William P. Nobis, Ph.D., M.D.


Faculty Appointments
Instructor in Neurology
M.D., Vanderbilt University, Nashville, TennesseePh.D., Neuroscience, Vanderbilt University, Nashville, TennesseeB.S., Biochemistry, Michigan State University, East Lansing, Michigan
Office Address
465 21ST AVE S
Nashville, TN 37232
Research Keywords
Epilepsy, SUDEP, apnea, seizure induced apnea, brainstem, amygdala, extended amygdala, electrophysiology, optogenetics, chemogenetics, dravet syndrome
Nobis WP, Schuele S, Templer JW, Zhou G, Lane G, Rosenow JM, Zelano C. Amygdala-stimulation-induced apnea is attention and nasal-breathing dependent. Ann. Neurol [print-electronic]. 2018 Mar; 83(3): 460-71. PMID: 29420859, PMCID: PMC5867259, DOI: 10.1002/ana.25178, ISSN: 1531-8249.

Hedrick TP, Nobis WP, Foote KM, Ishii T, Chetkovich DM, Swanson GT. Excitatory Synaptic Input to Hilar Mossy Cells under Basal and Hyperexcitable Conditions. ENeuro. 2017 Nov; 4(6): PMID: 29214210, PMCID: PMC5714709, PII: eN-NWR-0364-17, DOI: 10.1523/ENEURO.0364-17.2017, ISSN: 2373-2822.

Nobis WP, Kash TL, Silberman Y, Winder DG. ß-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism. Biol. Psychiatry [print-electronic]. 2011 Jun 6/1/2011; 69(11): 1083-90. PMID: 21334600, PMCID: PMC3090515, PII: S0006-3223(10)01362-4, DOI: 10.1016/j.biopsych.2010.12.030, ISSN: 1873-2402.

McElligott ZA, Klug JR, Nobis WP, Patel S, Grueter BA, Kash TL, Winder DG. Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Feb 2/2/2010; 107(5): 2271-6. PMID: 20133871, PMCID: PMC2836642, PII: 0905568107, DOI: 10.1073/pnas.0905568107, ISSN: 1091-6490.

Kash TL, Nobis WP, Matthews RT, Winder DG. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. J. Neurosci. 2008 Dec 12/17/2008; 28(51): 13856-65. PMID: 19091975, PMCID: PMC2630395, PII: 28/51/13856, DOI: 10.1523/JNEUROSCI.4715-08.2008, ISSN: 1529-2401.

Coussens PM, Coussens MJ, Tooker BC, Nobis W. Structure of the bovine natural resistance associated macrophage protein (NRAMP 1) gene and identification of a novel polymorphism. DNA Seq. 2004 Feb; 15(1): 15-25. PMID: 15354350, ISSN: 1042-5179.

Nobis W, Ren X, Suchyta SP, Suchyta TR, Zanella AJ, Coussens PM. Development of a porcine brain cDNA library, EST database, and microarray resource. Physiol. Genomics. 2003 Dec 12/16/2003; 16(1): 153-9. PMID: 14559975, PII: 00099.2003, DOI: 10.1152/physiolgenomics.00099.2003, ISSN: 1531-2267.

Coussens PM, Nobis W. Bioinformatics and high throughput approach to create genomic resources for the study of bovine immunobiology. Vet. Immunol. Immunopathol. 2002 Jul; 86(3-4): 229-44. PMID: 12007889, PII: S0165242702000053, ISSN: 0165-2427.