Faculty Appointments
Assistant Professor of Medicine
Education
M.D., Robert Wood Johnson Medical School, New Brunswick, New JerseyB.S., Biology, Pepperdine University, Malibu, California
Research Description
Dr. Cahill’s research focuses on elucidating the innate immune mechanisms that drive the development of asthma in adulthood. She has a clinical and research interest in aspirin-exacerbated respiratory disease (AERD), the triad of asthma, chronic rhinosinusitis with nasal polyps, and respiratory reactions to inhibitors of cyclooxygenase-1 such as aspirin, ibuprofen and naproxen. Through the study of a large cohort of patients with AERD and mechanistic clinical trials in adults with asthma, Dr. Cahill’s goal is to devise therapeutics that target the mechanisms driving disease for each individual adult with asthma.
Clinical Research Keywords
Aspirin-exacerbated Respiratory Disease (AERD), Adult-onset Asthma, NSAID drug allergy, Chronic Rhinosinusitis with Nasal Polyps, Clinical Trials, Eicosanoid Biology, Cells and Mediators of Allergic Inflammation
Publications
Laidlaw TM, Cahill KN, Cardet JC, Murphy K, Cui J, Dioneda B, Kothari P, Raby BA, Israel E, Boyce JA. A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol [print-electronic]. 2018 Jun 6/8/2018; PMID: 29890239, PII: S0091-6749(18)30843-1, DOI: 10.1016/j.jaci.2018.06.001, ISSN: 1097-6825.
Tuttle KL, Buchheit KM, Laidlaw TM, Cahill KN. A retrospective analysis of mepolizumab in subjects with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract [print-electronic]. 2018 May; 6(3): 1045-7. PMID: 29501519, PMCID: PMC5997393, PII: S2213-2198(18)30118-1, DOI: 10.1016/j.jaip.2018.01.038, ISSN: 2213-2201.
Schneider TR, Johns CB, Palumbo ML, Murphy KC, Cahill KN, Laidlaw TM. Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial. J Allergy Clin Immunol Pract [print-electronic]. 2018 May; 6(3): 825-31. PMID: 29133219, PMCID: PMC5945343, PII: S2213-2198(17)30794-8, DOI: 10.1016/j.jaip.2017.10.011, ISSN: 2213-2201.
Cahill KN, Boyce JA, Israel E. Novel Treatments for Airway Disease [letter]. N. Engl. J. Med. 2017 Aug 8/10/2017; 377(6): 597. PMID: 28813135, PII: 10.1056/NEJMc1708004#SA5, DOI: 10.1056/NEJMc1708004, ISSN: 1533-4406.
Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel E. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N. Engl. J. Med. 2017 May 5/18/2017; 376(20): 1911-20. PMID: 28514613, PMCID: PMC5568669, DOI: 10.1056/NEJMoa1613125, ISSN: 1533-4406.
Laidlaw TM, Cahill KN. Current Knowledge and Management of Hypersensitivity to Aspirin and NSAIDs. J Allergy Clin Immunol Pract. 2017 May; 5(3): 537-45. PMID: 28483309, PII: S2213-2198(16)30559-1, DOI: 10.1016/j.jaip.2016.10.021, ISSN: 2213-2201.
Cahill KN, Boyce JA. Aspirin-exacerbated respiratory disease: Mediators and mechanisms of a clinical disease [editorial]. J. Allergy Clin. Immunol [print-electronic]. 2017 Mar; 139(3): 764-6. PMID: 27771324, PII: S0091-6749(16)31187-3, DOI: 10.1016/j.jaci.2016.09.025, ISSN: 1097-6825.
Cahill KN, Johns CB, Cui J, Wickner P, Bates DW, Laidlaw TM, Beeler PE. Automated identification of an aspirin-exacerbated respiratory disease cohort. J. Allergy Clin. Immunol [print-electronic]. 2017 Mar; 139(3): 819-825.e6. PMID: 27567328, PMCID: PMC5266739, PII: S0091-6749(16)30700-X, DOI: 10.1016/j.jaci.2016.05.048, ISSN: 1097-6825.
Cahill KN, Laidlaw TM. Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease. Immunol Allergy Clin North Am [print-electronic]. 2016 Nov; 36(4): 681-91. PMID: 27712763, PII: S0889-8561(16)30050-9, DOI: 10.1016/j.iac.2016.06.005, ISSN: 1557-8607.
Shah NH, Schneider TR, DeFaria Yeh D, Cahill KN, Laidlaw TM. Eosinophilia-Associated Coronary Artery Vasospasm in Patients with Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract [print-electronic]. 2016 Nov; 4(6): 1215-9. PMID: 27396680, PMCID: PMC5107156, PII: S2213-2198(16)30159-3, DOI: 10.1016/j.jaip.2016.04.028, ISSN: 2213-2201.
Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol [print-electronic]. 2016 May; 137(5): 1566-1576.e5. PMID: 26691435, PMCID: PMC4860132, PII: S0091-6749(15)01576-6, DOI: 10.1016/j.jaci.2015.10.020, ISSN: 1097-6825.
Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM. Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease. Am. J. Respir. Cell Mol. Biol. 2016 Jan; 54(1): 34-40. PMID: 26051534, PMCID: PMC4742927, DOI: 10.1165/rcmb.2014-0486OC, ISSN: 1535-4989.
Stevens W, Buchheit K, Cahill KN. Aspirin-Exacerbated Diseases: Advances in Asthma with Nasal Polyposis, Urticaria, Angioedema, and Anaphylaxis. Curr Allergy Asthma Rep. 2015 Dec; 15(12): 69. PMID: 26475526, PII: 10.1007/s11882-015-0569-2, DOI: 10.1007/s11882-015-0569-2, ISSN: 1534-6315.
Lee-Sarwar K, Johns C, Laidlaw TM, Cahill KN. Tolerance of daily low-dose aspirin does not preclude aspirin-exacerbated respiratory disease [letter]. J Allergy Clin Immunol Pract [print-electronic]. 2015 May; 3(3): 449-51. PMID: 25634222, PMCID: PMC4426242, PII: S2213-2198(15)00012-4, DOI: 10.1016/j.jaip.2015.01.007, ISSN: 2213-2201.
Cahill KN, Bensko JC, Boyce JA, Laidlaw TM. Prostaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol [print-electronic]. 2015 Jan; 135(1): 245-52. PMID: 25218285, PMCID: PMC4289104, PII: S0091-6749(14)01030-6, DOI: 10.1016/j.jaci.2014.07.031, ISSN: 1097-6825.
Cahill KN, Laidlaw TM. Aspirin exacerbated respiratory disease: the search for a biomarker [editorial]. Ann. Allergy Asthma Immunol [print-electronic]. 2014 Nov; 113(5): 500-1. PMID: 25442693, PII: S1081-1206(14)00598-5, DOI: 10.1016/j.anai.2014.08.017, ISSN: 1534-4436.
Hong DI, Bankova L, Cahill KN, Kyin T, Castells MC. Allergy to monoclonal antibodies: cutting-edge desensitization methods for cutting-edge therapies. Expert Rev Clin Immunol. 2012 Jan; 8(1): 43-52; quiz 53. PMID: 22149339, DOI: 10.1586/eci.11.75, ISSN: 1744-8409.
Cahill KN, Kucharik CJ, Foley JA. Prairie restoration and carbon sequestration: difficulties quantifying C sources and sinks using a biometric approach. Ecol Appl. 2009 Dec; 19(8): 2185-201. PMID: 20014587, ISSN: 1051-0761.
Hayhoe K, Cayan D, Field CB, Frumhoff PC, Maurer EP, Miller NL, Moser SC, Schneider SH, Cahill KN, Cleland EE, Dale L, Drapek R, Hanemann RM, Kalkstein LS, Lenihan J, Lunch CK, Neilson RP, Sheridan SC, Verville JH. Emissions pathways, climate change, and impacts on California. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Aug 8/24/2004; 101(34): 12422-7. PMID: 15314227, PMCID: PMC514653, PII: 0404500101, DOI: 10.1073/pnas.0404500101, ISSN: 0027-8424.
Tuttle KL, Buchheit KM, Laidlaw TM, Cahill KN. A retrospective analysis of mepolizumab in subjects with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract [print-electronic]. 2018 May; 6(3): 1045-7. PMID: 29501519, PMCID: PMC5997393, PII: S2213-2198(18)30118-1, DOI: 10.1016/j.jaip.2018.01.038, ISSN: 2213-2201.
Schneider TR, Johns CB, Palumbo ML, Murphy KC, Cahill KN, Laidlaw TM. Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial. J Allergy Clin Immunol Pract [print-electronic]. 2018 May; 6(3): 825-31. PMID: 29133219, PMCID: PMC5945343, PII: S2213-2198(17)30794-8, DOI: 10.1016/j.jaip.2017.10.011, ISSN: 2213-2201.
Cahill KN, Boyce JA, Israel E. Novel Treatments for Airway Disease [letter]. N. Engl. J. Med. 2017 Aug 8/10/2017; 377(6): 597. PMID: 28813135, PII: 10.1056/NEJMc1708004#SA5, DOI: 10.1056/NEJMc1708004, ISSN: 1533-4406.
Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel E. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N. Engl. J. Med. 2017 May 5/18/2017; 376(20): 1911-20. PMID: 28514613, PMCID: PMC5568669, DOI: 10.1056/NEJMoa1613125, ISSN: 1533-4406.
Laidlaw TM, Cahill KN. Current Knowledge and Management of Hypersensitivity to Aspirin and NSAIDs. J Allergy Clin Immunol Pract. 2017 May; 5(3): 537-45. PMID: 28483309, PII: S2213-2198(16)30559-1, DOI: 10.1016/j.jaip.2016.10.021, ISSN: 2213-2201.
Cahill KN, Boyce JA. Aspirin-exacerbated respiratory disease: Mediators and mechanisms of a clinical disease [editorial]. J. Allergy Clin. Immunol [print-electronic]. 2017 Mar; 139(3): 764-6. PMID: 27771324, PII: S0091-6749(16)31187-3, DOI: 10.1016/j.jaci.2016.09.025, ISSN: 1097-6825.
Cahill KN, Johns CB, Cui J, Wickner P, Bates DW, Laidlaw TM, Beeler PE. Automated identification of an aspirin-exacerbated respiratory disease cohort. J. Allergy Clin. Immunol [print-electronic]. 2017 Mar; 139(3): 819-825.e6. PMID: 27567328, PMCID: PMC5266739, PII: S0091-6749(16)30700-X, DOI: 10.1016/j.jaci.2016.05.048, ISSN: 1097-6825.
Cahill KN, Laidlaw TM. Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease. Immunol Allergy Clin North Am [print-electronic]. 2016 Nov; 36(4): 681-91. PMID: 27712763, PII: S0889-8561(16)30050-9, DOI: 10.1016/j.iac.2016.06.005, ISSN: 1557-8607.
Shah NH, Schneider TR, DeFaria Yeh D, Cahill KN, Laidlaw TM. Eosinophilia-Associated Coronary Artery Vasospasm in Patients with Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract [print-electronic]. 2016 Nov; 4(6): 1215-9. PMID: 27396680, PMCID: PMC5107156, PII: S2213-2198(16)30159-3, DOI: 10.1016/j.jaip.2016.04.028, ISSN: 2213-2201.
Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol [print-electronic]. 2016 May; 137(5): 1566-1576.e5. PMID: 26691435, PMCID: PMC4860132, PII: S0091-6749(15)01576-6, DOI: 10.1016/j.jaci.2015.10.020, ISSN: 1097-6825.
Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM. Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease. Am. J. Respir. Cell Mol. Biol. 2016 Jan; 54(1): 34-40. PMID: 26051534, PMCID: PMC4742927, DOI: 10.1165/rcmb.2014-0486OC, ISSN: 1535-4989.
Stevens W, Buchheit K, Cahill KN. Aspirin-Exacerbated Diseases: Advances in Asthma with Nasal Polyposis, Urticaria, Angioedema, and Anaphylaxis. Curr Allergy Asthma Rep. 2015 Dec; 15(12): 69. PMID: 26475526, PII: 10.1007/s11882-015-0569-2, DOI: 10.1007/s11882-015-0569-2, ISSN: 1534-6315.
Lee-Sarwar K, Johns C, Laidlaw TM, Cahill KN. Tolerance of daily low-dose aspirin does not preclude aspirin-exacerbated respiratory disease [letter]. J Allergy Clin Immunol Pract [print-electronic]. 2015 May; 3(3): 449-51. PMID: 25634222, PMCID: PMC4426242, PII: S2213-2198(15)00012-4, DOI: 10.1016/j.jaip.2015.01.007, ISSN: 2213-2201.
Cahill KN, Bensko JC, Boyce JA, Laidlaw TM. Prostaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol [print-electronic]. 2015 Jan; 135(1): 245-52. PMID: 25218285, PMCID: PMC4289104, PII: S0091-6749(14)01030-6, DOI: 10.1016/j.jaci.2014.07.031, ISSN: 1097-6825.
Cahill KN, Laidlaw TM. Aspirin exacerbated respiratory disease: the search for a biomarker [editorial]. Ann. Allergy Asthma Immunol [print-electronic]. 2014 Nov; 113(5): 500-1. PMID: 25442693, PII: S1081-1206(14)00598-5, DOI: 10.1016/j.anai.2014.08.017, ISSN: 1534-4436.
Hong DI, Bankova L, Cahill KN, Kyin T, Castells MC. Allergy to monoclonal antibodies: cutting-edge desensitization methods for cutting-edge therapies. Expert Rev Clin Immunol. 2012 Jan; 8(1): 43-52; quiz 53. PMID: 22149339, DOI: 10.1586/eci.11.75, ISSN: 1744-8409.
Cahill KN, Kucharik CJ, Foley JA. Prairie restoration and carbon sequestration: difficulties quantifying C sources and sinks using a biometric approach. Ecol Appl. 2009 Dec; 19(8): 2185-201. PMID: 20014587, ISSN: 1051-0761.
Hayhoe K, Cayan D, Field CB, Frumhoff PC, Maurer EP, Miller NL, Moser SC, Schneider SH, Cahill KN, Cleland EE, Dale L, Drapek R, Hanemann RM, Kalkstein LS, Lenihan J, Lunch CK, Neilson RP, Sheridan SC, Verville JH. Emissions pathways, climate change, and impacts on California. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Aug 8/24/2004; 101(34): 12422-7. PMID: 15314227, PMCID: PMC514653, PII: 0404500101, DOI: 10.1073/pnas.0404500101, ISSN: 0027-8424.