Anandharajan Rathinasabapathy, Ph.D.

Research Instructor

anandharajan.rathinasabapathy@vanderbilt.edu
Faculty Appointments
Research Instructor in Medicine
Education
Ph.D., Pharmacodynamics, University of Florida, Gainesville, FloridaM.S., Research, Anna University, Chennai, India
Publications
Rathinasabapathy A, West JD. Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension. Pulm Circ [print-electronic]. 2018 Jul; 8(3): 2045894018796782. PMID: 30124137, PMCID: PMC6109854, DOI: 10.1177/2045894018796782, ISSN: 2045-8932.

Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J. A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. Eur. Respir. J [electronic-print]. 2018 Jun; 51(6): PMID: 29903860, PII: 13993003.02638-2017, DOI: 10.1183/13993003.02638-2017, ISSN: 1399-3003.

Sharma RK, Oliveira AC, Kim S, Rigatto K, Zubcevic J, Rathinasabapathy A, Kumar A, Lebowitz JJ, Khoshbouei H, Lobaton G, Aquino V, Richards EM, Katovich MJ, Shenoy V, Raizada MK. Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension. Hypertension [print-electronic]. 2018 Jun; 71(6): 1156-63. PMID: 29712738, PMCID: PMC5945302, PII: HYPERTENSIONAHA.118.10934, DOI: 10.1161/HYPERTENSIONAHA.118.10934, ISSN: 1524-4563.

Rathinasabapathy A, Bryant AJ, Suzuki T, Moore C, Shay S, Gladson S, West JD, Carrier EJ. RhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling. Front Physiol. 2018; 9: 271. PMID: 29731719, PMCID: PMC5922219, DOI: 10.3389/fphys.2018.00271, ISSN: 1664-042X.

Rathinasabapathy A, Horowitz A, Horton K, Kumar A, Gladson S, Unger T, Martinez D, Bedse G, West J, Raizada MK, Steckelings UM, Sumners C, Katovich MJ, Shenoy V. The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury. Front Physiol. 2018; 9: 180. PMID: 29636695, PMCID: PMC5881224, DOI: 10.3389/fphys.2018.00180, ISSN: 1664-042X.

Suzuki T, Carrier EJ, Talati MH, Rathinasabapathy A, Chen X, Nishimura R, Tada Y, Tatsumi K, West J. Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2018 Jan 1/1/2018; 314(1): L118-L126. PMID: 28935639, PMCID: PMC5866427, PII: ajplung.00296.2017, DOI: 10.1152/ajplung.00296.2017, ISSN: 1522-1504.

Rathinasabapathy A, Bruce E, Espejo A, Horowitz A, Sudhan DR, Nair A, Guzzo D, Francis J, Raizada MK, Shenoy V, Katovich MJ. Therapeutic potential of adipose stem cell-derived conditioned medium against pulmonary hypertension and lung fibrosis. Br. J. Pharmacol [print-electronic]. 2016 Oct; 173(19): 2859-79. PMID: 27448286, PMCID: PMC5275771, DOI: 10.1111/bph.13562, ISSN: 1476-5381.

Rubiano A, Qi Y, Guzzo D, Rathinasabapathy A, Rowe K, Pepine C, Simmons C. Stem cell therapy restores viscoelastic properties of myocardium in rat model of hypertension. J Mech Behav Biomed Mater [print-electronic]. 2016 Jun; 59: 71-7. PMID: 26748260, PMCID: PMC4860127, PII: S1751-6161(15)00476-2, DOI: 10.1016/j.jmbbm.2015.11.041, ISSN: 1878-0180.

Shenoy V, Kwon KC, Rathinasabapathy A, Lin S, Jin G, Song C, Shil P, Nair A, Qi Y, Li Q, Francis J, Katovich MJ, Daniell H, Raizada MK. Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension. Hypertension [print-electronic]. 2014 Dec; 64(6): 1248-59. PMID: 25225206, PMCID: PMC4239698, PII: HYPERTENSIONAHA.114.03871, DOI: 10.1161/HYPERTENSIONAHA.114.03871, ISSN: 1524-4563.

Shenoy V, Gjymishka A, Jarajapu YP, Qi Y, Afzal A, Rigatto K, Ferreira AJ, Fraga-Silva RA, Kearns P, Douglas JY, Agarwal D, Mubarak KK, Bradford C, Kennedy WR, Jun JY, Rathinasabapathy A, Bruce E, Gupta D, Cardounel AJ, Mocco J, Patel JM, Francis J, Grant MB, Katovich MJ, Raizada MK. Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. Am. J. Respir. Crit. Care Med [print-electronic]. 2013 Mar 3/15/2013; 187(6): 648-57. PMID: 23370913, PMCID: PMC3733435, PII: rccm.201205-0880OC, DOI: 10.1164/rccm.201205-0880OC, ISSN: 1535-4970.

Anandharajan R, Sayyed SG, Doshi LS, Dixit P, Chandak PG, Dixit AV, Brahma MK, Deshmukh NJ, Gupte R, Damre A, Suthar J, Padigaru M, Sharma SD, Nemmani KV. 18F9 (4-(3,6-bis (ethoxycarbonyl)-4,5,6,7-tetrahydrothieno (2,3-c) pyridin-2-ylamino)-4-oxobutanoic acid) enhances insulin-mediated glucose uptake in vitro and exhibits antidiabetic activity in vivo in db/db mice. Metab. Clin. Exp [print-electronic]. 2009 Oct; 58(10): 1503-16. PMID: 19608207, PII: S0026-0495(09)00195-4, DOI: 10.1016/j.metabol.2009.04.036, ISSN: 1532-8600.