, Giedraitis V, Gieger C, Girotto G, Goel A, Gow AJ, Gudnason V, Guo X, Gyllensten U, Hamsten A, Harris TB, Harris SE, Hartman CA, Havulinna AS, Hicks AA, Hofer E, Hofman A, Hottenga JJ, Huffman JE, Hwang SJ, Ingelsson E, James A, Jansen R, Jarvelin MR, Joehanes R, Johansson Å, Johnson AD, Joshi PK, Jousilahti P, Jukema JW, Jula A, Kähönen M, Kathiresan S, Keavney BD, Khaw KT, Knekt P, Knight J, Kolcic I, Kooner JS, Koskinen S, Kristiansson K, Kutalik Z, Laan M, Larson M, Launer LJ, Lehne B, Lehtimäki T, Liewald DCM, Lin L, Lind L, Lindgren CM, Liu Y, Loos RJF, Lopez LM, Lu Y, Lyytikäinen LP, Mahajan A, Mamasoula C, Marrugat J, Marten J, Milaneschi Y, Morgan A, Morris AP, Morrison AC, Munson PJ, Nalls MA, Nandakumar P, Nelson CP, Niiranen T, Nolte IM, Nutile T, Oldehinkel AJ, Oostra BA, O'Reilly PF, Org E, Padmanabhan S, Palmas W, Palotie A, Pattie A, Penninx BWJH, Perola M, Peters A, Polasek O, Pramstaller PP, Nguyen QT, Raitakari OT, Ren M, Rettig R, Rice K, Ridker PM, Ried JS, Riese H, Ripatti S, Robino A, Rose LM, Rotter JI, Rudan I, Ruggiero D, Saba Y, Sala CF, Salomaa V, Samani NJ, Sarin AP, Schmidt R, Schmidt H, Shrine N, Siscovick D, Smith AV, Snieder H, Sõber S, Sorice R, Starr JM, Stott DJ, Strachan DP, Strawbridge RJ, Sundström J, Swertz MA, Taylor KD, Teumer A, Tobin MD, Tomaszewski M, Toniolo D, Traglia M, Trompet S, Tuomilehto J, Tzourio C, Uitterlinden AG, Vaez A, van der Most PJ, van Duijn CM, Vergnaud AC, Verwoert GC, Vitart V, Völker U, Vollenweider P, Vuckovic D, Watkins H, Wild SH, Willemsen G, Wilson JF, Wright AF, Yao J, Zemunik T, Zhang W, Attia JR, Butterworth AS, Chasman DI, Conen D, Cucca F, Danesh J, Hayward C, Howson JMM, Laakso M, Lakatta EG, Langenberg C, Melander O, Mook-Kanamori DO, Palmer CNA, Risch L, Scott RA, Scott RJ, Sever P, Spector TD, van der Harst P, Wareham NJ, Zeggini E, Levy D, Munroe PB, Newton-Cheh C, Brown MJ, Metspalu A, Hung AM, O'Donnell CJ, Edwards TL, Psaty BM, Tzoulaki I, Barnes MR, Wain LV, Elliott P, Caulfield MJ, . Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat. Genet [print-electronic]. 2018 Oct; 50(10): 1412-25. PMID: 30224653, PMCID: PMC6284793, PII: 10.1038/s41588-018-0205-x, DOI: 10.1038/s41588-018-0205-x, ISSN: 1546-1718.

Keaton JM, Gao C, Guan M, Hellwege JN, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YI, Taylor KD, Rich SS, Wagenknecht LE, Freedman BI, Ng MCY, Bowden DW. Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans. Genet. Epidemiol [print-electronic]. 2018 Sep; 42(6): 559-70. PMID: 29691896, PMCID: PMC6160319, DOI: 10.1002/gepi.22126, ISSN: 1098-2272.

Weigl K, Thomsen H, Balavarca Y, Hellwege JN, Shrubsole MJ, Brenner H. Genetic Risk Score Is Associated With Prevalence of Advanced Neoplasms in a Colorectal Cancer Screening Population. Gastroenterology [print-electronic]. 2018 Jul; 155(1): 88-98.e10. PMID: 29574091, PMCID: PMC6035076, PII: S0016-5085(18)30337-8, DOI: 10.1053/j.gastro.2018.03.030, ISSN: 1528-0012.

Hellwege JN, Russell SB, Williams SM, Edwards TL, Velez Edwards DR. Gene-based evaluation of low-frequency variation and genetically-predicted gene expression impacting risk of keloid formation. Ann. Hum. Genet [print-electronic]. 2018 Jul; 82(4): 206-15. PMID: 29484647, PMCID: PMC5993571, DOI: 10.1111/ahg.12245, ISSN: 1469-1809.

Gao C, Langefeld CD, Ziegler JT, Taylor KD, Norris JM, Chen YI, Hellwege JN, Guo X, Allison MA, Speliotes EK, Rotter JI, Bowden DW, Wagenknecht LE, Palmer ND. Genome-Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex-Specific Adiposity Loci in Mexican Americans. Obesity (Silver Spring) [print-electronic]. 2018 Jan; 26(1): 202-12. PMID: 29178545, PMCID: PMC5740005, DOI: 10.1002/oby.22074, ISSN: 1930-739X.

Hellwege JN, Keaton JM, Giri A, Gao X, Velez Edwards DR, Edwards TL. Population Stratification in Genetic Association Studies. Curr Protoc Hum Genet. 2017 Oct 10/18/2017; 95: 1.22.1-1.22.23. PMID: 29044472, PMCID: PMC6007879, DOI: 10.1002/cphg.48, ISSN: 1934-8258.

Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, Mancuso N, Im HK, Hinds DA, Palmer JR, Rosenberg L, Denny JC, Roden DM, Stewart EA, Morton CC, Kenny EE, Edwards TL, Velez Edwards DR. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum. Genet [print-electronic]. 2017 Oct; 136(10): 1363-73. PMID: 28836065, PMCID: PMC5628188, PII: 10.1007/s00439-017-1836-1, DOI: 10.1007/s00439-017-1836-1, ISSN: 1432-1203.

Mollan KR, Tierney C, Hellwege JN, Eron JJ, Hudgens MG, Gulick RM, Haubrich R, Sax PE, Campbell TB, Daar ES, Robertson KR, Ventura D, Ma Q, Edwards DRV, Haas DW, . Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants. J. Infect. Dis. 2017 Sep 9/1/2017; 216(5): 554-64. PMID: 28931220, PMCID: PMC5853681, PII: 3927196, DOI: 10.1093/infdis/jix248, ISSN: 1537-6613.

Giri A, Hartmann KE, Hellwege JN, Velez Edwards DR, Edwards TL. Obesity and pelvic organ prolapse: a systematic review and meta-analysis of observational studies. Am. J. Obstet. Gynecol [print-electronic]. 2017 Jul; 217(1): 11-26.e3. PMID: 28188775, PII: S0002-9378(17)30174-6, DOI: 10.1016/j.ajog.2017.01.039, ISSN: 1097-6868.

Tabb KL, Hellwege JN, Palmer ND, Dimitrov L, Sajuthi S, Taylor KD, Ng MC, Hawkins GA, Chen YI, Brown WM, McWilliams D, Williams A, Lorenzo C, Norris JM, Long J, Rotter JI, Curran JE, Blangero J, Wagenknecht LE, Langefeld CD, Bowden DW. Analysis of Whole Exome Sequencing with Cardiometabolic Traits Using Family-Based Linkage and Association in the IRAS Family Study. Ann. Hum. Genet [print-electronic]. 2017 Mar; 81(2): 49-58. PMID: 28067407, PMCID: PMC5719883, DOI: 10.1111/ahg.12184, ISSN: 1469-1809.

Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW. Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. J. Hum. Genet [print-electronic]. 2017 Feb; 62(2): 175-84. PMID: 27535031, PMCID: PMC5266668, PII: jhg2016103, DOI: 10.1038/jhg.2016.103, ISSN: 1435-232X.

Hellwege JN, Torstenson ES, Russell SB, Edwards TL, Velez Edwards DR. Evidence of selection as a cause for racial disparities in fibroproliferative disease. PLoS ONE. 2017; 12(8): e0182791. PMID: 28792542, PMCID: PMC5549739, PII: PONE-D-17-27618, DOI: 10.1371/journal.pone.0182791, ISSN: 1932-6203.

Hellwege JN, Velez Edwards DR, Acra S, Chen K, Buchowski MS, Edwards TL. Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults. BMC Obes. 2017; 4: 12. PMID: 28417008, PMCID: PMC5381071, PII: 145, DOI: 10.1186/s40608-017-0145-5, ISSN: 2052-9538.

Keaton JM, Hellwege JN, Ng MCY, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YI, Taylor KD, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW. GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS. Pac Symp Biocomput. 2017; 22: 242-53. PMID: 27896979, PMCID: PMC5146756, PII: 9789813207813_0024, DOI: 10.1142/9789813207813_0024, ISSN: 2335-6936.

Keaton JM, Hellwege JN, Ng MC, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YD, Taylor KD, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW. Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans. PLoS ONE. 2016; 11(7): e0159977. PMID: 27448167, PMCID: PMC4957757, PII: PONE-D-16-20120, DOI: 10.1371/journal.pone.0159977, ISSN: 1932-6203.

Hellwege JN, Palmer ND, Mark Brown W, Ziegler JT, Sandy An S, Guo X, Ida Chen YD, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW. Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hum. Genet [print-electronic]. 2015 Feb; 134(2): 203-13. PMID: 25447270, PMCID: PMC4293344, DOI: 10.1007/s00439-014-1511-8, ISSN: 1432-1203.

Hellwege JN, Palmer ND, Raffield LM, Ng MC, Hawkins GA, Long J, Lorenzo C, Norris JM, Ida Chen YD, Speliotes EK, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW. Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk. Genet. Epidemiol [print-electronic]. 2014 May; 38(4): 345-52. PMID: 24719370, PMCID: PMC4281959, DOI: 10.1002/gepi.21801, ISSN: 1098-2272.

Hellwege JN, Palmer ND, Ziegler JT, Langefeld CD, Lorenzo C, Norris JM, Takamura T, Bowden DW. Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics. Gene [print-electronic]. 2014 Jan 1/15/2014; 534(1): 33-9. PMID: 24161883, PMCID: PMC3856675, PII: S0378-1119(13)01430-3, DOI: 10.1016/j.gene.2013.10.035, ISSN: 1879-0038.

Cooke JN, Bostrom MA, Hicks PJ, Ng MC, Hellwege JN, Comeau ME, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans. Nephrol. Dial. Transplant [print-electronic]. 2012 Apr; 27(4): 1505-11. PMID: 21968013, PMCID: PMC3315672, PII: gfr522, DOI: 10.1093/ndt/gfr522, ISSN: 1460-2385.

Hellwege JN, Hicks PJ, Palmer ND, Ng MC, Freedman BI, Bowden DW. Examination of Rare Variants in HNF4 a in European Americans with Type 2 Diabetes. J Diabetes Metab. 2011 Oct 10/20/2011; 2(145): PMID: 23227446, PMCID: PMC3515062, DOI: 10.4172/2155-6156.1000145, ISSN: 2155-6156.