Mariana Xavier Byndloss, D.V.M., Ph.D.

Assistant Professor

mariana.x.byndloss@vanderbilt.edu
Faculty Appointments
Assistant Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Veterinary Sciences, Universidade Federal de Minas Gerais , Belo Horizonte, BrazilM.V.Sc., Universidade Federal de Minas Gerais , Belo Horizonte, BrazilD.V.M., Universidade Federal de Minas Gerais , Belo Horizonte, Brazil
Office Address
U-2210 MCN
1161 21st Avenue South
Nashville, TN 37232
Research Description
In high-income countries, the leading causes of death are non-communicable diseases, such as Inflammatory Bowel Disease (IBD), cancer and cardiovascular disease. An important feature of most non-communicable diseases is inflammation-induced gut dysbiosis characterized by a shift in the microbial community structure from obligate to facultative anaerobes such as Proteobacteria. This microbial imbalance can contribute to disease pathogenesis due to either a microbiota-derived metabolite being depleted or produced at a harmful concentration. However, little is known about the mechanism by which inflammation mediates changes in the host physiology to induce disruption of the microbial ecosystem in our large intestine leading to disease.

Our group uses a multidisciplinary approach combining microbiology, molecular biology, cell biology, immunology and pathology to try to understand how inflammation-dependent changes in gut epithelial metabolism can result in gut dysbiosis and increased risk to non- communicable disease. Specifically, we used a variety of mouse models, including diet-induced-obesity, chemical-induced colitis, infectious gastroenteritis (Salmonella enterica serovar Typhiumurium), and germ-free animals with the goal to identify metabolic pathways in the gut bacteria and in the host response to microbiota-induced metabolites that will aid in prevention of human disease. The major questions in our lab include:

How high-fat diet induced gut dysbiosis can promote increased risk for cardiovascular disease?
What is the contribution of exposure to antibiotics during early age in changes in colonic epithelial metabolism, prolonged intestinal dysbiosis and increased risk of weight gain?
Can we target colonic epithelial metabolism as a way to prevent the bloom of colon cancer-associated Enterobacteriaceae?
Research Keywords
gut microbiota; inflammation; metabolism; inflammatory bowel disease; obesity; Enterobacteriaceae; Salmonella Typhimurium; bacterial pathogenesis; Host-pathogen interactions; colonic epithelium; colon cancer
Publications
Litvak Y, Byndloss MX, Bäumler AJ. Colonocyte metabolism shapes the gut microbiota. Science. 2018 Nov 11/30/2018; 362(6418): PMID: 30498100, PII: 362/6418/eaat9076, DOI: 10.1126/science.aat9076, ISSN: 1095-9203.

Byndloss MX, Pernitzsch SR, Bäumler AJ. Healthy hosts rule within: ecological forces shaping the gut microbiota. Mucosal Immunol [print-electronic]. 2018 May 5/9/2018; PMID: 29743614, PII: 10.1038/s41385-018-0010-y, DOI: 10.1038/s41385-018-0010-y, ISSN: 1935-3456.

Bronner DN, Faber F, Olsan EE, Byndloss MX, Sayed NA, Xu G, Yoo W, Kim D, Ryu S, Lebrilla CB, Bäumler AJ. Genetic Ablation of Butyrate Utilization Attenuates Gastrointestinal Salmonella Disease. Cell Host Microbe. 2018 Feb 2/14/2018; 23(2): 266-273.e4. PMID: 29447698, PII: S1931-3128(18)30039-8, DOI: 10.1016/j.chom.2018.01.004, ISSN: 1934-6069.

Byndloss MX, Bäumler AJ. The germ-organ theory of non-communicable diseases. Nat. Rev. Microbiol [print-electronic]. 2018 Feb; 16(2): 103-10. PMID: 29307890, PII: nrmicro.2017.158, DOI: 10.1038/nrmicro.2017.158, ISSN: 1740-1534.

Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE. Precision editing of the gut microbiota ameliorates colitis. Nature [print-electronic]. 2018 Jan 1/11/2018; 553(7687): 208-11. PMID: 29323293, PMCID: PMC5804340, PII: nature25172, DOI: 10.1038/nature25172, ISSN: 1476-4687.

Litvak Y, Byndloss MX, Tsolis RM, Bäumler AJ. Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction. Curr. Opin. Microbiol [print-electronic]. 2017 Oct; 39: 1-6. PMID: 28783509, PII: S1369-5274(16)30220-X, DOI: 10.1016/j.mib.2017.07.003, ISSN: 1879-0364.

Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Bäumler AJ. Microbiota-activated PPAR-¿ signaling inhibits dysbiotic Enterobacteriaceae expansion. Science. 2017 Aug 8/11/2017; 357(6351): 570-5. PMID: 28798125, PMCID: PMC5642957, PII: 357/6351/570, DOI: 10.1126/science.aam9949, ISSN: 1095-9203.

Olsan EE, Byndloss MX, Faber F, Rivera-Chávez F, Tsolis RM, Bäumler AJ. Colonization resistance: The deconvolution of a complex trait. J. Biol. Chem [print-electronic]. 2017 May 5/26/2017; 292(21): 8577-81. PMID: 28389556, PMCID: PMC5448087, PII: R116.752295, DOI: 10.1074/jbc.R116.752295, ISSN: 1083-351X.

Byndloss MX, Rivera-Chávez F, Tsolis RM, Bäumler AJ. How bacterial pathogens use type III and type IV secretion systems to facilitate their transmission. Curr. Opin. Microbiol [print-electronic]. 2017 Feb; 35: 1-7. PMID: 27621139, PII: S1369-5274(16)30124-2, DOI: 10.1016/j.mib.2016.08.007, ISSN: 1879-0364.

Faber F, Thiennimitr P, Spiga L, Byndloss MX, Litvak Y, Lawhon S, Andrews-Polymenis HL, Winter SE, Bäumler AJ. Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis. PLoS Pathog. 2017 Jan; 13(1): e1006129. PMID: 28056091, PMCID: PMC5215881, PII: PPATHOGENS-D-16-01914, DOI: 10.1371/journal.ppat.1006129, ISSN: 1553-7374.

Costa LF, Mol JP, Silva AP, Macêdo AA, Silva TM, Alves GE, Winter S, Winter MG, Velazquez EM, Byndloss MX, Bäumler AJ, Tsolis RM, Paixão TA, Santos RL. Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium. Int. J. Med. Microbiol [print-electronic]. 2016 Dec; 306(8): 604-10. PMID: 27760693, PMCID: PMC5140723, PII: S1438-4221(16)30312-5, DOI: 10.1016/j.ijmm.2016.10.004, ISSN: 1618-0607.

Lopez CA, Miller BM, Rivera-Chávez F, Velazquez EM, Byndloss MX, Chávez-Arroyo A, Lokken KL, Tsolis RM, Winter SE, Bäumler AJ. Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration. Science [print-electronic]. 2016 Sep 9/16/2016; 353(6305): 1249-53. PMID: 27634526, PMCID: PMC5127919, PII: 353/6305/1249, DOI: 10.1126/science.aag3042, ISSN: 1095-9203.

Byndloss MX, Keestra-Gounder AM, Bäumler AJ, Tsolis RM. NOD1 and NOD2: New Functions Linking Endoplasmic Reticulum Stress and Inflammation. DNA Cell Biol [print-electronic]. 2016 Jul; 35(7): 311-3. PMID: 27341284, PMCID: PMC4939383, DOI: 10.1089/dna.2016.3396, ISSN: 1557-7430.

Faber F, Tran L, Byndloss MX, Lopez CA, Velazquez EM, Kerrinnes T, Nuccio SP, Wangdi T, Fiehn O, Tsolis RM, Bäumler AJ. Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature [print-electronic]. 2016 Jun 6/30/2016; 534(7609): 697-9. PMID: 27309805, PMCID: PMC4939260, PII: nature18597, DOI: 10.1038/nature18597, ISSN: 1476-4687.

Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Chávez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, Bäumler AJ, Tsolis RM. NOD1 and NOD2 signalling links ER stress with inflammation. Nature [print-electronic]. 2016 Apr 4/21/2016; 532(7599): 394-7. PMID: 27007849, PMCID: PMC4869892, PII: nature17631, DOI: 10.1038/nature17631, ISSN: 1476-4687.

Rivera-Chávez F, Zhang LF, Faber F, Lopez CA, Byndloss MX, Olsan EE, Xu G, Velazquez EM, Lebrilla CB, Winter SE, Bäumler AJ. Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella. Cell Host Microbe. 2016 Apr 4/13/2016; 19(4): 443-54. PMID: 27078066, PMCID: PMC4832419, PII: S1931-3128(16)30096-8, DOI: 10.1016/j.chom.2016.03.004, ISSN: 1934-6069.

Byndloss MX, Tsolis RM. Chronic Bacterial Pathogens: Mechanisms of Persistence. Microbiol Spectr. 2016 Apr; 4(2): PMID: 27227304, PMCID: PMC4888878, DOI: 10.1128/microbiolspec.VMBF-0020-2015, ISSN: 2165-0497.

Singletary LA, Karlinsey JE, Libby SJ, Mooney JP, Lokken KL, Tsolis RM, Byndloss MX, Hirao LA, Gaulke CA, Crawford RW, Dandekar S, Kingsley RA, Msefula CL, Heyderman RS, Fang FC. Loss of Multicellular Behavior in Epidemic African Nontyphoidal Salmonella enterica Serovar Typhimurium ST313 Strain D23580. MBio. 2016 Mar 3/1/2016; 7(2): e02265. PMID: 26933058, PMCID: PMC4810497, PII: mBio.02265-15, DOI: 10.1128/mBio.02265-15, ISSN: 2150-7511.

Byndloss MX, Tsolis RM. Brucella spp. Virulence Factors and Immunity. Annu Rev Anim Biosci [print-electronic]. 2016; 4: 111-27. PMID: 26734887, DOI: 10.1146/annurev-animal-021815-111326, ISSN: 2165-8110.

Mooney JP, Lokken KL, Byndloss MX, George MD, Velazquez EM, Faber F, Butler BP, Walker GT, Ali MM, Potts R, Tiffany C, Ahmer BM, Luckhart S, Tsolis RM. Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection. Sci Rep. 2015 Oct 10/5/2015; 5: 14603. PMID: 26434367, PMCID: PMC4592952, PII: srep14603, DOI: 10.1038/srep14603, ISSN: 2045-2322.

Lopez CA, Rivera-Chávez F, Byndloss MX, Bäumler AJ. The Periplasmic Nitrate Reductase NapABC Supports Luminal Growth of Salmonella enterica Serovar Typhimurium during Colitis. Infect. Immun [print-electronic]. 2015 Sep; 83(9): 3470-8. PMID: 26099579, PMCID: PMC4534643, PII: IAI.00351-15, DOI: 10.1128/IAI.00351-15, ISSN: 1098-5522.

Mooney JP, Butler BP, Lokken KL, Xavier MN, Chau JY, Schaltenberg N, Dandekar S, George MD, Santos RL, Luckhart S, Tsolis RM. The mucosal inflammatory response to non-typhoidal Salmonella in the intestine is blunted by IL-10 during concurrent malaria parasite infection. Mucosal Immunol [print-electronic]. 2014 Nov; 7(6): 1302-11. PMID: 24670425, PMCID: PMC4177018, PII: mi201418, DOI: 10.1038/mi.2014.18, ISSN: 1935-3456.

Lokken KL, Mooney JP, Butler BP, Xavier MN, Chau JY, Schaltenberg N, Begum RH, Müller W, Luckhart S, Tsolis RM. Malaria parasite infection compromises control of concurrent systemic non-typhoidal Salmonella infection via IL-10-mediated alteration of myeloid cell function. PLoS Pathog. 2014 May; 10(5): e1004049. PMID: 24787713, PMCID: PMC4006898, PII: PPATHOGENS-D-13-02297, DOI: 10.1371/journal.ppat.1004049, ISSN: 1553-7374.

Spees AM, Kingsbury DD, Wangdi T, Xavier MN, Tsolis RM, Bäumler AJ. Neutrophils are a source of gamma interferon during acute Salmonella enterica serovar Typhimurium colitis. Infect. Immun [print-electronic]. 2014 Apr; 82(4): 1692-7. PMID: 24421037, PMCID: PMC3993401, PII: IAI.01508-13, DOI: 10.1128/IAI.01508-13, ISSN: 1098-5522.

Silva TM, Mol JP, Winter MG, Atluri V, Xavier MN, Pires SF, Paixão TA, Andrade HM, Santos RL, Tsolis RM. The predicted ABC transporter AbcEDCBA is required for type IV secretion system expression and lysosomal evasion by Brucella ovis. PLoS ONE. 2014; 9(12): e114532. PMID: 25474545, PMCID: PMC4256435, PII: PONE-D-14-28265, DOI: 10.1371/journal.pone.0114532, ISSN: 1932-6203.

Xavier MN, Winter MG, Spees AM, den Hartigh AB, Nguyen K, Roux CM, Silva TM, Atluri VL, Kerrinnes T, Keestra AM, Monack DM, Luciw PA, Eigenheer RA, Bäumler AJ, Santos RL, Tsolis RM. PPAR¿-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages. Cell Host Microbe. 2013 Aug 8/14/2013; 14(2): 159-70. PMID: 23954155, PMCID: PMC3777723, PII: S1931-3128(13)00257-6, DOI: 10.1016/j.chom.2013.07.009, ISSN: 1934-6069.

Crawford RW, Wangdi T, Spees AM, Xavier MN, Tsolis RM, Bäumler AJ. Loss of very-long O-antigen chains optimizes capsule-mediated immune evasion by Salmonella enterica serovar Typhi. MBio. 2013 Jul 7/16/2013; 4(4): PMID: 23860765, PMCID: PMC3735119, PII: mBio.00232-13, DOI: 10.1128/mBio.00232-13, ISSN: 2150-7511.

Spees AM, Wangdi T, Lopez CA, Kingsbury DD, Xavier MN, Winter SE, Tsolis RM, Bäumler AJ. Streptomycin-induced inflammation enhances Escherichia coli gut colonization through nitrate respiration. MBio. 2013 Jul 7/2/2013; 4(4): PMID: 23820397, PMCID: PMC3705454, PII: mBio.00430-13, DOI: 10.1128/mBio.00430-13, ISSN: 2150-7511.

Terwagne M, Ferooz J, Rolán HG, Sun YH, Atluri V, Xavier MN, Franchi L, Núñez G, Legrand T, Flavell RA, De Bolle X, Letesson JJ, Tsolis RM. Innate immune recognition of flagellin limits systemic persistence of Brucella. Cell. Microbiol [print-electronic]. 2013 Jun; 15(6): 942-60. PMID: 23227931, PMCID: PMC4026035, DOI: 10.1111/cmi.12088, ISSN: 1462-5822.

Keestra AM, Winter MG, Auburger JJ, Frässle SP, Xavier MN, Winter SE, Kim A, Poon V, Ravesloot MM, Waldenmaier JF, Tsolis RM, Eigenheer RA, Bäumler AJ. Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1. Nature [print-electronic]. 2013 Apr 4/11/2013; 496(7444): 233-7. PMID: 23542589, PMCID: PMC3625479, PII: nature12025, DOI: 10.1038/nature12025, ISSN: 1476-4687.

Moustacas VS, Silva TM, Costa LF, Xavier MN, Carvalho CA, Costa ÉA, Paixão TA, Santos RL. Species-specific multiplex PCR for the diagnosis of Brucella ovis, Actinobacillus seminis, and Histophilus somni infection in rams. BMC Vet. Res. 2013 Mar 3/21/2013; 9: 51. PMID: 23514236, PMCID: PMC3614447, PII: 1746-6148-9-51, DOI: 10.1186/1746-6148-9-51, ISSN: 1746-6148.

Winter SE, Winter MG, Xavier MN, Thiennimitr P, Poon V, Keestra AM, Laughlin RC, Gomez G, Wu J, Lawhon SD, Popova IE, Parikh SJ, Adams LG, Tsolis RM, Stewart VJ, Bäumler AJ. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science. 2013 Feb 2/8/2013; 339(6120): 708-11. PMID: 23393266, PMCID: PMC4004111, PII: 339/6120/708, DOI: 10.1126/science.1232467, ISSN: 1095-9203.

Xavier MN, Winter MG, Spees AM, Nguyen K, Atluri VL, Silva TM, Bäumler AJ, Müller W, Santos RL, Tsolis RM. CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function. PLoS Pathog [print-electronic]. 2013; 9(6): e1003454. PMID: 23818855, PMCID: PMC3688575, PII: PPATHOGENS-D-13-00074, DOI: 10.1371/journal.ppat.1003454, ISSN: 1553-7374.

Rivera-Chávez F, Winter SE, Lopez CA, Xavier MN, Winter MG, Nuccio SP, Russell JM, Laughlin RC, Lawhon SD, Sterzenbach T, Bevins CL, Tsolis RM, Harshey R, Adams LG, Bäumler AJ. Salmonella uses energy taxis to benefit from intestinal inflammation. PLoS Pathog [print-electronic]. 2013; 9(4): e1003267. PMID: 23637594, PMCID: PMC3630101, PII: PPATHOGENS-D-12-02005, DOI: 10.1371/journal.ppat.1003267, ISSN: 1553-7374.

Crawford RW, Keestra AM, Winter SE, Xavier MN, Tsolis RM, Tolstikov V, Bäumler AJ. Very long O-antigen chains enhance fitness during Salmonella-induced colitis by increasing bile resistance. PLoS Pathog [print-electronic]. 2012 Sep; 8(9): e1002918. PMID: 23028318, PMCID: PMC3447750, PII: PPATHOGENS-D-12-00920, DOI: 10.1371/journal.ppat.1002918, ISSN: 1553-7374.

Lopez CA, Winter SE, Rivera-Chávez F, Xavier MN, Poon V, Nuccio SP, Tsolis RM, Bäumler AJ. Phage-mediated acquisition of a type III secreted effector protein boosts growth of salmonella by nitrate respiration. MBio [electronic-print]. 2012; 3(3): PMID: 22691391, PMCID: PMC3374392, PII: mBio.00143-12, DOI: 10.1128/mBio.00143-12, ISSN: 2150-7511.

Thiennimitr P, Winter SE, Winter MG, Xavier MN, Tolstikov V, Huseby DL, Sterzenbach T, Tsolis RM, Roth JR, Bäumler AJ. Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Oct 10/18/2011; 108(42): 17480-5. PMID: 21969563, PMCID: PMC3198331, PII: 1107857108, DOI: 10.1073/pnas.1107857108, ISSN: 1091-6490.

Santos RL, Almeida AP, Xavier MN, Paixão TA, Wilson RP, Dandekar S, Raffatellu M, Bäumler AJ. Enteric pathology and Salmonella-induced cell death in healthy and SIV-infected rhesus macaques. Vet. Pathol [print-electronic]. 2011 Sep; 48(5): 933-41. PMID: 21041540, PII: 0300985810386468, DOI: 10.1177/0300985810386468, ISSN: 1544-2217.

Keestra AM, Godinez I, Xavier MN, Winter MG, Winter SE, Tsolis RM, Bäumler AJ. Early MyD88-dependent induction of interleukin-17A expression during Salmonella colitis. Infect. Immun [print-electronic]. 2011 Aug; 79(8): 3131-40. PMID: 21576324, PMCID: PMC3147556, PII: IAI.00018-11, DOI: 10.1128/IAI.00018-11, ISSN: 1098-5522.

Tsolis RM, Xavier MN, Santos RL, Bäumler AJ. How to become a top model: impact of animal experimentation on human Salmonella disease research. Infect. Immun [print-electronic]. 2011 May; 79(5): 1806-14. PMID: 21343352, PMCID: PMC3088149, PII: IAI.01369-10, DOI: 10.1128/IAI.01369-10, ISSN: 1098-5522.

Silva TM, Paixão TA, Costa EA, Xavier MN, Sá JC, Moustacas VS, den Hartigh AB, Carvalho Neta AV, Oliveira SC, Tsolis R, Santos RL. Putative ATP-binding cassette transporter is essential for Brucella ovis pathogenesis in mice. Infect. Immun [print-electronic]. 2011 Apr; 79(4): 1706-17. PMID: 21300772, PMCID: PMC3067543, PII: IAI.01109-10, DOI: 10.1128/IAI.01109-10, ISSN: 1098-5522.

Keestra AM, Winter MG, Klein-Douwel D, Xavier MN, Winter SE, Kim A, Tsolis RM, Bäumler AJ. A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. MBio [electronic-print]. 2011; 2(6): PMID: 22186610, PMCID: PMC3238304, PII: mBio.00266-11, DOI: 10.1128/mBio.00266-11, ISSN: 2150-7511.

Atluri VL, Xavier MN, de Jong MF, den Hartigh AB, Tsolis RM. Interactions of the human pathogenic Brucella species with their hosts. Annu. Rev. Microbiol. 2011; 65: 523-41. PMID: 21939378, DOI: 10.1146/annurev-micro-090110-102905, ISSN: 1545-3251.

Moustacas VS, Xavier MN, Carvalho-Júnior CA, Costa EA, Henry M, Santos RL. Effect of extender supplementation with various antimicrobial agents on viability of Brucella ovis and Actinobacillus seminis in cryopreserved ovine semen. Theriogenology [print-electronic]. 2010 Nov; 74(8): 1476-81. PMID: 20708246, PII: S0093-691X(10)00337-7, DOI: 10.1016/j.theriogenology.2010.06.019, ISSN: 1879-3231.

Xavier MN, Silva TM, Costa EA, Paixão TA, Moustacas VS, Carvalho CA, Sant'Anna FM, Robles CA, Gouveia AM, Lage AP, Tsolis RM, Santos RL. Development and evaluation of a species-specific PCR assay for the detection of Brucella ovis infection in rams. Vet. Microbiol [print-electronic]. 2010 Sep 9/28/2010; 145(1-2): 158-64. PMID: 20347534, PII: S0378-1135(10)00132-X, DOI: 10.1016/j.vetmic.2010.02.037, ISSN: 1873-2542.

Carvalho Neta AV, Mol JP, Xavier MN, Paixão TA, Lage AP, Santos RL. Pathogenesis of bovine brucellosis. Vet. J [print-electronic]. 2010 May; 184(2): 146-55. PMID: 19733101, PII: S1090-0233(09)00151-8, DOI: 10.1016/j.tvjl.2009.04.010, ISSN: 1532-2971.

Malta MC, Tinoco HP, Xavier MN, Vieira AL, Costa EA, Santos RL. Naturally acquired visceral leishmaniasis in non-human primates in Brazil. Vet. Parasitol [print-electronic]. 2010 Apr 4/19/2010; 169(1-2): 193-7. PMID: 20056328, PII: S0304-4017(09)00739-0, DOI: 10.1016/j.vetpar.2009.12.016, ISSN: 1873-2550.

Rolán HG, Xavier MN, Santos RL, Tsolis RM. Natural antibody contributes to host defense against an attenuated Brucella abortus virB mutant. Infect. Immun [print-electronic]. 2009 Jul; 77(7): 3004-13. PMID: 19364836, PMCID: PMC2708545, PII: IAI.01114-08, DOI: 10.1128/IAI.01114-08, ISSN: 1098-5522.

Silva FL, Oliveira RG, Silva TM, Xavier MN, Nascimento EF, Santos RL. Venereal transmission of canine visceral leishmaniasis. Vet. Parasitol [print-electronic]. 2009 Mar 3/9/2009; 160(1-2): 55-9. PMID: 19046812, PII: S0304-4017(08)00603-1, DOI: 10.1016/j.vetpar.2008.10.079, ISSN: 0304-4017.

Bueno R, Carvalho Neta AV, Xavier MN, Oliveira RG, Diniz SA, Melo MN, Santos RL. CDNA sequencing and expression of Nramp1 (Slc11a1) in dogs phenotypically resistant or susceptible to visceral leishmaniasis. Vet. Immunol. Immunopathol [print-electronic]. 2009 Feb 2/15/2009; 127(3-4): 332-9. PMID: 19084282, PII: S0165-2427(08)00722-8, DOI: 10.1016/j.vetimm.2008.10.335, ISSN: 0165-2427.

Xavier MN, Paixão TA, Poester FP, Lage AP, Santos RL. Pathological, immunohistochemical and bacteriological study of tissues and milk of cows and fetuses experimentally infected with Brucella abortus. J. Comp. Pathol [print-electronic]. 2009 Feb; 140(2-3): 149-57. PMID: 19111839, PII: S0021-9975(08)00141-2, DOI: 10.1016/j.jcpa.2008.10.004, ISSN: 1532-3129.

Silva FL, Rodrigues AA, Rego IO, Santos RL, Oliveira RG, Silva TM, Xavier MN, Nascimento EF, Santos RL. Genital lesions and distribution of amastigotes in bitches naturally infected with Leishmania chagasi. Vet. Parasitol [print-electronic]. 2008 Jan 1/25/2008; 151(1): 86-90. PMID: 18006233, PII: S0304-4017(07)00528-6, DOI: 10.1016/j.vetpar.2007.09.032, ISSN: 0304-4017.