Rachelle Crescenzi, Ph.D.

Research Instructor

rachelle.crescenzi@vanderbilt.edu
Faculty Appointments
Research Instructor in Radiology & Radiological Sciences
Education
Ph.D., Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PennsylvaniaB.S., Physics, University of Delaware, Newark, Delaware
Research Description
Rachelle L. Crescenzi, PhD is a translational imaging scientist and Research Instructor in the Department of Radiology and Radiological Sciences at Vanderbilt University Medical Center (VUMC). She studied Physics at the University of Delaware and received a BS degree with honors in January 2009. She completed undergraduate internships at the National Institute of Standards and Technology (NIST) and the University of Pennsylvania where she was first introduced to radiology. In 2015 she earned her PhD in Biochemistry and Molecular Biophysics from the University of Pennsylvania in the Center for Magnetic Resonance and Optical Imaging (CMROI). Her postdoctoral training in the Vanderbilt University Institute of Imaging Science (VUIIS) focused on clinical vascular imaging in patients with lymphatic disease. She was awarded a postdoctoral research fellowship through the Lipedema Foundation (2015-2017), and a career development award through the American Heart Association before joining the VUMC faculty in 2018.

Dr. Crescenzi’s research focuses on the development of clinically-feasible molecular MRI techniques to image lymphatic vasculature and physiology related to sodium, protein, and adipose tissue accumulation in diseases of impaired vascular clearance. Her research applications include an understudied adipose disorder called lipedema, and cardiovascular disease risk factors related to sodium metabolism. Dr. Crescenzi is a member of the International Society for Magnetic Resonance in Medicine (ISMRM, since 2009), the Fat Disorders Resource Society (FDRS, since 2015), the Lymphatic Education & Research Network (LE&RN, since 2015), the American Heart Association (AHA, since 2018), and The Obesity Society (TOS, since 2018).

Section: Vanderbilt University Institute of Imaging Science

Selected Publications:
Crescenzi R, Donahue PMC, Braxton VG, Scott AO, Donahue MJ. 3.0T relaxation time measurements of human lymph nodes in adults with and without lymphatic insufficiency: implications for magnetic resonance lymphatic imaging. NMR in Biomedicine. 2018; e4009. https://doi.org/10.1002/nbm.4009.

Crescenzi R, Marton A, Donahue PM, Mahany HB, Lants SK, Wang P, Beckman JA, Donahue MJ, Titze J. Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema. Obesity. 2018 Feb;26(2):310-317. doi: 10.1002/oby.22090. PMID: 29280322.

Crescenzi R*, Donahue PM*, Hartley KG, Desai AA, Scott AO, Braxton V, Mahany HB, Lants SK, Donahue MJ. Lymphedema Evaluation Using Noninvasive 3T MR Lymphangiography. Journal of Magnetic Resonance Imaging. 2017 Nov;46(5):1349-1360. doi: 10.1002/jmri.25670. PMID: 28245075.

Donahue PM, Crescenzi R, Scott AO, Braxton V, Desai AA, Smith SA, Jordi J, Meszoely IM, Grau AM, Kauffmann RM, Sweeting RS, Spotanski K, Ridner SH, Donahue MJ. Bilateral Changes in Deep Tissue Environment After Manual Lymphatic Drainage in Patients with Breast Cancer Treatment-Related Lymphedema. Lymphatic Research and Biology. 2017 Mar;15(1):45-56. doi: 10.1089/lrb.2016.0020. PMID: 28323572.
Publications
Crescenzi R, Marton A, Donahue PMC, Mahany HB, Lants SK, Wang P, Beckman JA, Donahue MJ, Titze J. Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema. Obesity (Silver Spring) [print-electronic]. 2018 Feb; 26(2): 310-7. PMID: 29280322, PMCID: PMC5783748, DOI: 10.1002/oby.22090, ISSN: 1930-739X.

Crescenzi R, Donahue PMC, Hartley KG, Desai AA, Scott AO, Braxton V, Mahany H, Lants SK, Donahue MJ. Lymphedema evaluation using noninvasive 3T MR lymphangiography. J Magn Reson Imaging [print-electronic]. 2017 Nov; 46(5): 1349-60. PMID: 28245075, PMCID: PMC5573666, DOI: 10.1002/jmri.25670, ISSN: 1522-2586.

Donahue PM, Crescenzi R, Scott AO, Braxton V, Desai A, Smith SA, Jordi J, Meszoely IM, Grau AM, Kauffmann RM, Sweeting RS, Spotanski K, Ridner SH, Donahue MJ. Bilateral Changes in Deep Tissue Environment After Manual Lymphatic Drainage in Patients with Breast Cancer Treatment-Related Lymphedema. Lymphat Res Biol. 2017 Mar; 15(1): 45-56. PMID: 28323572, PMCID: PMC5369395, DOI: 10.1089/lrb.2016.0020, ISSN: 1557-8585.