Amanda C. Doran, Ph.D., M.D.

Assistant Professor

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Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Molecular Physiology & Biophysics
M.D., University of Virginia, Charlottesville, VirginiaPh.D., Molecular Physiology and Biophysics, University of Virginia, Charlottesville, VirginiaM.S., Biological Sciences, University of Virginia, Charlottesville, VirginiaB.A., Biological Chemistry, Wellesley College, Wellesley, Massachusetts
Research Description
Our lab is interested in the immunologic and molecular mechanisms underlying atherosclerotic and cardiometabolic disease. In particular, we are interested in the reasons why the chronic inflammation underlying these diseases fails to resolve.
Clinical Description
Dr. Doran is part of the Vanderbilt Lipid Clinic in the Division of Cardiovascular Medicine.
Research Keywords
atherosclerosis, inflammation resolution, immunology, immunity, macrophage, lymphocyte, monocyte
Clinical Research Keywords
cholesterol, lipids, familial hypercholesterolemia, statin intolerance
Doran AC, Yurdagul A, Tabas I. Efferocytosis in health and disease. Nat. Rev. Immunol [print-electronic]. 2019 Dec 12/10/2019; PMID: 31822793, PII: 10.1038/s41577-019-0240-6, DOI: 10.1038/s41577-019-0240-6, ISSN: 1474-1741.

Liu T, Xiang A, Peng T, Doran AC, Tracey KJ, Barnes BJ, Tabas I, Son M, Diamond B. HMGB1-C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2019 Nov 11/12/2019; 116(46): 23254-63. PMID: 31570601, PII: 1907490116, DOI: 10.1073/pnas.1907490116, ISSN: 1091-6490.

Thomas DG, Doran AC, Fotakis P, Westerterp M, Antonson P, Jiang H, Jiang XC, Gustafsson JÅ, Tabas I, Tall AR. LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux. Cell Rep. 2018 Dec 12/26/2018; 25(13): 3774-3785.e4. PMID: 30590048, PMCID: PMC6446575, PII: S2211-1247(18)31906-5, DOI: 10.1016/j.celrep.2018.11.100, ISSN: 2211-1247.

Moore KJ, Koplev S, Fisher EA, Tabas I, Björkegren JLM, Doran AC, Kovacic JC. Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2). J. Am. Coll. Cardiol. 2018 Oct 10/30/2018; 72(18): 2181-97. PMID: 30360827, PMCID: PMC6522246, PII: S0735-1097(18)38295-0, DOI: 10.1016/j.jacc.2018.08.2147, ISSN: 1558-3597.

Proto JD, Doran AC, Gusarova G, Yurdagul A, Sozen E, Subramanian M, Islam MN, Rymond CC, Du J, Hook J, Kuriakose G, Bhattacharya J, Tabas I. Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity [print-electronic]. 2018 Oct 10/16/2018; 49(4): 666-677.e6. PMID: 30291029, PMCID: PMC6192849, PII: S1074-7613(18)30335-2, DOI: 10.1016/j.immuni.2018.07.015, ISSN: 1097-4180.

Cai B, Kasikara C, Doran AC, Ramakrishnan R, Birge RB, Tabas I. MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity. Sci Signal. 2018 Sep 9/25/2018; 11(549): PMID: 30254055, PMCID: PMC6171110, PII: 11/549/eaar3721, DOI: 10.1126/scisignal.aar3721, ISSN: 1937-9145.

Kasikara C, Doran AC, Cai B, Tabas I. The role of non-resolving inflammation in atherosclerosis. J. Clin. Invest [print-electronic]. 2018 Jul 7/2/2018; 128(7): 2713-23. PMID: 30108191, PMCID: PMC6025992, PII: 97950, DOI: 10.1172/JCI97950, ISSN: 1558-8238.

Proto JD, Doran AC, Subramanian M, Wang H, Zhang M, Sozen E, Rymond CC, Kuriakose G, D'Agati V, Winchester R, Sykes M, Yang YG, Tabas I. Hypercholesterolemia induces T cell expansion in humanized immune mice. J. Clin. Invest [print-electronic]. 2018 Jun 6/1/2018; 128(6): 2370-5. PMID: 29708512, PMCID: PMC5983331, PII: 97785, DOI: 10.1172/JCI97785, ISSN: 1558-8238.

Doran AC, Ozcan L, Cai B, Zheng Z, Fredman G, Rymond CC, Dorweiler B, Sluimer JC, Hsieh J, Kuriakose G, Tall AR, Tabas I. CAMKII¿ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis. J. Clin. Invest [print-electronic]. 2017 Nov 11/1/2017; 127(11): 4075-89. PMID: 28972541, PMCID: PMC5663361, PII: 94735, DOI: 10.1172/JCI94735, ISSN: 1558-8238.

Cai B, Thorp EB, Doran AC, Sansbury BE, Daemen MJ, Dorweiler B, Spite M, Fredman G, Tabas I. MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis. J. Clin. Invest [print-electronic]. 2017 Feb 2/1/2017; 127(2): 564-8. PMID: 28067670, PMCID: PMC5272169, PII: 90520, DOI: 10.1172/JCI90520, ISSN: 1558-8238.

Yurdagul A, Doran AC, Cai B, Fredman G, Tabas IA. Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis. Front Cardiovasc Med. 2017; 4: 86. PMID: 29379788, PMCID: PMC5770804, DOI: 10.3389/fcvm.2017.00086, ISSN: 2297-055X.

Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G, Tabas I. MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2016 Jun 6/7/2016; 113(23): 6526-31. PMID: 27199481, PMCID: PMC4988577, PII: 1524292113, DOI: 10.1073/pnas.1524292113, ISSN: 1091-6490.

Colombo PC, Doran AC, Onat D, Wong KY, Ahmad M, Sabbah HN, Demmer RT. Venous congestion, endothelial and neurohormonal activation in acute decompensated heart failure: cause or effect?. Curr Heart Fail Rep. 2015 Jun; 12(3): 215-22. PMID: 25740404, PMCID: PMC4426008, DOI: 10.1007/s11897-015-0254-8, ISSN: 1546-9549.

Lipinski MJ, Campbell KA, Duong SQ, Welch TJ, Garmey JC, Doran AC, Skaflen MD, Oldham SN, Kelly KA, McNamara CA. Loss of Id3 increases VCAM-1 expression, macrophage accumulation, and atherogenesis in Ldlr-/- mice. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2012 Dec; 32(12): 2855-61. PMID: 23042815, PMCID: PMC3509414, PII: ATVBAHA.112.300352, DOI: 10.1161/ATVBAHA.112.300352, ISSN: 1524-4636.

Campbell KA, Lipinski MJ, Doran AC, Skaflen MD, Fuster V, McNamara CA. Lymphocytes and the adventitial immune response in atherosclerosis. Circ. Res. 2012 Mar 3/16/2012; 110(6): 889-900. PMID: 22427326, PMCID: PMC3373006, PII: 110/6/889, DOI: 10.1161/CIRCRESAHA.111.263186, ISSN: 1524-4571.

Cutchins A, Harmon DB, Kirby JL, Doran AC, Oldham SN, Skaflen M, Klibanov AL, Meller N, Keller SR, Garmey J, McNamara CA. Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2012 Feb; 32(2): 317-24. PMID: 22075252, PMCID: PMC3262109, PII: ATVBAHA.111.234856, DOI: 10.1161/ATVBAHA.111.234856, ISSN: 1524-4636.

Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, McNamara CA. B-cell aortic homing and atheroprotection depend on Id3. Circ. Res [print-electronic]. 2012 Jan 1/6/2012; 110(1): e1-12. PMID: 22034493, PMCID: PMC3253259, PII: CIRCRESAHA.111.256438, DOI: 10.1161/CIRCRESAHA.111.256438, ISSN: 1524-4571.

Bagavant H, Scindia Y, Nackiewicz D, Nandula SR, Doran A, Cutchins A, Oldham S, Deshmukh U, McNamara C. Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease. Am. J. Pathol [print-electronic]. 2011 Aug; 179(2): 651-60. PMID: 21801865, PMCID: PMC3157169, PII: S0002-9440(11)00437-8, DOI: 10.1016/j.ajpath.2011.04.029, ISSN: 1525-2191.

Lipinski MJ, Perry HM, Doran AC, Oldham SN, McNamara CA. Comment on "Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis" [letter]. J. Immunol. 2011 Jan 1/1/2011; 186(1): 4; author reply 6. PMID: 21172871, PII: 186/1/4, DOI: 10.4049/jimmunol.1090119, ISSN: 1550-6606.

Deliri H, Meller N, Kadakkal A, Malhotra R, Brewster J, Doran AC, Pei H, Oldham SN, Skaflen MD, Garmey JC, McNamara CA. Increased 12/15-lipoxygenase enhances cell growth, fibronectin deposition, and neointimal formation in response to carotid injury. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2011 Jan; 31(1): 110-6. PMID: 20947825, PII: ATVBAHA.110.212068, DOI: 10.1161/ATVBAHA.110.212068, ISSN: 1524-4636.

Kadl A, Meher AK, Sharma PR, Lee MY, Doran AC, Johnstone SR, Elliott MR, Gruber F, Han J, Chen W, Kensler T, Ravichandran KS, Isakson BE, Wamhoff BR, Leitinger N. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ. Res [print-electronic]. 2010 Sep 9/17/2010; 107(6): 737-46. PMID: 20651288, PMCID: PMC2941538, PII: CIRCRESAHA.109.215715, DOI: 10.1161/CIRCRESAHA.109.215715, ISSN: 1524-4571.

Doran AC, Lehtinen AB, Meller N, Lipinski MJ, Slayton RP, Oldham SN, Skaflen MD, Yeboah J, Rich SS, Bowden DW, McNamara CA. Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans. Circ. Res [print-electronic]. 2010 Apr 4/16/2010; 106(7): 1303-11. PMID: 20185798, PMCID: PMC2860382, PII: CIRCRESAHA.109.210294, DOI: 10.1161/CIRCRESAHA.109.210294, ISSN: 1524-4571.

Doran AC, Meller N, Cutchins A, Deliri H, Slayton RP, Oldham SN, Kim JB, Keller SR, McNamara CA. The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin. Circ. Res [print-electronic]. 2008 Sep 9/12/2008; 103(6): 624-34. PMID: 18669923, PMCID: PMC2746666, PII: CIRCRESAHA.108.175893, DOI: 10.1161/CIRCRESAHA.108.175893, ISSN: 1524-4571.

Doran AC, Meller N, McNamara CA. Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2008 May; 28(5): 812-9. PMID: 18276911, PMCID: PMC2734458, PII: ATVBAHA.107.159327, DOI: 10.1161/ATVBAHA.107.159327, ISSN: 1524-4636.

Doran AC, Wan YP, Kopin AS, Beinborn M. Established theory of radiation-induced decay is not generalizable to Bolton-Hunter labeled peptides. Biochem. Pharmacol. 2003 May 5/1/2003; 65(9): 1515-20. PMID: 12732364, PII: S0006295203001035, ISSN: 0006-2952.