Lee Emerson Wheless, Ph.D., M.D.

Instructor

lee.e.wheless@vanderbilt.edu
Faculty Appointments
Instructor in Dermatology
Education
M.D., Medical University of South Carolina, Charleston, South CarolinaPh.D., Epidemiology, Medical University of South Carolina, Charleston, South CarolinaM.S.C.R, Medical University of South Carolina, Charleston, South CarolinaB.S., Biology, Davidson College, Davidson, North Carolina
Publications
Isom C, Wheless L, Hooks MA, Kauffmann RM. Early Melanoma Nodal Positivity and Biopsy Rates Before and After Implementation of the 7th Edition of the AJCC Cancer Staging Manual. JAMA Dermatol [print-electronic]. 2019 Mar 3/6/2019; PMID: 30840034, PII: 2727366, DOI: 10.1001/jamadermatol.2018.5902, ISSN: 2168-6084.

Barnado A, Carroll RJ, Casey C, Wheless L, Denny JC, Crofford LJ. Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus. Lupus [print-electronic]. 2019 Jan; 28(1): 66-76. PMID: 30477398, PMCID: PMC6389392, DOI: 10.1177/0961203318815577, ISSN: 1477-0962.

Barnado A, Carroll RJ, Casey C, Wheless L, Denny JC, Crofford LJ. Phenome-Wide Association Studies Uncover a Novel Association of Increased Atrial Fibrillation in Male Patients With Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). 2018 Nov; 70(11): 1630-6. PMID: 29481723, PMCID: PMC6109620, DOI: 10.1002/acr.23553, ISSN: 2151-4658.

Wheless L, Isom CA, Hooks MA, Kauffmann RM. Mitotic rate is associated with positive lymph nodes in patients with thin melanomas. J. Am. Acad. Dermatol [print-electronic]. 2018 May; 78(5): 935-41. PMID: 29198779, PII: S0190-9622(17)32740-8, DOI: 10.1016/j.jaad.2017.11.041, ISSN: 1097-6787.

Barnado A, Carroll RJ, Casey C, Wheless L, Denny JC, Crofford LJ. Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus. Arthritis Res. Ther. 2018 Apr 4/10/2018; 20(1): 69. PMID: 29636090, PMCID: PMC5894248, PII: 10.1186/s13075-018-1561-8, DOI: 10.1186/s13075-018-1561-8, ISSN: 1478-6362.

Wheless L, Murray LE, Siddiqui F, Byers JD. Re: An unusual migratory polycyclic eruption after administration of prostaglandin E in a neonate. JAAD Case Rep. 2017 Jul; 3(4): 342-3. PMID: 28761916, PMCID: PMC5521021, PII: S2352-5126(17)30068-1, DOI: 10.1016/j.jdcr.2017.03.009, ISSN: 2352-5126.

Boyd AS, Wheless L, Brady BG, Ellis D. Cutaneous Yarrowia lipolytica infection in an immunocompetent woman. JAAD Case Rep. 2017 May; 3(3): 219-21. PMID: 28443314, PMCID: PMC5394197, PII: S2352-5126(17)30043-7, DOI: 10.1016/j.jdcr.2017.02.010, ISSN: 2352-5126.

Barnado A, Casey C, Carroll RJ, Wheless L, Denny JC, Crofford LJ. Developing Electronic Health Record Algorithms That Accurately Identify Patients With Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken) [print-electronic]. 2017 May; 69(5): 687-93. PMID: 27390187, PMCID: PMC5219863, DOI: 10.1002/acr.22989, ISSN: 2151-4658.

Smith AW, Rohrer B, Wheless L, Samantaray S, Ray SK, Inoue J, Azuma M, Banik NL. Calpain inhibition reduces structural and functional impairment of retinal ganglion cells in experimental optic neuritis. J. Neurochem [print-electronic]. 2016 Oct; 139(2): 270-84. PMID: 27513991, PMCID: PMC5056830, DOI: 10.1111/jnc.13770, ISSN: 1471-4159.

Wheless L, Zhu L, Mashayekhi M, Fissell RB. Livedoid Dermatitis Treated With Nifedipine. J Investig Med High Impact Case Rep. 2016 Jan; 4(1): 2324709616629786. PMID: 26885536, PMCID: PMC4740942, PII: 10.1177_2324709616629786, DOI: 10.1177/2324709616629786, ISSN: 2324-7096.

Wheless L, Concepcion BP. A 71-year-old kidney transplant recipient with hemorrhagic mucocutaneous lesions. Am. J. Transplant. 2015 Nov; 15(11): 3008-10. PMID: 26484841, DOI: 10.1111/ajt.13498, ISSN: 1600-6143.

Bohm N, Makowski C, Machado M, Davie A, Seabrook N, Wheless L, Bevill B, Clark B, Kyle TR. Case report and cohort analysis of drug-induced liver injury associated with daptomycin. Antimicrob. Agents Chemother [print-electronic]. 2014 Aug; 58(8): 4902-3. PMID: 24820087, PMCID: PMC4136030, PII: AAC.03157-14, DOI: 10.1128/AAC.03157-14, ISSN: 1098-6596.

Wheless L, Jacks S, Mooneyham Potter KA, Leach BC, Cook J. Skin cancer in organ transplant recipients: more than the immune system. J. Am. Acad. Dermatol [print-electronic]. 2014 Aug; 71(2): 359-65. PMID: 24725477, PMCID: PMC4104255, PII: S0190-9622(14)01157-8, DOI: 10.1016/j.jaad.2014.02.039, ISSN: 1097-6787.

Barnado A, Wheless L, Meyer AK, Gilkeson GS, Kamen DL. Pregnancy outcomes among African-American patients with systemic lupus erythematosus compared with controls. Lupus Sci Med. 2014; 1(1): e000020. PMID: 25360323, PMCID: PMC4211631, PII: lupus-2014-000020, DOI: 10.1136/lupus-2014-000020, ISSN: 2053-8790.

Alberg AJ, Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Smith MW, Strickland PT. DNA repair gene variants in relation to overall cancer risk: a population-based study. Carcinogenesis [print-electronic]. 2013 Jan; 34(1): 86-92. PMID: 23027618, PMCID: PMC3534189, PII: bgs304, DOI: 10.1093/carcin/bgs304, ISSN: 1460-2180.

Jorgensen TJ, Ruczinski I, Yao Shugart Y, Wheless L, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer. Cancer Epidemiol [print-electronic]. 2012 Oct; 36(5): e288-93. PMID: 22677152, PMCID: PMC3438291, PII: S1877-7821(12)00061-6, DOI: 10.1016/j.canep.2012.05.001, ISSN: 1877-783X.

Ruczinski I, Jorgensen TJ, Shugart YY, Schaad YB, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype. Carcinogenesis [print-electronic]. 2012 Sep; 33(9): 1692-8. PMID: 22581838, PMCID: PMC3514896, PII: bgs170, DOI: 10.1093/carcin/bgs170, ISSN: 1460-2180.

Wheless L, Kistner-Griffin E, Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Francis L, Shugart YY, Strickland PT, Kao WH, Alani RM, Smith MW, Alberg AJ. A community-based study of nucleotide excision repair polymorphisms in relation to the risk of non-melanoma skin cancer. J. Invest. Dermatol [print-electronic]. 2012 May; 132(5): 1354-62. PMID: 22336945, PMCID: PMC3326207, PII: S0022-202X(15)35721-3, DOI: 10.1038/jid.2012.4, ISSN: 1523-1747.

Barnado A, Wheless L, Meyer AK, Gilkeson GS, Kamen DL. Quality of life in patients with systemic lupus erythematosus (SLE) compared with related controls within a unique African American population. Lupus [print-electronic]. 2012 Apr; 21(5): 563-9. PMID: 22031537, PMCID: PMC3535475, PII: 0961203311426154, DOI: 10.1177/0961203311426154, ISSN: 1477-0962.

Tang PH, Wheless L, Crouch RK. Regeneration of photopigment is enhanced in mouse cone photoreceptors expressing RPE65 protein. J. Neurosci. 2011 Jul 7/13/2011; 31(28): 10403-11. PMID: 21753017, PMCID: PMC3153911, PII: 31/28/10403, DOI: 10.1523/JNEUROSCI.0182-11.2011, ISSN: 1529-2401.

Chuang GS, Leach BC, Wheless L, Lang PG, Cook J. Preoperative expectations and values of patients undergoing Mohs micrographic surgery. Dermatol Surg [print-electronic]. 2011 Mar; 37(3): 311-9. PMID: 21342309, DOI: 10.1111/j.1524-4725.2011.01878.x, ISSN: 1524-4725.

Kessides MC, Wheless L, Hoffman-Bolton J, Clipp S, Alani RM, Alberg AJ. Cigarette smoking and malignant melanoma: a case-control study. J. Am. Acad. Dermatol [print-electronic]. 2011 Jan; 64(1): 84-90. PMID: 20334951, PMCID: PMC2924442, PII: S0190-9622(10)00126-X, DOI: 10.1016/j.jaad.2010.01.041, ISSN: 1097-6787.

Tang PH, Fan J, Goletz PW, Wheless L, Crouch RK. Effective and sustained delivery of hydrophobic retinoids to photoreceptors. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Nov; 51(11): 5958-64. PMID: 20574023, PMCID: PMC3061517, PII: iovs.10-5766, DOI: 10.1167/iovs.10-5766, ISSN: 1552-5783.

Wheless L, Black J, Alberg AJ. Nonmelanoma skin cancer and the risk of second primary cancers: a systematic review. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2010 Jul; 19(7): 1686-95. PMID: 20570907, PMCID: PMC2901413, PII: 1055-9965.EPI-10-0243, DOI: 10.1158/1055-9965.EPI-10-0243, ISSN: 1538-7755.

Wheless L, Ruczinski I, Alani RM, Clipp S, Hoffman-Bolton J, Jorgensen TJ, LiƩgeois NJ, Strickland PT, Alberg AJ. The association between skin characteristics and skin cancer prevention behaviors. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2009 Oct; 18(10): 2613-9. PMID: 19755654, PMCID: PMC2759861, PII: 1055-9965.EPI-09-0383, DOI: 10.1158/1055-9965.EPI-09-0383, ISSN: 1538-7755.

Abdel-Wahab Z, Kalady MF, Emani S, Onaitis MW, Abdel-Wahab OI, Cisco R, Wheless L, Cheng TY, Tyler DS, Pruitt SK. Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution. Cell. Immunol. 2003 Aug; 224(2): 86-97. PMID: 14609574, PII: S0008874903001795, ISSN: 0008-8749.